(Q46268730)

English

Silibinin inhibits hypoxia-inducible factor-1alpha and mTOR/p70S6K/4E-BP1 signalling pathway in human cervical and hepatoma cancer cells: implications for anticancer therapy

scientific article

In more languages

Statements

scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

20 December 2017

http://europepmc.org/abstract/MED/18978810

Silibinin inhibits hypoxia-inducible factor-1alpha and mTOR/p70S6K/4E-BP1 signalling pathway in human cervical and hepatoma cancer cells: implications for anticancer therapy (English)

1 reference

Europe PubMed Central

PubMed publication ID

20 December 2017

http://europepmc.org/abstract/MED/18978810

0 references

hepatocellular carcinoma

1 reference

based on heuristic

inferred from title

author name string

P García-Maceira

1

1 reference

Europe PubMed Central

PubMed publication ID

20 December 2017

http://europepmc.org/abstract/MED/18978810

J Mateo

2

1 reference

Europe PubMed Central

PubMed publication ID

20 December 2017

http://europepmc.org/abstract/MED/18978810

language of work or name

0 references

publication date

3 November 2008

1 reference

Europe PubMed Central

PubMed publication ID

20 December 2017

http://europepmc.org/abstract/MED/18978810

1 reference

Europe PubMed Central

PubMed publication ID

20 December 2017

http://europepmc.org/abstract/MED/18978810

28

1 reference

Europe PubMed Central

PubMed publication ID

20 December 2017

http://europepmc.org/abstract/MED/18978810

3

1 reference

Europe PubMed Central

PubMed publication ID

20 December 2017

http://europepmc.org/abstract/MED/18978810

313-324

1 reference

Europe PubMed Central

PubMed publication ID

20 December 2017

http://europepmc.org/abstract/MED/18978810

Effects and mechanisms of silibinin on human hepatoma cell lines

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.398

21 January 2018

Translational control of gene expression during hypoxia

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.398

21 January 2018

Lack of evidence for the involvement of the phosphoinositide 3-kinase/Akt pathway in the activation of hypoxia-inducible factors by low oxygen tension.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.398

31 March 2020

Inhibition of human carcinoma cell growth and DNA synthesis by silibinin, an active constituent of milk thistle: comparison with silymarin

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.398

31 March 2020

The TOR pathway: a target for cancer therapy

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.398

31 March 2020

Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.398

31 March 2020

Silibinin inhibits cell invasion through inactivation of both PI3K-Akt and MAPK signaling pathways

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.398

31 March 2020

Isosilybin B causes androgen receptor degradation in human prostate carcinoma cells via PI3K-Akt-Mdm2-mediated pathway

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.398

31 March 2020

A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in glioma

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.398

31 March 2020

Vascular endothelial growth factor: basic science and clinical progress

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.398

31 March 2020

Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.398

31 March 2020

HIF-1 as a target for drug development

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.398

31 March 2020

Silibinin inhibits inflammatory and angiogenic attributes in photocarcinogenesis in SKH-1 hairless mice.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.398

31 March 2020

Defining the role of mTOR in cancer

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.398

31 March 2020

Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.398

31 March 2020

Tumor hypoxia: definitions and current clinical, biologic, and molecular aspects

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.398

31 March 2020

The TSC1-TSC2 complex is required for proper activation of mTOR complex 2

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.398

31 March 2020

Regulation of hypoxia-inducible factor 1alpha expression and function by the mammalian target of rapamycin.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.398

31 March 2020

Hypoxia-inducible factor 1 levels vary exponentially over a physiologically relevant range of O2 tension

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.398

31 March 2020

HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1alpha (HIF-1alpha) synthesis: novel mechanism for HIF-1-mediated vascular endothelial growth factor expression

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.398

31 March 2020

Balancing Akt with S6K: implications for both metabolic diseases and tumorigenesis

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.398

31 March 2020

Independent function of two destruction domains in hypoxia-inducible factor-alpha chains activated by prolyl hydroxylation

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.398

31 March 2020

Regulation of hypoxia-inducible factor-1alpha by nitric oxide through mitochondria-dependent and -independent pathways.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.398

31 March 2020

mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.398

31 March 2020

Sp1 is involved in Akt-mediated induction of VEGF expression through an HIF-1-independent mechanism.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.398

31 March 2020

mTOR and cancer: insights into a complex relationship

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.398

31 March 2020

The use of silymarin in the treatment of liver diseases

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.398

31 March 2020

Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.398

31 March 2020

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.398

31 March 2020

Oxygen sensing by HIF hydroxylases

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.398

31 March 2020

HIF-1 and tumor progression: pathophysiology and therapeutics

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.398

31 March 2020

Targeting HIF-1 for cancer therapy

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.398

31 March 2020

Silibinin strongly inhibits growth and survival of human endothelial cells via cell cycle arrest and downregulation of survivin, Akt and NF-kappaB: implications for angioprevention and antiangiogenic therapy

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.398

31 March 2020

Silibinin inhibits colorectal cancer growth by inhibiting tumor cell proliferation and angiogenesis

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.398

31 March 2020

Activation of Akt and eIF4E survival pathways by rapamycin-mediated mammalian target of rapamycin inhibition.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.398

31 March 2020

Hypoxia-inducible factor determines sensitivity to inhibitors of mTOR in kidney cancer

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.398

31 March 2020

Silibinin efficacy against human hepatocellular carcinoma

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.398

31 March 2020

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.398

31 March 2020

Purification and characterization of hypoxia-inducible factor 1

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.398

31 March 2020

Silymarin: a review of its clinical properties in the management of hepatic disorders

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.398

31 March 2020

Selection and analysis of a mutant cell line defective in the hypoxia-inducible factor-1 alpha-subunit (HIF-1alpha). Characterization of hif-1alpha-dependent and -independent hypoxia-inducible gene expression

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.398

31 March 2020

Activation of the prolyl hydroxylase oxygen-sensor results in induction of GLUT1, heme oxygenase-1, and nitric-oxide synthase proteins and confers protection from metabolic inhibition to cardiomyocytes

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.398

31 March 2020

Targeting Stat3 blocks both HIF-1 and VEGF expression induced by multiple oncogenic growth signaling pathways

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.398

31 March 2020

Silibinin decreases prostate-specific antigen with cell growth inhibition via G1 arrest, leading to differentiation of prostate carcinoma cells: implications for prostate cancer intervention

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.398

31 March 2020

Identifiers

10.1038/ONC.2008.398

1 reference

Europe PubMed Central

PubMed publication ID

20 December 2017

http://europepmc.org/abstract/MED/18978810

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

20 December 2017

http://europepmc.org/abstract/MED/18978810

ResearchGate publication ID

0 references

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q46268730&oldid=2207767767"