(Q44243172)

English

Preclinical factors influencing the relative contributions of Phase I and II enzymes to the metabolism of the experimental anti-cancer drug 5,6-dimethylxanthenone-4-acetic acid

scientific article published in January 2003

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scholarly article

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Europe PubMed Central

PubMed publication ID

1 December 2017

Preclinical factors influencing the relative contributions of Phase I and II enzymes to the metabolism of the experimental anti-cancer drug 5,6-dimethylxanthenone-4-acetic acid (English)

1 reference

Europe PubMed Central

PubMed publication ID

1 December 2017

James W. Paxton

4

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Europe PubMed Central

PubMed publication ID

1 December 2017

author name string

Shufeng Zhou

1

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Europe PubMed Central

PubMed publication ID

1 December 2017

Philip Kestell

2

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Europe PubMed Central

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1 December 2017

Bruce C Baguley

3

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Europe PubMed Central

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1 December 2017

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publication date

1 January 2003

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1 December 2017

Biochemical Pharmacology

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1 December 2017

65

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Europe PubMed Central

PubMed publication ID

1 December 2017

1

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Europe PubMed Central

PubMed publication ID

1 December 2017

109-120

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Europe PubMed Central

PubMed publication ID

1 December 2017

Glucuronidation of drugs. A re-evaluation of the pharmacological significance of the conjugates and modulating factors

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The structure and function of the UDP-glucuronosyltransferase gene family

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Use of in vitro and in vivo data to estimate the likelihood of metabolic pharmacokinetic interactions

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Inhibition and induction of human cytochrome P450 (CYP) enzymes

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Pharmacokinetic-pharmacodynamic consequences and clinical relevance of cytochrome P450 3A4 inhibition

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Interindividual variability in inhibition and induction of cytochrome P450 enzymes

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Induction of tumour necrosis factor-alpha by single and repeated doses of the antitumour agent 5,6-dimethylxanthenone-4-acetic acid

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Identification and reactivity of the major metabolite (beta-1-glucuronide) of the anti-tumour agent 5,6-dimethylxanthenone-4-acetic acid (DMXAA) in humans

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Plasma disposition, metabolism and excretion of the experimental antitumour agent 5,6-dimethylxanthenone-4-acetic acid in the mouse, rat and rabbit

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Microsomal enzyme induction

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Potential antitumor agents. 58. Synthesis and structure-activity relationships of substituted xanthenone-4-acetic acids active against the colon 38 tumor in vivo

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Light-induced breakdown of flavone acetic acid and xanthenone analogues in solution

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Characterisation of theophylline metabolism in human liver microsomes

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Measurement of protein using bicinchoninic acid

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Determination of two major metabolites of the novel anti-tumour agent 5,6-dimethylxanthenone-4-acetic acid in hepatic microsomal incubations by high-performance liquid chromatography with fluorescence detection

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Selective inhibitors of cytochromes P450.

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Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

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Application of Akaike's information criterion (AIC) in the evaluation of linear pharmacokinetic equations.

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Modulation of the pharmacokinetics of the antitumour agent 5,6-dimethylxanthenone-4-acetic acid (DMXAA) in mice by thalidomide

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Properties of acyl glucuronides: implications for studies of the pharmacokinetics and metabolism of acidic drugs

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Acyl glucuronides revisited: is the glucuronidation process a toxification as well as a detoxification mechanism?

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Mechanisms for tamoxifen resistance in breast cancer: possible role of tamoxifen metabolism

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Nortriptyline E-10-hydroxylation in vitro is mediated by human CYP2D6 (high affinity) and CYP3A4 (low affinity): implications for interactions with enzyme-inducing drugs

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Genetic polymorphism of UDP-glucuronosyltransferase 2B7 (UGT2B7) at amino acid 268: ethnic diversity of alleles and potential clinical significance

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Identifiers

10.1016/S0006-2952(02)01425-9

1 reference

Europe PubMed Central

PubMed publication ID

1 December 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

1 December 2017

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