(Q46250581)

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AMP-activated protein kinase (AMPK)/Ulk1-dependent autophagic pathway contributes to C6 ceramide-induced cytotoxic effects in cultured colorectal cancer HT-29 cells

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Europe PubMed Central

PubMed publication ID

20 December 2017

http://europepmc.org/abstract/MED/23508272

AMP-activated protein kinase (AMPK)/Ulk1-dependent autophagic pathway contributes to C6 ceramide-induced cytotoxic effects in cultured colorectal cancer HT-29 cells (English)

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Europe PubMed Central

PubMed publication ID

20 December 2017

http://europepmc.org/abstract/MED/23508272

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colorectal cancer

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based on heuristic

inferred from title

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based on heuristic

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author name string

Hai-zhong Huo

1

1 reference

Europe PubMed Central

PubMed publication ID

20 December 2017

http://europepmc.org/abstract/MED/23508272

Bing Wang

2

1 reference

Europe PubMed Central

PubMed publication ID

20 December 2017

http://europepmc.org/abstract/MED/23508272

Jian Qin

3

1 reference

Europe PubMed Central

PubMed publication ID

20 December 2017

http://europepmc.org/abstract/MED/23508272

Shan-yu Guo

4

1 reference

Europe PubMed Central

PubMed publication ID

20 December 2017

http://europepmc.org/abstract/MED/23508272

Wen-yong Liu

5

1 reference

Europe PubMed Central

PubMed publication ID

20 December 2017

http://europepmc.org/abstract/MED/23508272

Yan Gu

6

1 reference

Europe PubMed Central

PubMed publication ID

20 December 2017

http://europepmc.org/abstract/MED/23508272

publication date

19 March 2013

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Europe PubMed Central

PubMed publication ID

20 December 2017

http://europepmc.org/abstract/MED/23508272

number of pages

11

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Molecular and Cellular Biochemistry

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Europe PubMed Central

PubMed publication ID

20 December 2017

http://europepmc.org/abstract/MED/23508272

378

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Europe PubMed Central

PubMed publication ID

20 December 2017

http://europepmc.org/abstract/MED/23508272

1-2

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Europe PubMed Central

PubMed publication ID

20 December 2017

http://europepmc.org/abstract/MED/23508272

171-181

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Europe PubMed Central

PubMed publication ID

20 December 2017

http://europepmc.org/abstract/MED/23508272

Chemoprevention of colon cancer: current status and future prospects

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Patients' expectations about effects of chemotherapy for advanced cancer

1 reference

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Mechanisms involved in exogenous C2- and C6-ceramide-induced cancer cell toxicity

1 reference

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Ceramidases: regulators of cellular responses mediated by ceramide, sphingosine, and sphingosine-1-phosphate

1 reference

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Ceramide in apoptotic signaling and anticancer therapy

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Ceramide in chemotherapy of tumors

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Ceramide induces p38 MAPK and JNK activation through a mechanism involving a thioredoxin-interacting protein-mediated pathway

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C6-ceramide and targeted inhibition of acid ceramidase induce synergistic decreases in breast cancer cell growth

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Ceramide promotes apoptosis in lung cancer-derived A549 cells by a mechanism involving c-Jun NH2-terminal kinase

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Sphingolipids and cancer: ceramide and sphingosine-1-phosphate in the regulation of cell death and drug resistance

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Ceramide and reactive oxygen species generated by H2O2 induce caspase-3-independent degradation of Akt/protein kinase B.

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Exogenous cell-permeable C6 ceramide sensitizes multiple cancer cell lines to Doxorubicin-induced apoptosis by promoting AMPK activation and mTORC1 inhibition

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Sphingosine kinase activity counteracts ceramide-mediated cell death in human melanoma cells: role of Bcl-2 expression

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3-Methyladenine: specific inhibitor of autophagic/lysosomal protein degradation in isolated rat hepatocytes

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The roles of therapy-induced autophagy and necrosis in cancer treatment

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21 January 2018

Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy

1 reference

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21 January 2018

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

1 reference

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21 January 2018

Enhanced muscle fat oxidation and glucose transport by ACRP30 globular domain: acetyl-CoA carboxylase inhibition and AMP-activated protein kinase activation

1 reference

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21 January 2018

The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress

1 reference

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21 January 2018

LKB1 is the upstream kinase in the AMP-activated protein kinase cascade

1 reference

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21 January 2018

Activation of AMP-activated protein kinase is involved in vincristine-induced cell apoptosis in B16 melanoma cell

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21 January 2018

Metformin amplifies chemotherapy-induced AMPK activation and antitumoral growth.

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21 January 2018

Co-administration of perifosine with paclitaxel synergistically induces apoptosis in ovarian cancer cells: more than just AKT inhibition

1 reference

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Activation of AMP-activated Protein Kinase by Temozolomide Contributes to Apoptosis in Glioblastoma Cells via p53 Activation and mTORC1 Inhibition

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21 January 2018

Activation of AMP-activated protein kinase contributes to doxorubicin-induced cell death and apoptosis in cultured myocardial H9c2 cells

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21 January 2018

Ursolic acid-induced AMP-activated protein kinase (AMPK) activation contributes to growth inhibition and apoptosis in human bladder cancer T24 cells

1 reference

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21 January 2018

Honokiol activates AMP-activated protein kinase in breast cancer cells via an LKB1-dependent pathway and inhibits breast carcinogenesis

1 reference

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21 January 2018

Apoptotic effect of EGCG in HT-29 colon cancer cells via AMPK signal pathway.

1 reference

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21 January 2018

Induction of apoptosis by quercetin is mediated through AMPKalpha1/ASK1/p38 pathway

1 reference

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21 January 2018

Berberine-induced AMPK activation inhibits the metastatic potential of melanoma cells via reduction of ERK activity and COX-2 protein expression.

1 reference

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21 January 2018

Activation of reactive oxygen species/AMP activated protein kinase signaling mediates fisetin-induced apoptosis in multiple myeloma U266 cells

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21 January 2018

AMP-activated protein kinase can induce apoptosis of insulin-producing MIN6 cells through stimulation of c-Jun-N-terminal kinase

1 reference

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Sustained activation of AMP-activated protein kinase induces c-Jun N-terminal kinase activation and apoptosis in liver cells

1 reference

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AMP-activated protein kinase induces a p53-dependent metabolic checkpoint

1 reference

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TSC2 mediates cellular energy response to control cell growth and survival

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The regulation of AMP-activated protein kinase by upstream kinases.

1 reference

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Ca2+/calmodulin-dependent protein kinase kinase-beta acts upstream of AMP-activated protein kinase in mammalian cells.

1 reference

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Calmodulin-dependent protein kinase kinase-beta is an alternative upstream kinase for AMP-activated protein kinase

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ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS

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Autophagy as a regulated pathway of cellular degradation

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Autophagy in cell death: an innocent convict?

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Autophagy as a cell death and tumor suppressor mechanism

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The multiple roles of autophagy in cancer

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TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth

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AMPK and Raptor: matching cell growth to energy supply.

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The association of AMPK with ULK1 regulates autophagy

1 reference

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Nutrient starvation elicits an acute autophagic response mediated by Ulk1 dephosphorylation and its subsequent dissociation from AMPK.

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AMP-activated protein kinase: a target for drugs both ancient and modern

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Aspirin inhibits mTOR signaling, activates AMP-activated protein kinase, and induces autophagy in colorectal cancer cells

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Drug resistance, predictive markers and pharmacogenomics in colorectal cancer

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Widdrol induces apoptosis via activation of AMP-activated protein kinase in colon cancer cells

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Epidemiology of digestive tract cancers in India. V. Large and small bowel

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Ceramide induces apoptosis in PC12 cells

1 reference

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Drug resistance in colon cancer.

1 reference

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Divergent induction of apoptosis and IL-8 secretion in HT-29 cells in response to TNF-alpha and ligation of Fas antigen

1 reference

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Identifiers

10.1007/S11010-013-1608-8

1 reference

Europe PubMed Central

PubMed publication ID

20 December 2017

http://europepmc.org/abstract/MED/23508272

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

20 December 2017

http://europepmc.org/abstract/MED/23508272

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