(Q46285732)

21 February 2018

title

Genetic effects on gene expression across human tissues (English)

1 reference

21 February 2018

Erratum: Genetic effects on gene expression across human tissues

corrigendum / erratum

1 reference

http://api.crossref.org/works/10.1038/nature25160

13 October 2019

Stephen B Montgomery

27

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author name string

GTEx Consortium

1

1 reference

21 February 2018

Laboratory, Data Analysis &Coordinating Center (LDACC)—Analysis Working Group

2

1 reference

21 February 2018

Statistical Methods groups—Analysis Working Group

3

1 reference

21 February 2018

Enhancing GTEx (eGTEx) groups

4

1 reference

21 February 2018

NIH Common Fund

5

1 reference

21 February 2018

NIH/NCI

6

1 reference

21 February 2018

NIH/NHGRI

7

1 reference

21 February 2018

NIH/NIMH

8

1 reference

21 February 2018

NIH/NIDA

9

1 reference

21 February 2018

Biospecimen Collection Source Site—NDRI

10

1 reference

21 February 2018

Biospecimen Collection Source Site—RPCI

11

1 reference

21 February 2018

Biospecimen Core Resource—VARI

12

1 reference

21 February 2018

Brain Bank Repository—University of Miami Brain Endowment Bank

13

1 reference

21 February 2018

Leidos Biomedical—Project Management

14

1 reference

21 February 2018

ELSI Study

15

1 reference

21 February 2018

Genome Browser Data Integration &Visualization—EBI

16

1 reference

21 February 2018

Genome Browser Data Integration &Visualization—UCSC Genomics Institute, University of California Santa Cruz

17

1 reference

21 February 2018

Lead analysts:

18

1 reference

21 February 2018

Laboratory, Data Analysis &Coordinating Center (LDACC):

19

1 reference

21 February 2018

NIH program management:

20

1 reference

21 February 2018

Biospecimen collection:

21

1 reference

21 February 2018

Pathology:

22

1 reference

21 February 2018

eQTL manuscript working group:

23

1 reference

21 February 2018

Alexis Battle

24

1 reference

21 February 2018

Christopher D Brown

25

1 reference

21 February 2018

Barbara E Engelhardt

26

1 reference

21 February 2018

language of work or name

English

0 references

publication date

1 October 2017

1 reference

21 February 2018

published in

Nature

1 reference

21 February 2018

volume

550

1 reference

21 February 2018

issue

7675

1 reference

21 February 2018

page(s)

204-213

1 reference

21 February 2018

Landscape of X chromosome inactivation across human tissues

cites work

1 reference

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Whole-genome sequencing identifies common-to-rare variants associated with human blood metabolites

24 May 2018

1 reference

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PANTHER version 11: expanded annotation data from Gene Ontology and Reactome pathways, and data analysis tool enhancements

24 May 2018

1 reference

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The International Human Epigenome Consortium: A Blueprint for Scientific Collaboration and Discovery

24 May 2018

1 reference

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Genome-wide association analyses using electronic health records identify new loci influencing blood pressure variation

24 May 2018

1 reference

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Genome-wide associations for birth weight and correlations with adult disease

24 May 2018

1 reference

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Analysis of protein-coding genetic variation in 60,706 humans

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5776756

Tensor decomposition for multiple-tissue gene expression experiments

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5776756

Efficient Integrative Multi-SNP Association Analysis via Deterministic Approximation of Posteriors

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5776756

Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5776756

Integration of summary data from GWAS and eQTL studies predicts complex trait gene targets

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5776756

Modelling local gene networks increases power to detect trans-acting genetic effects on gene expression

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5776756

The Molecular Signatures Database (MSigDB) hallmark gene set collection

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5776756

Fast and efficient QTL mapper for thousands of molecular phenotypes.

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5776756

Bayesian integration of genetics and epigenetics detects causal regulatory SNPs underlying expression variability

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5776756

A global reference for human genetic variation

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5776756

Tools and best practices for data processing in allelic expression analysis

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5776756

Dissecting the genetics of the human transcriptome identifies novel trait-related trans-eQTLs and corroborates the regulatory relevance of non-protein coding loci†.

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5776756

Human genomics. Effect of predicted protein-truncating genetic variants on the human transcriptome

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5776756

Human genomics. The Genotype-Tissue Expression (GTEx) pilot analysis: multitissue gene regulation in humans

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5776756

The landscape of genomic imprinting across diverse adult human tissues

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5776756

A meta-analysis of gene expression signatures of blood pressure and hypertension

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5776756

The role of regulatory variation in complex traits and disease

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5776756

Integrative analysis of 111 reference human epigenomes

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5776756

A single nucleotide polymorphism associated with isolated cleft lip and palate, thyroid cancer and hypothyroidism alters the activity of an oral epithelium and thyroid enhancer near FOXE1

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5776756

Gene-gene and gene-environment interactions detected by transcriptome sequence analysis in twins

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5776756

Integrated genomic characterization of papillary thyroid carcinoma

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5776756

Genetic and epigenetic fine mapping of causal autoimmune disease variants

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5776756

Allelic mapping bias in RNA-sequencing is not a major confounder in eQTL studies

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5776756

Identifying causal variants at loci with multiple signals of association

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5776756

Cis and trans effects of human genomic variants on gene expression.

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5776756

A comprehensive analysis of piRNAs from adult human testis and their relationship with genes and mobile elements

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5776756

Bayesian test for colocalisation between pairs of genetic association studies using summary statistics

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5776756

A general approach for haplotype phasing across the full spectrum of relatedness

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5776756

Heritability and genomics of gene expression in peripheral blood

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5776756

The NHGRI GWAS Catalog, a curated resource of SNP-trait associations

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5776756

Characterizing the genetic basis of transcriptome diversity through RNA-sequencing of 922 individuals

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5776756

Transcriptome and genome sequencing uncovers functional variation in humans

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5776756

Systematic identification of trans eQTLs as putative drivers of known disease associations

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5776756

Integrative modeling of eQTLs and cis-regulatory elements suggests mechanisms underlying cell type specificity of eQTLs

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5776756

Effectively identifying eQTLs from multiple tissues by combining mixed model and meta-analytic approaches

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5776756

A statistical framework for joint eQTL analysis in multiple tissues

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5776756

Transcription factor and chromatin features predict genes associated with eQTLs

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5776756

An integrated map of genetic variation from 1,092 human genomes

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5776756

Mapping cis- and trans-regulatory effects across multiple tissues in twins

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5776756

Matrix eQTL: ultra fast eQTL analysis via large matrix operations

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5776756

Genotype imputation with thousands of genomes

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5776756

Using probabilistic estimation of expression residuals (PEER) to obtain increased power and interpretability of gene expression analyses

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5776756

Fibrinogen as a key regulator of inflammation in disease

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5776756

Variants near FOXE1 are associated with hypothyroidism and other thyroid conditions: using electronic medical records for genome- and phenome-wide studies

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5776756

REVIGO summarizes and visualizes long lists of gene ontology terms

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5776756

Identification, replication, and functional fine-mapping of expression quantitative trait loci in primary human liver tissue

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5776756

Identification of an imprinted master trans regulator at the KLF14 locus related to multiple metabolic phenotypes

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5776756

Random-effects model aimed at discovering associations in meta-analysis of genome-wide association studies

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5776756

The architecture of gene regulatory variation across multiple human tissues: the MuTHER study

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5776756

Genetics and beyond--the transcriptome of human monocytes and disease susceptibility

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5776756

BEDTools: a flexible suite of utilities for comparing genomic features

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5776756

Association of novel genetic Loci with circulating fibrinogen levels: a genome-wide association study in 6 population-based cohorts

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5776756

Histone modifications at human enhancers reflect global cell-type-specific gene expression

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5776756

Fibrinogen drives dystrophic muscle fibrosis via a TGFbeta/alternative macrophage activation pathway

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5776756

Capturing heterogeneity in gene expression studies by surrogate variable analysis

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5776756

uPA deficiency exacerbates muscular dystrophy in MDX mice

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5776756

Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5776756

Statistical significance for genomewide studies

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5776756

Genetic dissection of transcriptional regulation in budding yeast

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5776756

IRF family of transcription factors as regulators of host defense

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5776756

The interferon regulatory transcription factor IRF-1 controls positive and negative selection of CD8+ thymocytes.

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5776756

Predicting causal variants affecting expression by using whole-genome sequencing and RNA-seq from multiple human tissues

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5776756

An empirical Bayes approach for multiple tissue eQTL analysis.

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5776756

Dynamic landscape and regulation of RNA editing in mammals.

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5776756

The impact of rare variation on gene expression across tissues

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5776756

Quantifying the regulatory effect size of cis-acting genetic variation using allelic fold change.

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5776756

Co-expression networks reveal the tissue-specific regulation of transcription and splicing.

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5776756

Enhancing GTEx by bridging the gaps between genotype, gene expression, and disease.

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5776756

Quantifying the degree of sharing of genetic and non-genetic causes of gene expression variability across four tissues

15 August 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE24277

7 January 2021

The piRNA Pathway Guards the Germline Genome Against Transposable Elements

1 reference

https://api.crossref.org/works/10.1038%2FNATURE24277

7 January 2021

Erratum: Corrigendum: Identification of an imprinted master trans regulator at the KLF14 locus related to multiple metabolic phenotypes

1 reference

https://api.crossref.org/works/10.1038%2FNATURE24277

7 January 2021

Molecular QTL discovery incorporating genomic annotations using Bayesian false discovery rate control

1 reference

https://api.crossref.org/works/10.1038%2FNATURE24277

7 January 2021

Identifiers

DOI

10.1038/NATURE24277

1 reference

21 February 2018

PMC publication ID

5776756

1 reference

21 February 2018

PubMed publication ID

29022597

1 reference

21 February 2018