(Q46344926)

21 December 2017

review article

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title

Human tumour viruses and the deregulation of cell polarity in cancer (English)

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21 December 2017

author name string

Lawrence Banks

series ordinal

1

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21 December 2017

David Pim

series ordinal

2

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21 December 2017

Miranda Thomas

series ordinal

3

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21 December 2017

language of work or name

English

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publication date

1 December 2012

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21 December 2017

published in

Nature Reviews Cancer

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21 December 2017

volume

12

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21 December 2017

page(s)

877-886

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21 December 2017

issue

12

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21 December 2017

https://scigraph.springernature.com/pub.10.1038/nrc3400

exact match

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cites work

Epithelial organization, cell polarity and tumorigenesis

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The mammalian Scribble polarity protein regulates epithelial cell adhesion and migration through E-cadherin

21 January 2018

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Cdc42, Par6, and aPKC regulate Arp2/3-mediated endocytosis to control local adherens junction stability.

21 January 2018

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Tight junction-based epithelial microenvironment and cell proliferation

21 January 2018

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Loss of human Scribble cooperates with H-Ras to promote cell invasion through deregulation of MAPK signalling

21 January 2018

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The cell polarity regulator hScrib controls ERK activation through a KIM site-dependent interaction

21 January 2018

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The Hippo transducer TAZ confers cancer stem cell-related traits on breast cancer cells

21 January 2018

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The Crumbs complex couples cell density sensing to Hippo-dependent control of the TGF-β-SMAD pathway.

21 January 2018

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Scrib controls Cdc42 localization and activity to promote cell polarization during astrocyte migration

21 January 2018

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The tumour-suppressor Scribble dictates cell polarity during directed epithelial migration: regulation of Rho GTPase recruitment to the leading edge

21 January 2018

1 reference

Deregulation of scribble promotes mammary tumorigenesis and reveals a role for cell polarity in carcinoma

21 January 2018

1 reference

Regulated protein-protein interaction between aPKC and PAR-3 plays an essential role in the polarization of epithelial cells

21 January 2018

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The Par complex directs asymmetric cell division by phosphorylating the cytoskeletal protein Lgl.

21 January 2018

1 reference

Epithelial polarity and proliferation control: links from the Drosophila neoplastic tumor suppressors

21 January 2018

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Human discs large and scrib are localized at the same regions in colon mucosa and changes in their expression patterns are correlated with loss of tissue architecture during malignant progression.

21 January 2018

1 reference

SCRIB expression is deregulated in human prostate cancer, and its deficiency in mice promotes prostate neoplasia

21 January 2018

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Craniofacial dysmorphogenesis including cleft palate in mice with an insertional mutation in the discs large gene

21 January 2018

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Loss of cell polarity causes severe brain dysplasia in Lgl1 knockout mice

21 January 2018

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A review of human carcinogens--Part B: biological agents

21 January 2018

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Carcinogenicity of malaria and of some polyomaviruses.

21 January 2018

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Why do viruses cause cancer? Highlights of the first century of human tumour virology

21 January 2018

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Interpreting cancer genomes using systematic host network perturbations by tumour virus proteins

21 January 2018

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Kaposi's sarcoma and its associated herpesvirus

21 January 2018

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Interaction between Ras(V12) and scribbled clones induces tumour growth and invasion

21 January 2018

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Primary human cervical carcinoma cells require human papillomavirus E6 and E7 expression for ongoing proliferation

21 January 2018

1 reference

siRNA targeting of the viral E6 oncogene efficiently kills human papillomavirus-positive cancer cells

21 January 2018

1 reference

Human papillomaviruses, cervical cancer and cell polarity

21 January 2018

1 reference

Molecular biology of human papillomavirus infection and cervical cancer

21 January 2018

1 reference

Human papillomavirus oncoproteins: pathways to transformation

21 January 2018

1 reference

Oncogenic human papillomavirus E6 proteins target the discs large tumour suppressor for proteasome-mediated degradation

21 January 2018

1 reference

Human scribble (Vartul) is targeted for ubiquitin-mediated degradation by the high-risk papillomavirus E6 proteins and the E6AP ubiquitin-protein ligase

21 January 2018

1 reference

Interactions of the PDZ-protein MAGI-1 with adenovirus E4-ORF1 and high-risk papillomavirus E6 oncoproteins

21 January 2018

1 reference

PATJ, a tight junction-associated PDZ protein, is a novel degradation target of high-risk human papillomavirus E6 and the alternatively spliced isoform 18 E6

21 January 2018

1 reference

The hScrib/Dlg apico-basal control complex is differentially targeted by HPV-16 and HPV-18 E6 proteins

21 January 2018

1 reference

Human and primate tumour viruses use PDZ binding as an evolutionarily conserved mechanism of targeting cell polarity regulators

21 January 2018

1 reference

Structures of a human papillomavirus (HPV) E6 polypeptide bound to MAGUK proteins: mechanisms of targeting tumor suppressors by a high-risk HPV oncoprotein

21 January 2018

1 reference

Role of the PDZ domain-binding motif of the oncoprotein E6 in the pathogenesis of human papillomavirus type 31

21 January 2018

1 reference

Stabilization of HPV16 E6 protein by PDZ proteins, and potential implications for genome maintenance

21 January 2018

1 reference

Asymmetric cell divisions promote stratification and differentiation of mammalian skin

21 January 2018

1 reference

Robust control of mitotic spindle orientation in the developing epidermis

21 January 2018

1 reference

Par3 controls epithelial spindle orientation by aPKC-mediated phosphorylation of apical Pins

21 January 2018

1 reference

Identification of an Aurora-A/PinsLINKER/Dlg spindle orientation pathway using induced cell polarity in S2 cells

21 January 2018

1 reference

Mechanisms of asymmetric stem cell division

21 January 2018

1 reference

Optimization of cottontail rabbit papilloma virus challenge technique

21 January 2018

1 reference

Protein kinase Cα promotes cell migration through a PDZ-dependent interaction with its novel substrate discs large homolog 1 (DLG1)

21 January 2018

1 reference

Identification of Vangl2 and Scrb1 as planar polarity genes in mammals

21 January 2018

1 reference

Depletion of Langerhans cells in human papillomavirus type 16-infected skin is associated with E6-mediated down regulation of E-cadherin

21 January 2018

1 reference

Epigenetic repression of E-cadherin by human papillomavirus 16 E7 protein

21 January 2018

1 reference

A systematic analysis of human papillomavirus (HPV) E6 PDZ substrates identifies MAGI-1 as a major target of HPV type 16 (HPV-16) and HPV-18 whose loss accompanies disruption of tight junctions

21 January 2018

1 reference

A discrete population of squamocolumnar junction cells implicated in the pathogenesis of cervical cancer

21 January 2018

1 reference

The human papillomavirus E6 oncogene dysregulates the cell cycle and contributes to cervical carcinogenesis through two independent activities

21 January 2018

1 reference

The PDZ ligand domain of the human papillomavirus type 16 E6 protein is required for E6's induction of epithelial hyperplasia in vivo

21 January 2018

1 reference

Activity of the human papillomavirus E6 PDZ-binding motif correlates with an enhanced morphological transformation of immortalized human keratinocytes.

21 January 2018

1 reference

Changes in expression of the human homologue of the Drosophila discs large tumour suppressor protein in high-grade premalignant cervical neoplasias

21 January 2018

1 reference

Cadherins and cancer: how does cadherin dysfunction promote tumor progression?

21 January 2018

1 reference

Phosphorylation of the discs large tumour suppressor protein controls its membrane localisation and enhances its susceptibility to HPV E6-induced degradation

21 January 2018

1 reference

The invasive capacity of HPV transformed cells requires the hDlg-dependent enhancement of SGEF/RhoG activity

21 January 2018

1 reference

Oncogenic function for the Dlg1 mammalian homolog of the Drosophila discs-large tumor suppressor

21 January 2018

1 reference

The E6 oncoprotein from HPV16 enhances the canonical Wnt/β-catenin pathway in skin epidermis in vivo

21 January 2018

1 reference

Epstein-Barr virus infection of polarized epithelial cells via the basolateral surface by memory B cell-mediated transfer infection.

21 January 2018

1 reference

The Epstein-Barr virus oncogene product, latent membrane protein 1, induces the downregulation of E-cadherin gene expression via activation of DNA methyltransferases

21 January 2018

1 reference

Epstein-Barr virus LMP2A transforms epithelial cells, inhibits cell differentiation, and activates Akt.

21 January 2018

1 reference

Twist and epithelial-mesenchymal transition are induced by the EBV oncoprotein latent membrane protein 1 and are associated with metastatic nasopharyngeal carcinoma

21 January 2018

1 reference

Epstein-Barr Virus latent membrane protein 1 induces Snail and epithelial-mesenchymal transition in metastatic nasopharyngeal carcinoma

21 January 2018

1 reference

The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression

21 January 2018

1 reference

Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis

21 January 2018

1 reference

Cloning and functional analysis of the promoter region of the human Disc large gene

21 January 2018

1 reference

Epstein-Barr virus-encoded LMP1 interacts with FGD4 to activate Cdc42 and thereby promote migration of nasopharyngeal carcinoma cells

21 January 2018

1 reference

Epstein-Barr virus activates beta-catenin in type III latently infected B lymphocyte lines: association with deubiquitinating enzymes

21 January 2018

1 reference

Roles of the ITAM and PY motifs of Epstein-Barr virus latent membrane protein 2A in the inhibition of epithelial cell differentiation and activation of {beta}-catenin signaling

21 January 2018

1 reference

Regulation of the DLG tumor suppressor by β-catenin

21 January 2018

1 reference

A novel viral mechanism for dysregulation of beta-catenin in Kaposi's sarcoma-associated herpesvirus latency.

21 January 2018

1 reference

Loss of Fat4 disrupts PCP signaling and oriented cell division and leads to cystic kidney disease.

21 January 2018

1 reference

Mammalian Fat and Dachsous cadherins regulate apical membrane organization in the embryonic cerebral cortex

21 January 2018

1 reference

Separating planar cell polarity and Hippo pathway activities of the protocadherins Fat and Dachsous

21 January 2018

1 reference

Remodeling of endothelial adherens junctions by Kaposi's sarcoma-associated herpesvirus

21 January 2018

1 reference

Kaposi's sarcoma-associated herpesvirus disrupts adherens junctions and increases endothelial permeability by inducing degradation of VE-cadherin

21 January 2018

1 reference

Remodeling of VE-cadherin junctions by the human herpes virus 8 G-protein coupled receptor.

21 January 2018

1 reference

Latent KSHV infection increases the vascular permeability of human endothelial cells

21 January 2018

1 reference

HTLV-1 bZIP factor induces T-cell lymphoma and systemic inflammation in vivo

21 January 2018

1 reference

Binding of human virus oncoproteins to hDlg/SAP97, a mammalian homolog of the Drosophila discs large tumor suppressor protein

21 January 2018

1 reference

The PDZ domain-binding motif of the human T cell leukemia virus type 1 tax protein induces mislocalization of the tumor suppressor hScrib in T cells

21 January 2018

1 reference

Human T-cell leukemia virus type 1 Tax oncoprotein induces and interacts with a multi-PDZ domain protein, MAGI-3.

21 January 2018

1 reference

The C-terminus of the HTLV-1 Tax oncoprotein mediates interaction with the PDZ domain of cellular proteins

21 January 2018

1 reference

Cooperation of NF-kappaB2/p100 activation and the PDZ domain binding motif signal in human T-cell leukemia virus type 1 (HTLV-1) Tax1 but not HTLV-2 Tax2 is crucial for interleukin-2-independent growth transformation of a T-cell line

21 January 2018

1 reference

Human papillomavirus type 16 E6 activates NF-kappaB, induces cIAP-2 expression, and protects against apoptosis in a PDZ binding motif-dependent manner

21 January 2018

1 reference

Human Dlg protein binds to the envelope glycoproteins of human T-cell leukemia virus type 1 and regulates envelope mediated cell-cell fusion in T lymphocytes

21 January 2018

1 reference

Induction of ICAM-1 and LFA-3 by Tax1 of human T-cell leukemia virus type 1 and mechanism of down-regulation of ICAM-1 or LFA-1 in adult-T-cell-leukemia cell lines

21 January 2018

1 reference

HTLV-1-Tax and ICAM-1 act on T-cell signal pathways to polarize the microtubule-organizing center at the virological synapse.

21 January 2018

1 reference

Upsides and downsides to polarity and asymmetric cell division in leukemia.

21 January 2018

1 reference

Human immunodeficiency virus type 1 Nef selectively associates with a catalytically active subpopulation of p21-activated kinase 2 (PAK2) independently of PAK2 binding to Nck or beta-PIX

21 January 2018

1 reference

21 January 2018

1 reference

A novel human WD protein, h-beta TrCp, that interacts with HIV-1 Vpu connects CD4 to the ER degradation pathway through an F-box motif

21 January 2018

1 reference

HIV-1 Vpu sequesters beta-transducin repeat-containing protein (betaTrCP) in the cytoplasm and provokes the accumulation of beta-catenin and other SCFbetaTrCP substrates.

21 January 2018

1 reference

Modulation of beta-catenin and E-cadherin interaction by Vpu increases human immunodeficiency virus type 1 particle release

21 January 2018

1 reference

HIV-1 Tat protein-induced alterations of ZO-1 expression are mediated by redox-regulated ERK 1/2 activation

21 January 2018

1 reference

Exposure to HIV-1 directly impairs mucosal epithelial barrier integrity allowing microbial translocation

21 January 2018

1 reference

The hepatitis C virus and its hepatic environment: a toxic but finely tuned partnership

21 January 2018

1 reference

The hepatitis B virus HBx protein induces adherens junction disruption in a src-dependent manner.

21 January 2018

1 reference

Hepatitis B virus X protein represses E-cadherin expression via activation of DNA methyltransferase 1.

21 January 2018

1 reference

Hepatitis B viral X protein interacts with tumor suppressor adenomatous polyposis coli to activate Wnt/β-catenin signaling.

21 January 2018

1 reference

Viral hepatocarcinogenesis

21 January 2018

1 reference

Hepatitis C virus core protein downregulates E-cadherin expression via activation of DNA methyltransferase 1 and 3b.

21 January 2018

1 reference

Hepatitis C virus NS5A-mediated activation of phosphoinositide 3-kinase results in stabilization of cellular beta-catenin and stimulation of beta-catenin-responsive transcription

21 January 2018

1 reference

Hepatitis C viral protein NS5A induces EMT and participates in oncogenic transformation of primary hepatocyte precursors

21 January 2018

1 reference

Liver cancer-derived hepatitis C virus core proteins shift TGF-beta responses from tumor suppression to epithelial-mesenchymal transition

21 January 2018

1 reference

Effect of Cell Polarization on Hepatitis C Virus Entry

21 January 2018

1 reference

The Tight Junction-Associated Protein Occludin Is Required for a Postbinding Step in Hepatitis C Virus Entry and Infection

21 January 2018

1 reference

Tight Junction Proteins Claudin-1 and Occludin Control Hepatitis C Virus Entry and Are Downregulated during Infection To Prevent Superinfection

21 January 2018

1 reference

Clonal integration of a polyomavirus in human Merkel cell carcinoma

21 January 2018

1 reference

T antigen mutations are a human tumor-specific signature for Merkel cell polyomavirus

21 January 2018

1 reference

The LINC complex and human disease

21 January 2018

1 reference

The inner nuclear membrane protein emerin regulates beta-catenin activity by restricting its accumulation in the nucleus

21 January 2018

1 reference

Cellular transformation by Simian Virus 40 and Murine Polyoma Virus T antigens

21 January 2018

1 reference

Identification of TAZ as a binding partner of the polyomavirus T antigens

21 January 2018

1 reference

Epithelial cell polarity, stem cells and cancer

21 January 2018

1 reference

The manipulation of miRNA-gene regulatory networks by KSHV induces endothelial cell motility

31 March 2020

1 reference

Epigenetic repression of E-cadherin expression by hepatitis B virus x antigen in liver cancer.

31 March 2020

1 reference

CD44 regulates tight-junction assembly and barrier function

31 March 2020

1 reference

Dissection of human papillomavirus E6 and E7 function in transgenic mouse models of cervical carcinogenesis.

31 March 2020

1 reference

12 December 2020

Hepatitis B virus X protein modulates oncogene Yes-associated protein by CREB to promote growth of hepatoma cells.

1 reference

12 December 2020

HTLV-1 bZIP factor dysregulates the Wnt pathways to support proliferation and migration of adult T-cell leukemia cells

1 reference

12 December 2020

The E6 and E7 genes of HPV-18 are sufficient for inducing two-stage in vitro transformation of human keratinocytes

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRC3400

1 reference

21 December 2017

PubMed ID

23175122

1 reference

21 December 2017