(Q44540468)

4 December 2017

title

Estrogens down-regulate p27Kip1 in breast cancer cells through Skp2 and through nuclear export mediated by the ERK pathway (English)

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4 December 2017

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James S Foster

1

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4 December 2017

Romaine I Fernando

2

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4 December 2017

Noriko Ishida

3

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4 December 2017

Keiichi I Nakayama

4

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4 December 2017

Jay Wimalasena

5

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4 December 2017

language of work or name

English

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publication date

6 August 2003

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Journal of Biological Chemistry

4 December 2017

published in

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4 December 2017

volume

278

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4 December 2017

issue

42

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4 December 2017

page(s)

41355-41366

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Estrogen Receptor Null Mice: What Have We Learned and Where Will They Lead Us?

4 December 2017

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Down-regulation of p21WAF1/CIP1 or p27Kip1 abrogates antiestrogen-mediated cell cycle arrest in human breast cancer cells

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A pure estrogen antagonist inhibits cyclin E-Cdk2 activity in MCF-7 breast cancer cells and induces accumulation of p130-E2F4 complexes characteristic of quiescence

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Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27

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Differential regulation of p27(Kip1) expression by mitogenic and hypertrophic factors: Involvement of transcriptional and posttranscriptional mechanisms

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Translational control of p27Kip1 accumulation during the cell cycle

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Repression of p27kip1 synthesis by platelet-derived growth factor in BALB/c 3T3 cells

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Down-regulation of p27(Kip1) by two mechanisms, ubiquitin-mediated degradation and proteolytic processing

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MAP kinase-dependent degradation of p27Kip1 by calpains in choroidal melanoma cells. Requirement of p27Kip1 nuclear export

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Removal of Cdk inhibitors through both sequestration and downregulation in zearalenone-treated MCF-7 breast cancer cells

21 January 2018

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p19Skp1 and p45Skp2 are essential elements of the cyclin A-CDK2 S phase kinase

21 January 2018

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SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27

21 January 2018

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p45SKP2 promotes p27Kip1 degradation and induces S phase in quiescent cells

21 January 2018

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p27(Kip1) ubiquitination and degradation is regulated by the SCF(Skp2) complex through phosphorylated Thr187 in p27

21 January 2018

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Degradation of p27(Kip1) at the G(0)-G(1) transition mediated by a Skp2-independent ubiquitination pathway

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Leptomycin B inhibition of signal-mediated nuclear export by direct binding to CRM1

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Involvement of Myc activity in a G(1)/S-promoting mechanism parallel to the pRb/E2F pathway

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Targeted disruption of Skp2 results in accumulation of cyclin E and p27(Kip1), polyploidy and centrosome overduplication

21 January 2018

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Phosphorylation at serine 10, a major phosphorylation site of p27(Kip1), increases its protein stability

21 January 2018

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Phosphorylation of p27Kip1 on serine 10 is required for its binding to CRM1 and nuclear export

21 January 2018

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Interleukin-8 regulation of the Ras/Raf/mitogen-activated protein kinase pathway in human neutrophils

21 January 2018

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Distinct requirements for Ras oncogenesis in human versus mouse cells

21 January 2018

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The SCF(HOS/beta-TRCP)-ROC1 E3 ubiquitin ligase utilizes two distinct domains within CUL1 for substrate targeting and ubiquitin ligation

21 January 2018

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CRM1/Ran-mediated nuclear export of p27(Kip1) involves a nuclear export signal and links p27 export and proteolysis

21 January 2018

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Effects of adenovirus-mediated p16INK4A expression on cell cycle arrest are determined by endogenous p16 and Rb status in human cancer cells

21 January 2018

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A recombinant adenovirus expressing p27Kip1 induces cell cycle arrest and loss of cyclin-Cdk activity in human breast cancer cells

21 January 2018

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Myc and Ras collaborate in inducing accumulation of active cyclin E/Cdk2 and E2F.

21 January 2018

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21 January 2018

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The cell-cycle regulatory protein Cks1 is required for SCF(Skp2)-mediated ubiquitinylation of p27

21 January 2018

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Interaction between ubiquitin-protein ligase SCFSKP2 and E2F-1 underlies the regulation of E2F-1 degradation

21 January 2018

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Phosphorylation-dependent degradation of the cyclin-dependent kinase inhibitor p27

21 January 2018

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Cyclin E-CDK2 is a regulator of p27Kip1.

21 January 2018

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Ubiquitination of p27 is regulated by Cdk-dependent phosphorylation and trimeric complex formation

21 January 2018

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Skp2 is oncogenic and overexpressed in human cancers

21 January 2018

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Role of the F-box protein Skp2 in lymphomagenesis

21 January 2018

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A mouse knock-in model exposes sequential proteolytic pathways that regulate p27Kip1 in G1 and S phase

21 January 2018

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p27 cytoplasmic localization is regulated by phosphorylation on Ser10 and is not a prerequisite for its proteolysis

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M302830200

Degradation of the cyclin-dependent-kinase inhibitor p27Kip1 is instigated by Jab1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302830200

The cytoplasmic shuttling and subsequent degradation of p27Kip1 mediated by Jab1/CSN5 and the COP9 signalosome complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302830200

Induction of p27Kip1 degradation and anchorage independence by Ras through the MAP kinase signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302830200

Oncogenic signals of HER-2/neu in regulating the stability of the cyclin-dependent kinase inhibitor p27.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302830200

The p42/p44 mitogen-activated protein kinase activation triggers p27Kip1 degradation independently of CDK2/cyclin E in NIH 3T3 cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302830200

Constitutive MEK/MAPK activation leads to p27(Kip1) deregulation and antiestrogen resistance in human breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302830200

Signal transduction through the Ras/Erk pathway is essential for the mycoestrogen zearalenone-induced cell-cycle progression in MCF-7 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302830200

Non-transcriptional action of oestradiol and progestin triggers DNA synthesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302830200

Bidirectional signaling between the estrogen receptor and the epidermal growth factor receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302830200

Increased proteasome-dependent degradation of the cyclin-dependent kinase inhibitor p27 in aggressive colorectal carcinomas.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302830200

A low abundance pool of nascent p21WAF1/Cip1 is targeted by estrogen to activate cyclin E*Cdk2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302830200

Formation and activation of a cyclin E-cdk2 complex during the G1 phase of the human cell cycle

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302830200

Direct binding of the signal-transducing adaptor Grb2 facilitates down-regulation of the cyclin-dependent kinase inhibitor p27Kip1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302830200

p27Kip1 Inhibition of GRB2-SOS Formation Can Regulate Ras Activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302830200

A growth factor-dependent nuclear kinase phosphorylates p27(Kip1) and regulates cell cycle progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302830200

Akt-dependent phosphorylation of p27Kip1 promotes binding to 14-3-3 and cytoplasmic localization

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302830200

Ras activity late in G1 phase required for p27kip1 downregulation, passage through the restriction point, and entry into S phase in growth factor-stimulated NIH 3T3 fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302830200

Deletion of the p27Kip1 gene restores normal development in cyclin D1-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302830200

Specific protection against breast cancers by cyclin D1 ablation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302830200

c-Myc or cyclin D1 mimics estrogen effects on cyclin E-Cdk2 activation and cell cycle reentry

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302830200

Mechanisms of cyclin-dependent kinase inactivation by progestins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302830200

Oncogenic role of the ubiquitin ligase subunit Skp2 in human breast cancer

21 January 2018

1 reference

30 December 2023

https://opencitations.net/index/api/v1/citations/10.1172/JCI0215795

Identifiers

DOI

10.1074/JBC.M302830200

1 reference

4 December 2017

1 reference