(Q46178162)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19118173%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

title

Cytoplasmic inclusions of Htt exon1 containing an expanded polyglutamine tract suppress execution of apoptosis in sympathetic neurons (English)

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19 January 2020

4

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19 January 2020

author name string

Matthew A King

1

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19 January 2020

Christoph G Goemans

2

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19 January 2020

Farida Hafiz

3

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19 January 2020

Andreas Wyttenbach

5

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19 January 2020

Aviva M Tolkovsky

6

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19 January 2020

language of work or name

English

0 references

publication date

1 December 2008

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19 January 2020

published in

Journal of Neuroscience

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19 January 2020

volume

28

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19 January 2020

issue

53

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19 January 2020

page(s)

14401-14415

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Caspase-8 is required for cell death induced by expanded polyglutamine repeats.

19 January 2020

cites work

1 reference

12 December 2020

Inhibition of caspase-1 slows disease progression in a mouse model of Huntington's disease

1 reference

12 December 2020

Nerve growth factor-induced PKB/Akt activity is sustained by phosphoinositide 3-kinase dependent and independent signals in sympathetic neurons.

1 reference

12 December 2020

Transgenic models of Huntington's disease

1 reference

12 December 2020

BAX translocation is a critical event in neuronal apoptosis: regulation by neuroprotectants, BCL-2, and caspases

1 reference

12 December 2020

Insoluble detergent-resistant aggregates form between pathological and nonpathological lengths of polyglutamine in mammalian cells

1 reference

12 December 2020

Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor

1 reference

12 December 2020

Effects of heat shock, heat shock protein 40 (HDJ-2), and proteasome inhibition on protein aggregation in cellular models of Huntington's disease

1 reference

12 December 2020

Heat Shock Protein 70 Inhibits Caspase-Dependent and -Independent Apoptosis in Jurkat T Cells

1 reference

12 December 2020

Nonapoptotic neurodegeneration in a transgenic mouse model of Huntington's disease

1 reference

12 December 2020

Minocycline inhibits caspase-1 and caspase-3 expression and delays mortality in a transgenic mouse model of Huntington disease

1 reference

12 December 2020

Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosome

1 reference

12 December 2020

Negative regulation of the Apaf-1 apoptosome by Hsp70

1 reference

12 December 2020

Phosphatidylinositol 3-kinase is required for the trophic, but not the survival-promoting, actions of NGF on sympathetic neurons

1 reference

12 December 2020

c-Jun and the transcriptional control of neuronal apoptosis

1 reference

12 December 2020

Formic acid dissolves aggregates of an N-terminal huntingtin fragment containing an expanded polyglutamine tract: applying to quantification of protein components of the aggregates

1 reference

12 December 2020

Stress management - heat shock protein-70 and the regulation of apoptosis

1 reference

12 December 2020

Mitochondria are selectively eliminated from eukaryotic cells after blockade of caspases during apoptosis

1 reference

12 December 2020

Dominant-negative c-Jun promotes neuronal survival by reducing BIM expression and inhibiting mitochondrial cytochrome c release

1 reference

12 December 2020

Identities of sequestered proteins in aggregates from cells with induced polyglutamine expression

1 reference

12 December 2020

Altered proteasomal function due to the expression of polyglutamine-expanded truncated N-terminal huntingtin induces apoptosis by caspase activation through mitochondrial cytochrome c release

1 reference

12 December 2020

Proteasomal inhibition leads to formation of ubiquitin/alpha-synuclein-immunoreactive inclusions in PC12 cells

1 reference

12 December 2020

Expression of full-length polyglutamine-expanded Huntingtin disrupts growth factor receptor signaling in rat pheochromocytoma (PC12) cells

1 reference

12 December 2020

Cyclosporin A inhibits caspase-independent death of NGF-deprived sympathetic neurons: a potential role for mitochondrial permeability transition

1 reference

12 December 2020

Nerve Growth Factor is Required for Induction of c-Fos Immunoreactivity by Serum, Depolarization, Cyclic AMP or Trauma in Cultured Rat Sympathetic Neurons

1 reference

12 December 2020

Molecular chaperones as modulators of polyglutamine protein aggregation and toxicity

1 reference

12 December 2020

Nerve growth factor (NGF) down-regulates the Bcl-2 homology 3 (BH3) domain-only protein Bim and suppresses its proapoptotic activity by phosphorylation

1 reference

12 December 2020

Aggresomes protect cells by enhancing the degradation of toxic polyglutamine-containing protein

1 reference

12 December 2020

Bax, Reactive Oxygen, and CytochromecRelease in Neuronal Apoptosis

1 reference

12 December 2020

Men are but worms: neuronal cell death in C elegans and vertebrates

1 reference

12 December 2020

Heat shock protein 70 participates in the neuroprotective response to intracellularly expressed beta-amyloid in neurons.

1 reference

12 December 2020

Potentiation of NMDA receptor-mediated excitotoxicity linked with intrinsic apoptotic pathway in YAC transgenic mouse model of Huntington's disease

1 reference

12 December 2020

Nerve growth factor promotes the survival of sympathetic neurons through the cooperative function of the protein kinase C and phosphatidylinositol 3-kinase pathways.

1 reference

12 December 2020

Expanded huntingtin activates the c-Jun terminal kinase/c-Jun pathway prior to aggregate formation in striatal neurons in culture.

1 reference

12 December 2020

Application of proteasomal inhibitors to mouse sympathetic neurons activates the intrinsic apoptotic pathway

1 reference

12 December 2020

Proteasome inhibitors suppress formation of polyglutamine-induced nuclear inclusions in cultured postmitotic neurons

1 reference

12 December 2020

Global impairment of the ubiquitin-proteasome system by nuclear or cytoplasmic protein aggregates precedes inclusion body formation.

1 reference

12 December 2020

Disturbed Ca2+ signaling and apoptosis of medium spiny neurons in Huntington's disease.

1 reference

12 December 2020

Early apoptotic and late necrotic components associated with altered Ca2+ homeostasis in a peptide-delivery model of polyglutamine-induced neuronal death

1 reference

12 December 2020

BH3-only proteins: key regulators of neuronal apoptosis

1 reference

12 December 2020

Regulatory phosphorylation of Bim: sorting out the ERK from the JNK

1 reference

12 December 2020

Proteasome inhibition by lactacystin in primary neuronal cells induces both potentially neuroprotective and pro-apoptotic transcriptional responses: a microarray analysis

1 reference

12 December 2020

p53 mediates cellular dysfunction and behavioral abnormalities in Huntington's disease

1 reference

12 December 2020

The limited role of NH2-terminal c-Jun phosphorylation in neuronal apoptosis: identification of the nuclear pore complex as a potential target of the JNK pathway.

1 reference

12 December 2020

Proteasome inhibition elicits a biphasic effect on neuronal apoptosis via differential regulation of pro-survival and pro-apoptotic transcription factors

1 reference

12 December 2020

Increased susceptibility of cytoplasmic over nuclear polyglutamine aggregates to autophagic degradation

1 reference

12 December 2020

Hsp70 inhibits heat-induced apoptosis upstream of mitochondria by preventing Bax translocation

1 reference

12 December 2020

HDAC6 and microtubules are required for autophagic degradation of aggregated huntingtin

1 reference

12 December 2020

Monitoring activity and inhibition of 26S proteasomes with fluorogenic peptide substrates

1 reference

12 December 2020

Protein synthesis upon acute nutrient restriction relies on proteasome function

1 reference

12 December 2020

Transcriptional repression induces a slowly progressive atypical neuronal death associated with changes of YAP isoforms and p73

1 reference

12 December 2020

The BH3-only protein Puma is both necessary and sufficient for neuronal apoptosis induced by DNA damage in sympathetic neurons

1 reference

12 December 2020

AEG3482 is an antiapoptotic compound that inhibits Jun kinase activity and cell death through induced expression of heat shock protein 70.

1 reference

12 December 2020

Stochastic kinetics of intracellular huntingtin aggregate formation.

1 reference

12 December 2020

Lysosomal turnover, but not a cellular level, of endogenous LC3 is a marker for autophagy

1 reference

12 December 2020

Apoptosis induced by proteasome inhibition in cancer cells: predominant role of the p53/PUMA pathway

1 reference

12 December 2020

Aggregate-prone proteins are cleared from the cytosol by autophagy: therapeutic implications

1 reference

12 December 2020

Endoplasmic reticulum stress-induced apoptosis requires bax for commitment and Apaf-1 for execution in primary neurons.

1 reference

12 December 2020

NGF augments the autophosphorylation of Ret via inhibition of ubiquitin-dependent degradation.

1 reference

12 December 2020

The induction levels of heat shock protein 70 differentiate the vulnerabilities to mutant huntingtin among neuronal subtypes

1 reference

12 December 2020

BH3-only proteins Bid and Bim(EL) are differentially involved in neuronal dysfunction in mouse models of Huntington's disease

1 reference

12 December 2020

Trinucleotide Repeat Disorders

1 reference

12 December 2020

Bcl-2-regulated apoptosis: mechanism and therapeutic potential

1 reference

12 December 2020

Hsp70 suppresses apoptosis in sympathetic neurones by preventing the activation of c-Jun.

1 reference

12 December 2020

Intra-mitochondrial degradation of Tim23 curtails the survival of cells rescued from apoptosis by caspase inhibitors

1 reference

12 December 2020

Suppression of neurodegeneration and increased neurotransmission caused by expanded full-length huntingtin accumulating in the cytoplasm

1 reference

12 December 2020

A novel cell death pathway that is partially caspase dependent, but morphologically non-apoptotic, elicited by proteasomal inhibition of rat sympathetic neurons

1 reference

12 December 2020

Combinational approach of intrabody with enhanced Hsp70 expression addresses multiple pathologies in a fly model of Huntington's disease.

1 reference

12 December 2020

Rapamycin inhibits polyglutamine aggregation independently of autophagy by reducing protein synthesis

1 reference

12 December 2020

Inhibitors of cytochrome c release with therapeutic potential for Huntington's disease

1 reference

12 December 2020

53 Long-term culture of dissociated sympathetic neurons

1 reference

12 December 2020

Ubiquitinylation is not an absolute requirement for degradation of c-Jun protein by the 26 S proteasome

1 reference

12 December 2020

Neutralizing anti-p21ras Fabs suppress rat sympathetic neuron survival induced by NGF, LIF, CNTF and cAMP

1 reference

12 December 2020

Involvement of the proteasome in the programmed cell death of NGF-deprived sympathetic neurons.

1 reference

12 December 2020

BAX is required for neuronal death after trophic factor deprivation and during development

1 reference

12 December 2020

Phosphorylation-dependent targeting of c-Jun ubiquitination by Jun N-kinase

1 reference

12 December 2020

Antisense oligodeoxynucleotides to bax mRNA promote survival of rat sympathetic neurons in culture

1 reference

12 December 2020

Bafilomycins and concanamycins as inhibitors of V-ATPases and P-ATPases.

1 reference

12 December 2020

Comparison between the timing of JNK activation, c-Jun phosphorylation, and onset of death commitment in sympathetic neurones.

1 reference

12 December 2020

Role of the human heat shock protein hsp70 in protection against stress-induced apoptosis

1 reference

12 December 2020

Mitochondrial membrane potential and hydroethidine-monitored superoxide generation in cultured cerebellar granule cells.

1 reference

12 December 2020

Length of huntingtin and its polyglutamine tract influences localization and frequency of intracellular aggregates

1 reference

12 December 2020

A simplified system for generating recombinant adenoviruses

1 reference

12 December 2020

1 reference

12 December 2020

The influence of huntingtin protein size on nuclear localization and cellular toxicity.

1 reference

12 December 2020

Control of neuronal size homeostasis by trophic factor-mediated coupling of protein degradation to protein synthesis

1 reference

12 December 2020

Polyglutamine-expanded human huntingtin transgenes induce degeneration of Drosophila photoreceptor neurons.

1 reference

12 December 2020

Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions.

1 reference

12 December 2020

Aggresomes: a cellular response to misfolded proteins

1 reference

12 December 2020

A role for MAPK/ERK in sympathetic neuron survival: protection against a p53-dependent, JNK-independent induction of apoptosis by cytosine arabinoside.

1 reference

12 December 2020

Generation of neuronal intranuclear inclusions by polyglutamine-GFP: analysis of inclusion clearance and toxicity as a function of polyglutamine length.

1 reference

12 December 2020

10.1523/JNEUROSCI.4751-08.2008

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19118173%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19118173%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

1 reference