(Q46949056)

26 December 2017

title

Rational design of modular polyketide synthases: morphing the aureothin pathway into a luteoreticulin assembly line (English)

1 reference

26 December 2017

author

Christian Hertweck

series ordinal

4

1 reference

26 December 2017

Ling Ding

object named as

Ling Ding

series ordinal

2

0 references

Keishi Ishida

series ordinal

3

object named as

Keishi Ishida

1 reference

26 December 2017

Yuki Sugimoto

1

1 reference

26 December 2017

language of work or name

English

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publication date

8 January 2014

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26 December 2017

Angewandte Chemie International Edition

number of pages

5

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based on heuristic

inferred from page(s)

published in

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volume

53

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26 December 2017

issue

6

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26 December 2017

page(s)

1560-1564

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26 December 2017

The biosynthetic logic of polyketide diversity

cites work

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201308176

Assembly-line enzymology for polyketide and nonribosomal Peptide antibiotics: logic, machinery, and mechanisms.

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Revisiting the modularity of modular polyketide synthases

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Polyketide and nonribosomal peptide antibiotics: modularity and versatility

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Genome mining for novel natural product discovery

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Genomics-inspired discovery of natural products

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Combinatorial biosynthesis of polyketides--a perspective.

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Minimally invasive mutagenesis gives rise to a biosynthetic polyketide library.

21 January 2018

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Combinatorial polyketide biosynthesis by de novo design and rearrangement of modular polyketide synthase genes.

21 January 2018

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Evolutionary implications of bacterial polyketide synthases

21 January 2018

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Evolution of polyketide synthases in bacteria

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Exploiting the mosaic structure of trans-acyltransferase polyketide synthases for natural product discovery and pathway dissection

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Natural biocombinatorics in the polyketide synthase genes of the actinobacterium Streptomyces avermitilis

21 January 2018

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Evolution of metabolic diversity in polyketide-derived pyrones: using the non-colinear aureothin assembly line as a model system

21 January 2018

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Iteration as programmed event during polyketide assembly; molecular analysis of the aureothin biosynthesis gene cluster

21 January 2018

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Non-colinear polyketide biosynthesis in the aureothin and neoaureothin pathways: an evolutionary perspective

21 January 2018

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Multifactorial control of iteration events in a modular polyketide assembly line

21 January 2018

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Loss of co-linearity by modular polyketide synthases: a mechanism for the evolution of chemical diversity

21 January 2018

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Dissection of the late steps in aureothin biosynthesis

21 January 2018

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Pyran formation by an atypical CYP-mediated four-electron oxygenation-cyclization cascade in an engineered aureothin pathway

21 January 2018

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Formation of the aureothin tetrahydrofuran ring by a bifunctional cytochrome p450 monooxygenase

21 January 2018

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Sequential asymmetric polyketide heterocyclization catalyzed by a single cytochrome P450 monooxygenase (AurH).

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Exploiting enzymatic promiscuity to engineer a focused library of highly selective antifungal and antiproliferative aureothin analogues

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Structural fine-tuning of a multifunctional cytochrome P450 monooxygenase

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Designed divergent evolution of enzyme function

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Rational Conversion of Substrate and Product Specificity in a Salvia Monoterpene Synthase: Structural Insights into the Evolution of Terpene Synthase Function

21 January 2018

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Increasing complexity of a diterpene synthase reaction with a single residue switch

21 January 2018

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Elucidation of anthracyclinone biosynthesis by stepwise cloning of genes for anthracyclines from three different Streptomyces spp

21 January 2018

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Orchestration of discoid polyketide cyclization in the resistomycin pathway

21 January 2018

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Rational domain swaps decipher programming in fungal highly reducing polyketide synthases and resurrect an extinct metabolite.

21 January 2018

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Convergent Asymmetric Synthesis of (+)-Aureothin Employing an Oxygenase-Mediated Resolution Step

21 January 2018

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Photochemical Origin of the Immunosuppressive SNF4435C/D and Formation of Orinocin through “Polyene Splicing”

21 January 2018

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9 March 2024

https://opencitations.net/index/api/v1/citations/10.1002/ANIE.200602840

Identifiers

DOI

10.1002/ANIE.201308176

1 reference

26 December 2017

1 reference

26 December 2017