(Q47195394)

http://europepmc.org/abstract/PMC/5748217

11 July 2018

title

Discovery of the leinamycin family of natural products by mining actinobacterial genomes (English)

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http://europepmc.org/abstract/PMC/5748217

11 July 2018

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(1'S,2S,5'R,12'E,16'R,17'S)-3',17'-dihydroxy-5',17'-dimethyl-11'-propyl-7',20'-dithia-4',21'-diazaspiro[oxirane-2,14'-tricyclo[14.3.1.1⁶,⁹]henicosane]-3',6'(21'),8',10',12'-pentaen-1'-ylacetic acid

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1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29229819%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

Hindra

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29229819%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

Dong Yang

6

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29229819%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

Yannick Gansemans

8

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29229819%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

Xiangcheng Zhu

9

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29229819%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

Ben Shen

17

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29229819%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

author name string

Zhengren Xu

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29229819%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

Zhikai Guo

3

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29229819%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

Ming Ma

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29229819%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

Hao Zhou

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29229819%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

Yong Huang

10

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29229819%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

Li-Xing Zhao

11

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29229819%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

Yi Jiang

12

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29229819%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

Jinhua Cheng

13

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29229819%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

Joo-Won Suh

15

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29229819%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

Yanwen Duan

16

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29229819%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

Filip Van Nieuwerburgh

14

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29229819%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

language of work or name

English

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publication date

11 December 2017

1 reference

http://europepmc.org/abstract/PMC/5748217

11 July 2018

full work available at URL

https://www.pnas.org/content/pnas/114/52/E11131.full.pdf

1 reference

19 March 2024

https://api.unpaywall.org/v2/10.1073/pnas.1716245115?email=unpaywall_01@example.com

published in

Proceedings of the National Academy of Sciences of the United States of America

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29229819%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

volume

114

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29229819%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

issue

52

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29229819%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

page(s)

E11131-E11140

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29229819%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

1 reference

19 March 2024

https://api.unpaywall.org/v2/10.1073/pnas.1716245115?email=unpaywall_01@example.com

access restriction status

open access

1 reference

inferred from online access status

cites work

Retrospective analysis of natural products provides insights for future discovery trends

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5748217

Strain Prioritization and Genome Mining for Enediyne Natural Products

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5748217

Synthetic biology to access and expand nature's chemical diversity

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5748217

Natural Products as Sources of New Drugs from 1981 to 2014.

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5748217

Natural product discovery: past, present, and future

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5748217

Biosynthesis of polyketides by trans-AT polyketide synthases

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5748217

A New Golden Age of Natural Products Drug Discovery

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5748217

Structural and evolutionary relationships of "AT-less" type I polyketide synthase ketosynthases

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5748217

Discovery of phosphonic acid natural products by mining the genomes of 10,000 actinomycetes

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5748217

Genome neighborhood network reveals insights into enediyne biosynthesis and facilitates prediction and prioritization for discovery

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5748217

Reinvigorating natural product combinatorial biosynthesis with synthetic biology

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5748217

C-S bond cleavage by a polyketide synthase domain

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5748217

Synthesis and evaluation of 8,4'-dideshydroxy-leinamycin revealing new insights into the structure-activity relationship of the anticancer natural product leinamycin

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5748217

Leinamycin E1 acting as an anticancer prodrug activated by reactive oxygen species

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5748217

Multiplexed metagenome mining using short DNA sequence tags facilitates targeted discovery of epoxyketone proteasome inhibitors

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5748217

Strain prioritization for natural product discovery by a high-throughput real-time PCR method.

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5748217

Structure of the Bifunctional Acyltransferase/Decarboxylase LnmK from the Leinamycin Biosynthetic Pathway Revealing Novel Activity for a Double-Hot-Dog Fold

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5748217

Beyond ethylmalonyl-CoA: the functional role of crotonyl-CoA carboxylase/reductase homologs in expanding polyketide diversity

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5748217

Characterization of the lnmKLM genes unveiling key intermediates for β-alkylation in leinamycin biosynthesis

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5748217

Characterization of DNA damage induced by a natural product antitumor antibiotic leinamycin in human cancer cells

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5748217

Genomic basis for natural product biosynthetic diversity in the actinomycetes

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5748217

Bifunctional acyltransferase/decarboxylase LnmK as the missing link for beta-alkylation in polyketide biosynthesis

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5748217

Isoprenoid-like alkylations in polyketide biosynthesis

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5748217

The chemical versatility of natural-product assembly lines

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5748217

Assembly-line enzymology for polyketide and nonribosomal Peptide antibiotics: logic, machinery, and mechanisms.

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5748217

Polyketide biosynthesis beyond the type I, II and III polyketide synthase paradigms

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5748217

Type I polyketide synthase requiring a discrete acyltransferase for polyketide biosynthesis

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5748217

A multiplasmid approach to preparing large libraries of polyketides

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5748217

The specificity-conferring code of adenylation domains in nonribosomal peptide synthetases

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5748217

Multiple genetic modifications of the erythromycin polyketide synthase to produce a library of novel "unnatural" natural products.

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5748217

Colibactin assembly line enzymes use S-adenosylmethionine to build a cyclopropane ring.

15 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5748217

Chapter 17. Siderophore biosynthesis a substrate specificity assay for nonribosomal peptide synthetase-independent siderophore synthetases involving trapping of acyl-adenylate intermediates with hydroxylamine

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5748217

Exploiting the mosaic structure of trans-acyltransferase polyketide synthases for natural product discovery and pathway dissection

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5748217

Leinamycin biosynthesis revealing unprecedented architectural complexity for a hybrid polyketide synthase and nonribosomal peptide synthetase

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5748217

Synthesis and antitumor activity of novel C-8 ester derivatives of leinamycin

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5748217

Leinamycin, a new antitumor antibiotic from Streptomyces: producing organism, fermentation and isolation

14 August 2018

1 reference

12 December 2020

DC 107, a novel antitumor antibiotic produced by a Streptomyces sp

1 reference

12 December 2020

Harnessing the biosynthetic code: combinations, permutations, and mutations

1 reference

12 December 2020

Synthesis and antitumor activity of leinamycin derivatives: modifications of C-8 hydroxy and C-9 keto groups

1 reference

12 December 2020

Synthesis and antitumor activity of novel thioester derivatives of leinamycin

1 reference

12 December 2020

Phenylglycine methyl ester, a useful tool for absolute configuration determination of various chiral carboxylic acids

1 reference

12 December 2020

Chain initiation in the leinamycin-producing hybrid nonribosomal peptide/polyketide synthetase from Streptomyces atroolivaceus S-140. Discrete, monofunctional adenylation enzyme and peptidyl carrier protein that directly load D-alanine

1 reference

12 December 2020

Progress in combinatorial biosynthesis for drug discovery

1 reference

12 December 2020

Conformational features of secondary N-cyclopropyl amides

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.1716245115

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29229819%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29229819%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

PubMed publication ID

29229819

1 reference