(Q46572457)

23 December 2017

title

Defective DNA strand break repair causes chromosomal instability and accelerates liver carcinogenesis in mice (English)

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23 December 2017

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Narci C Teoh

1

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23 December 2017

Yock Young Dan

2

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23 December 2017

Karen Swisshelm

3

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23 December 2017

Stacey Lehman

4

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23 December 2017

Jocelyn H Wright

5

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23 December 2017

Jamil Haque

6

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23 December 2017

Yansong Gu

7

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23 December 2017

Nelson Fausto

8

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23 December 2017

language of work or name

English

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publication date

1 June 2008

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23 December 2017

published in

Hepatology

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23 December 2017

volume

47

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23 December 2017

page(s)

2078-2088

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23 December 2017

issue

6

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23 December 2017

Bcl-2 expression inhibits liver carcinogenesis and delays the development of proliferating foci

cites work

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Caspase-3-Dependent Cleavage of the Glutamate-L-Cysteine Ligase Catalytic Subunit during Apoptotic Cell Death

21 January 2018

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Focus on hepatocellular carcinoma.

21 January 2018

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7 January 2021

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Mouse liver tumorigenesis: models, mechanisms, and relevance to human disease

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Clonal analysis of precancerous lesion of hepatocellular carcinoma

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M6P/IGF2R gene is mutated in human hepatocellular carcinomas with loss of heterozygosity

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7 January 2021

DNA double-strand breaks: signaling, repair and the cancer connection

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7 January 2021

Chromosomal stability and the DNA double-stranded break connection

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7 January 2021

Growth retardation and leaky SCID phenotype of Ku70-deficient mice.

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7 January 2021

DNA-PK, ATM and ATR as sensors of DNA damage: variations on a theme?

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7 January 2021

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7 January 2021

The language of covalent histone modifications

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7 January 2021

Surfing the p53 network

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7 January 2021

Live or let die: the cell's response to p53

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7 January 2021

Aurora kinases link chromosome segregation and cell division to cancer susceptibility

1 reference

7 January 2021

Aurora-A overexpression reveals tetraploidization as a major route to centrosome amplification in p53-/- cells

1 reference

7 January 2021

Application of comparative functional genomics to identify best-fit mouse models to study human cancer

1 reference

7 January 2021

Novel recurrent genetic imbalances in human hepatocellular carcinoma cell lines identified by comparative genomic hybridization

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7 January 2021

The life and death of DNA-PK.

1 reference

7 January 2021

p53: traffic cop at the crossroads of DNA repair and recombination

1 reference

7 January 2021

p53 Deficiency in liver reduces local control of survival and proliferation, but does not affect apoptosis after DNA damage

1 reference

7 January 2021

The p53-Mdm2 module and the ubiquitin system.

1 reference

7 January 2021

HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation

1 reference

7 January 2021

SUMO: a regulator of gene expression and genome integrity.

1 reference

7 January 2021

Role of SUMO/Ubc9 in DNA damage repair and tumorigenesis

1 reference

7 January 2021

Expression of the FAT10 gene is highly upregulated in hepatocellular carcinoma and other gastrointestinal and gynecological cancers

1 reference

7 January 2021

FAT10, a gene up-regulated in various cancers, is cell-cycle regulated.

1 reference

7 January 2021

FAT10 plays a role in the regulation of chromosomal stability

1 reference

7 January 2021

Cells adapted to the proteasome inhibitor 4-hydroxy- 5-iodo-3-nitrophenylacetyl-Leu-Leu-leucinal-vinyl sulfone require enzymatically active proteasomes for continued survival

1 reference

7 January 2021

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

1 reference

7 January 2021

mdm2 expression is induced by wild type p53 activity

1 reference

7 January 2021

Characterizing the role of MDM2 in diethylnitrosamine induced acute liver damage and development of pre-neoplastic lesions

1 reference

7 January 2021

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

1 reference

7 January 2021

MDM2 can promote the ubiquitination, nuclear export, and degradation of p53 in the absence of direct binding

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7 January 2021

Loss of nuclear p53 protein in preneoplastic rat hepatocytes is accompanied by Mdm2 and Bcl-2 overexpression and by defective response to DNA damage in vivo

1 reference

7 January 2021

TP53 and liver carcinogenesis.

1 reference

7 January 2021

p53 mutations are absent from carcinogen-induced mouse liver tumors but occur in cell lines established from these tumors

1 reference

7 January 2021

Medicine. Building better mouse models for studying cancer.

1 reference

7 January 2021

Telomere dysfunction and the initiation of genome instability.

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7 January 2021

Regulating the p53 system through ubiquitination

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7 January 2021

Ubiquitin is a possible new predictive marker for the recurrence of human hepatocellular carcinoma

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7 January 2021

Identifiers

DOI

10.1002/HEP.22194

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23 December 2017

PubMed ID

18506893

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23 December 2017