(Q45882377)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15805578%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

review article

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title

Introduction to the background, principles, and state of the art in suicide gene therapy (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15805578%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

0 references

0 references

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15805578%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

author name string

Ion Niculescu-Duvaz

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15805578%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

publication date

1 May 2005

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15805578%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

published in

Molecular Biotechnology

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15805578%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

volume

30

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15805578%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

issue

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15805578%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

page(s)

71-88

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15805578%20AND%20SRC:MED&resulttype=core&format=json

https://scigraph.springernature.com/pub.10.1385/mb:30:1:071

10 January 2020

exact match

0 references

cites work

Expression of endogenously activated secreted or cell surface carboxypeptidase A sensitizes tumor cells to methotrexate-alpha-peptide prodrugs.

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12 December 2020

A cell surface tethered enzyme improves efficiency in gene-directed enzyme prodrug therapy

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12 December 2020

Prodrug-activating systems in suicide gene therapy.

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12 December 2020

Gap junctions: the "kiss of death" and the "kiss of life"

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12 December 2020

Herpes simplex virus thymidine kinase gene therapy in experimental rat BT4C glioma model: effect of the percentage of thymidine kinase-positive glioma cells on treatment effect, survival time, and tissue reactions

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12 December 2020

Combined chemotherapy of murine mammary tumors by local activation of the prodrugs ifosfamide and 5-fluorocytosine

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12 December 2020

Bystander tumoricidal effect and gap junctional communication in lung cancer cell lines.

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12 December 2020

Impact of liver P450 reductase suppression on cyclophosphamide activation, pharmacokinetics and antitumoral activity in a cytochrome P450-based cancer gene therapy model

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12 December 2020

Metabolism of 5-fluorocytosine to 5-fluorouracil in human colorectal tumor cells transduced with the cytosine deaminase gene: significant antitumor effects when only a small percentage of tumor cells express cytosine deaminase

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12 December 2020

Direct correlation between positron emission tomographic images of two reporter genes delivered by two distinct adenoviral vectors

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12 December 2020

Development and application of adenoviral vectors for gene therapy of cancer

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12 December 2020

Combination suicide/cytokine gene therapy as adjuvants to a defective herpes simplex virus-based cancer vaccine.

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12 December 2020

Gene therapy for cancer: what have we done and where are we going?

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12 December 2020

Radiosensitization of rat glioma with bromodeoxycytidine and adenovirus expressing herpes simplex virus-thymidine kinase delivered by slow, rate-controlled positive pressure infusion

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12 December 2020

Frequent, moderate-dose cyclophosphamide administration improves the efficacy of cytochrome P-450/cytochrome P-450 reductase-based cancer gene therapy

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12 December 2020

Enhanced antitumoral effect of adenovirus-mediated cytosine deaminase gene therapy by induction of antigen-presenting cells through stem cell factor/granulocyte-macrophage colony-stimulating factor gene transfer

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12 December 2020

Cytosine deaminase suicide gene therapy for peritoneal carcinomatosis

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12 December 2020

Viral vectors for gene therapy

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12 December 2020

Creation of drug-specific herpes simplex virus type 1 thymidine kinase mutants for gene therapy

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12 December 2020

Comparison of [18F]FHPG and [124/125I]FIAU for imaging herpes simplex virus type 1 thymidine kinase gene expression

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12 December 2020

Substantially improved in vivo radiosensitization of rat glioma with mutant HSV-TK and acyclovir

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12 December 2020

Herpes simplex virus-1 thymidine kinase mutants created by semi-random sequence mutagenesis improve prodrug-mediated tumor cell killing

1 reference

12 December 2020

Expression of the bacterial nitroreductase enzyme in mammalian cells renders them selectively sensitive to killing by the prodrug CB1954.

1 reference

12 December 2020

Immune-dependent distant bystander effect after adenovirus-mediated suicide gene transfer in a rat model of liver colorectal metastasis

1 reference

12 December 2020

Superior cytotoxicity with ganciclovir compared with acyclovir and 1-beta-D-arabinofuranosylthymine in herpes simplex virus-thymidine kinase-expressing cells: a novel paradigm for cell killing.

1 reference

12 December 2020

Expression of Escherichia coli uracil phosphoribosyltransferase gene in murine colon carcinoma cells augments the antitumoral effect of 5-fluorouracil and induces protective immunity

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12 December 2020

Potentiation of ganciclovir toxicity in the herpes simplex virus thymidine kinase/ganciclovir administration system by ponicidin

1 reference

12 December 2020

Avoidance of bone marrow suppression using A-5021 as a nucleoside analog for retrovirus-mediated herpes simplex virus type I thymidine kinase gene therapy

1 reference

12 December 2020

Tyrosinase mutants are capable of prodrug activation in transfected nonmelanotic cells.

1 reference

12 December 2020

Regressions of established breast carcinoma xenografts by carboxypeptidase G2 suicide gene therapy and the prodrug CMDA are due to a bystander effect

1 reference

12 December 2020

Increasing specificity of anti-tumor therapy: cytotoxic protein delivery by non-pathogenic clostridia under regulation of radio-induced promoters

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12 December 2020

Fluoropyrimidine sensitivity of human MCF-7 breast cancer cells stably transfected with human uridine phosphorylase

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12 December 2020

Regression of hepatocellular carcinoma in vitro and in vivo by radiosensitizing suicide gene therapy under the inducible and spatial control of radiation

1 reference

12 December 2020

Clinical research results with dl1520 (Onyx-015), a replication-selective adenovirus for the treatment of cancer: what have we learned?

1 reference

12 December 2020

(E)-5-(2-bromovinyl)-2'-deoxyuridine potentiates ganciclovir-mediated cytotoxicity on herpes simplex virus-thymidine kinase--expressing cells

1 reference

12 December 2020

Improved radiosensitization of rat glioma cells with adenovirus-expressed mutant herpes simplex virus-thymidine kinase in combination with acyclovir

1 reference

12 December 2020

Transduction of human pancreatic tumor cells with vesicular stomatitis virus G-pseudotyped retroviral vectors containing a herpes simplex virus thymidine kinase mutant gene enhances bystander effects and sensitivity to ganciclovir

1 reference

12 December 2020

Improving enzymes for cancer gene therapy

1 reference

12 December 2020

The design of selectively-activated anti-cancer prodrugs for use in antibody-directed and gene-directed enzyme-prodrug therapies

1 reference

12 December 2020

Comparative in vitro and in vivo cytotoxic activity of (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU) and its arabinosyl derivative, (E)-5-(2-bromovinyl)-1-beta-D-arabinofuranosyluracil (BVaraU), against tumor cells expressing either the Varicella zost

1 reference

12 December 2020

Prodrugs for antibody- and gene-directed enzyme prodrug therapies (ADEPT and GDEPT).

1 reference

12 December 2020

Genetic prodrug activation therapy (GPAT) in two rat prostate models generates an immune bystander effect and can be monitored by magnetic resonance techniques

1 reference

12 December 2020

Double suicide gene therapy augments the antitumor activity of a replication-competent lytic adenovirus through enhanced cytotoxicity and radiosensitization

1 reference

12 December 2020

The role of cellular- and prodrug-associated factors in the bystander effect induced by the Varicella zoster and Herpes simplex viral thymidine kinases in suicide gene therapy

1 reference

12 December 2020

Efficacy of herpes simplex virus thymidine kinase in combination with cytokine gene therapy in an experimental metastatic breast cancer model

1 reference

12 December 2020

Gene-Directed Enzyme Prodrug Therapy

1 reference

12 December 2020

Noninvasive imaging of herpes virus thymidine kinase gene transfer and expression: a potential method for monitoring clinical gene therapy

1 reference

12 December 2020

Two-drug combinations that increase apoptosis and modulate bak and bcl-X(L) expression in human colon tumor cell lines transduced with herpes simplex virus thymidine kinase

1 reference

12 December 2020

Secreted human beta-glucuronidase: a novel tool for gene-directed enzyme prodrug therapy

1 reference

12 December 2020

Use of a herpes thymidine kinase/neomycin phosphotransferase chimeric gene for metabolic suicide gene transfer

1 reference

12 December 2020

In vivo cancer gene therapy by adenovirus-mediated transfer of a bifunctional yeast cytosine deaminase/uracil phosphoribosyltransferase fusion gene

1 reference

12 December 2020

Enhancement of the herpes simplex virus thymidine kinase/ganciclovir bystander effect and its antitumor efficacy in vivo by pharmacologic manipulation of gap junctions

1 reference

12 December 2020

The potential of acetaminophen as a prodrug in gene-directed enzyme prodrug therapy

1 reference

12 December 2020

Appropriate subcellular localisation of prodrug-activating enzymes has important consequences for suicide gene therapy

1 reference

12 December 2020

Combination of the bioreductive drug tirapazamine with the chemotherapeutic prodrug cyclophosphamide for P450/P450-reductase-based cancer gene therapy.

1 reference

12 December 2020

Gene delivery from replication-selective viruses: arming guided missiles in the war against cancer

1 reference

12 December 2020

Purified herpes simplex thymidine kinase retroviral particles. II. Influence of clinical parameters and bystander killing mechanisms

1 reference

12 December 2020

Imaging herpes virus thymidine kinase gene transfer and expression by positron emission tomography.

1 reference

12 December 2020

Progress in cancer gene therapy

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12 December 2020

Comparison of the genotoxic and apoptosis-inducing properties of ganciclovir and penciclovir in Chinese hamster ovary cells transfected with the thymidine kinase gene of herpes simplex virus-1: implications for gene therapeutic approaches

1 reference

12 December 2020

Usefulness of repeated direct intratumoral gene transfer using hemagglutinating virus of Japan-liposome method for cytosine deaminase suicide gene therapy

1 reference

12 December 2020

Necrotic, rather than apoptotic, cell death caused by cytochrome P450-activated ifosfamide

1 reference

12 December 2020

The bystander effect in the HSVtk/ganciclovir system and its relationship to gap junctional communication

1 reference

12 December 2020

Ganciclovir-mediated cell killing and bystander effect is enhanced in cells with two copies of the herpes simplex virus thymidine kinase gene

1 reference

12 December 2020

Synergistic enhancement of herpes simplex virus thymidine kinase/ganciclovir-mediated cytoxicity by hydroxyurea

1 reference

12 December 2020

Bystander effect in herpes simplex virus-thymidine kinase/ganciclovir cancer gene therapy: role of gap-junctional intercellular communication.

1 reference

12 December 2020

Potentiation of cytochrome P450/cyclophosphamide-based cancer gene therapy by coexpression of the P450 reductase gene

1 reference

12 December 2020

Gene-directed enzyme prodrug therapy with a mustard prodrug/carboxypeptidase G2 combination

1 reference

12 December 2020

Gene therapy of hepatoma: bystander effects and non-apoptotic cell death induced by thymidine kinase and ganciclovir

1 reference

12 December 2020

Towards the optimal vector for prostate cancer gene therapy; a caPCURE meeting report

1 reference

12 December 2020

Adeno-associated virus-mediated delivery of antiangiogenic factors as an antitumor strategy.

1 reference

12 December 2020

The use of radiation-induced bacterial promoters in anaerobic conditions: a means to control gene expression in clostridium-mediated therapy for cancer

1 reference

12 December 2020

Non-viral vectors in cancer gene therapy: principles and progress

1 reference

12 December 2020

Development of a novel enzyme/prodrug combination for gene therapy of cancer: horseradish peroxidase/indole-3-acetic acid

1 reference

12 December 2020

The nitroreductase/CB1954 combination in Epstein-Barr virus-positive B-cell lines: induction of bystander killing in vitro and in vivo

1 reference

12 December 2020

Human prostate carcinoma cells as targets for herpes simplex virus thymidine kinase-mediated suicide gene therapy.

1 reference

12 December 2020

Protection of herpes simplex virus thymidine kinase-transduced cells from ganciclovir-mediated cytotoxicity by bystander cells: the Good Samaritan effect

1 reference

12 December 2020

In vivo analysis of the 'bystander effect': a cytokine cascade

1 reference

12 December 2020

Cell surface display of a lysosomal enzyme for extracellular gene-directed enzyme prodrug therapy

1 reference

12 December 2020

Combined suicide and granulocyte-macrophage colony-stimulating factor gene therapy induces complete tumor regression and generates antitumor immunity

1 reference

12 December 2020

Absence of in vitro or in vivo bystander effects in a thymidine kinase-transduced murine T lymphoma

1 reference

12 December 2020

Enhanced green fluorescent protein fusion proteins of herpes simplex virus type 1 thymidine kinase and cytochrome P450 4B1: applications for prodrug-activating gene therapy

1 reference

12 December 2020

Bystander-mediated regression of osteosarcoma via retroviral transfer of the herpes simplex virus thymidine kinase and human interleukin-2 genes

1 reference

12 December 2020