(Q46027540)

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The New Chemical Reporter 6-Alkynyl-6-deoxy-GlcNAc Reveals O-GlcNAc Modification of the Apoptotic Caspases That Can Block the Cleavage/Activation of Caspase-8.

scientific article published on 22 May 2017

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scholarly article

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Europe PubMed Central

18 December 2017

http://europepmc.org/abstract/MED/28528544

The New Chemical Reporter 6-Alkynyl-6-deoxy-GlcNAc Reveals O-GlcNAc Modification of the Apoptotic Caspases That Can Block the Cleavage/Activation of Caspase-8. (English)

1 reference

Europe PubMed Central

18 December 2017

http://europepmc.org/abstract/MED/28528544

apoptotic process

1 reference

based on heuristic

inferred from title

3

1 reference

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11 June 2020

Matthew R Pratt

8

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11 June 2020

author name string

Kelly N Chuh

1

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11 June 2020

Anna R Batt

2

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11 June 2020

Narek Darabedian

4

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11 June 2020

Nicholas P Marotta

5

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11 June 2020

Caroline K Brennan

6

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11 June 2020

Arya Amirhekmat

7

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11 June 2020

language of work or name

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publication date

22 May 2017

1 reference

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18 December 2017

http://europepmc.org/abstract/MED/28528544

Journal of the American Chemical Society

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11 June 2020

139

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11 June 2020

23

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11 June 2020

7872-7885

1 reference

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11 June 2020

Molecular mechanisms of caspase regulation during apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/28528544

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Changes in metabolic chemical reporter structure yield a selective probe of O-GlcNAc modification

1 reference

https://pubmed.ncbi.nlm.nih.gov/28528544

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The roles of O-linked β-N-acetylglucosamine in cardiovascular physiology and disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/28528544

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

O-GlcNAcylation of G6PD promotes the pentose phosphate pathway and tumor growth

1 reference

https://pubmed.ncbi.nlm.nih.gov/28528544

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The emerging significance of O-GlcNAc in cellular regulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/28528544

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

O-GlcNAc modification blocks the aggregation and toxicity of the protein α-synuclein associated with Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/28528544

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The O-GlcNAc transferase gene resides on the X chromosome and is essential for embryonic stem cell viability and mouse ontogeny

1 reference

https://pubmed.ncbi.nlm.nih.gov/28528544

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dynamic O-GlcNAc modification of nucleocytoplasmic proteins in response to stress. A survival response of mammalian cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/28528544

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein O-linked β-N-acetylglucosamine: a novel effector of cardiomyocyte metabolism and function

1 reference

https://pubmed.ncbi.nlm.nih.gov/28528544

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Internally quenched fluorescent peptide substrates disclose the subsite preferences of human caspases 1, 3, 6, 7 and 8

1 reference

https://pubmed.ncbi.nlm.nih.gov/28528544

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

O-GlcNAcase is essential for embryonic development and maintenance of genomic stability

1 reference

https://pubmed.ncbi.nlm.nih.gov/28528544

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functions of caspase 8: the identified and the mysterious

1 reference

https://pubmed.ncbi.nlm.nih.gov/28528544

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Solid-phase synthesis of O-linked glycopeptide analogues of enkephalin

1 reference

https://pubmed.ncbi.nlm.nih.gov/28528544

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alkynyl sugar analogs for the labeling and visualization of glycoconjugates in cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/28528544

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interdimer processing mechanism of procaspase-8 activation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/28528544

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of proteolysis in caspase-8 activation and stabilization

1 reference

https://pubmed.ncbi.nlm.nih.gov/28528544

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A unified model for apical caspase activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/28528544

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fast, cell-compatible click chemistry with copper-chelating azides for biomolecular labeling

1 reference

https://pubmed.ncbi.nlm.nih.gov/28528544

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Advances in understanding glycosyltransferases from a structural perspective

1 reference

https://pubmed.ncbi.nlm.nih.gov/28528544

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Global mapping of the topography and magnitude of proteolytic events in apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/28528544

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

O-GlcNAc in cancer biology

1 reference

https://pubmed.ncbi.nlm.nih.gov/28528544

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A potent mechanism-inspired O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/28528544

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Robust fluorescent detection of protein fatty-acylation with chemical reporters.

1 reference

https://pubmed.ncbi.nlm.nih.gov/28528544

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

O-GlcNAc modification prevents peptide-dependent acceleration of α-synuclein aggregation

1 reference

https://pubmed.ncbi.nlm.nih.gov/28528544

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A peptide panel investigation reveals the acceptor specificity of O-GlcNAc transferase

1 reference

https://pubmed.ncbi.nlm.nih.gov/28528544

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Caspases in apoptosis and beyond

1 reference

https://pubmed.ncbi.nlm.nih.gov/28528544

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MerCASBA: an updated and refined database of caspase substrates

1 reference

https://pubmed.ncbi.nlm.nih.gov/28528544

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hyper-O-GlcNAcylation is anti-apoptotic and maintains constitutive NF-κB activity in pancreatic cancer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/28528544

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

6''-Azido-6''-deoxy-UDP-N-acetylglucosamine as a glycosyltransferase substrate

1 reference

https://pubmed.ncbi.nlm.nih.gov/28528544

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dynamic O-GlcNAcylation and its roles in the cellular stress response and homeostasis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/28528544

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chemical reporters for fluorescent detection and identification of O-GlcNAc-modified proteins reveal glycosylation of the ubiquitin ligase NEDD4-1

1 reference

https://pubmed.ncbi.nlm.nih.gov/28528544

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A synthetic lethal screen identifies FAT1 as an antagonist of caspase-8 in extrinsic apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/28528544

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A little sugar goes a long way: the cell biology of O-GlcNAc

1 reference

https://pubmed.ncbi.nlm.nih.gov/28528544

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Direct in-gel fluorescence detection and cellular imaging of O-GlcNAc-modified proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/28528544

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ogt-dependent X-chromosome-linked protein glycosylation is a requisite modification in somatic cell function and embryo viability

1 reference

https://pubmed.ncbi.nlm.nih.gov/28528544

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of caspase cleavage-site phosphorylation on proteolysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/28528544

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increasing O-GlcNAc slows neurodegeneration and stabilizes tau against aggregation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/28528544

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphofructokinase 1 glycosylation regulates cell growth and metabolism

1 reference

https://pubmed.ncbi.nlm.nih.gov/28528544

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hijacking a biosynthetic pathway yields a glycosyltransferase inhibitor within cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/28528544

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human caspases: activation, specificity, and regulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/28528544

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apoptosis: a review of programmed cell death

1 reference

https://pubmed.ncbi.nlm.nih.gov/28528544

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Global sequencing of proteolytic cleavage sites in apoptosis by specific labeling of protein N termini

1 reference

https://pubmed.ncbi.nlm.nih.gov/28528544

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Drosophila O-GlcNAc transferase (OGT) is encoded by the Polycomb group (PcG) gene, super sex combs (sxc).

1 reference

https://pubmed.ncbi.nlm.nih.gov/28528544

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional interplay between caspase cleavage and phosphorylation sculpts the apoptotic proteome

1 reference

https://pubmed.ncbi.nlm.nih.gov/28528544

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A metabolic labeling approach toward proteomic analysis of mucin-type O-linked glycosylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/28528544

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Caspase substrates and cellular remodeling

1 reference

https://pubmed.ncbi.nlm.nih.gov/28528544

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Live to die another way: modes of programmed cell death and the signals emanating from dying cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/28528544

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The active site of O-GlcNAc transferase imposes constraints on substrate sequence

1 reference

https://pubmed.ncbi.nlm.nih.gov/28528544

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

O-GlcNAc processing enzymes: catalytic mechanisms, substrate specificity, and enzyme regulation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/28528544

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Post-translational modification of Bid has differential effects on its susceptibility to cleavage by caspase 8 or caspase 3.

1 reference

https://pubmed.ncbi.nlm.nih.gov/28528544

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inducible dimerization and inducible cleavage reveal a requirement for both processes in caspase-8 activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/28528544

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1021/JACS.7B02213

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28528544%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28528544%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28528544%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

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