(Q44988763)

8 December 2017

title

mGluR5: exploration of orthosteric and allosteric ligand binding pockets and their applications to drug discovery (English)

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8 December 2017

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8 December 2017

6

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8 December 2017

Jesper M Mathiesen

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Kasper Skytte Harpsøe

object named as

Kasper Harpsøe

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2

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author name string

Christina Mølck

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8 December 2017

Søren M Nielsen

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5

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8 December 2017

language of work or name

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4 February 2014

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8 December 2017

published in

Neurochemical Research

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8 December 2017

volume

39

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8 December 2017

issue

10

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8 December 2017

page(s)

1862-1875

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https://scigraph.springernature.com/pub.10.1007/s11064-014-1248-8

8 December 2017

exact match

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cites work

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Pharmacological characterization of a new, orally active and potent allosteric metabotropic glutamate receptor 1 antagonist, 4-[1-(2-fluoropyridin-3-yl)-5-methyl-1H-1,2,3-triazol-4-yl]-N-isopropyl-N-methyl-3,6-dihydropyridine-1(2H)-carboxamide (FTID

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Probing the metabotropic glutamate receptor 5 (mGlu₅) positive allosteric modulator (PAM) binding pocket: discovery of point mutations that engender a "molecular switch" in PAM pharmacology

21 January 2018

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High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor

21 January 2018

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Crystal structure of the human beta2 adrenergic G-protein-coupled receptor

21 January 2018

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GPCR engineering yields high-resolution structural insights into beta2-adrenergic receptor function

21 January 2018

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Structure of the Human Dopamine D3 Receptor in Complex with a D2/D3 Selective Antagonist

21 January 2018

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The 2.6 angstrom crystal structure of a human A2A adenosine receptor bound to an antagonist

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The structural basis for agonist and partial agonist action on a β(1)-adrenergic receptor

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Structure of a beta1-adrenergic G-protein-coupled receptor

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Structures of the CXCR4 chemokine GPCR with small-molecule and cyclic peptide antagonists

21 January 2018

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Investigating metabotropic glutamate receptor 5 allosteric modulator cooperativity, affinity, and agonism: enriching structure-function studies and structure-activity relationships

21 January 2018

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Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disorders

21 January 2018

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Discovery of novel allosteric modulators of metabotropic glutamate receptor subtype 5 reveals chemical and functional diversity and in vivo activity in rat behavioral models of anxiolytic and antipsychotic activity

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11064-014-1248-8

Positive allosteric modulation of the human metabotropic glutamate receptor 4 (hmGluR4) by SIB-1893 and MPEP

21 January 2018

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"Molecular switches" on mGluR allosteric ligands that modulate modes of pharmacology

21 January 2018

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A novel metabotropic glutamate receptor 5 positive allosteric modulator acts at a unique site and confers stimulus bias to mGlu5 signaling

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The glutamate receptor ion channels

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12 December 2020

CPCCOEt, a noncompetitive metabotropic glutamate receptor 1 antagonist, inhibits receptor signaling without affecting glutamate binding

1 reference

12 December 2020

The non-competitive antagonists 2-methyl-6-(phenylethynyl)pyridine and 7-hydroxyiminocyclopropan[b]chromen-1a-carboxylic acid ethyl ester interact with overlapping binding pockets in the transmembrane region of group I metabotropic glutamate recepto

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12 December 2020

The activation of inositol phospholipid metabolism as a signal-transducing system for excitatory amino acids in primary cultures of cerebellar granule cells.

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12 December 2020

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12 December 2020

SIB-1757 and SIB-1893: selective, noncompetitive antagonists of metabotropic glutamate receptor type 5

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12 December 2020

Exploration of structure-based drug design opportunities for mGluRs

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12 December 2020

A close structural analog of 2-methyl-6-(phenylethynyl)-pyridine acts as a neutral allosteric site ligand on metabotropic glutamate receptor subtype 5 and blocks the effects of multiple allosteric modulators

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12 December 2020

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12 December 2020

10.1007/S11064-014-1248-8

Identifiers

DOI

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8 December 2017

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