(Q47411648)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29129717%20AND%20SRC:MED&resulttype=core&format=json

2 April 2020

title

A Chemoproteomic Approach to Query the Degradable Kinome Using a Multi-kinase Degrader (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29129717%20AND%20SRC:MED&resulttype=core&format=json

2 April 2020

1 reference

16

1 reference

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2 April 2020

Li Tan

18

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29129717%20AND%20SRC:MED&resulttype=core&format=json

2 April 2020

19

Nathanael S Gray

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29129717%20AND%20SRC:MED&resulttype=core&format=json

2 April 2020

author name string

Hai-Tsang Huang

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29129717%20AND%20SRC:MED&resulttype=core&format=json

2 April 2020

Dennis Dobrovolsky

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29129717%20AND%20SRC:MED&resulttype=core&format=json

2 April 2020

Joshiawa Paulk

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29129717%20AND%20SRC:MED&resulttype=core&format=json

2 April 2020

Guang Yang

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29129717%20AND%20SRC:MED&resulttype=core&format=json

2 April 2020

Ellen L Weisberg

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29129717%20AND%20SRC:MED&resulttype=core&format=json

2 April 2020

Zainab M Doctor

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29129717%20AND%20SRC:MED&resulttype=core&format=json

2 April 2020

Dennis L Buckley

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29129717%20AND%20SRC:MED&resulttype=core&format=json

2 April 2020

Joong-Heui Cho

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29129717%20AND%20SRC:MED&resulttype=core&format=json

2 April 2020

Eunhwa Ko

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29129717%20AND%20SRC:MED&resulttype=core&format=json

2 April 2020

Jaebong Jang

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29129717%20AND%20SRC:MED&resulttype=core&format=json

2 April 2020

Kun Shi

11

1 reference

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2 April 2020

Hwan Geun Choi

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29129717%20AND%20SRC:MED&resulttype=core&format=json

2 April 2020

James D Griffin

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29129717%20AND%20SRC:MED&resulttype=core&format=json

2 April 2020

Ying Li

14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29129717%20AND%20SRC:MED&resulttype=core&format=json

2 April 2020

Steven P Treon

15

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29129717%20AND%20SRC:MED&resulttype=core&format=json

2 April 2020

James E Bradner

17

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29129717%20AND%20SRC:MED&resulttype=core&format=json

2 April 2020

publication date

9 November 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29129717%20AND%20SRC:MED&resulttype=core&format=json

2 April 2020

published in

Cell chemical biology

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29129717%20AND%20SRC:MED&resulttype=core&format=json

2 April 2020

volume

25

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29129717%20AND%20SRC:MED&resulttype=core&format=json

2 April 2020

issue

1

1 reference

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2 April 2020

page(s)

88-99.e6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29129717%20AND%20SRC:MED&resulttype=core&format=json

describes a project that uses

2 April 2020

limma

1 reference

22 June 2022

https://europepmc.org/article/PMC/6427047

inferred from PubMed Central ID database lookup

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M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCFbeta-TrCP

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Mechanism of Aurora-B degradation and its dependency on intact KEN and A-boxes: identification of an aneuploidy-promoting property

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Functional interrogation of the kinome using nucleotide acyl phosphates

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Prognostic relevance of FLT3-TKD mutations in AML: the combination matters--an analysis of 3082 patients

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A quantitative analysis of kinase inhibitor selectivity

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Small molecules destabilize cIAP1 by activating auto-ubiquitylation

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B-cell depletion with rituximab in relapsing-remitting multiple sclerosis

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12 December 2020

Leukotriene A4 hydrolase. Inhibition by bestatin and intrinsic aminopeptidase activity establish its functional resemblance to metallohydrolase enzymes

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12 December 2020

Targeted intracellular protein degradation induced by a small molecule: En route to chemical proteomics

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12 December 2020

Global target profile of the kinase inhibitor bosutinib in primary chronic myeloid leukemia cells

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12 December 2020

AC220 is a uniquely potent and selective inhibitor of FLT3 for the treatment of acute myeloid leukemia (AML)

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12 December 2020

Identification of a primary target of thalidomide teratogenicity

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12 December 2020

Protein knockdown using methyl bestatin-ligand hybrid molecules: design and synthesis of inducers of ubiquitination-mediated degradation of cellular retinoic acid-binding proteins.

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12 December 2020

Crystal structures of anaplastic lymphoma kinase in complex with ATP competitive inhibitors

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12 December 2020

Mechanisms of drug resistance in kinases

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12 December 2020

Efficacy and safety of belimumab in patients with active systemic lupus erythematosus: a randomised, placebo-controlled, phase 3 trial

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12 December 2020

In situ kinase profiling reveals functionally relevant properties of native kinases

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12 December 2020

Reversible resistance induced by FLT3 inhibition: a novel resistance mechanism in mutant FLT3-expressing cells

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12 December 2020

Targeting the von Hippel–Lindau E3 Ubiquitin Ligase Using Small Molecules To Disrupt the VHL/HIF-1α Interaction

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12 December 2020

Validation of ITD mutations in FLT3 as a therapeutic target in human acute myeloid leukaemia

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12 December 2020

The chromosomal passenger complex (CPC): from easy rider to the godfather of mitosis

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12 December 2020

A comprehensive mathematical model for three-body binding equilibria

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12 December 2020

Crenolanib is active against models of drug-resistant FLT3-ITD-positive acute myeloid leukemia

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12 December 2020

Genome engineering using the CRISPR-Cas9 system

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12 December 2020

Crenolanib is a potent inhibitor of FLT3 with activity against resistance-conferring point mutants

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12 December 2020

The myeloma drug lenalidomide promotes the cereblon-dependent destruction of Ikaros proteins

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12 December 2020

Lenalidomide causes selective degradation of IKZF1 and IKZF3 in multiple myeloma cells

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12 December 2020

FLT3 mutations in acute myeloid leukemia: what is the best approach in 2013?

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12 December 2020

Targeting Bruton's tyrosine kinase in B cell malignancies

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12 December 2020

Structure-based drug design of RN486, a potent and selective Bruton's tyrosine kinase (BTK) inhibitor, for the treatment of rheumatoid arthritis

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12 December 2020

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12 December 2020

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12 December 2020

Structure of the DDB1–CRBN E3 ubiquitin ligase in complex with thalidomide

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12 December 2020

Structure-Guided Design and Optimization of Small Molecules Targeting the Protein–Protein Interaction between the von Hippel–Lindau (VHL) E3 Ubiquitin Ligase and the Hypoxia Inducible Factor (HIF) Alpha Subunit with in Vitro Nanomolar Affinities

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12 December 2020

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12 December 2020

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DRUG DEVELOPMENT. Phthalimide conjugation as a strategy for in vivo target protein degradation

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Selective Small Molecule Induced Degradation of the BET Bromodomain Protein BRD4.

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Hijacking the E3 Ubiquitin Ligase Cereblon to Efficiently Target BRD4.

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12 December 2020

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12 December 2020

Protein degradation: Prime time for PROTACs

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Proteasome inhibitors induce FLT3-ITD degradation through autophagy in AML cells.

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Modular PROTAC Design for the Degradation of Oncogenic BCR-ABL.

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Cul3-KLHL20 Ubiquitin Ligase Governs the Turnover of ULK1 and VPS34 Complexes to Control Autophagy Termination.

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PROTAC-induced BET protein degradation as a therapy for castration-resistant prostate cancer

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12 December 2020

A novel cereblon modulator recruits GSPT1 to the CRL4(CRBN) ubiquitin ligase

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12 December 2020

Chemoproteomic Evaluation of Target Engagement by the Cyclin-Dependent Kinase 4 and 6 Inhibitor Palbociclib Correlates with Cancer Cell Response

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12 December 2020

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12 December 2020

Degradation of the BAF Complex Factor BRD9 by Heterobifunctional Ligands.

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12 December 2020

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10.1016/J.CHEMBIOL.2017.10.005

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29129717%20AND%20SRC:MED&resulttype=core&format=json

2 April 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29129717%20AND%20SRC:MED&resulttype=core&format=json

2 April 2020

PubMed publication ID

29129717

1 reference