(Q36200921)

12 August 2017

O-GlcNAc modification blocks the aggregation and toxicity of the protein α-synuclein associated with Parkinson's disease (English)

1 reference

12 August 2017

1 reference

1 reference

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26492012%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

9

Matthew R Pratt

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26492012%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

author name string

Nicholas P Marotta

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26492012%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

Yu Hsuan Lin

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26492012%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

Yuka E Lewis

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26492012%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

Mark R Ambroso

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26492012%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

Maxwell T Roth

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26492012%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

Don B Arnold

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26492012%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

Ralf Langen

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26492012%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

publication date

12 October 2015

1 reference

12 August 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26492012%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

volume

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26492012%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

page(s)

913-920

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26492012%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

issue

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26492012%20AND%20SRC:MED&resulttype=core&format=json

https://scigraph.springernature.com/pub.10.1038/nchem.2361

5 June 2020

exact match

0 references

cites work

Mechanisms of alpha-synuclein action on neurotransmission: cell-autonomous and non-cell autonomous role

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A little sugar goes a long way: the cell biology of O-GlcNAc

1 October 2017

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Elucidating the Role of Site-Specific Nitration of α-Synuclein in the Pathogenesis of Parkinson's Disease via Protein Semisynthesis and Mutagenesis.

1 October 2017

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Spreading of pathology in neurodegenerative diseases: a focus on human studies

1 October 2017

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Alpha-synuclein spreading in Parkinson's disease

1 October 2017

1 reference

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The emerging link between O-GlcNAc and Alzheimer disease.

1 October 2017

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Nutrient regulation of signaling, transcription, and cell physiology by O-GlcNAcylation.

1 October 2017

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Synucleins regulate the kinetics of synaptic vesicle endocytosis.

1 October 2017

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The H50Q mutation enhances α-synuclein aggregation, secretion, and toxicity

1 October 2017

1 reference

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O-GlcNAc and neurodegeneration: biochemical mechanisms and potential roles in Alzheimer's disease and beyond.

1 October 2017

1 reference

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Synthetic polyubiquitinated α-Synuclein reveals important insights into the roles of the ubiquitin chain in regulating its pathophysiology

1 October 2017

1 reference

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Polo-like kinase 2 regulates selective autophagic α-synuclein clearance and suppresses its toxicity in vivo

1 October 2017

1 reference

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α-Synuclein: the long distance runner

1 October 2017

1 reference

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Mapping the subcellular distribution of α-synuclein in neurons using genetically encoded probes for correlated light and electron microscopy: implications for Parkinson's disease pathogenesis

1 October 2017

1 reference

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Parkinson's disease and alpha synuclein: is Parkinson's disease a prion-like disorder?

1 October 2017

1 reference

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The many faces of α-synuclein: from structure and toxicity to therapeutic target

1 October 2017

1 reference

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O-GlcNAc modification prevents peptide-dependent acceleration of α-synuclein aggregation

1 October 2017

1 reference

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Remodeling of lipid vesicles into cylindrical micelles by α-synuclein in an extended α-helical conformation.

1 October 2017

1 reference

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Characterization of semisynthetic and naturally Nα-acetylated α-synuclein in vitro and in intact cells: implications for aggregation and cellular properties of α-synuclein

1 October 2017

1 reference

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Tandem mass spectrometry identifies many mouse brain O-GlcNAcylated proteins including EGF domain-specific O-GlcNAc transferase targets

1 October 2017

1 reference

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Elucidating the role of C-terminal post-translational modifications using protein semisynthesis strategies: α-synuclein phosphorylation at tyrosine 125.

1 October 2017

1 reference

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Role of post-translational modifications in modulating the structure, function and toxicity of alpha-synuclein: implications for Parkinson's disease pathogenesis and therapies

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4618406

Membrane curvature induction and tubulation are common features of synucleins and apolipoproteins

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4618406

Phosphorylation at S87 is enhanced in synucleinopathies, inhibits alpha-synuclein oligomerization, and influences synuclein-membrane interactions

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4618406

Phosphorylation of synucleins by members of the Polo-like kinase family

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4618406

Enrichment and site mapping of O-linked N-acetylglucosamine by a combination of chemical/enzymatic tagging, photochemical cleavage, and electron transfer dissociation mass spectrometry

1 October 2017

1 reference

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Aggregation-defective alpha-synuclein mutants inhibit the fibrillation of Parkinson's disease-linked alpha-synuclein variants

1 October 2017

1 reference

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Structure of membrane-bound alpha-synuclein from site-directed spin labeling and computational refinement

1 October 2017

1 reference

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Site-specific GlcNAcylation of human erythrocyte proteins: potential biomarker(s) for diabetes

1 October 2017

1 reference

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Aggregates assembled from overexpression of wild-type alpha-synuclein are not toxic to human neuronal cells

1 October 2017

1 reference

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O-linked beta-N-acetylglucosaminyltransferase substrate specificity is regulated by myosin phosphatase targeting and other interacting proteins.

1 October 2017

1 reference

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An efficient Fmoc-SPPS approach for the generation of thioester peptide precursors for use in native chemical ligation

1 October 2017

1 reference

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A potent mechanism-inspired O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo

1 October 2017

1 reference

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The fold of alpha-synuclein fibrils

1 October 2017

1 reference

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Phosphorylation at Ser-129 but not the phosphomimics S129E/D inhibits the fibrillation of alpha-synuclein.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4618406

Investigation of alpha-synuclein fibril structure by site-directed spin labeling

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4618406

The aggregation and fibrillation of alpha-synuclein

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4618406

O-GlcNAcylation regulates phosphorylation of tau: a mechanism involved in Alzheimer's disease

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4618406

Ogt-dependent X-chromosome-linked protein glycosylation is a requisite modification in somatic cell function and embryo viability

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4618406

Clinical overview of the synucleinopathies

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4618406

Effect of the overexpression of wild-type or mutant alpha-synuclein on cell susceptibility to insult

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4618406

Expression of mutant alpha-synuclein causes increased susceptibility to dopamine toxicity

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4618406

Mapping O-GlcNAc modification sites on tau and generation of a site-specific O-GlcNAc tau antibody

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4618406

O-GlcNAcylation prevents aggregation of the Polycomb group repressor polyhomeotic

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4618406

High stability and cooperative unfolding of α-synuclein oligomers

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4618406

The role of stable α-synuclein oligomers in the molecular events underlying amyloid formation.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4618406

Increasing O-GlcNAc slows neurodegeneration and stabilizes tau against aggregation.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4618406

Evidence of a balance between phosphorylation and O-GlcNAc glycosylation of Tau proteins--a role in nuclear localization

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4618406

Pitfalls associated with the use of Thioflavin-T to monitor anti-fibrillogenic activity

22 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26492012

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Towards elucidation of the role of ubiquitination in the pathogenesis of Parkinson's disease with semisynthetic ubiquitinated α-synuclein

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26492012

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NCHEM.2361

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26492012%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26492012%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

1 reference