(Q47737481)

5 February 2018

title

Fibroblast dysfunction is a key factor in the non-healing of chronic venous leg ulcers. (English)

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5 February 2018

author

Duncan Baird

3

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5 February 2018

author name string

Ivan B Wall

1

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5 February 2018

Ryan Moseley

2

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5 February 2018

David Kipling

4

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5 February 2018

Peter Giles

5

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5 February 2018

Iraj Laffafian

6

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5 February 2018

Patricia E Price

7

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5 February 2018

David W Thomas

8

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5 February 2018

Phil Stephens

9

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5 February 2018

language of work or name

English

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publication date

1 May 2008

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5 February 2018

Journal of Investigative Dermatology

published in

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5 February 2018

volume

128

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5 February 2018

issue

10

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5 February 2018

page(s)

2526-2540

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5 February 2018

https://scigraph.springernature.com/pub.10.1038/jid.2008.114

exact match

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cites work

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Extensive allelic variation and ultrashort telomeres in senescent human cells.

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7 January 2021

Thiol-based mechanisms of the thioredoxin and glutaredoxin systems: implications for diseases in the cardiovascular system

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7 January 2021

Palladin is a novel binding partner for Ena/VASP family members.

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7 January 2021

Rheumatoid fibroblast-like synoviocytes overexpress the chemokine stromal cell-derived factor 1 (CXCL12), which supports distinct patterns and rates of CD4+ and CD8+ T cell migration within synovial tissue

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7 January 2021

Michael Mason prize essay 2003. Why do leucocytes accumulate within chronically inflamed joints?

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7 January 2021

A chemokine-dependent stromal induction mechanism for aberrant lymphocyte accumulation and compromised lymphatic return in rheumatoid arthritis

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https://api.crossref.org/works/10.1038%2FJID.2008.114

7 January 2021

Chemokines in the systemic organization of immunity

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7 January 2021

Loss of proliferative capacity and induction of senescence in oxidatively stressed human fibroblasts

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https://api.crossref.org/works/10.1038%2FJID.2008.114

7 January 2021

Cultured murine dermal fibroblast-like cells from senescence-accelerated mice as in vitro models for higher oxidative stress due to mitochondrial alterations

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https://api.crossref.org/works/10.1038%2FJID.2008.114

7 January 2021

Proteasome inhibition induces a senescence-like phenotype in primary human fibroblasts cultures

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https://api.crossref.org/works/10.1038%2FJID.2008.114

7 January 2021

Modulation of skin collagen metabolism in aged and photoaged human skin in vivo.

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7 January 2021

Defective extracellular matrix reorganization by chronic wound fibroblasts is associated with alterations in TIMP-1, TIMP-2, and MMP-2 activity

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https://api.crossref.org/works/10.1038%2FJID.2008.114

7 January 2021

Relationship between donor age and the replicative lifespan of human cells in culture: a reevaluation

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https://api.crossref.org/works/10.1038%2FJID.2008.114

7 January 2021

A biomarker that identifies senescent human cells in culture and in aging skin in vivo

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7 January 2021

Induction of replicative senescence biomarkers by sublethal oxidative stresses in normal human fibroblast

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https://api.crossref.org/works/10.1038%2FJID.2008.114

7 January 2021

Gene Expression Omnibus: NCBI gene expression and hybridization array data repository

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7 January 2021

Signal transduction by reactive oxygen species in non-phagocytic cells.

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https://api.crossref.org/works/10.1038%2FJID.2008.114

7 January 2021

Oxidants, oxidative stress and the biology of ageing

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https://api.crossref.org/works/10.1038%2FJID.2008.114

7 January 2021

Mammalian homolog of the yeast cyclase associated protein, CAP/Srv2p, regulates actin filament assembly

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https://api.crossref.org/works/10.1038%2FJID.2008.114

7 January 2021

Chemokines, cytokines, and growth factors in keratinocytes and dermal endothelial cells in the margin of chronic diabetic foot ulcers

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https://api.crossref.org/works/10.1038%2FJID.2008.114

7 January 2021

THE LIMITED IN VITRO LIFETIME OF HUMAN DIPLOID CELL STRAINS

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https://api.crossref.org/works/10.1038%2FJID.2008.114

7 January 2021

Venous ulcer fibroblasts compared with normal fibroblasts show differences in collagen but not fibronectin production under both normal and hypoxic conditions

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https://api.crossref.org/works/10.1038%2FJID.2008.114

7 January 2021

F-box proteins: the key to protein degradation

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https://api.crossref.org/works/10.1038%2FJID.2008.114

7 January 2021

Summaries of Affymetrix GeneChip probe level data

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https://api.crossref.org/works/10.1038%2FJID.2008.114

7 January 2021

Modulation of cell-phenotype during in vitro aging. Glycosaminoglycan biosynthesis by skin fibroblasts and corneal keratocytes

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https://api.crossref.org/works/10.1038%2FJID.2008.114

7 January 2021

The transcriptional program in the response of human fibroblasts to serum

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https://api.crossref.org/works/10.1038%2FJID.2008.114

7 January 2021

Evidence of oxidative stress in chronic venous ulcers

1 reference

https://api.crossref.org/works/10.1038%2FJID.2008.114

7 January 2021

Antioxidant characteristics of chronic wound fluid.

1 reference

https://api.crossref.org/works/10.1038%2FJID.2008.114

7 January 2021

The LIM domain: from the cytoskeleton to the nucleus

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https://api.crossref.org/works/10.1038%2FJID.2008.114

7 January 2021

Mechanism of telomere shortening by oxidative stress

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https://api.crossref.org/works/10.1038%2FJID.2008.114

7 January 2021

Analysis of the effect of aging on the response to hypoxia by cDNA microarray

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https://api.crossref.org/works/10.1038%2FJID.2008.114

7 January 2021

Transglutaminase-mediated crosslinking of specific core histone subunits and cellular senescence.

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https://api.crossref.org/works/10.1038%2FJID.2008.114

7 January 2021

Telomeres, replicative senescence and human ageing

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https://api.crossref.org/works/10.1038%2FJID.2008.114

7 January 2021

https://api.crossref.org/works/10.1038%2FJID.2008.114

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7 January 2021

Interaction of alpha-actinin with the cadherin/catenin cell-cell adhesion complex via alpha-catenin

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https://api.crossref.org/works/10.1038%2FJID.2008.114

7 January 2021

Expression of interleukin-1 alpha and beta in early passage fibroblasts from aging individuals

1 reference

https://api.crossref.org/works/10.1038%2FJID.2008.114

7 January 2021

Aged skin: a study by light, transmission electron, and scanning electron microscopy

1 reference

https://api.crossref.org/works/10.1038%2FJID.2008.114

7 January 2021

CXCL1/KC and CXCL5/LIX are selectively produced by corneal fibroblasts and mediate neutrophil infiltration to the corneal stroma in LPS keratitis

1 reference

https://api.crossref.org/works/10.1038%2FJID.2008.114

7 January 2021

Differences in cellular infiltrate and extracellular matrix of chronic diabetic and venous ulcers versus acute wounds

1 reference

https://api.crossref.org/works/10.1038%2FJID.2008.114

7 January 2021

Type I and III collagen content and fibre distribution in normal human skin during ageing

1 reference

https://api.crossref.org/works/10.1038%2FJID.2008.114

7 January 2021

Venous leg ulcer: incidence and prevalence in the elderly

1 reference

https://api.crossref.org/works/10.1038%2FJID.2008.114

7 January 2021

Stochastic variation in telomere shortening rate causes heterogeneity of human fibroblast replicative life span

1 reference

https://api.crossref.org/works/10.1038%2FJID.2008.114

7 January 2021

The proliferative capacity of neonatal skin fibroblasts is reduced after exposure to venous ulcer wound fluid: A potential mechanism for senescence in venous ulcers

1 reference

https://api.crossref.org/works/10.1038%2FJID.2008.114

7 January 2021

Fibroblasts cultured from venous ulcers display cellular characteristics of senescence

1 reference

https://api.crossref.org/works/10.1038%2FJID.2008.114

7 January 2021

Differential expression of metalloproteinase and tissue inhibitor of metalloproteinase genes in aged human fibroblasts

1 reference

https://api.crossref.org/works/10.1038%2FJID.2008.114

7 January 2021

Structural Changes in Aging Human Skin

1 reference

https://api.crossref.org/works/10.1038%2FJID.2008.114

7 January 2021

Extracellular matrix metabolites as potential biomarkers of disease activity in wound fluid: lessons learned from other inflammatory diseases?

1 reference

https://api.crossref.org/works/10.1038%2FJID.2008.114

7 January 2021

Stress-induced premature senescence in hTERT-expressing ataxia telangiectasia fibroblasts.

1 reference

https://api.crossref.org/works/10.1038%2FJID.2008.114

7 January 2021

Characterization of palladin, a novel protein localized to stress fibers and cell adhesions

1 reference

https://api.crossref.org/works/10.1038%2FJID.2008.114

7 January 2021

A stromal address code defined by fibroblasts

1 reference

https://api.crossref.org/works/10.1038%2FJID.2008.114

7 January 2021

Heme oxygenase-1 and interleukin-11 are overexpressed in stress-induced premature senescence of human WI-38 fibroblasts induced by tert-butylhydroperoxide and ethanol

1 reference

https://api.crossref.org/works/10.1038%2FJID.2008.114

7 January 2021

Mitochondrial dysfunction accounts for the stochastic heterogeneity in telomere-dependent senescence

1 reference

https://api.crossref.org/works/10.1038%2FJID.2008.114

7 January 2021

Busulfan-induced senescence is dependent on ROS production upstream of the MAPK pathway

1 reference

https://api.crossref.org/works/10.1038%2FJID.2008.114

7 January 2021

Changes in cellular motility and cytoskeletal actin in fibroblasts from patients with chronic venous insufficiency and in neonatal fibroblasts in the presence of chronic wound fluid

1 reference

https://api.crossref.org/works/10.1038%2FJID.2008.114

7 January 2021

Deficiency of ATP2C1, a Golgi ion pump, induces secretory pathway defects in endoplasmic reticulum (ER)-associated degradation and sensitivity to ER stress

1 reference

https://api.crossref.org/works/10.1038%2FJID.2008.114

7 January 2021

Wound infection. A failure of wound healing caused by an imbalance of bacteria

1 reference

https://api.crossref.org/works/10.1038%2FJID.2008.114

7 January 2021

Chronic wound fluid suppresses proliferation of dermal fibroblasts through a Ras-mediated signaling pathway.

1 reference

https://api.crossref.org/works/10.1038%2FJID.2008.114

7 January 2021

CD40 mediated activation of gingival and periodontal ligament fibroblasts

1 reference

https://api.crossref.org/works/10.1038%2FJID.2008.114

7 January 2021

Human orbital fibroblasts are activated through CD40 to induce proinflammatory cytokine production.

1 reference

https://api.crossref.org/works/10.1038%2FJID.2008.114

7 January 2021

The general case for redox control of wound repair

1 reference

https://api.crossref.org/works/10.1038%2FJID.2008.114

7 January 2021

Depletion of reduced glutathione, ascorbic acid, vitamin E and antioxidant defence enzymes in a healing cutaneous wound

1 reference

https://api.crossref.org/works/10.1038%2FJID.2008.114

7 January 2021

Delayed healing of chronic leg ulcers can result from impaired trafficking of bone marrow-derived precursors of keratinocytes to the skin

1 reference

https://api.crossref.org/works/10.1038%2FJID.2008.114

7 January 2021

Cutaneous wound healing

1 reference

https://api.crossref.org/works/10.1038%2FJID.2008.114

7 January 2021

Dinstinct ROS and biochemical profiles in cells undergoing DNA damage-induced senescence and apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FJID.2008.114

7 January 2021

Senescence and the healing rates of venous ulcers

1 reference

https://api.crossref.org/works/10.1038%2FJID.2008.114

7 January 2021

Reduced growth of dermal fibroblasts from chronic venous ulcers can be stimulated with growth factors

1 reference

https://api.crossref.org/works/10.1038%2FJID.2008.114

7 January 2021

Different types of ROS-scavenging enzymes are expressed during cutaneous wound repair

1 reference

https://api.crossref.org/works/10.1038%2FJID.2008.114

7 January 2021

An analysis of replicative senescence in dermal fibroblasts derived from chronic leg wounds predicts that telomerase therapy would fail to reverse their disease-specific cellular and proteolytic phenotype

1 reference

https://api.crossref.org/works/10.1038%2FJID.2008.114

7 January 2021

A comparison of the ability of intra-oral and extra-oral fibroblasts to stimulate extracellular matrix reorganization in a model of wound contraction

1 reference

https://api.crossref.org/works/10.1038%2FJID.2008.114

7 January 2021

Proteasome inhibitors shorten replicative life span and induce a senescent-like phenotype of human fibroblasts

1 reference

https://api.crossref.org/works/10.1038%2FJID.2008.114

7 January 2021

Cellular and molecular mechanisms of stress-induced premature senescence (SIPS) of human diploid fibroblasts and melanocytes

1 reference

https://api.crossref.org/works/10.1038%2FJID.2008.114

7 January 2021

Keratinocyte superoxide generation

1 reference

https://api.crossref.org/works/10.1038%2FJID.2008.114

7 January 2021

Cultured pressure ulcer fibroblasts show replicative senescence with elevated production of plasmin, plasminogen activator inhibitor-1, and transforming growth factor-beta1.

1 reference

https://api.crossref.org/works/10.1038%2FJID.2008.114

7 January 2021

Fibroblast senescence in pressure ulcers

1 reference

https://api.crossref.org/works/10.1038%2FJID.2008.114

7 January 2021

Reduced fibroblast interaction with intact collagen as a mechanism for depressed collagen synthesis in photodamaged skin

1 reference

https://api.crossref.org/works/10.1038%2FJID.2008.114

7 January 2021

Immunocytochemical localization of collagen types I, III, IV, and fibronectin in the human dermis. Modifications with ageing

1 reference

https://api.crossref.org/works/10.1038%2FJID.2008.114

7 January 2021

Role of oxidative stress in telomere length regulation and replicative senescence

1 reference

https://api.crossref.org/works/10.1038%2FJID.2008.114

7 January 2021

Oxidative stress shortens telomeres

1 reference

https://api.crossref.org/works/10.1038%2FJID.2008.114

7 January 2021

Accumulation of single-strand breaks is the major cause of telomere shortening in human fibroblasts.

1 reference

https://api.crossref.org/works/10.1038%2FJID.2008.114

7 January 2021

Fibrillin-rich microfibrils are reduced in photoaged skin. Distribution at the dermal-epidermal junction

1 reference

https://api.crossref.org/works/10.1038%2FJID.2008.114

7 January 2021

Targeted lung expression of interleukin-11 enhances murine tolerance of 100% oxygen and diminishes hyperoxia-induced DNA fragmentation

1 reference

https://api.crossref.org/works/10.1038%2FJID.2008.114

7 January 2021

The human Arp2/3 complex is composed of evolutionarily conserved subunits and is localized to cellular regions of dynamic actin filament assembly

1 reference

https://api.crossref.org/works/10.1038%2FJID.2008.114

7 January 2021

Selective pick-up of increased iron by deferoxamine-coupled cellulose abrogates the iron-driven induction of matrix-degrading metalloproteinase 1 and lipid peroxidation in human dermal fibroblasts in vitro: a new dressing concept

1 reference

https://api.crossref.org/works/10.1038%2FJID.2008.114

7 January 2021

Replicative senescence of human skin fibroblasts correlates with a loss of regulation and overexpression of collagenase activity

1 reference

https://api.crossref.org/works/10.1038%2FJID.2008.114

7 January 2021

Altered expression of plasminogen activator and plasminogen activator inhibitor during cellular senescence.

1 reference

https://api.crossref.org/works/10.1038%2FJID.2008.114

7 January 2021

Photoaging as a consequence of natural and therapeutic ultraviolet irradiation--studies on PUVA-induced senescence-like growth arrest of human dermal fibroblasts

1 reference

https://api.crossref.org/works/10.1038%2FJID.2008.114

7 January 2021

Oxidative stress in chronic venous leg ulcers

1 reference

https://api.crossref.org/works/10.1038%2FJID.2008.114

7 January 2021

Cellular senescence as a tumor-protection mechanism: the essential role of counting

1 reference

https://api.crossref.org/works/10.1038%2FJID.2008.114

7 January 2021

Historical claims and current interpretations of replicative aging

1 reference

https://api.crossref.org/works/10.1038%2FJID.2008.114

7 January 2021

Iron and 8-isoprostane levels in acute and chronic wounds

1 reference

https://api.crossref.org/works/10.1038%2FJID.2008.114

7 January 2021

ER stress and diseases.

1 reference

https://api.crossref.org/works/10.1038%2FJID.2008.114

7 January 2021

Establishment of H2O2-induced premature senescence in human fibroblasts concomitant with increased cellular production of H2O2

1 reference

https://api.crossref.org/works/10.1038%2FJID.2008.114

7 January 2021

Molecular signaling and genetic pathways of senescence: Its role in tumorigenesis and aging

1 reference

https://api.crossref.org/works/10.1038%2FJID.2008.114

7 January 2021

Identifiers

DOI

10.1038/JID.2008.114

1 reference

5 February 2018

PubMed ID

18449211

1 reference

5 February 2018