(Q44588569)

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Effects of ionic strength and sugars on the aggregation propensity of monoclonal antibodies: influence of colloidal and conformational stabilities

scientific article published on 15 January 2013

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

4 December 2017

Effects of ionic strength and sugars on the aggregation propensity of monoclonal antibodies: influence of colloidal and conformational stabilities (English)

1 reference

Europe PubMed Central

PubMed publication ID

4 December 2017

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Susumu Uchiyama

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Susumu Uchiyama

5

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author name string

Shuntaro Saito

1

1 reference

Europe PubMed Central

PubMed publication ID

4 December 2017

Jun Hasegawa

2

1 reference

Europe PubMed Central

PubMed publication ID

4 December 2017

Naoki Kobayashi

3

1 reference

Europe PubMed Central

PubMed publication ID

4 December 2017

Toshiaki Tomitsuka

4

1 reference

Europe PubMed Central

PubMed publication ID

4 December 2017

Kiichi Fukui

6

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Europe PubMed Central

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4 December 2017

publication date

15 January 2013

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Europe PubMed Central

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4 December 2017

Pharmaceutical Research

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Europe PubMed Central

PubMed publication ID

4 December 2017

30

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Europe PubMed Central

PubMed publication ID

4 December 2017

5

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Europe PubMed Central

PubMed publication ID

4 December 2017

1263-1280

1 reference

Europe PubMed Central

PubMed publication ID

4 December 2017

Effects of protein aggregates: an immunologic perspective

1 reference

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Protein aggregation: pathways, induction factors and analysis

1 reference

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21 January 2018

Physical stability of proteins in aqueous solution: mechanism and driving forces in nonnative protein aggregation

1 reference

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21 January 2018

Roles of conformational stability and colloidal stability in the aggregation of recombinant human granulocyte colony‐stimulating factor

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Nature and consequences of protein-protein interactions in high protein concentration solutions

1 reference

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21 January 2018

Distinct aggregation mechanisms of monoclonal antibody under thermal and freeze-thaw stresses revealed by hydrogen exchange

1 reference

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21 January 2018

A broad range of Fab stabilities within a host of therapeutic IgGs.

1 reference

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21 January 2018

Molecular origins of osmotic second virial coefficients of proteins

1 reference

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21 January 2018

Reversible self-association increases the viscosity of a concentrated monoclonal antibody in aqueous solution

1 reference

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21 January 2018

New methods for measuring macromolecular interactions in solution via static light scattering: basic methodology and application to nonassociating and self-associating proteins

1 reference

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Measurement of the second osmotic virial coefficient for protein solutions exhibiting monomer-dimer equilibrium

1 reference

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21 January 2018

Rapid measurement of protein osmotic second virial coefficients by self-interaction chromatography

1 reference

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A critical evaluation of self-interaction chromatography as a predictive tool for the assessment of protein-protein interactions in protein formulation development: a case study of a therapeutic monoclonal antibody

1 reference

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The influence of charge distribution on self-association and viscosity behavior of monoclonal antibody solutions

1 reference

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21 January 2018

Factors affecting the viscosity in high concentration solutions of different monoclonal antibodies.

1 reference

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Phase separation of an IgG1 antibody solution under a low ionic strength condition

1 reference

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Diffusion and Sedimentation Interaction Parameters for Measuring the Second Virial Coefficient and Their Utility as Predictors of Protein Aggregation

1 reference

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Characterization of globular protein solutions by dynamic light scattering, electrophoretic mobility, and viscosity measurements.

1 reference

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Understanding and modulating opalescence and viscosity in a monoclonal antibody formulation

1 reference

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Valence and anion binding of bovine ribonuclease A between pH 6 and 8.

1 reference

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The thermal stability of immunoglobulin: unfolding and aggregation of a multi-domain protein

1 reference

https://api.crossref.org/works/10.1007%2FS11095-012-0965-4

21 January 2018

Excipients differentially influence the conformational stability and pretransition dynamics of two IgG1 monoclonal antibodies.

1 reference

https://api.crossref.org/works/10.1007%2FS11095-012-0965-4

21 January 2018

Protein hydration, thermodynamic binding, and preferential hydration

1 reference

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21 January 2018

Establishing a link between amino acid sequences and self-associating and viscoelastic behavior of two closely related monoclonal antibodies

1 reference

https://api.crossref.org/works/10.1007%2FS11095-012-0965-4

21 January 2018

Strategies for the Assessment of Protein Aggregates in Pharmaceutical Biotech Product Development

1 reference

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21 January 2018

Why is trehalose an exceptional protein stabilizer? An analysis of the thermal stability of proteins in the presence of the compatible osmolyte trehalose

1 reference

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21 January 2018

Protein-protein and protein-salt interactions in aqueous protein solutions containing concentrated electrolytes.

1 reference

https://api.crossref.org/works/10.1007%2FS11095-012-0965-4

21 January 2018

Calculation of weak protein-protein interactions: the pH dependence of the second virial coefficient

1 reference

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21 January 2018

Impact of short range hydrophobic interactions and long range electrostatic forces on the aggregation kinetics of a monoclonal antibody and a dual-variable domain immunoglobulin at low and high concentrations.

1 reference

https://api.crossref.org/works/10.1007%2FS11095-012-0965-4

21 January 2018

Charge density-dependent strength of hydration and biological structure

1 reference

https://api.crossref.org/works/10.1007%2FS11095-012-0965-4

21 January 2018

On Interaction between Two Bodies Immersed in a Solution of Macromolecules

1 reference

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21 January 2018

Interaction between particles suspended in solutions of macromolecules

1 reference

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21 January 2018

Thermodynamic characterization of variants of mesophilic cytochrome c and its thermophilic counterpart

1 reference

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21 January 2018

Lysozyme-lysozyme self-interactions as assessed by the osmotic second virial coefficient: impact for physical protein stabilization.

1 reference

https://api.crossref.org/works/10.1007%2FS11095-012-0965-4

21 January 2018

Colloidal behavior of proteins: effects of the second virial coefficient on solubility, crystallization and aggregation of proteins in aqueous solution

1 reference

https://api.crossref.org/works/10.1007%2FS11095-012-0965-4

21 January 2018

Correlation of protein-protein interactions as assessed by affinity chromatography with colloidal protein stability: a case study with lysozyme

1 reference

https://api.crossref.org/works/10.1007%2FS11095-012-0965-4

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Cold denaturation of staphylococcal nuclease

1 reference

https://api.crossref.org/works/10.1007%2FS11095-012-0965-4

21 January 2018

Effect of mannitol crystallinity on the stabilization of enzymes during freeze-drying.

1 reference

https://api.crossref.org/works/10.1007%2FS11095-012-0965-4

21 January 2018

Conformation, pH-induced conformational changes, and thermal unfolding of anti-p24 (HIV-1) monoclonal antibody CB4-1 and its Fab and Fc fragments

1 reference

https://api.crossref.org/works/10.1007%2FS11095-012-0965-4

21 January 2018

Behavior of monoclonal antibodies: relation between the second virial coefficient (B (2)) at low concentrations and aggregation propensity and viscosity at high concentrations

1 reference

https://pubmed.ncbi.nlm.nih.gov/23319172

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Surface-induced denaturation of proteins during freezing and its inhibition by surfactants

1 reference

https://pubmed.ncbi.nlm.nih.gov/23319172

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nonequivalence of second virial coefficients from sedimentation equilibrium and static light scattering studies of protein solutions

1 reference

https://pubmed.ncbi.nlm.nih.gov/23319172

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Formulation Development of Therapeutic Monoclonal Antibodies Using High-Throughput Fluorescence and Static Light Scattering Techniques: Role of Conformational and Colloidal Stability

1 reference

https://pubmed.ncbi.nlm.nih.gov/23319172

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based on heuristic

inferred from PubMed ID database lookup

Long- and short-range electrostatic interactions affect the rheology of highly concentrated antibody solutions

1 reference

https://pubmed.ncbi.nlm.nih.gov/23319172

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based on heuristic

inferred from PubMed ID database lookup

Effect of ions on agitation- and temperature-induced aggregation reactions of antibodies

1 reference

https://pubmed.ncbi.nlm.nih.gov/23319172

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based on heuristic

inferred from PubMed ID database lookup

The peptide backbone plays a dominant role in protein stabilization by naturally occurring osmolytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/23319172

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based on heuristic

inferred from PubMed ID database lookup

Quantitative characterization of weak self-association in concentrated solutions of immunoglobulin G via the measurement of sedimentation equilibrium and osmotic pressure

1 reference

https://pubmed.ncbi.nlm.nih.gov/23319172

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inferred from PubMed ID database lookup

Physical stability of albinterferon-α(2b) in aqueous solution: effects of conformational stability and colloidal stability on aggregation

1 reference

https://pubmed.ncbi.nlm.nih.gov/23319172

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Structural properties of monoclonal antibody aggregates induced by freeze-thawing and thermal stress

1 reference

https://pubmed.ncbi.nlm.nih.gov/23319172

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based on heuristic

inferred from PubMed ID database lookup

Assessment of net charge and protein-protein interactions of different monoclonal antibodies

1 reference

https://pubmed.ncbi.nlm.nih.gov/23319172

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based on heuristic

inferred from PubMed ID database lookup

Use of T4 lysozyme charge mutants to examine electrophoretic models

1 reference

https://pubmed.ncbi.nlm.nih.gov/23319172

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fc domain mediated self-association of an IgG1 monoclonal antibody under a low ionic strength condition

1 reference

https://pubmed.ncbi.nlm.nih.gov/23319172

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based on heuristic

inferred from PubMed ID database lookup

Ions from the Hofmeister series and osmolytes: effects on proteins in solution and in the crystallization process

1 reference

https://pubmed.ncbi.nlm.nih.gov/23319172

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of Solution Conditions, Processing Parameters, and Container Materials on Aggregation of a Monoclonal Antibody during Freeze-Thawing

1 reference

https://pubmed.ncbi.nlm.nih.gov/23319172

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Control of protein stability and reactions by weakly interacting cosolvents: the simplicity of the complicated

1 reference

https://pubmed.ncbi.nlm.nih.gov/23319172

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based on heuristic

inferred from PubMed ID database lookup

Salt precipitation during the freeze-concentration of phosphate buffer solutions

1 reference

https://pubmed.ncbi.nlm.nih.gov/23319172

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based on heuristic

inferred from PubMed ID database lookup

Highly concentrated monoclonal antibody solutions: direct analysis of physical structure and thermal stability

1 reference

https://pubmed.ncbi.nlm.nih.gov/23319172

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based on heuristic

inferred from PubMed ID database lookup

Solution pH that minimizes self-association of three monoclonal antibodies is strongly dependent on ionic strength

1 reference

https://pubmed.ncbi.nlm.nih.gov/23319172

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S11095-012-0965-4

1 reference

Europe PubMed Central

PubMed publication ID

4 December 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

4 December 2017

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