(Q46269946)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29096557%20AND%20SRC:MED&resulttype=core&format=json

8 April 2020

title

NOD2 and bacterial recognition as therapeutic targets for Crohn's disease (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29096557%20AND%20SRC:MED&resulttype=core&format=json

8 April 2020

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29096557%20AND%20SRC:MED&resulttype=core&format=json

8 April 2020

Magali de Bruyn

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29096557%20AND%20SRC:MED&resulttype=core&format=json

8 April 2020

author name string

Magali de Bruyn

series ordinal

1

1 reference

http://europepmc.org/abstract/MED/29096557

20 December 2017

language of work or name

English

0 references

publication date

2 November 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29096557%20AND%20SRC:MED&resulttype=core&format=json

Expert Opinion on Therapeutic Targets

8 April 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29096557%20AND%20SRC:MED&resulttype=core&format=json

8 April 2020

volume

21

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29096557%20AND%20SRC:MED&resulttype=core&format=json

8 April 2020

issue

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29096557%20AND%20SRC:MED&resulttype=core&format=json

8 April 2020

page(s)

1123-1139

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29096557%20AND%20SRC:MED&resulttype=core&format=json

Unravelling the pathogenesis of inflammatory bowel disease

8 April 2020

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Insights into the molecular basis of the NOD2 signalling pathway

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Pathogen sensing by nucleotide-binding oligomerization domain-containing protein 2 (NOD2) is mediated by direct binding to muramyl dipeptide and ATP.

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The molecular chaperone HSP70 binds to and stabilizes NOD2, an important protein involved in Crohn disease

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A critical role of RICK/RIP2 polyubiquitination in Nod-induced NF-kappaB activation

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The tandem CARDs of NOD2: intramolecular interactions and recognition of RIP2.

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Coordinated regulation of Toll-like receptor and NOD2 signaling by K63-linked polyubiquitin chains

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Cellular inhibitors of apoptosis cIAP1 and cIAP2 are required for innate immunity signaling by the pattern recognition receptors NOD1 and NOD2.

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XIAP mediates NOD signaling via interaction with RIP2

21 January 2018

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From sensing to shaping microbiota: insights into the role of NOD2 in intestinal homeostasis and progression of Crohn's disease

21 January 2018

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Ubiquitin-mediated activation of TAK1 and IKK.

21 January 2018

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Molecular mechanisms involved in the regulation of cytokine production by muramyl dipeptide

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Activation and regulation of the inflammasomes

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NOD2 is a negative regulator of Toll-like receptor 2-mediated T helper type 1 responses

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Nod2 is required for the regulation of commensal microbiota in the intestine

21 January 2018

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Nod2 is essential for temporal development of intestinal microbial communities.

21 January 2018

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Nod1 and Nod2 signaling does not alter the composition of intestinal bacterial communities at homeostasis

21 January 2018

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Bacterial sensor Nod2 prevents inflammation of the small intestine by restricting the expansion of the commensal Bacteroides vulgatus.

21 January 2018

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Mouse Paneth cell antimicrobial function is independent of Nod2.

21 January 2018

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Helminth infection promotes colonization resistance via type 2 immunity.

21 January 2018

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Nod2 Deficiency Leads to a Specific and Transmissible Mucosa-associated Microbial Dysbiosis Which Is Independent of the Mucosal Barrier Defect.

21 January 2018

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Respective Roles of Hematopoietic and Nonhematopoietic Nod2 on the Gut Microbiota and Mucosal Homeostasis

21 January 2018

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Genetic deletion of the bacterial sensor NOD2 improves murine Crohn's disease-like ileitis independent of functional dysbiosis.

21 January 2018

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Nod2 mutation in Crohn's disease potentiates NF-kappaB activity and IL-1beta processing

21 January 2018

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Cutting edge: Crohn's disease-associated Nod2 mutation limits production of proinflammatory cytokines to protect the host from Enterococcus faecalis-induced lethality

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The nucleotide synthesis enzyme CAD inhibits NOD2 antibacterial function in human intestinal epithelial cells

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Caspase recruitment domain-containing protein 8 (CARD8) negatively regulates NOD2-mediated signaling

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A20 controls intestinal homeostasis through cell-specific activities

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21 January 2018

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Regulation of human enteric α-defensins by NOD2 in the Paneth cell lineage.

21 January 2018

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21 January 2018

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T cell-intrinsic role of Nod2 in promoting type 1 immunity to Toxoplasma gondii

21 January 2018

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Genetics of inflammatory bowel disease: beyond NOD2.

21 January 2018

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Fine-mapping inflammatory bowel disease loci to single-variant resolution

21 January 2018

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Genome-wide association study identifies distinct genetic contributions to prognosis and susceptibility in Crohn's disease.

21 January 2018

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A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease

21 January 2018

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Deep resequencing of GWAS loci identifies independent rare variants associated with inflammatory bowel disease

21 January 2018

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Prevalence of CARD15/NOD2 mutations in Caucasian healthy people

21 January 2018

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Inflammatory bowel disease genetics: Nod2.

21 January 2018

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Differential effects of NOD2 variants on Crohn's disease risk and phenotype in diverse populations: a metaanalysis.

21 January 2018

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CARD15/NOD2 gene variants are associated with familially occurring and complicated forms of Crohn's disease.

21 January 2018

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NOD2/CARD15, TLR4 and CD14 mutations in Scottish and Irish Crohn's disease patients: evidence for genetic heterogeneity within Europe?

21 January 2018

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21 January 2018

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Comparative phenotypic and CARD15 mutational analysis among African American, Hispanic, and White children with Crohn's disease

21 January 2018

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Characterization of genetic loci that affect susceptibility to inflammatory bowel diseases in African Americans

21 January 2018

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Genome-Wide Association Study Identifies African-Specific Susceptibility Loci in African Americans With Inflammatory Bowel Disease.

21 January 2018

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The molecular classification of the clinical manifestations of Crohn's disease

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Mutations in NOD2 are associated with fibrostenosing disease in patients with Crohn's disease

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21 January 2018

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21 January 2018

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NOD2 gene variant is a risk factor for postoperative complications in patients with Crohn's disease: A genetic association study

21 January 2018

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The effect of NOD2 polymorphism on postsurgical recurrence in Crohn's disease: a systematic review and meta-analysis of available literature

21 January 2018

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The pathogen recognition receptor NOD2 regulates human FOXP3+ T cell survival.

21 January 2018

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Genetic susceptibility to increased bacterial translocation influences the response to biological therapy in patients with Crohn's disease.

21 January 2018

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Crohn's disease genotypes of patients in remission vs relapses after infliximab discontinuation.

21 January 2018

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Predicting durable response or resistance to antitumor necrosis factor therapy in inflammatory bowel disease

21 January 2018

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Reduced Paneth cell alpha-defensins in ileal Crohn's disease

21 January 2018

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Reduced alpha-defensin expression is associated with inflammation and not NOD2 mutation status in ileal Crohn's disease.

21 January 2018

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Down-regulation of human enteric antimicrobial peptides by NOD2 during differentiation of the paneth cell lineage

21 January 2018

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Engagement of NOD2 has a dual effect on proIL-1beta mRNA transcription and secretion of bioactive IL-1beta

21 January 2018

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Muramyl dipeptide and toll-like receptor sensitivity in NOD2-associated Crohn's disease

21 January 2018

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Crohn's disease-associated NOD2 variants share a signaling defect in response to lipopolysaccharide and peptidoglycan

21 January 2018

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NOD2/CARD15 genotype influences MDP-induced cytokine release and basal IL-12p40 levels in primary isolated peripheral blood monocytes

21 January 2018

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The origin of the synergistic effect of muramyl dipeptide with endotoxin and peptidoglycan

21 January 2018

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Synergy between TLR9 and NOD2 innate immune responses is lost in genetic Crohn's disease

21 January 2018

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Genetic association and functional role of Crohn disease risk alleles involved in microbial sensing, autophagy, and endoplasmic reticulum (ER) stress.

21 January 2018

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NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation

21 January 2018

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ATG16L1 and NOD2 interact in an autophagy-dependent antibacterial pathway implicated in Crohn's disease pathogenesis

21 January 2018

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https://api.crossref.org/works/10.1080%2F14728222.2017.1397627

Pattern recognition receptor and autophagy gene variants are associated with development of antimicrobial antibodies in Crohn's disease

21 January 2018

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Multicenter analysis of fecal microbiota profiles in Japanese patients with Crohn's disease

21 January 2018

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Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases

21 January 2018

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Dysfunction of the intestinal microbiome in inflammatory bowel disease and treatment

21 January 2018

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Disease phenotype and genotype are associated with shifts in intestinal-associated microbiota in inflammatory bowel diseases

21 January 2018

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Complex host genetics influence the microbiome in inflammatory bowel disease

21 January 2018

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Interplay of host genetics and gut microbiota underlying the onset and clinical presentation of inflammatory bowel disease

21 January 2018

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NOD proteins: regulators of inflammation in health and disease

21 January 2018

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Nod2 regulates the host response towards microflora by modulating T cell function and epithelial permeability in mouse Peyer's patches.

21 January 2018

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Crohn disease--associated adherent-invasive E. coli bacteria target mouse and human Peyer's patches via long polar fimbriae

21 January 2018

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https://api.crossref.org/works/10.1080%2F14728222.2017.1397627

Role of Nod2 in the Response of Macrophages to Toll-Like Receptor Agonists

21 January 2018

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https://api.crossref.org/works/10.1080%2F14728222.2017.1397627

The ever-expanding function of NOD2: autophagy, viral recognition, and T cell activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1397627

Nod2 deficiency is associated with an increased mucosal immunoregulatory response to commensal microorganisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1397627

Gut microbiota. Antimicrobial peptide resistance mediates resilience of prominent gut commensals during inflammation

21 January 2018

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Recent advances in understanding and managing Crohn's disease

21 January 2018

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Defensins: natural component of human innate immunity

21 January 2018

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https://api.crossref.org/works/10.1080%2F14728222.2017.1397627

The effect of NOD2 on the microbiota in Crohn's disease

21 January 2018

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https://api.crossref.org/works/10.1080%2F14728222.2017.1397627

Oral butyrate for mildly to moderately active Crohn's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1397627

Identification of a synthetic muramyl peptide derivative with enhanced Nod2 stimulatory capacity

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1397627

Peptidoglycan Modifications Tune the Stability and Function of the Innate Immune Receptor Nod2

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1397627

Targeting innate receptors with MIS416 reshapes Th responses and suppresses CNS disease in a mouse model of multiple sclerosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1397627

miR-122 targets NOD2 to decrease intestinal epithelial cell injury in Crohn's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1397627

NOD2 expression is regulated by microRNAs in colonic epithelial HCT116 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1397627

NOD2 Is Regulated By Mir-320 in Physiological Conditions but this Control Is Altered in Inflamed Tissues of Patients with Inflammatory Bowel Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1397627

The intracellular sensor NOD2 induces microRNA-29 expression in human dendritic cells to limit IL-23 release.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1397627

In vivo inhibition of RIPK2 kinase alleviates inflammatory disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1397627

Inhibition of RICK/nuclear factor-kappaB and p38 signaling attenuates the inflammatory response in a murine model of Crohn disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1397627

A potent and orally active antagonist (SM-406/AT-406) of multiple inhibitor of apoptosis proteins (IAPs) in clinical development for cancer treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1397627

Targeting mitochondrial factor Smac/DIABLO as therapy for multiple myeloma (MM)

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1397627

Faecal Microbiota Transplantation for Inflammatory Bowel Disease: A Systematic Review and Meta-analysis

21 January 2018

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https://api.crossref.org/works/10.1080%2F14728222.2017.1397627

Molecular chaperone functions in protein folding and proteostasis

21 January 2018

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https://api.crossref.org/works/10.1080%2F14728222.2017.1397627

The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition

21 January 2018

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Anti-inflammatory properties of heat shock protein 70 and butyrate on Salmonella-induced interleukin-8 secretion in enterocyte-like Caco-2 cells

21 January 2018

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MIS416, a non-toxic microparticle adjuvant derived from Propionibacterium acnes comprising immunostimulatory muramyl dipeptide and bacterial DNA promotes cross-priming and Th1 immunity

21 January 2018

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The diverse functions of microRNAs in animal development and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1397627

Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1397627

Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1397627

Association between CARD8 rs2043211 polymorphism and inflammatory bowel disease: a meta-analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1397627

Inhibition of RIP2's tyrosine kinase activity limits NOD2-driven cytokine responses.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1397627

Inhibition of RIP2/RIck/CARDIAK activity by pyridinyl imidazole inhibitors of p38 MAPK.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1397627

A discrete ubiquitin-mediated network regulates the strength of NOD2 signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1397627

Inhibitors of apoptosis (IAPs) regulate intestinal immunity and inflammatory bowel disease (IBD) inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1397627

Cellular and molecular mechanisms underlying NOD2 risk-associated polymorphisms in Crohn's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1397627

Crohn's disease-associated Nod2 mutants reduce IL10 transcription.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1397627

Nucleotide binding oligomerization domain 2 deficiency leads to dysregulated TLR2 signaling and induction of antigen-specific colitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1397627

Impaired dendritic cell function in Crohn's disease patients with NOD2 3020insC mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1397627

In vivo genome editing restores haemostasis in a mouse model of haemophilia

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1397627

In vivo genome editing of the albumin locus as a platform for protein replacement therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1397627

CRISPR/Cas9-mediated gene editing ameliorates neurotoxicity in mouse model of Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1397627

Inducible in vivo genome editing with CRISPR-Cas9

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1397627

The Ubiquitin Ligase XIAP Recruits LUBAC for NOD2 Signaling in Inflammation and Innate Immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1397627

Genetic factors conferring an increased susceptibility to develop Crohn's disease also influence disease phenotype: results from the IBDchip European Project

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1397627

Response to infliximab treatment in Crohn's disease is not associated with mutations in the CARD15 (NOD2) gene: an analysis in 534 patients from two multicenter, prospective GCP-level trials

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1397627

miR-10a inhibits dendritic cell activation and Th1/Th17 cell immune responses in IBD

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1397627

Altered gut microbiota composition in immune-impaired Nod2(-/-) mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1397627

Genetic polymorphism inATG16L1gene influences the response to adalimumab in Crohn's disease patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1397627

10.1080/14728222.2017.1397627

21 January 2018

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29096557%20AND%20SRC:MED&resulttype=core&format=json

8 April 2020

1 reference