(Q47285927)

13 January 2018

review article

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title

Interleukin-18: Biological properties and role in disease pathogenesis (English)

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13 January 2018

author name string

Gilles Kaplanski

series ordinal

1

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13 January 2018

publication date

1 January 2018

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13 January 2018

published in

Immunological Reviews

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13 January 2018

volume

281

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13 January 2018

issue

1

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13 January 2018

page(s)

138-153

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13 January 2018

Cloning of a new cytokine that induces IFN-gamma production by T cells

cites work

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Interleukin-18 regulates both Th1 and Th2 responses

21 January 2018

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Interleukin-18 and IL-18 binding protein

21 January 2018

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Interleukin-18, more than a Th1 cytokine

21 January 2018

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Activation of interferon-gamma inducing factor mediated by interleukin-1beta converting enzyme

21 January 2018

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Caspase-1 processes IFN-gamma-inducing factor and regulates LPS-induced IFN-gamma production.

21 January 2018

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Pyroptotic cell death defends against intracellular pathogens

21 January 2018

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Cutting edge: FAS (CD95) mediates noncanonical IL-1β and IL-18 maturation via caspase-8 in an RIP3-independent manner

21 January 2018

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Involvement of caspase-1 and caspase-3 in the production and processing of mature human interleukin 18 in monocytic THP.1 cells

21 January 2018

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Granzyme B is a novel interleukin-18 converting enzyme.

21 January 2018

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Prointerleukin-18 is activated by meprin beta in vitro and in vivo in intestinal inflammation

21 January 2018

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Neutrophil proteinase 3-mediated induction of bioactive IL-18 secretion by human oral epithelial cells

21 January 2018

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Purification and characterization of the human interleukin-18 receptor

21 January 2018

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Interleukin-1, interleukin-1 receptors and interleukin-1 receptor antagonist

21 January 2018

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Differences in signaling pathways by IL-1beta and IL-18.

21 January 2018

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IL-18 activates STAT3 in the natural killer cell line 92, augments cytotoxic activity, and mediates IFN-gamma production by the stress kinase p38 and by the extracellular regulated kinases p44erk-1 and p42erk-21

21 January 2018

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Interleukin 18 activates MAPKs and STAT3 but not NF-κB in hippocampal HT-22 cells.

21 January 2018

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A complex of the IL-1 homologue IL-1F7b and IL-18-binding protein reduces IL-18 activity

21 January 2018

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IL-37 is a fundamental inhibitor of innate immunity

21 January 2018

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Responses of IL-18- and IL-18 receptor-deficient pancreatic islets with convergence of positive and negative signals for the IL-18 receptor

21 January 2018

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Increased cytokine production in interleukin-18 receptor alpha-deficient cells is associated with dysregulation of suppressors of cytokine signaling

21 January 2018

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IL-37 requires the receptors IL-18Rα and IL-1R8 (SIGIRR) to carry out its multifaceted anti-inflammatory program upon innate signal transduction

21 January 2018

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Extracellular forms of IL-37 inhibit innate inflammation in vitro and in vivo but require the IL-1 family decoy receptor IL-1R8.

21 January 2018

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Interleukin 37 expression protects mice from colitis

21 January 2018

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Interleukin-18 and interleukin-1 beta: two cytokine substrates for ICE (caspase-1).

21 January 2018

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M-CSF induces the expression of a membrane-bound form of IL-18 in a subset of human monocytes differentiating in vitro toward macrophages

21 January 2018

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Murine macrophages secrete interferon gamma upon combined stimulation with interleukin (IL)-12 and IL-18: A novel pathway of autocrine macrophage activation

21 January 2018

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IL-18 induction of IgE: dependence on CD4+ T cells, IL-4 and STAT6.

21 January 2018

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IL-18, although antiallergic when administered with IL-12, stimulates IL-4 and histamine release by basophils

21 January 2018

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Interleukin-1 and IL-23 induce innate IL-17 production from gammadelta T cells, amplifying Th17 responses and autoimmunity.

21 January 2018

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Proinflammatory Cytokine Environments Can Drive Interleukin-17 Overexpression by γ/δ T Cells in Systemic Juvenile Idiopathic Arthritis.

21 January 2018

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Targeting IL-17A attenuates neonatal sepsis mortality induced by IL-18.

21 January 2018

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DC-derived IL-18 drives Treg differentiation, murine Helicobacter pylori-specific immune tolerance, and asthma protection

21 January 2018

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A novel role for interleukin-18 in adhesion molecule induction through NF kappa B and phosphatidylinositol (PI) 3-kinase-dependent signal transduction pathways

21 January 2018

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IL-18 regulates IL-1beta-dependent hepatic melanoma metastasis via vascular cell adhesion molecule-1.

21 January 2018

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Interleukin-18 (IFNgamma-inducing factor) induces IL-8 and IL-1beta via TNFalpha production from non-CD14+ human blood mononuclear cells

21 January 2018

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Interleukin-18 induces rheumatoid arthritis synovial fibroblast CXC chemokine production through NFkappaB activation

21 January 2018

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Pathophysiological roles of interleukin-18 in inflammatory liver diseases

21 January 2018

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Effect of interleukin-18 on mouse core body temperature

21 January 2018

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Interleukin-18 binding protein: a novel modulator of the Th1 cytokine response

21 January 2018

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Structural requirements of six naturally occurring isoforms of the IL-18 binding protein to inhibit IL-18

21 January 2018

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A novel IL-18BP ELISA shows elevated serum IL-18BP in sepsis and extensive decrease of free IL-18.

21 January 2018

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Severe imbalance of IL-18/IL-18BP in patients with secondary hemophagocytic syndrome

21 January 2018

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Interferon-gamma mediates gene expression of IL-18 binding protein in nonleukocytic cells

21 January 2018

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The promoter of IL-18 binding protein: activation by an IFN-gamma -induced complex of IFN regulatory factor 1 and CCAAT/enhancer binding protein beta

21 January 2018

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The Goldilocks Conundrum: NLR Inflammasome Modulation of Gastrointestinal Inflammation during Inflammatory Bowel Disease

21 January 2018

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An activating NLRC4 inflammasome mutation causes autoinflammation with recurrent macrophage activation syndrome

21 January 2018

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Macrophage-derived IL-18-mediated intestinal inflammation in the murine model of Crohn's disease

21 January 2018

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Blockade of endogenous IL-18 ameliorates TNBS-induced colitis by decreasing local TNF-alpha production in mice

21 January 2018

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Interleukin 18 is a primary mediator of the inflammation associated with dextran sulphate sodium induced colitis: blocking interleukin 18 attenuates intestinal damage

21 January 2018

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Epithelial IL-18 Equilibrium Controls Barrier Function in Colitis

21 January 2018

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IL-1 beta -converting enzyme (caspase-1) in intestinal inflammation

21 January 2018

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Myeloid-derived miR-223 regulates intestinal inflammation via repression of the NLRP3 inflammasome.

21 January 2018

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Common variants in the NLRP3 region contribute to Crohn's disease susceptibility

21 January 2018

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Genetic analysis of innate immunity in Crohn's disease and ulcerative colitis identifies two susceptibility loci harboring CARD9 and IL18RAP.

21 January 2018

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The NLRP3 inflammasome protects against loss of epithelial integrity and mortality during experimental colitis

21 January 2018

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NLRP6: A Multifaceted Innate Immune Sensor

21 January 2018

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Microbiota-Modulated Metabolites Shape the Intestinal Microenvironment by Regulating NLRP6 Inflammasome Signaling.

21 January 2018

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NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis

21 January 2018

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NLRP6 inflammasome orchestrates the colonic host-microbial interface by regulating goblet cell mucus secretion

21 January 2018

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New insights into the dichotomous role of innate cytokines in gut homeostasis and inflammation

21 January 2018

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Opposing Functions of Classic and Novel IL-1 Family Members in Gut Health and Disease

21 January 2018

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Epithelial-derived IL-18 regulates Th17 cell differentiation and Foxp3⁺ Treg cell function in the intestine.

21 January 2018

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Interleukin-18 in intestinal inflammation: friend and foe?

21 January 2018

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Interleukin-18: The Bouncer at the Mucosal Bar.

21 January 2018

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Non-redundant properties of IL-1α and IL-1β during acute colon inflammation in mice

21 January 2018

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First-line therapy in adult Crohn's disease: who should receive anti-TNF agents?

21 January 2018

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Anti-IL-12/23 in Crohn's disease: bench and bedside

21 January 2018

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21 January 2018

The metabolic syndrome

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Diagnosis and management of the metabolic syndrome: an American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement

21 January 2018

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Elevated interleukin-18 levels are associated with the metabolic syndrome independent of obesity and insulin resistance.

21 January 2018

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Interleukin-18, the metabolic syndrome, and subclinical atherosclerosis: results from the Dallas Heart Study.

21 January 2018

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Elevated plasma interleukin-18 is a marker of insulin-resistance in type 2 diabetic and non-diabetic humans

21 January 2018

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IL-18 gene polymorphism and metabolic syndrome

21 January 2018

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Interleukin-18 in plasma and adipose tissue: effects of obesity, insulin resistance, and weight loss

21 January 2018

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The proatherogenic cytokine interleukin-18 is secreted by human adipocytes.

21 January 2018

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Effect of massive weight loss induced by bariatric surgery on serum levels of interleukin-18 and monocyte-chemoattractant-protein-1 in morbid obesity

21 January 2018

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Interleukin-18 controls energy homeostasis by suppressing appetite and feed efficiency

21 January 2018

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Interleukin-18 activates skeletal muscle AMPK and reduces weight gain and insulin resistance in mice

21 January 2018

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The role of interleukin-18 in the metabolic syndrome

21 January 2018

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IL-1 family members in the pathogenesis and treatment of metabolic disease: Focus on adipose tissue inflammation and insulin resistance

21 January 2018

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A Study to Investigate the Efficacy and Safety of an Anti-Interleukin-18 Monoclonal Antibody in the Treatment of Type 2 Diabetes Mellitus

21 January 2018

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NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

21 January 2018

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Expression of interleukin (IL)-18 and functional IL-18 receptor on human vascular endothelial cells, smooth muscle cells, and macrophages: implications for atherogenesis

21 January 2018

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Interleukin-18 enhances atherosclerosis in apolipoprotein E(-/-) mice through release of interferon-gamma

21 January 2018

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Reduced atherosclerosis in interleukin-18 deficient apolipoprotein E-knockout mice

21 January 2018

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Interleukin-18 is a strong predictor of cardiovascular death in stable and unstable angina

21 January 2018

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Interleukin-18 and the risk of coronary heart disease in European men: the Prospective Epidemiological Study of Myocardial Infarction (PRIME).

21 January 2018

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Plasma interleukin (IL)-18 concentrations is elevated in patients with previous myocardial infarction and related to severity of coronary atherosclerosis independently of C-reactive protein and IL-6.

21 January 2018

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Interleukin-18 levels are not associated with subclinical carotid atherosclerosis in a community population. The Perth Carotid Ultrasound Disease Assessment Study (CUDAS).

21 January 2018

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Interleukin 18 in acute myocardial infarction

21 January 2018

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Prospective study of IL-18 and risk of MI and stroke in men and women aged 60-79 years: a nested case-control study

21 January 2018

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Neutralization of interleukin-18 ameliorates ischemia/reperfusion-induced myocardial injury

21 January 2018

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IL-18 binding protein-expressing mesenchymal stem cells improve myocardial protection after ischemia or infarction

21 January 2018

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Interleukin-18 is a pro-hypertrophic cytokine that acts through a phosphatidylinositol 3-kinase-phosphoinositide-dependent kinase-1-Akt-GATA4 signaling pathway in cardiomyocytes

21 January 2018

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Daily administration of interleukin-18 causes myocardial dysfunction in healthy mice

21 January 2018

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Inhibition of caspase 1 reduces human myocardial ischemic dysfunction via inhibition of IL-18 and IL-1beta

21 January 2018

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Interleukin-18 mediates interleukin-1-induced cardiac dysfunction

21 January 2018

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The effect of daily administration of IL-18 on cardiac structure and function.

21 January 2018

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IL-18 induction of osteopontin mediates cardiac fibrosis and diastolic dysfunction in mice

21 January 2018

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IL-18 might reflect disease activity in mild and moderate asthma exacerbation

21 January 2018

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Interleukin-18 expression, CD8(+) T cells, and eosinophils in lungs of nonsmokers with fatal asthma.

21 January 2018

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IL-18 induces airway hyperresponsiveness and pulmonary inflammation via CD4+ T cell and IL-13

21 January 2018

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The nature of small-airway obstruction in chronic obstructive pulmonary disease

21 January 2018

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Effects of cigarette smoke on the immune system

21 January 2018

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IL-18 is induced and IL-18 receptor alpha plays a critical role in the pathogenesis of cigarette smoke-induced pulmonary emphysema and inflammation.

21 January 2018

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Interleukin-18 production and pulmonary function in COPD.

21 January 2018

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Role of IL-18 in second-hand smoke-induced emphysema

21 January 2018

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Pulmonary inflammation and emphysema: role of the cytokines IL-18 and IL-13.

21 January 2018

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IL-18 induces emphysema and airway and vascular remodeling via IFN-γ, IL-17A, and IL-13

21 January 2018

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Inflammasomes in the lung.

21 January 2018

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Acute Lung Injury: A Clinical and Molecular Review

21 January 2018

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Inflammasome-regulated cytokines are critical mediators of acute lung injury

21 January 2018

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Interleukin-18 levels reflect the long-term prognosis of acute lung injury and acute respiratory distress syndrome

21 January 2018

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The NLRP3 inflammasome mediates in vivo innate immunity to influenza A virus through recognition of viral RNA.

21 January 2018

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The intracellular sensor NLRP3 mediates key innate and healing responses to influenza A virus via the regulation of caspase-1

21 January 2018

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Interleukin-18 improves the early defence system against influenza virus infection by augmenting natural killer cell-mediated cytotoxicity

21 January 2018

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Enhanced viral clearance in interleukin-18 gene-deficient mice after pulmonary infection with influenza A virus

21 January 2018

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IL-18, but not IL-12, is required for optimal cytokine production by influenza virus-specific CD8+ T cells

21 January 2018

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Activation of the NLRP3 inflammasome by IAV virulence protein PB1-F2 contributes to severe pathophysiology and disease

21 January 2018

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Re-emergence of fatal human influenza A subtype H5N1 disease

21 January 2018

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Clinical, virological and immunological features from patients infected with re-emergent avian-origin human H7N9 influenza disease of varying severity in Guangdong province

21 January 2018

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The Serum Profile of Hypercytokinemia Factors Identified in H7N9-Infected Patients can Predict Fatal Outcomes

21 January 2018

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An interferon-gamma-related cytokine storm in SARS patients

21 January 2018

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Influenza: fatal immunity and the 1918 virus

21 January 2018

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Aberrant innate immune response in lethal infection of macaques with the 1918 influenza virus

21 January 2018

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Reassessing the role of the NLRP3 inflammasome during pathogenic influenza A virus infection via temporal inhibition

21 January 2018

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Hero turned villain: NLRP3 inflammasome-induced inflammation during influenza A virus infection

21 January 2018

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The immunopathology of sepsis and potential therapeutic targets

21 January 2018

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Neutralization of IL-18 reduces neutrophil tissue accumulation and protects mice against lethal Escherichia coli and Salmonella typhimurium endotoxemia.

21 January 2018

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Simultaneous targeting of IL-1 and IL-18 is required for protection against inflammatory and septic shock.

21 January 2018

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Hemin inhibits NLRP3 inflammasome activation in sepsis-induced acute lung injury, involving heme oxygenase-1.

21 January 2018

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IL-18 levels and the outcome of innate immune response to lipopolysaccharide: importance of a positive feedback loop with caspase-1 in IL-18 expression

21 January 2018

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Role of caspase 1 in murine antibacterial host defenses and lethal endotoxemia

21 January 2018

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Neutralization of the IL-17 axis diminishes neutrophil invasion and protects from ischemic stroke.

21 January 2018

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Non-canonical inflammasome activation targets caspase-11

21 January 2018

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Molecular mechanisms of biogenesis and exocytosis of cytotoxic granules

21 January 2018

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Macrophage activation syndrome in the era of biologic therapy.

21 January 2018

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An animal model of hemophagocytic lymphohistiocytosis (HLH): CD8+ T cells and interferon gamma are essential for the disorder

21 January 2018

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Graded defects in cytotoxicity determine severity of hemophagocytic lymphohistiocytosis in humans and mice

21 January 2018

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Repeated TLR9 stimulation results in macrophage activation syndrome-like disease in mice.

21 January 2018

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Amplification of the response to Toll-like receptor ligands by prolonged exposure to interleukin-6 in mice: implication for the pathogenesis of macrophage activation syndrome.

21 January 2018

1 reference

Mouse Cytomegalovirus Infection in BALB/c Mice Resembles Virus-Associated Secondary Hemophagocytic Lymphohistiocytosis and Shows a Pathogenesis Distinct from Primary Hemophagocytic Lymphohistiocytosis

21 January 2018

1 reference

Use of a mouse model to identify a blood biomarker for IFNγ activity in pediatric secondary hemophagocytic lymphohistiocytosis.

21 January 2018

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Interferon-γ mediates anemia but is dispensable for fulminant toll-like receptor 9-induced macrophage activation syndrome and hemophagocytosis in mice

21 January 2018

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Hemophagocytic lymphohistiocytosis in 2 patients with underlying IFN-γ receptor deficiency.

21 January 2018

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Increased interleukin-18 expression in bone marrow of a patient with systemic juvenile idiopathic arthritis and unrecognized macrophage-activation syndrome

21 January 2018

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Sustained elevation of serum interleukin-18 and its association with hemophagocytic lymphohistiocytosis in XIAP deficiency

21 January 2018

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Failure of interferon gamma to induce the anti-inflammatory interleukin 18 binding protein in familial hemophagocytosis

21 January 2018

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Protection from inflammatory organ damage in a murine model of hemophagocytic lymphohistiocytosis using treatment with IL-18 binding protein

21 January 2018

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Janus kinase inhibition lessens inflammation and ameliorates disease in murine models of hemophagocytic lymphohistiocytosis

21 January 2018

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Mutation of NLRC4 causes a syndrome of enterocolitis and autoinflammation

21 January 2018

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A Disease-associated Mutant of NLRC4 Shows Enhanced Interaction with SUG1 Leading to Constitutive FADD-dependent Caspase-8 Activation and Cell Death.

21 January 2018

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Life-threatening NLRC4-associated hyperinflammation successfully treated with IL-18 inhibition.

21 January 2018

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Systemic juvenile idiopathic arthritis

21 January 2018

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Role of interleukin-1 (IL-1) in the pathogenesis of systemic onset juvenile idiopathic arthritis and clinical response to IL-1 blockade

21 January 2018

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Gene expression profiling of peripheral blood from patients with untreated new-onset systemic juvenile idiopathic arthritis reveals molecular heterogeneity that may predict macrophage activation syndrome.

21 January 2018

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The pattern of response to anti-interleukin-1 treatment distinguishes two subsets of patients with systemic-onset juvenile idiopathic arthritis

21 January 2018

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Correlation of serum interleukin-6 levels with joint involvement and thrombocytosis in systemic juvenile rheumatoid arthritis

21 January 2018

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Randomized trial of tocilizumab in systemic juvenile idiopathic arthritis

21 January 2018

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Levels of interleukin-18 and its binding inhibitors in the blood circulation of patients with adult-onset Still's disease

21 January 2018

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Elevated serum levels of free interleukin-18 in adult-onset Still's disease.

21 January 2018

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Upregulation of circulating microRNA-134 in adult-onset Still's disease and its use as potential biomarker.

21 January 2018

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The limited role of interferon-γ in systemic juvenile idiopathic arthritis cannot be explained by cellular hyporesponsiveness

21 January 2018

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Natural killer cell dysfunction in patients with systemic-onset juvenile rheumatoid arthritis and macrophage activation syndrome

21 January 2018

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Natural killer cell dysfunction is a distinguishing feature of systemic onset juvenile rheumatoid arthritis and macrophage activation syndrome

21 January 2018

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Natural killer cell cytolytic function in Korean patients with adult-onset Still's disease.

21 January 2018

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Whole-exome sequencing reveals overlap between macrophage activation syndrome in systemic juvenile idiopathic arthritis and familial hemophagocytic lymphohistiocytosis

21 January 2018

1 reference

Inflammatory Gene Expression Profile and Defective Interferon-γ and Granzyme K in Natural Killer Cells From Systemic Juvenile Idiopathic Arthritis Patients

21 January 2018

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Defective phosphorylation of interleukin-18 receptor beta causes impaired natural killer cell function in systemic-onset juvenile idiopathic arthritis.

21 January 2018

1 reference

A novel role for interleukin-18 in human natural killer cell death: high serum levels and low natural killer cell numbers in patients with systemic autoimmune diseases

21 January 2018

1 reference

Genetic architecture distinguishes systemic juvenile idiopathic arthritis from other forms of juvenile idiopathic arthritis: clinical and therapeutic implications

21 January 2018

1 reference

Control of Intestinal Homeostasis, Colitis, and Colitis-Associated Colorectal Cancer by the Inflammatory Caspases

21 January 2018

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Expression of Interleukin-18 in Human Atherosclerotic Plaques and Relation to Plaque Instability

21 January 2018

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Interleukin-18/Interleukin-18 Binding Protein Signaling Modulates Atherosclerotic Lesion Development and Stability

21 January 2018

1 reference

Interleukin 18 receptor 1 gene polymorphisms are associated with asthma

21 January 2018

1 reference

Hypercytokinemia in familial hemophagocytic lymphohistiocytosis

21 January 2018

1 reference

12 December 2020

IL-1 induces IL-1. III. Specific inhibition of IL-1 production by IFN-gamma

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12 December 2020

Purification of a factor which provides a costimulatory signal for gamma interferon production

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12 December 2020

IFN-gamma-inducing factor up-regulates Fas ligand-mediated cytotoxic activity of murine natural killer cell clones.

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12 December 2020

Overview of interleukin-18: more than an interferon-gamma inducing factor

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12 December 2020

Interleukin-18/interferon-gamma-inducing factor, a novel cytokine, up-regulates ICAM-1 (CD54) expression in KG-1 cells

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12 December 2020

IL-18: A TH1-inducing, proinflammatory cytokine and new member of the IL-1 family

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12 December 2020

IL-18-deficient mice are resistant to endotoxin-induced liver injury but highly susceptible to endotoxin shock

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12 December 2020

Cutting edge: generation of IL-18 receptor-deficient mice: evidence for IL-1 receptor-related protein as an essential IL-18 binding receptor

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12 December 2020

IL-18 is a potent coinducer of IL-13 in NK and T cells: a new potential role for IL-18 in modulating the immune response

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12 December 2020

IL-18, a novel immunoregulatory cytokine, is up-regulated in Crohn's disease: expression and localization in intestinal mucosal cells

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12 December 2020

Bioactive IL-18 expression is up-regulated in Crohn's disease

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12 December 2020

Interleukin-18 enhances antigen-induced eosinophil recruitment into the mouse airways

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12 December 2020

Caspase-1-independent, Fas/Fas ligand-mediated IL-18 secretion from macrophages causes acute liver injury in mice

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12 December 2020

1 reference

12 December 2020

Neutralization of interleukin-18 reduces severity in murine colitis and intestinal IFN-gamma and TNF-alpha production

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12 December 2020

Interleukin-18 in patients with congestive heart failure: induction of atrial natriuretic peptide gene expression

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12 December 2020

Physiological levels of interleukin-18 stimulate multiple neutrophil functions through p38 MAP kinase activation.

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12 December 2020

Highly elevated serum levels of interleukin-18 in systemic juvenile idiopathic arthritis but not in other juvenile idiopathic arthritis subtypes or in Kawasaki disease: comment on the article by Kawashima et al

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12 December 2020

Differential regulation of systemic IL-18 and IL-12 release during postoperative sepsis: high serum IL-18 as an early predictive indicator of lethal outcome

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12 December 2020

Plasma levels of interleukin-18 and interleukin-18 binding protein are elevated in patients with chronic liver disease

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12 December 2020

Mechanisms of inhibition of collagen-induced arthritis by murine IL-18 binding protein

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12 December 2020

Increased cardiac IL-18 mRNA, pro-IL-18 and plasma IL-18 after myocardial infarction in the mouse; a potential role in cardiac dysfunction

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12 December 2020

Interleukin-18 overproduction exacerbates the development of colitis with markedly infiltrated macrophages in interleukin-18 transgenic mice

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12 December 2020

Inflammatory status in sepsis alters efficacy of interleukin-18 binding protein therapy

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12 December 2020

Multifactorial risk analysis of bone marrow histiocytic hyperplasia with hemophagocytosis in critically ill medical patients--a postmortem clinicopathologic analysis

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12 December 2020

Evidence for altered interleukin 18 (IL)-18 pathway in human heart failure.

1 reference

12 December 2020

Association between IL-18 gene promoter polymorphisms and inflammatory bowel disease in a Japanese population

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12 December 2020

Deficiency of interleukin-18 in mice leads to hyperphagia, obesity and insulin resistance

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12 December 2020

Perforin and Granzymes Have Distinct Roles in Defensive Immunity and Immunopathology

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12 December 2020

Human mast cell chymase cleaves pro-IL-18 and generates a novel and biologically active IL-18 fragment

1 reference

12 December 2020

Occult macrophage activation syndrome in patients with systemic juvenile idiopathic arthritis.

1 reference

12 December 2020

Interleukin-18 induces angiogenic factors in rheumatoid arthritis synovial tissue fibroblasts via distinct signaling pathways

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12 December 2020

Specific gene expression profiles in systemic juvenile idiopathic arthritis

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12 December 2020

Interleukin-18 and its binding protein in patients with inflammatory bowel disease during remission and exacerbation

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12 December 2020

Local and systemic interleukin-18 and interleukin-18-binding protein in children with inflammatory bowel disease

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12 December 2020

Increased apoptosis of peripheral blood lymphocytes and its association with interleukin-18 in patients with active untreated adult-onset Still's disease

1 reference

12 December 2020

Interleukin-18 resistance in patients with obesity and type 2 diabetes mellitus

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12 December 2020

Cigarette smoke selectively enhances viral PAMP- and virus-induced pulmonary innate immune and remodeling responses in mice.

1 reference

12 December 2020

A Functional Polymorphism inIL-18Is Associated with Severity of Bronchial Asthma

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12 December 2020

Colitis induced in mice with dextran sulfate sodium (DSS) is mediated by the NLRP3 inflammasome

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12 December 2020

Role of IL-1beta in type 2 diabetes

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12 December 2020

Interleukin-18 and interleukin-18 receptor- expression in allergic asthma

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12 December 2020

Familial and acquired hemophagocytic lymphohistiocytosis

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12 December 2020

Caspase-1 Has Both Proinflammatory and Regulatory Properties in Helicobacter Infections, Which Are Differentially Mediated by Its Substrates IL-1 and IL-18

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12 December 2020

Increased expression of interleukin-18 and its receptor in peripheral blood of patients with chronic obstructive pulmonary disease

1 reference

12 December 2020

Compensated inflammation in systemic juvenile idiopathic arthritis: role of alternatively activated macrophages

1 reference

12 December 2020

Interleukin-18: a potent pro-inflammatory cytokine in atherosclerosis: EXPERT'S PERSPECTIVE

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12 December 2020

Distinct subsets of patients with systemic juvenile idiopathic arthritis based on their cytokine profiles

1 reference

12 December 2020

Clinical manifestations of Adult-onset Still's disease presenting with erosive arthritis: Association with low levels of ferritin and Interleukin-18

1 reference

12 December 2020

Systemic juvenile idiopathic arthritis-like syndrome in mice following stimulation of the immune system with Freund's complete adjuvant: regulation by interferon-γ

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12 December 2020

Inflammatory caspases are innate immune receptors for intracellular LPS.

1 reference

12 December 2020

Cytokines in systemic juvenile idiopathic arthritis and haemophagocytic lymphohistiocytosis: tipping the balance between interleukin-18 and interferon-γ

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12 December 2020

Interleukin-18 for predicting the development of macrophage activation syndrome in systemic juvenile idiopathic arthritis

1 reference

12 December 2020

Inhibition of Natural Killer Cell Cytotoxicity by Interleukin-6: Implications for the Pathogenesis of Macrophage Activation Syndrome

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12 December 2020

Identifiers

DOI

10.1111/IMR.12616

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13 January 2018

PMC publication ID

7165732

0 references

1 reference

13 January 2018