(Q48473494)

English

Endogenous alpha-synuclein is induced by valproic acid through histone deacetylase inhibition and participates in neuroprotection against glutamate-induced excitotoxicity.

scientific article published in July 2006

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scholarly article

1 reference

Europe PubMed Central

11 February 2018

http://europepmc.org/abstract/MED/16837598

Endogenous alpha-synuclein is induced by valproic acid through histone deacetylase inhibition and participates in neuroprotection against glutamate-induced excitotoxicity (English)

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6674182&resulttype=core&format=json

11 May 2020

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

2

0 references

author name string

Yan Leng

1

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6674182&resulttype=core&format=json

11 May 2020

language of work or name

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publication date

1 July 2006

1 reference

Europe PubMed Central

11 February 2018

http://europepmc.org/abstract/MED/16837598

Journal of Neuroscience

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6674182&resulttype=core&format=json

11 May 2020

26

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6674182&resulttype=core&format=json

11 May 2020

7502-7512

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6674182&resulttype=core&format=json

11 May 2020

28

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6674182&resulttype=core&format=json

11 May 2020

Noncanonical MMS2-encoded ubiquitin-conjugating enzyme functions in assembly of novel polyubiquitin chains for DNA repair

1 reference

https://pubmed.ncbi.nlm.nih.gov/16837598

12 December 2020

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inferred from PubMed ID database lookup

alpha-Synuclein shares physical and functional homology with 14-3-3 proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/16837598

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bcl-2 proteins: regulators of apoptosis or of mitochondrial homeostasis?

1 reference

https://pubmed.ncbi.nlm.nih.gov/16837598

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Wild-type but not Parkinson's disease-related ala-53 --> Thr mutant alpha -synuclein protects neuronal cells from apoptotic stimuli

1 reference

https://pubmed.ncbi.nlm.nih.gov/16837598

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

1 reference

https://pubmed.ncbi.nlm.nih.gov/16837598

12 December 2020

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inferred from PubMed ID database lookup

alpha-Synuclein membrane interactions and lipid specificity

1 reference

https://pubmed.ncbi.nlm.nih.gov/16837598

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased expression of endoplasmic reticulum stress proteins following chronic valproate treatment of rat C6 glioma cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16837598

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interaction of alpha-synuclein and synphilin-1: effect of Parkinson's disease-associated mutations

1 reference

https://pubmed.ncbi.nlm.nih.gov/16837598

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Muscarinic receptor stimulation induces translocation of an alpha-synuclein oligomer from plasma membrane to a light vesicle fraction in cytoplasm

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https://pubmed.ncbi.nlm.nih.gov/16837598

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The mood stabilizer valproic acid activates mitogen-activated protein kinases and promotes neurite growth

1 reference

https://pubmed.ncbi.nlm.nih.gov/16837598

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen

1 reference

https://pubmed.ncbi.nlm.nih.gov/16837598

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chronic lithium treatment increases the expression of brain-derived neurotrophic factor in the rat brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/16837598

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/16837598

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of allelic variation at the NACP-Rep1 repeat upstream of the alpha-synuclein gene (SNCA) on transcription in a cell culture luciferase reporter system

1 reference

https://pubmed.ncbi.nlm.nih.gov/16837598

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

alpha-Synuclein protects against oxidative stress via inactivation of the c-Jun N-terminal kinase stress-signaling pathway in neuronal cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/16837598

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Life extension in Drosophila by feeding a drug.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16837598

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lithium protection against glutamate excitotoxicity in rat cerebral cortical neurons: involvement of NMDA receptor inhibition possibly by decreasing NR2B tyrosine phosphorylation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16837598

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alpha-synuclein regulates neuronal survival via Bcl-2 family expression and PI3/Akt kinase pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/16837598

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synaptic vesicle depletion correlates with attenuated synaptic responses to prolonged repetitive stimulation in mice lacking alpha-synuclein

1 reference

https://pubmed.ncbi.nlm.nih.gov/16837598

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alpha-synuclein lowers p53-dependent apoptotic response of neuronal cells. Abolishment by 6-hydroxydopamine and implication for Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/16837598

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of Akt and glycogen synthase kinase-3 beta phosphorylation by sodium valproate and lithium

1 reference

https://pubmed.ncbi.nlm.nih.gov/16837598

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of c-Jun N-terminal kinase, p38 kinase and AP-1 DNA binding in cultured brain neurons: roles in glutamate excitotoxicity and lithium neuroprotection

1 reference

https://pubmed.ncbi.nlm.nih.gov/16837598

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Histone deacetylase inhibitors prevent oxidative neuronal death independent of expanded polyglutamine repeats via an Sp1-dependent pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/16837598

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apoptosis and caspases in neurodegenerative diseases

1 reference

https://pubmed.ncbi.nlm.nih.gov/16837598

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

α-Synuclein Overexpression Protects against Paraquat-Induced Neurodegeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/16837598

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Valproic acid, a mood stabilizer and anticonvulsant, protects rat cerebral cortical neurons from spontaneous cell death: a role of histone deacetylase inhibition

1 reference

https://pubmed.ncbi.nlm.nih.gov/16837598

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alpha-synuclein protects naive but not dbcAMP-treated dopaminergic cell types from 1-methyl-4-phenylpyridinium toxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/16837598

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The histone deacetylase inhibitor valproic acid selectively induces proteasomal degradation of HDAC2

1 reference

https://pubmed.ncbi.nlm.nih.gov/16837598

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interactions between double-stranded RNA regulators and the protein kinase DAI

1 reference

https://pubmed.ncbi.nlm.nih.gov/16837598

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alpha-synuclein implicated in Parkinson's disease is present in extracellular biological fluids, including human plasma.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16837598

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular Pathways of Neurodegeneration in Parkinson's Disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/16837598

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ubiquitination and translocation of TRAF2 is required for activation of JNK but not of p38 or NF-kappaB.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16837598

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia

1 reference

https://pubmed.ncbi.nlm.nih.gov/16837598

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alpha-synuclein: normal function and role in neurodegenerative diseases.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16837598

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

BDNF is induced by wild-type alpha-synuclein but not by the two mutants, A30P or A53T, in glioma cell line

1 reference

https://pubmed.ncbi.nlm.nih.gov/16837598

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Valproic acid reduces brain damage induced by transient focal cerebral ischemia in rats: potential roles of histone deacetylase inhibition and heat shock protein induction

1 reference

https://pubmed.ncbi.nlm.nih.gov/16837598

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mood stabilizer valproate promotes ERK pathway-dependent cortical neuronal growth and neurogenesis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16837598

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Valproic acid inhibits histone deacetylase activity and suppresses excitotoxicity-induced GAPDH nuclear accumulation and apoptotic death in neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/16837598

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protective effect of TAT-delivered alpha-synuclein: relevance of the C-terminal domain and involvement of HSP70.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16837598

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

alpha-Synuclein produces a long-lasting increase in neurotransmitter release

1 reference

https://pubmed.ncbi.nlm.nih.gov/16837598

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Histone deacetylase inhibition-mediated neuronal differentiation of multipotent adult neural progenitor cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/16837598

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Adapter protein 14-3-3 is required for a presynaptic form of LTP in the cerebellum

1 reference

https://pubmed.ncbi.nlm.nih.gov/16837598

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Valproate protects cells from ER stress-induced lipid accumulation and apoptosis by inhibiting glycogen synthase kinase-3.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16837598

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

RNA interference and the use of small interfering RNA to study gene function in mammalian systems

1 reference

https://pubmed.ncbi.nlm.nih.gov/16837598

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protracted lithium treatment protects against the ER stress elicited by thapsigargin in rat PC12 cells: roles of intracellular calcium, GRP78 and Bcl-2.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16837598

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alpha-synuclein and parkin contribute to the assembly of ubiquitin lysine 63-linked multiubiquitin chains

1 reference

https://pubmed.ncbi.nlm.nih.gov/16837598

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Remodeling chromatin and stress resistance in the central nervous system: histone deacetylase inhibitors as novel and broadly effective neuroprotective agents.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16837598

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Parkin mediates nonclassical, proteasomal-independent ubiquitination of synphilin-1: implications for Lewy body formation

1 reference

https://pubmed.ncbi.nlm.nih.gov/16837598

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Valproate pretreatment protects dopaminergic neurons from LPS-induced neurotoxicity in rat primary midbrain cultures: role of microglia.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16837598

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Proteolytic cleavage of extracellular secreted {alpha}-synuclein via matrix metalloproteinases

1 reference

https://pubmed.ncbi.nlm.nih.gov/16837598

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intravesicular localization and exocytosis of alpha-synuclein and its aggregates.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16837598

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alpha-synuclein cooperates with CSPalpha in preventing neurodegeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/16837598

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/16837598

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/16837598

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chronic lithium treatment robustly protects neurons in the central nervous system against excitotoxicity by inhibiting N-methyl-D-aspartate receptor-mediated calcium influx

1 reference

https://pubmed.ncbi.nlm.nih.gov/16837598

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The mood-stabilizing agents lithium and valproate robustly increase the levels of the neuroprotective protein bcl-2 in the CNS

1 reference

https://pubmed.ncbi.nlm.nih.gov/16837598

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.0096-06.2006

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6674182&resulttype=core&format=json

11 May 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6674182&resulttype=core&format=json

11 May 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6674182&resulttype=core&format=json

11 May 2020

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