(Q41599367)

4 October 2017

title

Cryo-EM structure of a human spliceosome activated for step 2 of splicing (English)

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cryogenic electron microscopy

4 October 2017

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1

Karl Bertram

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Reinhard Georg Lührmann

10

object named as

Reinhard Lührmann

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4 October 2017

5

Cindy L Will

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4 October 2017

8

Berthold Kastner

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4 October 2017

7

Henning Urlaub

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4 October 2017

Dmitry E Agafonov

2

1 reference

4 October 2017

Wen-Ti Liu

3

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4 October 2017

Olexandr Dybkov

4

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4 October 2017

Klaus Hartmuth

6

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4 October 2017

Holger Stark

9

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4 October 2017

language of work or name

English

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publication date

11 January 2017

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4 October 2017

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4 October 2017

volume

542

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4 October 2017

issue

7641

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4 October 2017

page(s)

318-323

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The spliceosome: design principles of a dynamic RNP machine

4 October 2017

cites work

1 reference

https://api.crossref.org/works/10.1038%2FNATURE21079

7 January 2021

Spliceosome activation by PRP2 ATPase prior to the first transesterification reaction of pre-mRNA splicing

1 reference

https://api.crossref.org/works/10.1038%2FNATURE21079

7 January 2021

Reconstitution of both steps of Saccharomyces cerevisiae splicing with purified spliceosomal components

1 reference

https://api.crossref.org/works/10.1038%2FNATURE21079

7 January 2021

Evidence for a group II intron-like catalytic triplex in the spliceosome

1 reference

https://api.crossref.org/works/10.1038%2FNATURE21079

7 January 2021

Structural basis of pre-mRNA splicing.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE21079

7 January 2021

Crystal structure of a eukaryotic group II intron lariat

1 reference

https://api.crossref.org/works/10.1038%2FNATURE21079

7 January 2021

PRP16 is an RNA-dependent ATPase that interacts transiently with the spliceosome

1 reference

https://api.crossref.org/works/10.1038%2FNATURE21079

7 January 2021

Molecular dissection of step 2 catalysis of yeast pre-mRNA splicing investigated in a purified system

1 reference

https://api.crossref.org/works/10.1038%2FNATURE21079

7 January 2021

An essential splicing factor, SLU7, mediates 3' splice site choice in yeast

1 reference

https://api.crossref.org/works/10.1038%2FNATURE21079

7 January 2021

A U5 small nuclear ribonucleoprotein particle protein involved only in the second step of pre-mRNA splicing in Saccharomyces cerevisiae

1 reference

https://api.crossref.org/works/10.1038%2FNATURE21079

7 January 2021

Prp22, a DExH-box RNA helicase, plays two distinct roles in yeast pre-mRNA splicing

1 reference

https://api.crossref.org/works/10.1038%2FNATURE21079

7 January 2021

Human step II splicing factor hSlu7 functions in restructuring the spliceosome between the catalytic steps of splicing

1 reference

https://api.crossref.org/works/10.1038%2FNATURE21079

7 January 2021

A human protein required for the second step of pre-mRNA splicing is functionally related to a yeast splicing factor

1 reference

https://api.crossref.org/works/10.1038%2FNATURE21079

7 January 2021

Structure of a yeast spliceosome at 3.6-angstrom resolution

1 reference

https://api.crossref.org/works/10.1038%2FNATURE21079

7 January 2021

The architecture of the spliceosomal U4/U6.U5 tri-snRNP.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE21079

7 January 2021

Cryo-EM structure of the yeast U4/U6.U5 tri-snRNP at 3.7 Å resolution

1 reference

https://api.crossref.org/works/10.1038%2FNATURE21079

7 January 2021

The 3.8 Å structure of the U4/U6.U5 tri-snRNP: Insights into spliceosome assembly and catalysis

1 reference

https://api.crossref.org/works/10.1038%2FNATURE21079

7 January 2021

Molecular architecture of the human U4/U6.U5 tri-snRNP

1 reference

https://api.crossref.org/works/10.1038%2FNATURE21079

7 January 2021

Molecular architecture of the Saccharomyces cerevisiae activated spliceosome

1 reference

https://api.crossref.org/works/10.1038%2FNATURE21079

7 January 2021

Structure of a yeast activated spliceosome at 3.5 Å resolution

1 reference

https://api.crossref.org/works/10.1038%2FNATURE21079

7 January 2021

Structure of a yeast catalytic step I spliceosome at 3.4 Å resolution

1 reference

https://api.crossref.org/works/10.1038%2FNATURE21079

7 January 2021

Cryo-EM structure of the spliceosome immediately after branching

1 reference

https://api.crossref.org/works/10.1038%2FNATURE21079

7 January 2021

Crystal structure of Prp8 reveals active site cavity of the spliceosome

1 reference

https://api.crossref.org/works/10.1038%2FNATURE21079

7 January 2021

Cwc2 and its human homologue RBM22 promote an active conformation of the spliceosome catalytic centre

1 reference

https://api.crossref.org/works/10.1038%2FNATURE21079

7 January 2021

The HAT helix, a repetitive motif implicated in RNA processing.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE21079

7 January 2021

RNA structure analysis of human spliceosomes reveals a compact 3D arrangement of snRNAs at the catalytic core

1 reference

https://api.crossref.org/works/10.1038%2FNATURE21079

7 January 2021

RNA catalyses nuclear pre-mRNA splicing

1 reference

https://api.crossref.org/works/10.1038%2FNATURE21079

7 January 2021

U5 snRNA interacts with exon sequences at 5′ and 3′ splice sites

1 reference

https://api.crossref.org/works/10.1038%2FNATURE21079

7 January 2021

The spliceosome deposits multiple proteins 20-24 nucleotides upstream of mRNA exon-exon junctions

1 reference

https://api.crossref.org/works/10.1038%2FNATURE21079

7 January 2021

Suppression of multiple substrate mutations by spliceosomal prp8 alleles suggests functional correlations with ribosomal ambiguity mutants

1 reference

https://api.crossref.org/works/10.1038%2FNATURE21079

7 January 2021

Functional interactions of Prp8 with both splice sites at the spliceosomal catalytic center

1 reference

https://api.crossref.org/works/10.1038%2FNATURE21079

7 January 2021

Allele-specific genetic interactions between Prp8 and RNA active site residues suggest a function for Prp8 at the catalytic core of the spliceosome.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE21079

7 January 2021

Characterization and functional ordering of Slu7p and Prp17p during the second step of pre-mRNA splicing in yeast

1 reference

https://api.crossref.org/works/10.1038%2FNATURE21079

7 January 2021

Release of SF3 from the intron branchpoint activates the first step of pre-mRNA splicing

1 reference

https://api.crossref.org/works/10.1038%2FNATURE21079

7 January 2021

Prp2-mediated protein rearrangements at the catalytic core of the spliceosome as revealed by dcFCCS.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE21079

7 January 2021

DEAH-box ATPase Prp16 has dual roles in remodeling of the spliceosome in catalytic steps

1 reference

https://api.crossref.org/works/10.1038%2FNATURE21079

7 January 2021

Insights into the mechanisms of splicing: more lessons from the ribosome

1 reference

https://api.crossref.org/works/10.1038%2FNATURE21079

7 January 2021

The mechanism of the second step of pre-mRNA splicing

1 reference

https://api.crossref.org/works/10.1038%2FNATURE21079

7 January 2021

Functional domains of the yeast splicing factor Prp22p

1 reference

https://api.crossref.org/works/10.1038%2FNATURE21079

7 January 2021

Identification and characterization of Prp45p and Prp46p, essential pre-mRNA splicing factors

1 reference

https://api.crossref.org/works/10.1038%2FNATURE21079

7 January 2021

Prp45 affects Prp22 partition in spliceosomal complexes and splicing efficiency of non-consensus substrates.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE21079

7 January 2021

Requirement of the RNA helicase-like protein PRP22 for release of messenger RNA from spliceosomes

1 reference

https://api.crossref.org/works/10.1038%2FNATURE21079

7 January 2021

A conformational rearrangement in the spliceosome sets the stage for Prp22-dependent mRNA release

1 reference

https://api.crossref.org/works/10.1038%2FNATURE21079

7 January 2021

Dissection of the factor requirements for spliceosome disassembly and the elucidation of its dissociation products using a purified splicing system

1 reference

https://api.crossref.org/works/10.1038%2FNATURE21079

7 January 2021

Spliceosomal DEAH-Box ATPases Remodel Pre-mRNA to Activate Alternative Splice Sites

1 reference

https://api.crossref.org/works/10.1038%2FNATURE21079

7 January 2021

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

1 reference

https://api.crossref.org/works/10.1038%2FNATURE21079

7 January 2021

Isolation of an active step I spliceosome and composition of its RNP core.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE21079

7 January 2021

Three-dimensional structure of C complex spliceosomes by electron microscopy.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE21079

7 January 2021

3D cryo-EM structure of an active step I spliceosome and localization of its catalytic core

1 reference

https://api.crossref.org/works/10.1038%2FNATURE21079

7 January 2021

Gel electrophoretic isolation of splicing complexes containing U1 small nuclear ribonucleoprotein particles

1 reference

https://api.crossref.org/works/10.1038%2FNATURE21079

7 January 2021

GraFix: sample preparation for single-particle electron cryomicroscopy

1 reference

https://api.crossref.org/works/10.1038%2FNATURE21079

7 January 2021

Semiquantitative proteomic analysis of the human spliceosome via a novel two-dimensional gel electrophoresis method

1 reference

https://api.crossref.org/works/10.1038%2FNATURE21079

7 January 2021

The mammalian homologue of Prp16p is overexpressed in a cell line tolerant to Leflunomide, a new immunoregulatory drug effective against rheumatoid arthritis

1 reference

https://api.crossref.org/works/10.1038%2FNATURE21079

7 January 2021

Lysine-specific chemical cross-linking of protein complexes and identification of cross-linking sites using LC-MS/MS and the xQuest/xProphet software pipeline

1 reference

https://api.crossref.org/works/10.1038%2FNATURE21079

7 January 2021

Identification of cross-linked peptides from complex samples.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE21079

7 January 2021

Organization of core spliceosomal components U5 snRNA loop I and U4/U6 Di-snRNP within U4/U6.U5 Tri-snRNP as revealed by electron cryomicroscopy

1 reference

https://api.crossref.org/works/10.1038%2FNATURE21079

7 January 2021

Movies of ice-embedded particles enhance resolution in electron cryo-microscopy

1 reference

https://api.crossref.org/works/10.1038%2FNATURE21079

7 January 2021

Visualizing density maps with UCSF Chimera

1 reference

https://api.crossref.org/works/10.1038%2FNATURE21079

7 January 2021

Features and development of Coot

1 reference

https://api.crossref.org/works/10.1038%2FNATURE21079

7 January 2021

SWISS-MODEL and the Swiss-PdbViewer: an environment for comparative protein modeling

1 reference

https://api.crossref.org/works/10.1038%2FNATURE21079

7 January 2021

Structural bioinformatics of the human spliceosomal proteome

1 reference

https://api.crossref.org/works/10.1038%2FNATURE21079

7 January 2021

ModeRNA: a tool for comparative modeling of RNA 3D structure

1 reference

https://api.crossref.org/works/10.1038%2FNATURE21079

7 January 2021

PHENIX: a comprehensive Python-based system for macromolecular structure solution

1 reference

https://api.crossref.org/works/10.1038%2FNATURE21079

7 January 2021

MolProbity: all-atom contacts and structure validation for proteins and nucleic acids

1 reference

https://api.crossref.org/works/10.1038%2FNATURE21079

7 January 2021

Solution structure of human peptidyl prolyl isomerase-like protein 1 and insights into its interaction with SKIP

1 reference

https://api.crossref.org/works/10.1038%2FNATURE21079

7 January 2021

A large intrinsically disordered region in SKIP and its disorder-order transition induced by PPIL1 binding revealed by NMR

1 reference

https://api.crossref.org/works/10.1038%2FNATURE21079

7 January 2021

The crystal structure of PPIL1 bound to cyclosporine A suggests a binding mode for a linear epitope of the SKIP protein

1 reference

https://api.crossref.org/works/10.1038%2FNATURE21079

7 January 2021

Rearrangement of competing U2 RNA helices within the spliceosome promotes multiple steps in splicing

1 reference

https://api.crossref.org/works/10.1038%2FNATURE21079

7 January 2021

RELION: implementation of a Bayesian approach to cryo-EM structure determination

1 reference

https://api.crossref.org/works/10.1038%2FNATURE21079

7 January 2021

The U5 and U6 small nuclear RNAs as active site components of the spliceosome

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/28076346

12 December 2020

inferred from PubMed ID database lookup

Genetic and physical interactions between factors involved in both cell cycle progression and pre-mRNA splicing in Saccharomyces cerevisiae

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/28076346

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1038/NATURE21079

1 reference

Dimensions Publication ID

4 October 2017

1023854792

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1 reference