(Q46500208)

22 December 2017

title

Cell size reduction induced by inhibition of the mTOR/S6K-signaling pathway protects Jurkat cells from apoptosis (English)

1 reference

22 December 2017

author name string

C Fumarola

1

1 reference

22 December 2017

S La Monica

2

1 reference

22 December 2017

R R Alfieri

3

1 reference

22 December 2017

E Borra

4

1 reference

22 December 2017

G G Guidotti

5

1 reference

22 December 2017

publication date

1 October 2005

1 reference

22 December 2017

Cell Death & Differentiation

published in

1 reference

22 December 2017

volume

12

1 reference

22 December 2017

issue

10

1 reference

22 December 2017

page(s)

1344-1357

1 reference

22 December 2017

TOR, a central controller of cell growth

cites work

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401660

Integration of Growth Factor and Nutrient Signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401660

Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401660

Matrix-specific activation of Src and Rho initiates capillary morphogenesis of endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401660

Akt maintains cell size and survival by increasing mTOR-dependent nutrient uptake

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401660

Amino acid signaling through the mammalian target of rapamycin (mTOR) pathway: Role of glutamine and of cell shrinkage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401660

Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401660

Intracellular sensing of amino acids in Xenopus laevis oocytes stimulates p70 S6 kinase in a target of rapamycin-dependent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401660

Tsc tumour suppressor proteins antagonize amino-acid-TOR signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401660

Regulation of targets of mTOR (mammalian target of rapamycin) signalling by intracellular amino acid availability

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401660

Mammalian TOR: a homeostatic ATP sensor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401660

FKBP12-rapamycin-associated protein associates with mitochondria and senses osmotic stress via mitochondrial dysfunction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401660

AMP-activated protein kinase suppresses protein synthesis in rat skeletal muscle through down-regulated mammalian target of rapamycin (mTOR) signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401660

Size control in animal development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401660

A mammalian protein targeted by G1-arresting rapamycin-receptor complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401660

RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401660

mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401660

Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401660

GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401660

Translational homeostasis: eukaryotic translation initiation factor 4E control of 4E-binding protein 1 and p70 S6 kinase activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401660

Regulation of translation initiation by FRAP/mTOR

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401660

Drosophila S6 kinase: a regulator of cell size

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401660

Genetic and biochemical characterization of dTOR, the Drosophila homolog of the target of rapamycin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401660

Regulation of cellular growth by the Drosophila target of rapamycin dTOR

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401660

Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401660

RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401660

Protein kinases: getting NEKed for S6K activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401660

Paclitaxel induces inactivation of p70 S6 kinase and phosphorylation of Thr421 and Ser424 via multiple signaling pathways in mitosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401660

B cell receptor-associated protein alpha4 displays rapamycin-sensitive binding directly to the catalytic subunit of protein phosphatase 2A

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401660

Regulation of protein phosphatase 2A catalytic activity by alpha4 protein and its yeast homolog Tap42

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401660

Protein phosphatase 2A interacts with the 70-kDa S6 kinase and is activated by inhibition of FKBP12-rapamycinassociated protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401660

Osmotic stress inhibits p70/85 S6 kinase through activation of a protein phosphatase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401660

Parallel purification of three catalytic subunits of the protein serine/threonine phosphatase 2A family (PP2A(C), PP4(C), and PP6(C)) and analysis of the interaction of PP2A(C) with alpha4 protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401660

Genetic control of cell size

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401660

An encore for ribosome biogenesis in the control of cell proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401660

Two CD95 tumor classes with different sensitivities to antitumor drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401660

Biochemical pathways of caspase activation during apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401660

Regulation of death receptor-mediated apoptosis pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401660

Inhibition of PI-3 kinase sensitizes human leukemic cells to histone deacetylase inhibitor-mediated apoptosis through p44/42 MAP kinase inactivation and abrogation of p21(CIP1/WAF1) induction rather than AKT inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401660

A novel method for measurement of submembrane ATP concentration

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401660

Glucose generates sub-plasma membrane ATP microdomains in single islet beta-cells. Potential role for strategically located mitochondria.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401660

Induction of apoptosis and modulation of activation and effector function in T cells by immunosuppressive drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401660

Glutamine deprivation-mediated cell shrinkage induces ligand-independent CD95 receptor signaling and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401660

The antitumor ether lipid ET-18-OCH(3) induces apoptosis through translocation and capping of Fas/CD95 into membrane rafts in human leukemic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401660

Intracellular triggering of Fas aggregation and recruitment of apoptotic molecules into Fas-enriched rafts in selective tumor cell apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401660

Induction of apoptosis in fibroblasts by c-myc protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401660

Amino acid-induced translation of TOP mRNAs is fully dependent on phosphatidylinositol 3-kinase-mediated signaling, is partially inhibited by rapamycin, and is independent of S6K1 and rpS6 phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401660

Transduction of growth or mitogenic signals into translational activation of TOP mRNAs is fully reliant on the phosphatidylinositol 3-kinase-mediated pathway but requires neither S6K1 nor rpS6 phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401660

Apoptosis-inducing factor (AIF): a novel caspase-independent death effector released from mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401660

Stress-induced apoptosis: toward a symmetry with receptor-mediated cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401660

Ordering the cytochrome c-initiated caspase cascade: hierarchical activation of caspases-2, -3, -6, -7, -8, and -10 in a caspase-9-dependent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401660

Bcl-2 and Bcl-xL inhibit CD95-mediated apoptosis by preventing mitochondrial release of Smac/DIABLO and subsequent inactivation of X-linked inhibitor-of-apoptosis protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401660

Caspase-2 can function upstream of bid cleavage in the TRAIL apoptosis pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401660

The biochemical mechanism of caspase-2 activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401660

Processed caspase-2 can induce mitochondria-mediated apoptosis independently of its enzymatic activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401660

Caspase-2 permeabilizes the outer mitochondrial membrane and disrupts the binding of cytochrome c to anionic phospholipids

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401660

Mammalian target of rapamycin inhibition as therapy for hematologic malignancies

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401660

Targeting mTOR signaling for cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401660

Rapamycin sensitizes multiple myeloma cells to apoptosis induced by dexamethasone.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401660

Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401660

Dissecting p53 tumor suppressor functions in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401660

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401660

Amino acid uptake in isolated chick embryo heart cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401660

Apoptosis-associated release of Smac/DIABLO from mitochondria requires active caspases and is blocked by Bcl-2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401660

Involvement of the CD95 (APO–1/Fas) receptor/ligand system in drug–induced apoptosis in leukemia cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401660

Integration of growth factor and nutrient signaling: implications for cancer biology

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401660

7 January 2021

The p70 S6 kinase integrates nutrient and growth signals to control translational capacity.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401660

7 January 2021

Platelet-derived growth factor stimulates LAT1 gene expression in vascular smooth muscle: role in cell growth

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401660

7 January 2021

Amino acids as regulators of gene expression at the level of mRNA translation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401660

7 January 2021

Amino acids as regulators and components of nonproteinogenic pathways

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401660

7 January 2021

Amino acid-dependent control of p70(s6k). Involvement of tRNA aminoacylation in the regulation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401660

7 January 2021

The principal target of rapamycin-induced p70s6k inactivation is a novel phosphorylation site within a conserved hydrophobic domain.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401660

7 January 2021

Protein phosphatase 2A: who shall regulate the regulator?

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401660

7 January 2021

CD95(APO-1/Fas)-mediated apoptosis: live and let die

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401660

7 January 2021

The role of mitochondria in the regulation of calcium influx into Jurkat cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401660

7 January 2021

Direct inhibition of the signaling functions of the mammalian target of rapamycin by the phosphoinositide 3-kinase inhibitors, wortmannin and LY294002.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401660

7 January 2021

Phosphatidylinositol 3'-kinase blocks CD95 aggregation and caspase-8 cleavage at the death-inducing signaling complex by modulating lateral diffusion of CD95

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401660

7 January 2021

Identifiers

DOI

10.1038/SJ.CDD.4401660

1 reference

22 December 2017

Dimensions Publication ID

1009080344

0 references

1 reference

22 December 2017