(Q47183843)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28981077%20AND%20SRC:MED&resulttype=core&format=json

1 April 2020

title

Cryo-electron microscopy snapshots of the spliceosome: structural insights into a dynamic ribonucleoprotein machine (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28981077%20AND%20SRC:MED&resulttype=core&format=json

cryogenic electron microscopy

1 April 2020

main subject

spliceosome

0 references

0 references

ribonucleoprotein complex

1 reference

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28981077%20AND%20SRC:MED&resulttype=core&format=json

1 April 2020

author name string

Sebastian M Fica

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28981077%20AND%20SRC:MED&resulttype=core&format=json

1 April 2020

publication date

1 October 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28981077%20AND%20SRC:MED&resulttype=core&format=json

Nature Structural & Molecular Biology

1 April 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28981077%20AND%20SRC:MED&resulttype=core&format=json

1 April 2020

volume

24

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28981077%20AND%20SRC:MED&resulttype=core&format=json

1 April 2020

issue

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28981077%20AND%20SRC:MED&resulttype=core&format=json

1 April 2020

page(s)

791-799

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28981077%20AND%20SRC:MED&resulttype=core&format=json

https://scigraph.springernature.com/pub.10.1038/nsmb.3463

1 April 2020

exact match

0 references

cites work

Lariat RNA's as Intermediates and Products in the Splicing of Messenger RNA precursors

1 reference

Lariat structures are in vivo intermediates in yeast pre-mRNA splicing

21 January 2018

1 reference

Excision of an intact intron as a novel lariat structure during pre-mRNA splicing in vitro

21 January 2018

1 reference

Mechanical devices of the spliceosome: motors, clocks, springs, and things

21 January 2018

1 reference

The spliceosome: design principles of a dynamic RNP machine

21 January 2018

1 reference

A compensatory base change in U1 snRNA suppresses a 5' splice site mutation

21 January 2018

1 reference

5' splice site selection in yeast: genetic alterations in base-pairing with U1 reveal additional requirements

21 January 2018

1 reference

Recognition of the TACTAAC box during mRNA splicing in yeast involves base pairing to the U2-like snRNA.

21 January 2018

1 reference

Interactions between small nuclear ribonucleoprotein particles in formation of spliceosomes

21 January 2018

1 reference

Spliceosomal RNA U6 is remarkably conserved from yeast to mammals

21 January 2018

1 reference

An RNA switch at the 5' splice site requires ATP and the DEAD box protein Prp28p

21 January 2018

1 reference

A spliceosome intermediate with loosely associated tri-snRNP accumulates in the absence of Prp28 ATPase activity

21 January 2018

1 reference

The human U5-200kD DEXH-box protein unwinds U4/U6 RNA duplices in vitro

21 January 2018

1 reference

RNA unwinding in U4/U6 snRNPs requires ATP hydrolysis and the DEIH-box splicing factor Brr2

21 January 2018

1 reference

A novel base-pairing interaction between U2 and U6 snRNAs suggests a mechanism for the catalytic activation of the spliceosome

21 January 2018

1 reference

Mutations in U6 snRNA that alter splice site specificity: implications for the active site

21 January 2018

1 reference

Crystal Structure of a Self-Spliced Group II Intron

21 January 2018

1 reference

The Prp19p-associated complex in spliceosome activation

21 January 2018

1 reference

The Prp19-associated complex is required for specifying interactions of U5 and U6 with pre-mRNA during spliceosome activation

21 January 2018

1 reference

Characterization of interactions among the Cef1p-Prp19p-associated splicing complex

21 January 2018

1 reference

Cwc25 is a novel splicing factor required after Prp2 and Yju2 to facilitate the first catalytic reaction

21 January 2018

1 reference

Biased Brownian ratcheting leads to pre-mRNA remodeling and capture prior to first-step splicing

21 January 2018

1 reference

Spliceosomal DEAH-Box ATPases Remodel Pre-mRNA to Activate Alternative Splice Sites

21 January 2018

1 reference

DEAH-box ATPase Prp16 has dual roles in remodeling of the spliceosome in catalytic steps

21 January 2018

1 reference

Reconstitution of both steps of Saccharomyces cerevisiae splicing with purified spliceosomal components

21 January 2018

1 reference

How Slu7 and Prp18 cooperate in the second step of yeast pre-mRNA splicing

21 January 2018

1 reference

Requirement of the RNA helicase-like protein PRP22 for release of messenger RNA from spliceosomes

21 January 2018

1 reference

A conformational rearrangement in the spliceosome sets the stage for Prp22-dependent mRNA release

21 January 2018

1 reference

Spliceosome disassembly catalyzed by Prp43 and its associated components Ntr1 and Ntr2.

21 January 2018

1 reference

Dissection of the factor requirements for spliceosome disassembly and the elucidation of its dissociation products using a purified splicing system

21 January 2018

1 reference

Structure of a multipartite protein-protein interaction domain in splicing factor prp8 and its link to retinitis pigmentosa

21 January 2018

1 reference

Structural elucidation of a PRP8 core domain from the heart of the spliceosome

21 January 2018

1 reference

Structure and function of an RNase H domain at the heart of the spliceosome

21 January 2018

1 reference

Crystal structure of the -finger domain of Prp8 reveals analogy to ribosomal proteins

21 January 2018

1 reference

Crystal structure of Prp8 reveals active site cavity of the spliceosome

21 January 2018

1 reference

Structural basis for functional cooperation between tandem helicase cassettes in Brr2-mediated remodeling of the spliceosome

21 January 2018

1 reference

Inhibition of RNA helicase Brr2 by the C-terminal tail of the spliceosomal protein Prp8

21 January 2018

1 reference

Structural Basis of Brr2-Prp8 Interactions and Implications for U5 snRNP Biogenesis and the Spliceosome Active Site

21 January 2018

1 reference

Common design principles in the spliceosomal RNA helicase Brr2 and in the Hel308 DNA helicase.

21 January 2018

1 reference

Structure of the spliceosomal U4 snRNP core domain and its implication for snRNP biogenesis

21 January 2018

1 reference

Crystal structures of the Lsm complex bound to the 3' end sequence of U6 small nuclear RNA

21 January 2018

1 reference

Binding of the human Prp31 Nop domain to a composite RNA-protein platform in U4 snRNP

21 January 2018

1 reference

Structure and assembly of the SF3a splicing factor complex of U2 snRNP

21 January 2018

1 reference

Molecular Architecture of SF3b and Structural Consequences of Its Cancer-Related Mutations

21 January 2018

1 reference

Crystal structure of human spliceosomal U1 snRNP at 5.5 Å resolution

21 January 2018

1 reference

Crystal structure of human U1 snRNP, a small nuclear ribonucleoprotein particle, reveals the mechanism of 5' splice site recognition

21 January 2018

1 reference

Functional organization of the Sm core in the crystal structure of human U1 snRNP

21 January 2018

1 reference

Cryo-electron microscopy of spliceosomal components

21 January 2018

1 reference

Organization of core spliceosomal components U5 snRNA loop I and U4/U6 Di-snRNP within U4/U6.U5 Tri-snRNP as revealed by electron cryomicroscopy

21 January 2018

1 reference

Three-dimensional structure of a pre-catalytic human spliceosomal complex B.

21 January 2018

1 reference

Three-dimensional structure of C complex spliceosomes by electron microscopy.

21 January 2018

1 reference

3D cryo-EM structure of an active step I spliceosome and localization of its catalytic core

21 January 2018

1 reference

Structural characterization of the fission yeast U5.U2/U6 spliceosome complex

21 January 2018

1 reference

Exploring the architecture of the intact supraspliceosome using electron microscopy

21 January 2018

1 reference

The evolutionarily conserved core design of the catalytic activation step of the yeast spliceosome

21 January 2018

1 reference

Molecular architecture of the Saccharomyces cerevisiae activated spliceosome

21 January 2018

1 reference

Structure of a yeast activated spliceosome at 3.5 Å resolution

21 January 2018

1 reference

The architecture of the spliceosomal U4/U6.U5 tri-snRNP.

21 January 2018

1 reference

Cryo-EM structure of the yeast U4/U6.U5 tri-snRNP at 3.7 Å resolution

21 January 2018

1 reference

The 3.8 Å structure of the U4/U6.U5 tri-snRNP: Insights into spliceosome assembly and catalysis

21 January 2018

1 reference

Cryo-EM structure of the spliceosome immediately after branching

21 January 2018

1 reference

Structure of a yeast catalytic step I spliceosome at 3.4 Å resolution

21 January 2018

1 reference

A general two-metal-ion mechanism for catalytic RNA

21 January 2018

1 reference

Metal-ion coordination by U6 small nuclear RNA contributes to catalysis in the spliceosome.

21 January 2018

1 reference

Evidence for a group II intron-like catalytic triplex in the spliceosome

21 January 2018

1 reference

Structure of a spliceosome remodelled for exon ligation

21 January 2018

1 reference

Structure of a yeast step II catalytically activated spliceosome

21 January 2018

1 reference

Suppression of multiple substrate mutations by spliceosomal prp8 alleles suggests functional correlations with ribosomal ambiguity mutants

21 January 2018

1 reference

Repositioning of the reaction intermediate within the catalytic center of the spliceosome.

21 January 2018

1 reference

Opposing classes of prp8 alleles modulate the transition between the catalytic steps of pre-mRNA splicing

21 January 2018

1 reference

CEF1/CDC5 alleles modulate transitions between catalytic conformations of the spliceosome

21 January 2018

1 reference

A mechanism to enhance mRNA splicing fidelity: the RNA-dependent ATPase Prp16 governs usage of a discard pathway for aberrant lariat intermediates

21 January 2018

1 reference

Exon ligation is proofread by the DExD/H-box ATPase Prp22p

21 January 2018

1 reference

Competition between the ATPase Prp5 and branch region-U2 snRNA pairing modulates the fidelity of spliceosome assembly

21 January 2018

1 reference

Release of SF3 from the intron branchpoint activates the first step of pre-mRNA splicing

21 January 2018

1 reference

The DExD/H-box ATPase Prp2p destabilizes and proofreads the catalytic RNA core of the spliceosome

21 January 2018

1 reference

The DEAH box ATPases Prp16 and Prp43 cooperate to proofread 5' splice site cleavage during pre-mRNA splicing

21 January 2018

1 reference

The C-terminal region of hPrp8 interacts with the conserved GU dinucleotide at the 5' splice site

21 January 2018

1 reference

Functional interactions of Prp8 with both splice sites at the spliceosomal catalytic center

21 January 2018

1 reference

Allele-specific genetic interactions between Prp8 and RNA active site residues suggest a function for Prp8 at the catalytic core of the spliceosome.

21 January 2018

1 reference

Structure of a yeast spliceosome at 3.6-angstrom resolution

21 January 2018

1 reference

A homolog of lariat-debranching enzyme modulates turnover of branched RNA.

21 January 2018

1 reference

Cryo-EM structure of a human spliceosome activated for step 2 of splicing

21 January 2018

1 reference

An Atomic Structure of the Human Spliceosome

21 January 2018

1 reference

The RNA helicase Aquarius exhibits structural adaptations mediating its recruitment to spliceosomes

21 January 2018

1 reference

Molecular architecture of the human U4/U6.U5 tri-snRNP

21 January 2018

1 reference

Exon, intron and splice site locations in the spliceosomal B complex

21 January 2018

1 reference

Cryo-EM Structure of a Pre-catalytic Human Spliceosome Primed for Activation

21 January 2018

1 reference

In vivo characterization of yeast mRNA processing intermediates

21 January 2018

1 reference

A U1 snRNA:pre-mRNA base pairing interaction is required early in yeast spliceosome assembly but does not uniquely define the 5' cleavage site.

31 March 2020

1 reference

Involvement of U6 snRNA in 5' splice site selection

31 March 2020

1 reference

Crystal structure of a eukaryotic group II intron lariat

31 March 2020

1 reference

U5 snRNA interacts with exon sequences at 5′ and 3′ splice sites

31 March 2020

1 reference

31 March 2020

Cryo-EM enters a new era

1 reference

Structure of a pre-catalytic spliceosome

31 March 2020

1 reference

RNA catalyses nuclear pre-mRNA splicing

31 March 2020

1 reference

A conformational rearrangement in the spliceosome is dependent on PRP16 and ATP hydrolysis

31 March 2020

1 reference

12 December 2020

Role of Cwc24 in the First Catalytic Step of Splicing and Fidelity of 5' Splice Site Selection

1 reference

12 December 2020

The U5 and U6 small nuclear RNAs as active site components of the spliceosome

1 reference

12 December 2020

Requirement for SLU7 in yeast pre-mRNA splicing is dictated by the distance between the branchpoint and the 3' splice site.

1 reference

12 December 2020

Identifiers

DOI

10.1038/NSMB.3463

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28981077%20AND%20SRC:MED&resulttype=core&format=json

1 April 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28981077%20AND%20SRC:MED&resulttype=core&format=json

1 April 2020

PubMed publication ID

28981077

1 reference