(Q44628372)

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Large-scale analysis of somatic hypermutations in antibodies reveals which structural regions, positions and amino acids are modified to improve affinity

scientific article published on 26 November 2013

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scholarly article

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Europe PubMed Central

PubMed publication ID

4 December 2017

Large-scale analysis of somatic hypermutations in antibodies reveals which structural regions, positions and amino acids are modified to improve affinity (English)

1 reference

Europe PubMed Central

PubMed publication ID

4 December 2017

1 reference

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Inbal Sela-Culang

2

object named as

Inbal Sela-Culang

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3

object named as

Yanay Ofran

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author name string

Anat Burkovitz

1

1 reference

Europe PubMed Central

PubMed publication ID

4 December 2017

Inbal Sela-Culang

2

1 reference

Europe PubMed Central

PubMed publication ID

4 December 2017

Yanay Ofran

3

1 reference

Europe PubMed Central

PubMed publication ID

4 December 2017

language of work or name

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publication date

26 November 2013

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Europe PubMed Central

PubMed publication ID

4 December 2017

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Europe PubMed Central

PubMed publication ID

4 December 2017

281

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Europe PubMed Central

PubMed publication ID

4 December 2017

1

1 reference

Europe PubMed Central

PubMed publication ID

4 December 2017

306-319

1 reference

Europe PubMed Central

PubMed publication ID

4 December 2017

Immunoglobulin gene diversification

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12597

21 January 2018

Molecular mechanisms of antibody somatic hypermutation.

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12597

21 January 2018

Clonal selection and learning in the antibody system

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12597

21 January 2018

A germline knowledge based computational approach for determining antibody complementarity determining regions

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12597

21 January 2018

The generation of antibody diversity through somatic hypermutation and class switch recombination

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12597

21 January 2018

AID and somatic hypermutation.

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12597

21 January 2018

Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase family in germinal center B cells

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12597

21 January 2018

Processive AID-catalysed cytosine deamination on single-stranded DNA simulates somatic hypermutation

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12597

21 January 2018

The biochemistry of somatic hypermutation

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12597

21 January 2018

Linking class-switch recombination with somatic hypermutation

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12597

21 January 2018

Trends in antibody sequence changes during the somatic hypermutation process.

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12597

21 January 2018

Coupling mammalian cell surface display with somatic hypermutation for the discovery and maturation of human antibodies

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12597

21 January 2018

Improving antibody affinity by mimicking somatic hypermutation in vitro

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12597

21 January 2018

X-ray snapshots of the maturation of an antibody response to a protein antigen

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12597

21 January 2018

Substantial energetic improvement with minimal structural perturbation in a high affinity mutant antibody

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12597

21 January 2018

Molecular dynamics and free-energy calculations applied to affinity maturation in antibody 48G7.

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12597

21 January 2018

Preconfiguration of the antigen-binding site during affinity maturation of a broadly neutralizing influenza virus antibody

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12597

21 January 2018

Molecular evolution of affinity and flexibility in the immune system

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12597

21 January 2018

Structural consensus among antibodies defines the antigen binding site

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12597

21 January 2018

Probing a protein-protein interaction by in vitro evolution

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12597

21 January 2018

Antigen-binding site anatomy and somatic mutations in antibodies that recognize different types of antigens.

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12597

21 January 2018

Molecular evolution of specific human antibody against MUC1 mucin results in improved recognition of the antigen on tumor cells

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12597

21 January 2018

The FoldX web server: an online force field

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12597

21 January 2018

Predicting changes in the stability of proteins and protein complexes: a study of more than 1000 mutations

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12597

21 January 2018

Paratome: an online tool for systematic identification of antigen-binding regions in antibodies based on sequence or structure

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12597

21 January 2018

Automated identification of complementarity determining regions (CDRs) reveals peculiar characteristics of CDRs and B cell epitopes

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12597

21 January 2018

Analysis of the antigen combining site: correlations between length and sequence composition of the hypervariable loops and the nature of the antigen

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12597

21 January 2018

Divergence measures based on the Shannon entropy

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12597

21 January 2018

The indistinguishability of epitopes from protein surface is explained by the distinct binding preferences of each of the six antigen-binding loops.

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12597

21 January 2018

IMGT unique numbering for immunoglobulin and T cell receptor variable domains and Ig superfamily V-like domains

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12597

21 January 2018

Variable region sequences of five human immunoglobulin heavy chains of the VH3 subgroup: definitive identification of four heavy chain hypervariable regions

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12597

21 January 2018

Affinity maturation increases the stability and plasticity of the Fv domain of anti-protein antibodies

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12597

21 January 2018

Structure, function and properties of antibody binding sites

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12597

21 January 2018

The protein-protein interface evolution acts in a similar way to antibody affinity maturation.

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12597

21 January 2018

Assessing computational methods for predicting protein stability upon mutation: good on average but not in the details.

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12597

21 January 2018

How protein stability and new functions trade off

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12597

21 January 2018

The stability effects of protein mutations appear to be universally distributed

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12597

21 January 2018

Broad diversity of neutralizing antibodies isolated from memory B cells in HIV-infected individuals

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12597

21 January 2018

Human antibodies that neutralize HIV-1: identification, structures, and B cell ontogenies

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12597

21 January 2018

Rational design of envelope identifies broadly neutralizing human monoclonal antibodies to HIV-1

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12597

21 January 2018

Somatic Mutations of the Immunoglobulin Framework Are Generally Required for Broad and Potent HIV-1 Neutralization

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12597

21 January 2018

Strategies and challenges for the next generation of therapeutic antibodies

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12597

21 January 2018

Computational design of antibody-affinity improvement beyond in vivo maturation

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12597

21 January 2018

IMGT/3Dstructure-DB and IMGT/DomainGapAlign: a database and a tool for immunoglobulins or antibodies, T cell receptors, MHC, IgSF and MhcSF.

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12597

21 January 2018

IMGT/3Dstructure-DB and IMGT/StructuralQuery, a database and a tool for immunoglobulin, T cell receptor and MHC structural data

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12597

21 January 2018

The Imprint of Somatic Hypermutation on the Repertoire of Human Germline V Genes

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12597

21 January 2018

Effects of somatic mutations on CDR loop flexibility during affinity maturation

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12597

21 January 2018

Identifiers

10.1111/FEBS.12597

1 reference

Europe PubMed Central

PubMed publication ID

4 December 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

4 December 2017

ResearchGate publication ID

0 references

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