(Q44522486)

English

Insulin-like growth factor-I inhibits transcriptional responses of transforming growth factor-beta by phosphatidylinositol 3-kinase/Akt-dependent suppression of the activation of Smad3 but not Smad2.

scientific article published on 21 July 2003

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scholarly article

1 reference

Europe PubMed Central

3 December 2017

Insulin-like growth factor-I inhibits transcriptional responses of transforming growth factor-beta by phosphatidylinositol 3-kinase/Akt-dependent suppression of the activation of Smad3 but not Smad2. (English)

1 reference

Europe PubMed Central

3 December 2017

1 reference

based on heuristic

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author name string

Kyung Song

1

1 reference

Europe PubMed Central

3 December 2017

Susan C Cornelius

2

1 reference

Europe PubMed Central

3 December 2017

Michael Reiss

3

1 reference

Europe PubMed Central

3 December 2017

David Danielpour

4

1 reference

Europe PubMed Central

3 December 2017

language of work or name

0 references

publication date

21 July 2003

1 reference

Europe PubMed Central

3 December 2017

Journal of Biological Chemistry

1 reference

Europe PubMed Central

3 December 2017

278

1 reference

Europe PubMed Central

3 December 2017

38342-38351

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Europe PubMed Central

3 December 2017

40

1 reference

Europe PubMed Central

3 December 2017

Receptors for the TGF-β family

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304583200

21 January 2018

Bcl-xL blocks transforming growth factor-beta 1-induced apoptosis by inhibiting cytochrome c release and not by directly antagonizing Apaf-1-dependent caspase activation in prostate epithelial cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304583200

21 January 2018

The role of transforming growth factor-beta1, -beta2, and -beta3 in androgen-responsive growth of NRP-152 rat prostatic epithelial cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304583200

21 January 2018

The androgen receptor represses transforming growth factor-beta signaling through interaction with Smad3.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304583200

21 January 2018

Regulation of trespin expression by modulators of cell growth, differentiation, and apoptosis in prostatic epithelial cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304583200

21 January 2018

Signaling via hetero-oligomeric complexes of type I and type II serine/threonine kinase receptors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304583200

21 January 2018

TbetaRI phosphorylation of Smad2 on Ser465 and Ser467 is required for Smad2-Smad4 complex formation and signaling

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304583200

21 January 2018

SARA, a FYVE domain protein that recruits Smad2 to the TGFbeta receptor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304583200

21 January 2018

Hgs (Hrs), a FYVE domain protein, is involved in Smad signaling through cooperation with SARA.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304583200

21 January 2018

The adaptor molecule Disabled-2 links the transforming growth factor beta receptors to the Smad pathway

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304583200

21 January 2018

Internalization-dependent and -independent requirements for transforming growth factor beta receptor signaling via the Smad pathway

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304583200

21 January 2018

Heteromeric and homomeric interactions correlate with signaling activity and functional cooperativity of Smad3 and Smad4/DPC4

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304583200

21 January 2018

Importin beta mediates nuclear translocation of Smad 3

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304583200

21 January 2018

Identification and functional characterization of a Smad binding element (SBE) in the JunB promoter that acts as a transforming growth factor-beta, activin, and bone morphogenetic protein-inducible enhancer.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304583200

21 January 2018

TGF-beta receptors and signalling mechanisms

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304583200

21 January 2018

Critical role of Smads and AP-1 complex in transforming growth factor-beta -dependent apoptosis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304583200

21 January 2018

The IGF-I receptor in cancer research

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304583200

21 January 2018

Insulin-like growth factor-I and binding protein-3 and risk of cancer

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304583200

21 January 2018

Deregulated expression of insulin-like growth factor 1 in prostate epithelium leads to neoplasia in transgenic mice

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304583200

21 January 2018

Akt suppresses androgen-induced apoptosis by phosphorylating and inhibiting androgen receptor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304583200

21 January 2018

Phosphorylation-dependent ubiquitylation and degradation of androgen receptor by Akt require Mdm2 E3 ligase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304583200

21 January 2018

The protein kinase B/Akt signalling pathway in human malignancy

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304583200

21 January 2018

Oncogenic kinase signalling

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304583200

21 January 2018

The phosphatidylinositol 3-Kinase AKT pathway in human cancer

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304583200

21 January 2018

PTEN/MMAC1/TEP1 in signal transduction and tumorigenesis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304583200

21 January 2018

Smads 2 and 3 are differentially activated by transforming growth factor-beta (TGF-beta ) in quiescent and activated hepatic stellate cells. Constitutive nuclear localization of Smads in activated cells is TGF-beta-independent.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304583200

21 January 2018

Mechanisms and consequences of activation of protein kinase B/Akt

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304583200

21 January 2018

Induction of transforming growth factor-beta autocrine activity by all-trans-retinoic acid and 1 alpha,25-dihydroxyvitamin D3 in NRP-152 rat prostatic epithelial cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304583200

21 January 2018

Structural Determinants of Phosphoinositide 3-Kinase Inhibition by Wortmannin, LY294002, Quercetin, Myricetin, and Staurosporine

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304583200

21 January 2018

Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304583200

21 January 2018

Isolation of a protein target of the FKBP12-rapamycin complex in mammalian cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304583200

21 January 2018

TOR mutations confer rapamycin resistance by preventing interaction with FKBP12-rapamycin.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304583200

21 January 2018

Insulin-like growth factor (IGF)-binding protein-3 induces apoptosis and mediates the effects of transforming growth factor-beta1 on programmed cell death through a p53- and IGF-independent mechanism

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304583200

21 January 2018

Mechanism of TGFbeta receptor inhibition by FKBP12

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304583200

21 January 2018

Rapamycin potentiates transforming growth factor beta-induced growth arrest in nontransformed, oncogene-transformed, and human cancer cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304583200

21 January 2018

Cellular function of p70S6K: a role in regulating cell motility

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304583200

21 January 2018

The modular phosphorylation and activation of p70s6k.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304583200

21 January 2018

TOR, a central controller of cell growth

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304583200

21 January 2018

TGF-beta inhibits p70 S6 kinase via protein phosphatase 2A to induce G(1) arrest

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304583200

21 January 2018

Physical and functional interactions between type I transforming growth factor beta receptors and Balpha, a WD-40 repeat subunit of phosphatase 2A.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304583200

21 January 2018

The rat prostatic epithelial cell line NRP-152 can differentiate in vivo in response to its stromal environment

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304583200

21 January 2018

Interaction between Smad anchor for receptor activation and Smad3 is not essential for TGF-beta/Smad3-mediated signaling.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304583200

21 January 2018

SARA and Hgs attenuate susceptibility to TGF-beta1-mediated T cell suppression.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304583200

21 January 2018

Phosphatidylinositol 3-kinase function is required for transforming growth factor beta-mediated epithelial to mesenchymal transition and cell migration.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304583200

21 January 2018

Transforming growth factor beta enhances epithelial cell survival via Akt-dependent regulation of FKHRL1

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304583200

21 January 2018

Identifiers

10.1074/JBC.M304583200

1 reference

Europe PubMed Central

3 December 2017

1 reference

Europe PubMed Central

3 December 2017

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