(Q45870581)

17 December 2017

title

Biology and novel treatment options for XLA, the most common monogenetic immunodeficiency in man. (English)

1 reference

17 December 2017

author name string

Rudi W Hendriks

1

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17 December 2017

Robbert Gm Bredius

2

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17 December 2017

Karin Pike-Overzet

3

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17 December 2017

Frank Jt Staal

4

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17 December 2017

language of work or name

English

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publication date

2 June 2011

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17 December 2017

Expert Opinion on Therapeutic Targets

published in

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17 December 2017

volume

15

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17 December 2017

issue

8

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17 December 2017

page(s)

1003-1021

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17 December 2017

Gene therapy of human severe combined immunodeficiency (SCID)-X1 disease

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Failure of SCID-X1 gene therapy in older patients

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X-linked agammaglobulinemia: new approaches to old questions based on the identification of the defective gene.

21 January 2018

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Defects in early B-cell development: comparing the consequences of abnormalities in pre-BCR signaling in the human and the mouse

21 January 2018

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The Bruton's tyrosine kinase gene is expressed throughout B cell differentiation, from early precursor B cell stages preceding immunoglobulin gene rearrangement up to mature B cell stages

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Impaired precursor B cell differentiation in Bruton's tyrosine kinase-deficient mice.

21 January 2018

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Function of Bruton's tyrosine kinase during B cell development is partially independent of its catalytic activity.

21 January 2018

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Tumor suppressor function of Bruton tyrosine kinase is independent of its catalytic activity.

21 January 2018

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Deficient expression of a B cell cytoplasmic tyrosine kinase in human X-linked agammaglobulinemia

21 January 2018

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The gene involved in X-linked agammaglobulinaemia is a member of the src family of protein-tyrosine kinases

21 January 2018

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Tec kinases in T cell and mast cell signaling

21 January 2018

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Regulatory intramolecular association in a tyrosine kinase of the Tec family

21 January 2018

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Mutation of unique region of Bruton's tyrosine kinase in immunodeficient XID mice

21 January 2018

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Defective B cell development and function in Btk-deficient mice

21 January 2018

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Activation of Bruton's tyrosine kinase (BTK) by a point mutation in its pleckstrin homology (PH) domain

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2011.585971

Regulation of Btk function by a major autophosphorylation site within the SH3 domain

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2011.585971

Constitutive activation of Bruton's tyrosine kinase induces the formation of autoreactive IgM plasma cells.

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2011.585971

The pre-BCR checkpoint as a cell-autonomous proliferation switch

21 January 2018

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The nonimmunoglobulin portion of lambda5 mediates cell-autonomous pre-B cell receptor signaling

21 January 2018

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N-linked glycosylation selectively regulates autonomous precursor BCR function

21 January 2018

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Predominant autoantibody production by early human B cell precursors

21 January 2018

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Galectin-1 is a stromal cell ligand of the pre-B cell receptor (BCR) implicated in synapse formation between pre-B and stromal cells and in pre-BCR triggering

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2011.585971

Interaction of murine precursor B cell receptor with stroma cells is controlled by the unique tail of lambda 5 and stroma cell-associated heparan sulfate.

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2011.585971

Autoreactive B cell receptors mimic autonomous pre-B cell receptor signaling and induce proliferation of early B cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.585971

Interaction between the Btk PH domain and phosphatidylinositol-3,4,5-trisphosphate directly regulates Btk.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.585971

Src family protein tyrosine kinases induce autoactivation of Bruton's tyrosine kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.585971

Activation of BTK by a phosphorylation mechanism initiated by SRC family kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.585971

Phosphorylation of two regulatory tyrosine residues in the activation of Bruton's tyrosine kinase via alternative receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.585971

Engagement of the human pre-B cell receptor generates a lipid raft-dependent calcium signaling complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.585971

Bruton's tyrosine kinase is required for signaling the CD79b-mediated pro-B to pre-B cell transition

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.585971

Amplification of B cell antigen receptor signaling by a Syk/ITAM positive feedback loop

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.585971

Mimicry of pre-B cell receptor signaling by activation of the tyrosine kinase Blk.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.585971

Regulation of B-cell signal transduction by adaptor proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.585971

Bruton's tyrosine kinase is required for activation of IkappaB kinase and nuclear factor kappaB in response to B cell receptor engagement

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.585971

Bruton's tyrosine kinase links the B cell receptor to nuclear factor kappaB activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.585971

Unexpected requirement for ZAP-70 in pre-B cell development and allelic exclusion.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.585971

Severe B cell deficiency in mice lacking the tec kinase family members Tec and Btk.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.585971

An important role of phospholipase Cgamma1 in pre-B-cell development and allelic exclusion

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.585971

Phosphoinositide 3-kinase: diverse roles in immune cell activation

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2011.585971

Regulation of B-cell proliferation and differentiation by pre-B-cell receptor signalling

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2011.585971

Interaction of Btk and Akt in B cell signaling

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2011.585971

The adaptor protein SLP-65 acts as a tumor suppressor that limits pre-B cell expansion.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.585971

B cell signaling and tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.585971

Role of STAT5 in controlling cell survival and immunoglobulin gene recombination during pro-B cell development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.585971

Posttranscriptional regulation of Bruton's tyrosine kinase expression in antigen receptor-stimulated splenic B cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.585971

MicroRNAs prevent the generation of autoreactive antibodies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.585971

SHIP modulates immune receptor responses by regulating membrane association of Btk.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.585971

BTK regulates PtdIns-4,5-P2 synthesis: importance for calcium signaling and PI3K activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.585971

Bruton's tyrosine kinase is required for TLR2 and TLR4-induced TNF, but not IL-6, production

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.585971

Intracellular MHC class II molecules promote TLR-triggered innate immune responses by maintaining activation of the kinase Btk

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.585971

Pre-B cells in agammaglobulinemia: evidence for disease heterogeneity among affected boys

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.585971

Recent progress in the diagnosis and treatment of patients with defects in early B-cell development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.585971

Bruton's tyrosine kinase is essential for human B cell tolerance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.585971

Resolution of three nonproliferative immature splenic B cell subsets reveals multiple selection points during peripheral B cell maturation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.585971

Transitional B lymphocyte subsets operate as distinct checkpoints in murine splenic B cell development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.585971

Unbalanced X chromosome mosaicism in B cells of mice with X-linked immunodeficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.585971

Development of B lymphocytes in mice heterozygous for the X-linked immunodeficiency (xid) mutation. xid inhibits development of all splenic and lymph node B cells at a stage subsequent to their initial formation in bone marrow

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.585971

An essential role for Bruton's [corrected] tyrosine kinase in the regulation of B-cell apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.585971

Transgene expression of bcl-xL permits anti-immunoglobulin (Ig)-induced proliferation in xid B cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.585971

Bruton's tyrosine kinase regulates the activation of gene rearrangements at the lambda light chain locus in precursor B cells in the mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.585971

Bruton's tyrosine kinase cooperates with the B cell linker protein SLP-65 as a tumor suppressor in Pre-B cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.585971

BLNK suppresses pre-B-cell leukemogenesis through inhibition of JAK3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.585971

Bruton's tyrosine kinase and SLP-65 regulate pre-B cell differentiation and the induction of Ig light chain gene rearrangement.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.585971

Accessibility and the developmental regulation of V(D)J recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.585971

The spectrum of mutations in Btk that cause X-linked agammaglobulinemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.585971

Analysis of clinical presentations of Bruton disease: a review of 20 years of accumulated data from pediatric patients at Severance Hospital

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.585971

BTK: 22 novel and 25 recurrent mutations in European patients with X-linked agammaglobulinemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.585971

Mutation of the BTK gene and clinical feature of X-linked agammaglobulinemia in mainland China

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.585971

Clinical, immunological, and molecular analysis in a large cohort of patients with X-linked agammaglobulinemia: an Italian multicenter study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.585971

Chance or necessity? Insertional mutagenesis in gene therapy and its consequences

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.585971

Current developments in the design of onco-retrovirus and lentivirus vector systems for hematopoietic cell gene therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.585971

Clinical trials with retrovirus mediated gene therapy--what have we learned?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.585971

Combating oncogene activation associated with retrovirus-mediated gene therapy of X-linked severe combined immunodeficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.585971

HIV protease as a target for retrovirus vector-mediated gene therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.585971

Vector integration is nonrandom and clustered and influences the fate of lymphopoiesis in SCID-X1 gene therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.585971

Insertional oncogenesis in 4 patients after retrovirus-mediated gene therapy of SCID-X1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.585971

LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.585971

Mechanisms governing lentivirus integration site selection

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.585971

Moving gene therapy forward with mobile DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.585971

Sleeping Beauty, a wide host-range transposon vector for genetic transformation in vertebrates

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.585971

Somatic integration and long-term transgene expression in normal and haemophilic mice using a DNA transposon system

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.585971

Gene therapy of X-linked severe combined immunodeficiency by use of a pseudotyped gammaretroviral vector

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.585971

Gene therapy for immunodeficiency due to adenosine deaminase deficiency.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.585971

Ten years of gene therapy for primary immune deficiencies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.585971

Correction of X-linked chronic granulomatous disease by gene therapy, augmented by insertional activation of MDS1-EVI1, PRDM16 or SETBP1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.585971

Stem-cell gene therapy for the Wiskott-Aldrich syndrome

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2011.585971

Gene therapy: is IL2RG oncogenic in T-cell development?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.585971

In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.585971

Transfusion independence and HMGA2 activation after gene therapy of human β-thalassaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.585971

Sustained correction of B-cell development and function in a murine model of X-linked agammaglobulinemia (XLA) using retroviral-mediated gene transfer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.585971

Sola dosis facit venenum. Leukemia in gene therapy trials: a question of vectors, inserts and dosage?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.585971

B cell-specific lentiviral gene therapy leads to sustained B-cell functional recovery in a murine model of X-linked agammaglobulinemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.585971

Development of an enhanced B-specific lentiviral vector expressing BTK: a tool for gene therapy of XLA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.585971

Correction of B-cell development in Btk-deficient mice using lentiviral vectors with codon-optimized human BTK.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.585971

X-linked B-lymphocyte immune defect in CBA/N mice. II. Studies of the mechanisms underlying the immune defect

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.585971

Direct stimulation of Bruton's tyrosine kinase by G(q)-protein alpha-subunit

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.585971

New insights and unresolved issues regarding insertional mutagenesis in X-linked SCID gene therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.585971

Bruton tyrosine kinase is tyrosine phosphorylated and activated in pre-B lymphocytes and receptor-ligated B cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.585971

Temporal differences in the activation of three classes of non-transmembrane protein tyrosine kinases following B-cell antigen receptor surface engagement

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.585971

Btk is required for an efficient response to erythropoietin and for SCF-controlled protection against TRAIL in erythroid progenitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.585971

Tyrosine phosphorylation and activation of Bruton tyrosine kinase upon Fc epsilon RI cross-linking

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.585971

Dual functions of Bruton's tyrosine kinase and Tec kinase during Fcgamma receptor-induced signaling and phagocytosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.585971

A role for Bruton's tyrosine kinase (Btk) in platelet activation by collagen.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.585971

IL-5 receptor-mediated tyrosine phosphorylation of SH2/SH3-containing proteins and activation of Bruton's tyrosine and Janus 2 kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.585971

Bruton's tyrosine kinase is a Toll/interleukin-1 receptor domain-binding protein that participates in nuclear factor kappaB activation by Toll-like receptor 4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.585971

Signaling by Toll-like receptors 8 and 9 requires Bruton's tyrosine kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.585971

Toll-like receptor signaling is impaired in dendritic cells from patients with X-linked agammaglobulinemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.585971

Btk regulates localization, in vivo activation, and class switching of anti-DNA B cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.585971

Toll-like receptor 7 cooperates with IL-4 in activated B cells through antigen receptor or CD38 and induces class switch recombination and IgG1 production

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.585971

CD303 (BDCA-2) signals in plasmacytoid dendritic cells via a BCR-like signalosome involving Syk, Slp65 and PLCgamma2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.585971

Bruton's Tyrosine Kinase and Phospholipase Cγ2 Mediate Chemokine-Controlled B Cell Migration and Homing

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.585971

10.1517/14728222.2011.585971

21 January 2018

Identifiers

DOI

1 reference

17 December 2017

1 reference

17 December 2017