(Q45288581)

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Fingolimod (FTY720) enhances hippocampal synaptic plasticity and memory in Huntington's disease by preventing p75NTR up-regulation and astrocyte-mediated inflammation.

scientific article published on 10 June 2015

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scholarly article

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26063761%20AND%20SRC:MED&resulttype=core&format=json

17 February 2020

Fingolimod (FTY720) enhances hippocampal synaptic plasticity and memory in Huntington's disease by preventing p75NTR up-regulation and astrocyte-mediated inflammation (English)

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26063761%20AND%20SRC:MED&resulttype=core&format=json

17 February 2020

Huntington's disease

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synaptic plasticity

1 reference

based on heuristic

inferred from title

5

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26063761%20AND%20SRC:MED&resulttype=core&format=json

17 February 2020

Josep M. Canals

7

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17 February 2020

8

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17 February 2020

1

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17 February 2020

Alfonso Gerardo Garcia Diaz Barriga

2

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17 February 2020

Verónica Brito

3

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17 February 2020

4

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17 February 2020

author name string

Silvia Ginés

6

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17 February 2020

publication date

10 June 2015

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17 February 2020

Human Molecular Genetics

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17 February 2020

24

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17 February 2020

17

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17 February 2020

4958-4970

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26063761%20AND%20SRC:MED&resulttype=core&format=json

17 February 2020

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV218

21 January 2018

Evidence for specific cognitive deficits in preclinical Huntington's disease.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV218

21 January 2018

Detection of Huntington's disease decades before diagnosis: the Predict-HD study

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV218

21 January 2018

Cognitive impairment in Huntington disease: diagnosis and treatment

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV218

21 January 2018

Regional and progressive thinning of the cortical ribbon in Huntington's disease

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV218

21 January 2018

Evidence for more widespread cerebral pathology in early HD: an MRI-based morphometric analysis

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV218

21 January 2018

Shape analysis of subcortical nuclei in Huntington's disease, global versus local atrophy--results from the TRACK-HD study

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV218

21 January 2018

Increased PKA signaling disrupts recognition memory and spatial memory: role in Huntington's disease

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV218

21 January 2018

Long-term memory deficits in Huntington's disease are associated with reduced CBP histone acetylase activity.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV218

21 January 2018

Neurotrophin receptor p75(NTR) mediates Huntington's disease-associated synaptic and memory dysfunction

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV218

21 January 2018

Regulation of cell survival by secreted proneurotrophins

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV218

21 January 2018

Brain-derived neurotrophic factor regulates the onset and severity of motor dysfunction associated with enkephalinergic neuronal degeneration in Huntington's disease.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV218

21 January 2018

Brain-derived neurotrophic factor modulates the severity of cognitive alterations induced by mutant huntingtin: involvement of phospholipaseCgamma activity and glutamate receptor expression

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV218

21 January 2018

Brain-derived neurotrophic factor in neurodegenerative diseases

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV218

21 January 2018

Brain-derived neurotrophic factor binding to the p75 neurotrophin receptor reduces TrkA signaling while increasing serine phosphorylation in the TrkA intracellular domain.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV218

21 January 2018

The secreted brain-derived neurotrophic factor precursor pro-BDNF binds to TrkB and p75NTR but not to TrkA or TrkC.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV218

21 January 2018

Activation of p75NTR by proBDNF facilitates hippocampal long-term depression

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV218

21 January 2018

The p75 neurotrophin receptor negatively modulates dendrite complexity and spine density in hippocampal neurons.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV218

21 January 2018

Imbalance of p75(NTR)/TrkB protein expression in Huntington's disease: implication for neuroprotective therapies.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV218

21 January 2018

BDNF regulation under GFAP promoter provides engineered astrocytes as a new approach for long-term protection in Huntington's disease.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV218

21 January 2018

A small molecule TrkB ligand reduces motor impairment and neuropathology in R6/2 and BACHD mouse models of Huntington's disease

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV218

21 January 2018

Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV218

21 January 2018

Fingolimod, a sphingosine-1 phosphate receptor modulator, increases BDNF levels and improves symptoms of a mouse model of Rett syndrome.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV218

21 January 2018

FTY720 (fingolimod) is a neuroprotective and disease-modifying agent in cellular and mouse models of Huntington disease.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV218

21 January 2018

Second generation S1P pathway modulators: research strategies and clinical developments.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV218

21 January 2018

FTY720 (fingolimod) efficacy in an animal model of multiple sclerosis requires astrocyte sphingosine 1-phosphate receptor 1 (S1P1) modulation

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV218

21 January 2018

Functional consequences of S1P receptor modulation in rat oligodendroglial lineage cells.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV218

21 January 2018

Fingolimod phosphate promotes the neuroprotective effects of microglia

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV218

21 January 2018

Fingolimod may support neuroprotection via blockade of astrocyte nitric oxide.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV218

21 January 2018

Chronology of behavioral symptoms and neuropathological sequela in R6/2 Huntington's disease transgenic mice

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV218

21 January 2018

In vivo expression of polyglutamine-expanded huntingtin by mouse striatal astrocytes impairs glutamate transport: a correlation with Huntington's disease subjects

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV218

21 January 2018

Conditional BDNF release under pathological conditions improves Huntington's disease pathology by delaying neuronal dysfunction

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV218

21 January 2018

A critical role of astrocyte-mediated nuclear factor-κB-dependent inflammation in Huntington's disease

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV218

21 January 2018

Expression of mutant huntingtin in mouse brain astrocytes causes age-dependent neurological symptoms

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV218

21 January 2018

Mutant huntingtin in glial cells exacerbates neurological symptoms of Huntington disease mice

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV218

21 January 2018

Oral fingolimod rescues the functional deficits of synapses in experimental autoimmune encephalomyelitis

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV218

21 January 2018

FTY720 (fingolimod) attenuates beta-amyloid peptide (Aβ42)-induced impairment of spatial learning and memory in rats

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV218

21 January 2018

Fingolimod increases brain-derived neurotrophic factor levels and ameliorates amyloid β-induced memory impairment.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV218

21 January 2018

Dendritic spine pathology and deficits in experience-dependent dendritic plasticity in R6/1 Huntington's disease transgenic mice

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV218

21 January 2018

Gene-environment interactions modulating cognitive function and molecular correlates of synaptic plasticity in Huntington's disease transgenic mice.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV218

21 January 2018

Disruption of striatal glutamatergic transmission induced by mutant huntingtin involves remodeling of both postsynaptic density and NMDA receptor signaling

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV218

21 January 2018

Prostaglandin E2 EP1 receptor antagonist improves motor deficits and rescues memory decline in R6/1 mouse model of Huntington's disease

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV218

21 January 2018

The crystal structure of the IkappaBalpha/NF-kappaB complex reveals mechanisms of NF-kappaB inactivation

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV218

21 January 2018

Mechanisms underlying inflammation in neurodegeneration

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV218

21 January 2018

Immune modulation of learning, memory, neural plasticity and neurogenesis

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV218

21 January 2018

Brain-derived neurotrophic factor-dependent synaptic plasticity is suppressed by interleukin-1β via p38 mitogen-activated protein kinase

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV218

21 January 2018

Sustained, neuron-specific IKK/NF-κB activation generates a selective neuroinflammatory response promoting local neurodegeneration with aging

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV218

21 January 2018

Active, phosphorylated fingolimod inhibits histone deacetylases and facilitates fear extinction memory

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV218

21 January 2018

Inflammatory cytokines IL-1β and TNF-α regulate p75NTR expression in CNS neurons and astrocytes by distinct cell-type-specific signalling mechanisms

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV218

21 January 2018

Targeting the CREB pathway for memory enhancers

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV218

21 January 2018

PAM mediates sustained inhibition of cAMP signaling by sphingosine-1-phosphate

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV218

21 January 2018

Pathway specific modulation of S1P1 receptor signalling in rat and human astrocytes

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV218

21 January 2018

A deconvolution method to improve automated 3D-analysis of dendritic spines: application to a mouse model of Huntington's disease

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV218

21 January 2018

Dendritic spine instability leads to progressive neocortical spine loss in a mouse model of Huntington's disease.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV218

21 January 2018

Dynamics of retrieval strategies for remote memories.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV218

21 January 2018

Synaptic correlates of increased cognitive vulnerability with aging: peripheral immune challenge and aging interact to disrupt theta-burst late-phase long-term potentiation in hippocampal area CA1

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV218

21 January 2018

Aging and infection reduce expression of specific brain-derived neurotrophic factor mRNAs in hippocampus

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV218

21 January 2018

A novel pathogenic pathway of immune activation detectable before clinical onset in Huntington's disease

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV218

21 January 2018

Inhibition of soluble tumor necrosis factor is therapeutic in Huntington's disease

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV218

21 January 2018

Connecting TNF-alpha signaling pathways to iNOS expression in a mouse model of Alzheimer's disease: relevance for the behavioral and synaptic deficits induced by amyloid beta protein.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV218

21 January 2018

NOS2 gene deficiency protects from sepsis-induced long-term cognitive deficits

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV218

21 January 2018

TNF-α protein synthesis inhibitor restores neuronal function and reverses cognitive deficits induced by chronic neuroinflammation.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV218

21 January 2018

Tumor necrosis factor alters synaptic transmission in rat hippocampal slices

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV218

21 January 2018

Brain-derived neurotrophic factor modulates dopaminergic deficits in a transgenic mouse model of Huntington's disease

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV218

21 January 2018

Impaired TrkB receptor signaling underlies corticostriatal dysfunction in Huntington's disease

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV218

21 January 2018

Interleukin-1β enhances neuronal vulnerability to proNGF-mediated apoptosis by increasing surface expression of p75(NTR) and sortillin

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV218

21 January 2018

Serum TNF-alpha levels are increased and correlate negatively with free IGF-I in Alzheimer disease.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV218

21 January 2018

Increased p75(NTR) expression in hippocampal neurons containing hyperphosphorylated tau in Alzheimer patients

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV218

21 January 2018

Small molecule p75NTR ligand prevents cognitive deficits and neurite degeneration in an Alzheimer's mouse model.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV218

21 January 2018

PDE10 inhibition increases GluA1 and CREB phosphorylation and improves spatial and recognition memories in a Huntington's disease mouse model

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV218

21 January 2018

The phosphodiesterase-4 inhibitor rolipram reverses Aβ-induced cognitive impairment and neuroinflammatory and apoptotic responses in rats.

1 reference

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21 January 2018

GDIs: central regulatory molecules in Rho GTPase activation

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV218

21 January 2018

Tumor necrosis factor has positive and negative self regulatory feed back cycles centered around cAMP.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV218

21 January 2018

Phenylbutyrate rescues dendritic spine loss associated with memory deficits in a mouse model of Alzheimer disease

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV218

21 January 2018

Suppressing aberrant GluN3A expression rescues synaptic and behavioral impairments in Huntington's disease models

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV218

21 January 2018

Bone morphogenetic protein-2, but not bone morphogenetic protein-7, promotes dendritic growth and calbindin phenotype in cultured rat striatal neurons

1 reference

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21 January 2018

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

1 reference

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21 January 2018

Dendritic Spine Pathology: Cause or Consequence of Neurological Disorders?

1 reference

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21 January 2018

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