(Q46845410)

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A balancing act between net uptake of water during dihydrofolate binding and net release of water upon NADPH binding in R67 dihydrofolate reductase

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Europe PubMed Central

PubMed publication ID

25 December 2017

http://europepmc.org/abstract/MED/18086667

A balancing act between net uptake of water during dihydrofolate binding and net release of water upon NADPH binding in R67 dihydrofolate reductase (English)

1 reference

Europe PubMed Central

PubMed publication ID

25 December 2017

http://europepmc.org/abstract/MED/18086667

Elizabeth Howell

4

1 reference

Europe PubMed Central

PubMed publication ID

25 December 2017

http://europepmc.org/abstract/MED/18086667

author name string

Shaileja Chopra

1

1 reference

Europe PubMed Central

PubMed publication ID

25 December 2017

http://europepmc.org/abstract/MED/18086667

Russell M Dooling

2

1 reference

Europe PubMed Central

PubMed publication ID

25 December 2017

http://europepmc.org/abstract/MED/18086667

Caroline Glyn Horner

3

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Europe PubMed Central

PubMed publication ID

25 December 2017

http://europepmc.org/abstract/MED/18086667

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publication date

17 December 2007

1 reference

Europe PubMed Central

PubMed publication ID

25 December 2017

http://europepmc.org/abstract/MED/18086667

Journal of Biological Chemistry

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Europe PubMed Central

PubMed publication ID

25 December 2017

http://europepmc.org/abstract/MED/18086667

283

1 reference

Europe PubMed Central

PubMed publication ID

25 December 2017

http://europepmc.org/abstract/MED/18086667

8

1 reference

Europe PubMed Central

PubMed publication ID

25 December 2017

http://europepmc.org/abstract/MED/18086667

4690-4698

1 reference

Europe PubMed Central

PubMed publication ID

25 December 2017

http://europepmc.org/abstract/MED/18086667

Mechanism of inhibition of dihydrofolate reductases from bacterial and vertebrate sources by various classes of folate analogues

1 reference

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The Purification and Properties of the Trimethoprim-Resistant Dihydrofolate Reductase Mediated by the R-Factor, R 388

1 reference

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21 January 2018

Searching sequence space: two different approaches to dihydrofolate reductase catalysis

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A plasmid-encoded dihydrofolate reductase from trimethoprim-resistant bacteria has a novel D2-symmetric active site

1 reference

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21 January 2018

Unusual binding stoichiometries and cooperativity are observed during binary and ternary complex formation in the single active pore of R67 dihydrofolate reductase, a D2 symmetric protein

1 reference

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21 January 2018

CASTp: computed atlas of surface topography of proteins with structural and topographical mapping of functionally annotated residues

1 reference

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21 January 2018

Crystal Structure of a Type II Dihydrofolate Reductase Catalytic Ternary Complex †

1 reference

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21 January 2018

Interligand Overhauser effects in type II dihydrofolate reductase

1 reference

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21 January 2018

Effects of temperature and viscosity on R67 dihydrofolate reductase catalysis

1 reference

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21 January 2018

Conformation of NADP+ bound to a type II dihydrofolate reductase.

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21 January 2018

NMR studies of the interaction of a type II dihydrofolate reductase with pyridine nucleotides reveal unexpected phosphatase and reductase activity

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21 January 2018

Alpha-pyridine nucleotides as substrates for a plasmid-specified dihydrofolate reductase

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21 January 2018

Calorimetric studies of ligand binding in R67 dihydrofolate reductase

1 reference

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21 January 2018

Role of ionic interactions in ligand binding and catalysis of R67 dihydrofolate reductase

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21 January 2018

Role of Lys-32 residues in R67 dihydrofolate reductase probed by asymmetric mutations

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21 January 2018

Construction of a synthetic gene for an R-plasmid-encoded dihydrofolate reductase and studies on the role of the N-terminus in the protein.

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21 January 2018

Construction of an altered proton donation mechanism in Escherichia coli dihydrofolate reductase

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21 January 2018

Breaking symmetry: mutations engineered into R67 dihydrofolate reductase, a D2 symmetric homotetramer possessing a single active site pore

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21 January 2018

Nonlinear fitting of bisubstrate enzyme kinetic models using SAS computer software: application to R67 dihydrofolate reductase

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21 January 2018

The stabilization of proteins by osmolytes

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21 January 2018

The control of protein stability and association by weak interactions with water: how do solvents affect these processes?

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21 January 2018

A molecular mechanism for osmolyte-induced protein stability

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Rapid measurement of binding constants and heats of binding using a new titration calorimeter

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Role of hydration in the binding of lac repressor to DNA.

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21 January 2018

Macromolecules and water: probing with osmotic stress

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Molecular aspects in feedback regulation of gene expression by cholesterol in mammalian cells

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The effects of osmotic and hydrostatic pressures on macromolecular systems

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Hydration changes in the association of Hoechst 33258 with DNA.

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21 January 2018

Protein-solvent preferential interactions, protein hydration, and the modulation of biochemical reactions by solvent components

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Osmotic stress, crowding, preferential hydration, and binding: A comparison of perspectives

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21 January 2018

Differences in hydration coupled to specific and nonspecific competitive binding and to specific DNA Binding of the restriction endonuclease BamHI.

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21 January 2018

Protein stability in mixed solvents: a balance of contact interaction and excluded volume

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21 January 2018

A contribution to the theory of preferential interaction coefficients.

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21 January 2018

Exclusion of alcohols from spermidine-DNA assemblies: probing the physical basis of preferential hydration

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Effects of cell volume regulating osmolytes on glycerol 3-phosphate binding to triosephosphate isomerase

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Predicting the energetics of osmolyte-induced protein folding/unfolding.

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Preferential hydration of DNA: the magnitude and distance dependence of alcohol and polyol interactions

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Involvement of water molecules in the association of monoclonal antibody HyHEL-5 with bobwhite quail lysozyme

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Win some, lose some: enthalpy-entropy compensation in weak intermolecular interactions

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Solutes probe hydration in specific association of cyclodextrin and adamantane

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Roles of cytoplasmic osmolytes, water, and crowding in the response of Escherichia coli to osmotic stress: biophysical basis of osmoprotection by glycine betaine

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Growth and buoyant density of Escherichia coli at very low osmolarities

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Involvement of gamma-glutamyl peptides in osmoadaptation of Escherichia coli

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Time-dependent proteome alterations under osmotic stress during aerobic and anaerobic growth in Escherichia coli

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Functionally linked hydration changes in Escherichia coli aspartate transcarbamylase and its catalytic subunit.

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Hypersensitivity of an enzyme reaction to solvent water

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The role of water molecules in the association of cytochrome P450cam with putidaredoxin. An osmotic pressure study

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Water dynamics in the large cavity of three lipid-binding proteins monitored by (17)O magnetic relaxation dispersion

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One site fits both: a model for the ternary complex of folate + NADPH in R67 dihydrofolate reductase, a D2 symmetric enzyme

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21 January 2018

Role of S65, Q67, I68, and Y69 residues in homotetrameric R67 dihydrofolate reductase

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The entropic penalty of ordered water accounts for weaker binding of the antibiotic novobiocin to a resistant mutant of DNA gyrase: a thermodynamic and crystallographic study

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"Catch 222," the effects of symmetry on ligand binding and catalysis in R67 dihydrofolate reductase as determined by mutations at Tyr-69.

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Substrate specificity and affinity of a protein modulated by bound water molecules

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MHC-peptide binding is assisted by bound water molecules

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Water mediation in protein folding and molecular recognition

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Excluded volume as a determinant of macromolecular structure and reactivity

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A glutamine 67--> histidine mutation in homotetrameric R67 dihydrofolate reductase results in four mutations per single active site pore and causes substantial substrate and cofactor inhibition

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21 January 2018

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10.1074/JBC.M709443200

1 reference

Europe PubMed Central

PubMed publication ID

25 December 2017

http://europepmc.org/abstract/MED/18086667

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PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

25 December 2017

http://europepmc.org/abstract/MED/18086667

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