(Q46881400)

26 December 2017

title

The regulated cell surface zymogen activation of the proprotein convertase PC5A directs the processing of its secretory substrates (English)

1 reference

26 December 2017

1 reference

8

1 reference

26 December 2017

Antonella Pasquato

object named as

Antonella Pasquato

4

0 references

author name string

Gaétan Mayer

1

1 reference

26 December 2017

Josée Hamelin

2

1 reference

26 December 2017

Marie-Claude Asselin

3

1 reference

26 December 2017

Edwidge Marcinkiewicz

5

1 reference

26 December 2017

Meiyi Tang

6

1 reference

26 December 2017

Siamak Tabibzadeh

7

1 reference

26 December 2017

language of work or name

English

0 references

publication date

26 November 2007

1 reference

26 December 2017

Journal of Biological Chemistry

published in

1 reference

26 December 2017

volume

283

1 reference

26 December 2017

issue

4

1 reference

26 December 2017

page(s)

2373-2384

1 reference

26 December 2017

Proprotein and prohormone convertases: a family of subtilases generating diverse bioactive polypeptides

cites work

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708763200

Precursor convertases in the secretory pathway, cytosol and extracellular milieu

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708763200

The proprotein convertases are potential targets in the treatment of dyslipidemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708763200

Furin at the cutting edge: from protein traffic to embryogenesis and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708763200

Curbing activation: proprotein convertases in homeostasis and pathology

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708763200

The proprotein convertases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708763200

New insights into copper monooxygenases and peptide amidation: structure, mechanism and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708763200

Deletion of the gene encoding proprotein convertase 5/6 causes early embryonic lethality in the mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708763200

Furin-like proprotein convertases are central regulators of the membrane type matrix metalloproteinase-pro-matrix metalloproteinase-2 proteolytic cascade in atherosclerosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708763200

The proprotein convertase PC5A and a metalloprotease are involved in the proteolytic processing of the neural adhesion molecule L1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708763200

The isoforms of proprotein convertase PC5 are sorted to different subcellular compartments

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708763200

The PC6B cytoplasmic domain contains two acidic clusters that direct sorting to distinct trans-Golgi network/endosomal compartments

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708763200

Sorting of furin in polarized epithelial and endothelial cells: expression beyond the Golgi apparatus

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708763200

The proprotein convertase furin colocalizes with caveolin-1 in the Golgi apparatus and endosomes of hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708763200

The cysteine-rich domain of the secreted proprotein convertases PC5A and PACE4 functions as a cell surface anchor and interacts with tissue inhibitors of metalloproteinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708763200

Proprotein convertases [corrected] are responsible for proteolysis and inactivation of endothelial lipase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708763200

Maturation of the trans-Golgi network protease furin: compartmentalization of propeptide removal, substrate cleavage, and COOH-terminal truncation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708763200

Activation of the furin endoprotease is a multiple-step process: requirements for acidification and internal propeptide cleavage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708763200

The ordered and compartment-specfific autoproteolytic removal of the furin intramolecular chaperone is required for enzyme activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708763200

Structure-function analysis of the prosegment of the proprotein convertase PC5A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708763200

Identification of a pH sensor in the furin propeptide that regulates enzyme activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708763200

Lefty proteins exhibit unique processing and activate the MAPK pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708763200

A single mutation affects both N-acetylglucosaminyltransferase and glucuronosyltransferase activities in a Chinese hamster ovary cell mutant defective in heparan sulfate biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708763200

The prosegments of furin and PC7 as potent inhibitors of proprotein convertases. In vitro and ex vivo assessment of their efficacy and selectivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708763200

ADAMTS7B, the full-length product of the ADAMTS7 gene, is a chondroitin sulfate proteoglycan containing a mucin domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708763200

The secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1): liver regeneration and neuronal differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708763200

Heparan Sulfate Core Proteins in Cell-Cell Signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708763200

cDNA structure of the mouse and rat subtilisin/kexin-like PC5: a candidate proprotein convertase expressed in endocrine and nonendocrine cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708763200

Global profiles of gene expression induced by adrenocorticotropin in Y1 mouse adrenal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708763200

Identification of an isoform with an extremely large Cys-rich region of PC6, a Kex2-like processing endoprotease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708763200

Processing of viral glycoproteins by the subtilisin-like endoprotease furin and its inhibition by specific peptidylchloroalkylketones

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708763200

Implication of proprotein convertases in the processing and spread of severe acute respiratory syndrome coronavirus

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708763200

ADAMTS-4 (aggrecanase-1): N-terminal activation mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708763200

Evidence that furin is an authentic transforming growth factor-beta1-converting enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708763200

Endothelial lipase: a modulator of lipoprotein metabolism upregulated by inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708763200

Endothelial lipase is inactivated upon cleavage by the members of the proprotein convertase family.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708763200

The proprotein convertase (PC) PCSK9 is inactivated by furin and/or PC5/6A: functional consequences of natural mutations and post-translational modifications

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708763200

Novel mutations of the PCSK9 gene cause variable phenotype of autosomal dominant hypercholesterolemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708763200

Additive effect of mutations in LDLR and PCSK9 genes on the phenotype of familial hypercholesterolemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708763200

How matrix metalloproteinases regulate cell behavior

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708763200

ADAMs: key components in EGFR signalling and development

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708763200

The gene structure of tissue inhibitor of metalloproteinases (TIMP)-3 and its inhibitory activities define the distinct TIMP gene family

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708763200

Processing of alpha4 integrin by the proprotein convertases: histidine at position P6 regulates cleavage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708763200

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708763200

Secretory proprotein convertases PACE4 and PC6A are heparin-binding proteins which are localized in the extracellular matrix. Potential role of PACE4 in the activation of proproteins in the extracellular matrix

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708763200

Endoprotease PACE4 is Ca2+-dependent and temperature-sensitive and can partly rescue the phenotype of a furin-deficient cell strain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708763200

Structural basis of syndecan-4 phosphorylation as a molecular switch to regulate signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708763200

Functions of cell surface heparan sulfate proteoglycans

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708763200

Proteoglycans: master regulators of molecular encounter?

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708763200

Heparan sulfate: decoding a dynamic multifunctional cell regulator

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708763200

Cloning and characterization of two extracellular heparin-degrading endosulfatases in mice and humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708763200

SPC4, SPC6, and the novel protease SPC7 are coexpressed with bone morphogenetic proteins at distinct sites during embryogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708763200

BMP-4 is proteolytically activated by furin and/or PC6 during vertebrate embryonic development

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708763200

Mutation of an upstream cleavage site in the BMP4 prodomain leads to tissue-specific loss of activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708763200

Regulation of bone morphogenetic protein-4 activity by sequence elements within the prodomain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708763200

Furin interacts with proMT1-MMP and integrin alphaV at specialized domains of renal cell plasma membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708763200

21 January 2018

Identifiers

DOI

10.1074/JBC.M708763200

1 reference

26 December 2017

1 reference

26 December 2017