(Q45922508)

17 December 2017

title

Valproic acid is neuroprotective in the rotenone rat model of Parkinson's disease: involvement of alpha-synuclein. (English)

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17 December 2017

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Barbara Monti

1

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author name string

Valentina Gatta

2

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17 December 2017

Valentina Gatta

3

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17 December 2017

Francesca Piretti

4

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17 December 2017

Simonetta S Raffaelli

5

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17 December 2017

Marco Virgili

6

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17 December 2017

Antonio Contestabile

7

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17 December 2017

publication date

21 July 2009

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17 December 2017

published in

Neurotoxicity Research

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17 December 2017

volume

17

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17 December 2017

issue

2

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17 December 2017

page(s)

130-141

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17 December 2017

https://scigraph.springernature.com/pub.10.1007/s12640-009-9090-5

exact match

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cites work

Ubiquitination of alpha-synuclein and autophagy in Parkinson's disease.

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Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells

21 January 2018

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Nuclear localization of alpha-synuclein and its interaction with histones

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Extensive nuclear localization of alpha-synuclein in normal rat brain neurons revealed by a novel monoclonal antibody

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Biochemical, molecular and epigenetic mechanisms of valproic acid neuroprotection

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Treatment guidelines for bipolar disorder: a critical review.

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Monoubiquitylation of alpha-synuclein by seven in absentia homolog (SIAH) promotes its aggregation in dopaminergic cells

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Valproic acid-mediated Hsp70 induction and anti-apoptotic neuroprotection in SH-SY5Y cells

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12 December 2020

Alpha-synuclein lowers p53-dependent apoptotic response of neuronal cells. Abolishment by 6-hydroxydopamine and implication for Parkinson's disease

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Selective alteration of DNA fragmentation and caspase activity in the spinal cord of aged rats and effect of dietary restriction.

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Lack of nigral pathology in transgenic mice expressing human alpha-synuclein driven by the tyrosine hydroxylase promoter

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Short chain fatty acids regulate tyrosine hydroxylase gene expression through a cAMP-dependent signaling pathway

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Alpha-synuclein acts in the nucleus to inhibit histone acetylation and promote neurotoxicity

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Synuclein: a neuron-specific protein localized to the nucleus and presynaptic nerve terminal

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Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease

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Chronic systemic pesticide exposure reproduces features of Parkinson's disease

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12 December 2020

Overexpression of alpha-synuclein in rat substantia nigra results in loss of dopaminergic neurons, phosphorylation of alpha-synuclein and activation of caspase-9: resemblance to pathogenetic changes in Parkinson's disease

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Basic pharmacology of valproate: a review after 35 years of clinical use for the treatment of epilepsy

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An efficient method for simultaneous isolation of biologically active transcription factors and DNA.

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Valproic Acid: second generation

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Modulation of CNS signal transduction pathways and gene expression by mood-stabilizing agents: therapeutic implications

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Alpha-synuclein regulates neuronal survival via Bcl-2 family expression and PI3/Akt kinase pathway

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Dopaminergic loss and inclusion body formation in alpha-synuclein mice: implications for neurodegenerative disorders

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12 December 2020

Changes in tyrosine hydroxylase mRNA expression in the rat locus coeruleus following acute or chronic treatment with valproic acid

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Histone deacetylase inhibitors exhibit anti-inflammatory and neuroprotective effects in a rat permanent ischemic model of stroke: multiple mechanisms of action.

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Protein regulation by monoubiquitin

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Valproate is neuroprotective against malonate toxicity in rat striatum: an association with augmentation of high-affinity glutamate uptake.

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The antiapoptotic actions of mood stabilizers: molecular mechanisms and therapeutic potentials

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Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

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Changing venues for tumour suppression: balancing destruction and localization by monoubiquitylation

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Alpha-synuclein protects cerebellar granule neurons against 6-hydroxydopamine-induced death

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Valproic acid and other histone deacetylase inhibitors induce microglial apoptosis and attenuate lipopolysaccharide-induced dopaminergic neurotoxicity

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Multiple system atrophy: alpha-synuclein and neuronal degeneration

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12 December 2020

Valproate protects dopaminergic neurons in midbrain neuron/glia cultures by stimulating the release of neurotrophic factors from astrocytes.

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Parkinson-like neurodegeneration induced by targeted overexpression of alpha-synuclein in the nigrostriatal system.

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α-Synuclein Overexpression Protects against Paraquat-Induced Neurodegeneration

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Endogenous alpha-synuclein is induced by valproic acid through histone deacetylase inhibition and participates in neuroprotection against glutamate-induced excitotoxicity.

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Alpha-synuclein protects naive but not dbcAMP-treated dopaminergic cell types from 1-methyl-4-phenylpyridinium toxicity

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Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen

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Valproic acid-mediated neuroprotection in intracerebral hemorrhage via histone deacetylase inhibition and transcriptional activation.

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Qualitative and quantitative estimates of apoptosis from birth to senescence in the rat brain.

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12 December 2020

Subcutaneous rotenone exposure causes highly selective dopaminergic degeneration and alpha-synuclein aggregation.

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12 December 2020

Misattribution of eating and obsessive-compulsive disorder symptoms to repressed memories of childhood sexual or physical abuse.

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Treatment of Parkinson's Disease with Sodium Valproate: Clinical, Pharmacological, and Biochemical Observations

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The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia

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12 December 2020

Alpha-synuclein: normal function and role in neurodegenerative diseases.

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12 December 2020

Low dose rotenone treatment causes selective transcriptional activation of cell death related pathways in dopaminergic neurons in vivo.

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12 December 2020

Valproic acid regulates catecholaminergic pathways by concentration-dependent threshold effects on TH mRNA synthesis and degradation

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12 December 2020

Protein measurement with the Folin phenol reagent

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12 December 2020

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12 December 2020

Sodium valproate in the treatment of levodopa-induced dyskinesia

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12 December 2020

Valproic acid, a mood stabilizer and anticonvulsant, protects rat cerebral cortical neurons from spontaneous cell death: a role of histone deacetylase inhibition

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12 December 2020

Chronic dietary administration of valproic acid protects neurons of the rat nucleus basalis magnocellularis from ibotenic acid neurotoxicity

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12 December 2020

alpha-Synuclein redistributed and aggregated in rotenone-induced Parkinson's disease rats

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12 December 2020

Mood stabilizer valproate promotes ERK pathway-dependent cortical neuronal growth and neurogenesis.

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12 December 2020

Selective microglial activation in the rat rotenone model of Parkinson's disease

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12 December 2020

Alpha-synuclein immunoreactivity in neuronal nuclear inclusions and neurites in multiple system atrophy.

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12 December 2020

Sensitivity to MPTP is not increased in Parkinson's disease-associated mutant alpha-synuclein transgenic mice

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12 December 2020

Improvements in automated analysis of catecholamine and related metabolites in biological samples by column-switching high-performance liquid chromatography

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12 December 2020

Valproic acid: an old drug newly discovered as inhibitor of histone deacetylases

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12 December 2020

The neurobiology of antiepileptic drugs

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12 December 2020

10.1007/S12640-009-9090-5

Identifiers

DOI

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17 December 2017

Dimensions Publication ID

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17 December 2017