(Q47393629)

15 January 2018

title

Prefrontal Cortex-Mediated Impairments in a Genetic Model of NMDA Receptor Hypofunction Are Reversed by the Novel M1 PAM VU6004256. (English)

1 reference

15 January 2018

15

Craig W Lindsley

1 reference

15 January 2018

Colleen M. Niswender

13

Colleen M Niswender

1 reference

15 January 2018

P. Jeffrey Conn

14

P Jeffrey Conn

1 reference

15 January 2018

Hyekyung P Cho

10

Hyekyung P Cho

1 reference

15 January 2018

Michael Bubser

7

Michael Bubser

1 reference

15 January 2018

Michael D Grannan

1

Michael D Grannan

1 reference

15 January 2018

Anna Louise Blobaum

12

Anna L Blobaum

1 reference

15 January 2018

Kellie D. Nance

11

Kellie D Nance

1 reference

15 January 2018

Masahito Abe

9

Masahito Abe

1 reference

15 January 2018

Carrie K Jones

16

Carrie K Jones

1 reference

15 January 2018

Sean P Moran

3

Sean P Moran

1 reference

15 January 2018

author name string

Catharine A Mielnik

2

1 reference

15 January 2018

Robert W Gould

4

1 reference

15 January 2018

Jacob Ball

5

1 reference

15 January 2018

Zhuoyan Lu

6

1 reference

15 January 2018

Amy J Ramsey

8

1 reference

15 January 2018

publication date

12 September 2016

1 reference

15 January 2018

ACS Chemical Neuroscience

published in

1 reference

15 January 2018

volume

7

1 reference

15 January 2018

issue

12

1 reference

15 January 2018

page(s)

1706-1716

1 reference

15 January 2018

The NMDA Receptor and Schizophrenia: From Pathophysiology to Treatment

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Further optimization of the M1 PAM VU0453595: Discovery of novel heterobicyclic core motifs with improved CNS penetration

22 May 2018

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A quantitative review of the postmortem evidence for decreased cortical N-methyl-D-aspartate receptor expression levels in schizophrenia: How can we link molecular abnormalities to mismatch negativity deficits?

22 May 2018

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Role for the M1 Muscarinic Acetylcholine Receptor in Top-Down Cognitive Processing Using a Touchscreen Visual Discrimination Task in Mice

22 May 2018

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Potentiation of M1 Muscarinic Receptor Reverses Plasticity Deficits and Negative and Cognitive Symptoms in a Schizophrenia Mouse Model

22 May 2018

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22 May 2018

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Selective activation of M4 muscarinic acetylcholine receptors reverses MK-801-induced behavioral impairments and enhances associative learning in rodents

22 May 2018

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Early adolescent MK-801 exposure impairs the maturation of ventral hippocampal control of basolateral amygdala drive in the adult prefrontal cortex

22 May 2018

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Quinolizidinone carboxylic acids as CNS penetrant, selective m1 allosteric muscarinic receptor modulators

22 May 2018

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Sustained N-methyl-d-aspartate receptor hypofunction remodels the dopamine system and impairs phasic signaling.

22 May 2018

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Effects of selective activation of M1 and M4 muscarinic receptors on object recognition memory performance in rats

22 May 2018

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A polygenic burden of rare disruptive mutations in schizophrenia

22 May 2018

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De novo mutations in schizophrenia implicate synaptic networks

22 May 2018

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Antipsychotic drug-like effects of the selective M4 muscarinic acetylcholine receptor positive allosteric modulator VU0152100

22 May 2018

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N-aryl piperazine metabotropic glutamate receptor 5 positive allosteric modulators possess efficacy in preclinical models of NMDA hypofunction and cognitive enhancement.

22 May 2018

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The role of the hippocampo-prefrontal cortex system in phencyclidine-induced psychosis: a model for schizophrenia

22 May 2018

1 reference

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Decreased cortical muscarinic M1 receptors in schizophrenia are associated with changes in gene promoter methylation, mRNA and gene targeting microRNA.

22 May 2018

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Spirocyclic replacements for the isatin in the highly selective, muscarinic M1 PAM ML137: the continued optimization of an MLPCN probe molecule

22 May 2018

1 reference

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Isatin replacements applied to the highly selective, muscarinic M1 PAM ML137: continued optimization of an MLPCN probe molecule

22 May 2018

1 reference

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Targeting selective activation of M(1) for the treatment of Alzheimer's disease: further chemical optimization and pharmacological characterization of the M(1) positive allosteric modulator ML169.

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5231396

Novel allosteric agonists of M1 muscarinic acetylcholine receptors induce brain region-specific responses that correspond with behavioral effects in animal models

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5231396

The novel object recognition memory: neurobiology, test procedure, and its modifications

22 May 2018

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De novo CNV analysis implicates specific abnormalities of postsynaptic signalling complexes in the pathogenesis of schizophrenia.

22 May 2018

1 reference

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Contribution of both M1 and M4 receptors to muscarinic agonist-mediated attenuation of the cocaine discriminative stimulus in mice

22 May 2018

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Muscarinic and nicotinic acetylcholine receptor agonists and allosteric modulators for the treatment of schizophrenia

22 May 2018

1 reference

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Intact attentional processing but abnormal responding in M1 muscarinic receptor-deficient mice using an automated touchscreen method.

22 May 2018

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Behavioral analysis of NR2C knockout mouse reveals deficit in acquisition of conditioned fear and working memory

22 May 2018

1 reference

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Discovery and optimization of a novel, selective and brain penetrant M1 positive allosteric modulator (PAM): the development of ML169, an MLPCN probe

22 May 2018

1 reference

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Mechanisms underlying ketamine-induced synaptic depression in rat hippocampus-medial prefrontal cortex pathway

22 May 2018

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Thinking Glutamatergically: Changing Concepts of Schizophrenia Based Upon Changing Neurochemical Models

22 May 2018

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N-methyl-d-aspartate (NMDA) receptor dysfunction or dysregulation: the final common pathway on the road to schizophrenia?

22 May 2018

1 reference

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NR1 knockdown mice as a representative model of the glutamate hypothesis of schizophrenia.

22 May 2018

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Chemical lead optimization of a pan Gq mAChR M1, M3, M5 positive allosteric modulator (PAM) lead. Part II: development of a potent and highly selective M1 PAM

22 May 2018

1 reference

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N-heterocyclic derived M1 positive allosteric modulators.

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5231396

Postnatal NMDA receptor ablation in corticolimbic interneurons confers schizophrenia-like phenotypes

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5231396

A selective allosteric potentiator of the M1 muscarinic acetylcholine receptor increases activity of medial prefrontal cortical neurons and restores impairments in reversal learning

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5231396

Selective activation of the M1 muscarinic acetylcholine receptor achieved by allosteric potentiation

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5231396

Hyperdopaminergia and NMDA receptor hypofunction disrupt neural phase signaling

22 May 2018

1 reference

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Discovery and characterization of novel allosteric potentiators of M1 muscarinic receptors reveals multiple modes of activity

22 May 2018

1 reference

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Novel selective allosteric activator of the M1 muscarinic acetylcholine receptor regulates amyloid processing and produces antipsychotic-like activity in rats.

22 May 2018

1 reference

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Altered information processing in the prefrontal cortex of Huntington's disease mouse models

22 May 2018

1 reference

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Selective muscarinic receptor agonist xanomeline as a novel treatment approach for schizophrenia

22 May 2018

1 reference

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Models of schizophrenia in humans and animals based on inhibition of NMDA receptors

22 May 2018

1 reference

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NMDA receptor hypofunction produces concomitant firing rate potentiation and burst activity reduction in the prefrontal cortex

22 May 2018

1 reference

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N-desmethylclozapine, an allosteric agonist at muscarinic 1 receptor, potentiates N-methyl- d -aspartate receptor activity

22 May 2018

1 reference

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Muscarinic receptors as a target for drugs treating schizophrenia

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5231396

Decreased muscarinic1 receptors in the dorsolateral prefrontal cortex of subjects with schizophrenia

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5231396

Glutamatergic mechanisms in schizophrenia

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5231396

Enrichment induces structural changes and recovery from nonspatial memory deficits in CA1 NMDAR1-knockout mice

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5231396

Mice with reduced NMDA receptor expression display behaviors related to schizophrenia

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5231396

Muscarinic receptor subtypes involved in hippocampal circuits

22 May 2018

1 reference

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The neuropsychopharmacology of phencyclidine: from NMDA receptor hypofunction to the dopamine hypothesis of schizophrenia

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5231396

Activation of the genetically defined m1 muscarinic receptor potentiates N-methyl-D-aspartate (NMDA) receptor currents in hippocampal pyramidal cells

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5231396

Differential presynaptic and postsynaptic expression of m1-m4 muscarinic acetylcholine receptors at the perforant pathway/granule cell synapse

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5231396

Effects of xanomeline, a selective muscarinic receptor agonist, on cognitive function and behavioral symptoms in Alzheimer disease

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5231396

Subanesthetic effects of the noncompetitive NMDA antagonist, ketamine, in humans. Psychotomimetic, perceptual, cognitive, and neuroendocrine responses

22 May 2018

1 reference

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Cloning and expression of the human and rat m5 muscarinic acetylcholine receptor genes

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5231396

Identification of a family of muscarinic acetylcholine receptor genes

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5231396

Identification and localization of muscarinic acetylcholine receptor proteins in brain with subtype-specific antibodies

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5231396

Direct excitation of parvalbumin-positive interneurons by M1 muscarinic acetylcholine receptors: roles in cellular excitability, inhibitory transmission and cognition

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5231396

Synthesis and pharmacological profiling of analogues of benzyl quinolone carboxylic acid (BQCA) as allosteric modulators of the M1 muscarinic receptor.

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5231396

Using cholinergic M1 receptor positive allosteric modulators to improve memory via enhancement of brain cholinergic communication

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5231396

NMDA receptor blockade impairs the muscarinic conversion of sub-threshold transient depression into long-lasting LTD in the hippocampus-prefrontal cortex pathway in vivo: correlation with γ oscillations

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5231396

The muscarinic M1 receptor positive allosteric modulator PQCA improves cognitive measures in rat, cynomolgus macaque, and rhesus macaque.

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5231396

Widespread decreases in cortical muscarinic receptors in a subset of people with schizophrenia

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5231396

A new automated method to assess the rat recognition memory: validation of the method

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5231396

Activation of medial prefrontal cortex by phencyclidine is mediated via a hippocampo-prefrontal pathway

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5231396

Selective cognitive dysfunction in acetylcholine M1 muscarinic receptor mutant mice

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5231396

The muscarinic receptor agonist xanomeline has an antipsychotic-like profile in the rat.

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5231396

Hyperactivity and intact hippocampus-dependent learning in mice lacking the M1 muscarinic acetylcholine receptor.

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5231396

The selective muscarinic agonist xanomeline improves both the cognitive deficits and behavioral symptoms of Alzheimer disease.

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5231396

Expression of m1-m4 muscarinic acetylcholine receptor proteins in rat hippocampus and regulation by cholinergic innervation

14 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27617634

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Fused heterocyclic M1 positive allosteric modulators

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27617634

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1021/ACSCHEMNEURO.6B00230

1 reference

15 January 2018

release_viodhjtkprecbggqjiuz5irzie

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/viodhjtkprecbggqjiuz5irzie

mapped directly with Wikidata item

24 November 2022

based on heuristic

PMC publication ID

5231396

1 reference

15 January 2018

PubMed publication ID

27617634

1 reference

15 January 2018