(Q47370972)

15 January 2018

title

Organoselenium compounds as mimics of selenoproteins and thiol modifier agents (English)

1 reference

15 January 2018

Nilda V Barbosa

1

0 references

Cristina W. Nogueira

object named as

Cristina W Nogueira

2

0 references

Michael Aschner

5

object named as

Michael Aschner

1 reference

15 January 2018

author name string

Pablo A Nogara

3

1 reference

15 January 2018

Andreza F de Bem

4

1 reference

15 January 2018

João B T Rocha

6

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15 January 2018

publication date

23 November 2017

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15 January 2018

published in

Metallomics

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15 January 2018

volume

9

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15 January 2018

issue

12

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15 January 2018

page(s)

1703-1734

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15 January 2018

Selenoproteins: molecular pathways and physiological roles.

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Structural basis for catalytic activity and enzyme polymerization of phospholipid hydroperoxide glutathione peroxidase-4 (GPx4)

21 January 2018

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Crystal Structure of the Interferon Gamma Receptor Alpha Chain from Chicken Reveals an Undetected Extra Helix Compared with the Human Counterparts

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The Two Faces of Selenium - Can Selenophobia Be Cured?

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Chemistry of biologically important synthetic organoselenium compounds.

21 January 2018

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Organoselenium and organotellurium compounds: toxicology and pharmacology

21 January 2018

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Ebselen in acute ischemic stroke: a placebo-controlled, double-blind clinical trial. Ebselen Study Group

21 January 2018

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Ebselen in acute middle cerebral artery occlusion: a placebo-controlled, double-blind clinical trial.

21 January 2018

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https://api.crossref.org/works/10.1039%2FC7MT00083A

Neuroprotective effect of an antioxidant, ebselen, in patients with delayed neurological deficits after aneurysmal subarachnoid hemorrhage.

21 January 2018

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https://api.crossref.org/works/10.1039%2FC7MT00083A

Ebselen: prospective therapy for cerebral ischaemia

21 January 2018

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Seleno-organic compounds and the therapy of hydroperoxide-linked pathological conditions.

21 January 2018

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Ebselen, a useful tool for understanding cellular redox biology and a promising drug candidate for use in human diseases

21 January 2018

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The early research and development of ebselen.

21 January 2018

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A safe lithium mimetic for bipolar disorder

21 January 2018

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Effects of the potential lithium-mimetic, ebselen, on impulsivity and emotional processing

21 January 2018

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Effect of the Putative Lithium Mimetic Ebselen on Brain Myo-Inositol, Sleep, and Emotional Processing in Humans.

21 January 2018

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https://api.crossref.org/works/10.1039%2FC7MT00083A

Safety and efficacy of ebselen for the prevention of noise-induced hearing loss: a randomised, double-blind, placebo-controlled, phase 2 trial.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Repurposing ebselen for treatment of multidrug-resistant staphylococcal infections

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Ebselen and analogs as inhibitors of Bacillus anthracis thioredoxin reductase and bactericidal antibacterials targeting Bacillus species, Staphylococcus aureus and Mycobacterium tuberculosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Ebselen, a Small-Molecule Capsid Inhibitor of HIV-1 Replication.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

AChE Inhibition-based Multi-target-directed Ligands, a Novel Pharmacological Approach for the Symptomatic and Disease-modifying Therapy of Alzheimer's Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Evaluation of the antimicrobial activity of ebselen: role of the yeast plasma membrane H+-ATPase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Synthesis and biological evaluation of a new series of ebselen derivatives as glutathione peroxidase (GPx) mimics and cholinesterase inhibitors against Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Synthesis and evaluation of multi-target-directed ligands against Alzheimer's disease based on the fusion of donepezil and ebselen

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

A novel biologically active seleno-organic compound--III. Effects of PZ 51 (Ebselen) on glutathione peroxidase and secretory activities of mouse macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Small Organoselenium Compounds: More than just Glutathione Peroxidase Mimics

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

The need for selenite and molybdate in the formation of formic dehydrogenase by members of the coli-aerogenes group of bacteria

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Glutathione peroxidase: a selenoenzyme.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Selenium: Biochemical Role as a Component of Glutathione Peroxidase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

The impact of thiol peroxidases on redox regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

21 January 2018

Glutathione peroxidases

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Selenium as a component of glutathione peroxidase isolated from ovine erythrocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Crystallographic data of the selenoenzyme glutathione peroxidase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

The refined structure of the selenoenzyme glutathione peroxidase at 0.2-nm resolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Identification of the catalytic site of rat liver glutathione peroxidase as selenocysteine

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Chemical characterization of the selenoprotein component of clostridial glycine reductase: identification of selenocysteine as the organoselenium moiety

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Catalytic mechanisms and specificities of glutathione peroxidases: variations of a basic scheme

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Trends in selenium biochemistry.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

The diverse role of selenium within selenoproteins: a review

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

From selenium to selenoproteins: synthesis, identity, and their role in human health

21 January 2018

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https://api.crossref.org/works/10.1039%2FC7MT00083A

The selenoenzyme phospholipid hydroperoxide glutathione peroxidase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Tissue-specific functions of individual glutathione peroxidases

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Biological significance of phospholipid hydroperoxide glutathione peroxidase (PHGPx, GPx4) in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Structural organization of the human selenium-dependent phospholipid hydroperoxide glutathione peroxidase gene (GPX4): chromosomal localization to 19p13.3

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Probing the presumed catalytic triad of selenium-containing peroxidases by mutational analysis of phospholipid hydroperoxide glutathione peroxidase (PHGPx).

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

The catalytic site of glutathione peroxidases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Evolutionary and structural insights into the multifaceted glutathione peroxidase (Gpx) superfamily.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Glutathione peroxidase 4 prevents necroptosis in mouse erythroid precursors

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Glutathione peroxidase 4: a new player in neurodegeneration?

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Glutathione peroxidase 4 senses and translates oxidative stress into 12/15-lipoxygenase dependent- and AIF-mediated cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Glutathione peroxidase 4 (Gpx4) and ferroptosis: what's so special about it?

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

GPx4, Lipid Peroxidation, and Cell Death: Discoveries, Rediscoveries, and Open Issues

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Ferroptosis: an iron-dependent form of nonapoptotic cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Ferroptosis Inhibition: Mechanisms and Opportunities

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Mechanisms of ferroptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Ferroptosis: bug or feature?

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Redox active motifs in selenoproteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Selenocysteine oxidation in glutathione peroxidase catalysis: an MS-supported quantum mechanics study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Irreversible inactivation of glutathione peroxidase 1 and reversible inactivation of peroxiredoxin II by H2O2 in red blood cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Loss of selenium from selenoproteins: conversion of selenocysteine to dehydroalanine in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Simultaneous speciation of selenoproteins and selenometabolites in plasma and serum by dual size exclusion-affinity chromatography with online isotope dilution inductively coupled plasma mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Investigating the intra-individual variability in the human metabolic profile of urinary selenium.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Identification of a novel selenium-containing compound, selenoneine, as the predominant chemical form of organic selenium in the blood of bluefin tuna

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Identification and determination of selenoneine, 2-selenyl-N α , N α , N α -trimethyl-L-histidine, as the major organic selenium in blood cells in a fish-eating population on remote Japanese Islands

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Discovery of the strong antioxidant selenoneine in tuna and selenium redox metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Human excretory products of selenium are natural constituents of marine fish muscle.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Selenoneine, a novel selenium-containing compound, mediates detoxification mechanisms against methylmercury accumulation and toxicity in zebrafish embryo

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

SELENIUM IN HIGHER PLANTS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Plants, selenium and human health

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Selenium in chemistry and biochemistry in comparison to sulfur

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Ebselen: a substrate for human thioredoxin reductase strongly stimulating its hydroperoxide reductase activity and a superfast thioredoxin oxidant

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

A novel antioxidant mechanism of ebselen involving ebselen diselenide, a substrate of mammalian thioredoxin and thioredoxin reductase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Ebselen: a thioredoxin reductase-dependent catalyst for alpha-tocopherol quinone reduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Selenite is a substrate for calf thymus thioredoxin reductase and thioredoxin and elicits a large non-stoichiometric oxidation of NADPH in the presence of oxygen

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Synthesis and biological evaluation of new nitrogen-containing diselenides.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Diphenyl diselenide and analogs are substrates of cerebral rat thioredoxin reductase: a pathway for their neuroprotective effects.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Metabolism of selenium compounds catalyzed by the mammalian selenoprotein thioredoxin reductase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Modeling the mechanism of the glutathione peroxidase mimic ebselen

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Interaction of peroxynitrite with selenoproteins and glutathione peroxidase mimics

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Structure-activity correlation between natural glutathione peroxidase (GPx) and mimics: a biomimetic concept for the design and synthesis of more efficient GPx mimics

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Organochalcogen peroxidase mimetics as potential drugs: a long story of a promise still unfulfilled.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Ebselen, a selenoorganic compound as glutathione peroxidase mimic

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Molecular actions of ebselen--an antiinflammatory antioxidant

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Ebselen, a promising antioxidant drug: mechanisms of action and targets of biological pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Neuroprotective efficacy of ebselen, an anti-oxidant with anti-inflammatory actions, in a rodent model of permanent middle cerebral artery occlusion

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

The antioxidant ebselen prevents neurotoxicity and clinical symptoms in a primate model of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Ebselen prevents noise-induced excitotoxicity and temporary threshold shift

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Effects of ebselen versus nimodipine on cerebral vasospasm subsequent to experimental subarachnoid hemorrhage in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Ebselen treatment prevents islet apoptosis, maintains intranuclear Pdx-1 and MafA levels, and preserves β-cell mass and function in ZDF rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Glutathione peroxidase mimic ebselen improves glucose-stimulated insulin secretion in murine islets

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Functional mimics of glutathione peroxidase: bioinspired synthetic antioxidants.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Diselenides and Allyl Selenides as Glutathione Peroxidase Mimetics. Remarkable Activity of Cyclic Seleninates Produced in Situ by the Oxidation of Allyl ω-Hydroxyalkyl Selenides

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Antioxidant activity of the anti-inflammatory compound ebselen: a reversible cyclization pathway via selenenic and seleninic acid intermediates

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Glutathione peroxidase (GPx)-like antioxidant activity of the organoselenium drug ebselen: unexpected complications with thiol exchange reactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Effect of substituents on the GPx-like activity of ebselen: steric versus electronic

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Potential renal and hepatic toxicity of diphenyl diselenide, diphenyl ditelluride and Ebselen for rats and mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Multifunctional Antioxidants: Regenerable Radical-Trapping and Hydroperoxide-Decomposing Ebselenols.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Unusually short chalcogen bonds involving organoselenium: insights into the Se-N bond cleavage mechanism of the antioxidant ebselen and analogues

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Inhibitory effect of ebselen on cerebral acetylcholinesterase activity in vitro: kinetics and reversibility of inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

The significance of the cholinergic system in the brain during aging and in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Computer-assisted designed "selenoxy-chinolin": a new catalytic mechanism of the GPx-like cycle and inhibition of metal-free and metal-associated Aβ aggregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Synthesis and Antioxidant Activity of Peptide-Based Ebselen Analogues

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

The isolation and crystal structure of a cyclic selenenate ester derived from Bis(2,6-diformyl-4-tert-butylphenyl)diselenide and its glutathione peroxidase-like activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Remarkable activity of a novel cyclic seleninate ester as a glutathione peroxidase mimetic and its facile in situ generation from allyl 3-hydroxypropyl selenide.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Aromatic derivatives and tellurium analogues of cyclic seleninate esters and spirodioxyselenuranes that act as glutathione peroxidase mimetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Screening of new antioxidant molecules using flow cytometry.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

o-hydroxylmethylphenylchalcogens: synthesis, intramolecular nonbonded chalcogen...OH interactions, and glutathione peroxidase-like activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

2-Phenoxyethanol derived diselenide and related compounds; synthesis of a seven-membered seleninate ester.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Fluxional cyclic seleninate ester: NMR and computational studies, glutathione peroxidase-like behavior, and unexpected rearrangement

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Substituent effects upon the catalytic activity of aromatic cyclic seleninate esters and spirodioxyselenuranes that act as glutathione peroxidase mimetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Effect of Methoxy Substituents on the Activation Barriers of the Glutathione Peroxidase-Like Mechanism of an Aromatic Cyclic Seleninate.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Mimicking the lipid peroxidation inhibitory activity of phospholipid hydroperoxide glutathione peroxidase (GPx4) by using fatty acid conjugates of a water-soluble selenolane.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Fatty acid conjugates of water-soluble (±)-trans-Selenolane-3,4-diol: effects of alkyl chain length on the antioxidant capacity

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Combining benzo[d]isoselenazol-3-ones with sterically hindered alicyclic amines and nitroxides: enhanced activity as glutathione peroxidase mimics

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Synthesis, structure, spirocyclization mechanism, and glutathione peroxidase-like antioxidant activity of stable spirodiazaselenurane and spirodiazatellurane

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

In vitro radical scavenging and cytotoxic activities of novel hybrid selenocarbamates

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Enhanced Glutathione Peroxidase Activity of Water-Soluble and Polyethylene Glycol-Supported Selenides, Related Spirodioxyselenuranes, and Pincer Selenuranes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Synthesis, characterization and structures of 2-(3,5-dimethylpyrazol-1-yl)ethylseleno derivatives and their probable glutathione peroxidase (GPx) like activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Antioxidant activity of β-selenoamines and their capacity to mimic different enzymes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Selenium-containing chrysin and quercetin derivatives: attractive scaffolds for cancer therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Synthesis and antioxidant activity of O-alkyl selenocarbamates, selenoureas and selenohydantoins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Protective role of aryl and alkyl diselenides on lipid peroxidation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Aromatic ring strain in arylselenenyl bromides: role in facile synthesis of selenenate esters via intramolecular cyclization

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Toxicology and pharmacology of selenium: emphasis on synthetic organoselenium compounds.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Glutathione peroxidase-like antioxidant activity of diaryl diselenides: a mechanistic study

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Reduction of hydrogen peroxide by glutathione peroxidase mimics: reaction mechanism and energetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

A simple and efficient strategy to enhance the antioxidant activities of amino-substituted glutathione peroxidase mimics

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Synthesis and structure-activity correlation studies of secondary- and tertiary-amine-based glutathione peroxidase mimics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

In vitro evaluation of glutathione peroxidase (GPx)-like activity and antioxidant properties of an organoselenium compound.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Amide-based glutathione peroxidase mimics: effect of secondary and tertiary amide substituents on antioxidant activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Highly Efficient Glutathione Peroxidase and Peroxiredoxin Mimetics Protect Mammalian Cells against Oxidative Damage.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Design, synthesis and glutathione peroxidase-like properties of ovothiol-derived diselenides.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

A novel dicyclodextrinyl diselenide compound with glutathione peroxidase activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Stable selones in glutathione-peroxidase-like catalytic cycle of selenonicotinamide derivative

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Pyridoxine-derived organoselenium compounds with glutathione peroxidase-like and chain-breaking antioxidant activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Effect of a Bromo Substituent on the Glutathione Peroxidase Activity of a Pyridoxine-like Diselenide.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Synthesis and biological evaluation of 2-picolylamide-based diselenides with non-bonded interactions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Organoselenocyanates and symmetrical diselenides redox modulators: Design, synthesis and biological evaluation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Type I iodothyronine deiodinase is a selenocysteine-containing enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Cloning of the mammalian type II iodothyronine deiodinase. A selenoprotein differentially expressed and regulated in human and rat brain and other tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Cellular and molecular basis of deiodinase-regulated thyroid hormone signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

The human selenoproteome: recent insights into functions and regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Crystal structure of mammalian selenocysteine-dependent iodothyronine deiodinase suggests a peroxiredoxin-like catalytic mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

New insights into the structure and mechanism of iodothyronine deiodinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Cover Picture: Chemistry and Biology in the Biosynthesis and Action of Thyroid Hormones (Angew. Chem. Int. Ed. 27/2016)

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Antithyroid drugs and their analogues: synthesis, structure, and mechanism of action

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Novel thyroid hormone analogues, enzyme inhibitors and mimetics, and their action

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Think globally: act locally. New insights into the local regulation of thyroid hormone availability challenge long accepted dogmas.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Biomimetic studies on iodothyronine deiodinase intermediates: modeling the reduction of selenenyl iodide by thiols

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Biomimetic studies on anti-thyroid drugs and thyroid hormone synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

A chemical model for the inner-ring deiodination of thyroxine by iodothyronine deiodinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Regioselective deiodination of thyroxine by iodothyronine deiodinase mimics: an unusual mechanistic pathway involving cooperative chalcogen and halogen bonding.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Regioselective deiodination of iodothyronamines, endogenous thyroid hormone derivatives, by deiodinase mimics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Modeling of the 5'-deiodination of thyroxine by iodothyronine deiodinase: chemical corroboration of a selenenyl iodide intermediate

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Synthesis of a Stable Primary-Alkyl-Substituted Selenenyl Iodide and Its Hydrolytic Conversion to the Corresponding Selenenic Acid.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Glutathione S-transferase pi expression regulates the Nrf2-dependent response to hormetic diselenides.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Selenocysteine in thiol/disulfide-like exchange reactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Diphenyl diselenide modulates gene expression of antioxidant enzymes in the cerebral cortex, hippocampus and striatum of female hypothyroid rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Kinetic mechanism and substrate specificity of glutathione peroxidase activity of ebselen (PZ51).

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Kinetic study of the reaction of ebselen with peroxynitrite.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Ebselen, a seleno-organic antioxidant, as an electrophile

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Validation of the multiple sensor mechanism of the Keap1-Nrf2 system

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Protective effect of diphenyl diselenide against peroxynitrite-mediated endothelial cell death: a comparison with ebselen.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Impact of SIN-1-derived peroxynitrite flux on endothelial cell redox homeostasis and bioenergetics: protective role of diphenyl diselenide via induction of peroxiredoxins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Impairment of mitochondrial anti-oxidant defence in SOD1-related motor neuron injury and amelioration by ebselen

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Redox regulation of FoxO transcription factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

SWISS-MODEL: modelling protein tertiary and quaternary structure using evolutionary information

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Protein structure homology modeling using SWISS-MODEL workspace.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

The SWISS-MODEL workspace: a web-based environment for protein structure homology modelling

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

New strategies to inhibit KEAP1 and the Cul3-based E3 ubiquitin ligases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Structural Basis for Cul3 Protein Assembly with the BTB-Kelch Family of E3 Ubiquitin Ligases

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Making SharePoint® Chemically Aware™.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Merck molecular force field. I. Basis, form, scope, parameterization, and performance of MMFF94

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Diphenyl diselenide modulates oxLDL-induced cytotoxicity in macrophage by improving the redox signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Diphenyl diselenide-modulation of macrophage activation: down-regulation of classical and alternative activation markers

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Oxidative stress and gene expression: the AP-1 and NF-kappaB connections

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Diphenyl diselenide protects endothelial cells against oxidized low density lipoprotein-induced injury: Involvement of mitochondrial function

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Metabolic control of mitochondrial biogenesis through the PGC-1 family regulatory network

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

The Nrf2-antioxidant response element pathway: a target for regulating energy metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Insights into the differential toxicological and antioxidant effects of 4-phenylchalcogenil-7-chloroquinolines in Caenorhabditis elegans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Diphenyl diselenide, a simple organoselenium compound, decreases methylmercury-induced cerebral, hepatic and renal oxidative stress and mercury deposition in adult mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Protective effects of diphenyl diselenide in a mouse model of brain toxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Diphenyl diselenide administration enhances cortical mitochondrial number and activity by increasing hemeoxygenase type 1 content in a methylmercury-induced neurotoxicity mouse model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Role of calcium and mitochondria in MeHg-mediated cytotoxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Formation and possible role of bis(methylmercuric) selenide in rats treated with methylmercury and selenite.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

In vivo formation of natural HgSe nanoparticles in the liver and brain of pilot whales

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

The chemical nature of mercury in human brain following poisoning or environmental exposure

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Structural basis of the antagonism between inorganic mercury and selenium in mammals

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Selenium as an antidote in the treatment of mercury intoxication

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Effects of diphenyl diselenide on methylmercury toxicity in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Brain and blood mercury and selenium after chronic and developmental exposure to methylmercury.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Oxidative stress in MeHg-induced neurotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Mercury-selenium compounds and their toxicological significance: toward a molecular understanding of the mercury-selenium antagonism

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Selenium protection against mercury toxicity: high binding affinity of methylmercury by selenium-containing ligands in comparison with sulfur-containing ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Protective effects of organoselenium compounds against methylmercury-induced oxidative stress in mouse brain mitochondrial-enriched fractions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Selenium and mercury levels in rat liver slices co-treated with diphenyl diselenide and methylmercury.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Guanosine and synthetic organoselenium compounds modulate methylmercury-induced oxidative stress in rat brain cortical slices: involvement of oxidative stress and glutamatergic system

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Methylmercury-induced alterations in astrocyte functions are attenuated by ebselen.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Diphenyl diselenide protects against methylmercury-induced inhibition of thioredoxin reductase and glutathione peroxidase in human neuroblastoma cells: a comparison with ebselen.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Ebselen protects glutamate uptake inhibition caused by methyl mercury but does not by Hg2+.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Diphenyl ditelluride- and methylmercury-induced hyperphosphorilation of the high molecular weight neurofilament subunit is prevented by organoselenium compounds in cerebral cortex of young rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Selenium compounds prevent the effects of methylmercury on the in vitro phosphorylation of cytoskeletal proteins in cerebral cortex of young rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Diphenyl Diselenide Protects against Methylmercury-Induced Toxicity in Saccharomyces cerevisiae via the Yap1 Transcription Factor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Ebselen protects against methylmercury-induced inhibition of glutamate uptake by cortical slices from adult mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Methylmercury increases glutamate release from brain synaptosomes and glutamate uptake by cortical slices from suckling rat pups: modulatory effect of ebselen

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Additive pro-oxidative effects of methylmercury and ebselen in liver from suckling rat pups

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Post-transcriptional defects of antioxidant selenoenzymes cause oxidative stress under methylmercury exposure

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Interactions between selenium and methylmercury in rat brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Probucol increases glutathione peroxidase-1 activity and displays long-lasting protection against methylmercury toxicity in cerebellar granule cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

In vivo and in vitro inhibition of mice thioredoxin reductase by methylmercury.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Inhibition of the human thioredoxin system. A molecular mechanism of mercury toxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Effects of selenite and chelating agents on mammalian thioredoxin reductase inhibited by mercury: implications for treatment of mercury poisoning

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Methylmercury neurotoxicity is associated with inhibition of the antioxidant enzyme glutathione peroxidase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Effect of mercury(II) on Nrf2, thioredoxin reductase-1 and thioredoxin-1 in human monocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Mercury and selenium interaction in vivo: effects on thioredoxin reductase and glutathione peroxidase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

The structure of human thioredoxin reductase 1 provides insights into C-terminal rearrangements during catalysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Differences in the responses of three plasma selenium-containing proteins in relation to methylmercury-exposure through consumption of fish/whales

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Proteome profiling reveals regional protein alteration in cerebrum of common marmoset (Callithrix jacchus) exposed to methylmercury

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Inhibitory effect of ebselen on lactate dehydrogenase activity from mammals: a comparative study with diphenyl diselenide and diphenyl ditelluride.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

High-resolution structure of myo-inositol monophosphatase, the putative target of lithium therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Structural basis for altered activity of M- and H-isozyme forms of human lactate dehydrogenase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Structural studies of substrate and product complexes of 5-aminolaevulinic acid dehydratase from humans, Escherichia coli and the hyperthermophile Pyrobaculum calidifontis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

A novel biologically active seleno-organic compound—1

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Can you teach old drugs new tricks?

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Glutathione Peroxidase Protects against Peroxynitrite-mediated Oxidations

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Synthesis, Characterization, and Antioxidant Activity of Some Ebselen Analogues

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Synthetic organoselenium compounds as antioxidants: glutathione peroxidase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Spirodiazaselenuranes: synthesis, structure and antioxidant activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Tertiary amine-based glutathione peroxidase mimics: some insights into the role of steric and electronic effects on antioxidant activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

Deiodination of Thyroid Hormones by Iodothyronine Deiodinase Mimics: Does an Increase in the Reactivity Alter the Regioselectivity?

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC7MT00083A

21 January 2018

Identifiers

DOI

10.1039/C7MT00083A

1 reference

15 January 2018

PubMed ID

29168872

1 reference

15 January 2018