(Q47745372)

5 February 2018

title

The Ubiquitin Code in the Ubiquitin-Proteasome System and Autophagy (English)

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5 February 2018

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2

Aaron Ciechanover

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5 February 2018

Yong Tae Kwon

1

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5 February 2018

publication date

22 September 2017

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5 February 2018

Trends in Biochemical Sciences

number of pages

14

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based on heuristic

inferred from page(s)

published in

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5 February 2018

volume

42

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5 February 2018

issue

11

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5 February 2018

page(s)

873-886

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5 February 2018

The mitochondrial deubiquitinase USP30 opposes parkin-mediated mitophagy

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The Logic of the 26S Proteasome

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Ubiquitin-binding domains: mechanisms of ubiquitin recognition and use as tools to investigate ubiquitin-modified proteomes

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Gates, Channels, and Switches: Elements of the Proteasome Machine

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The life cycle of the 26S proteasome: from birth, through regulation and function, and onto its death

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https://opencitations.net/index/coci/api/v1/references/10.1016/J.TIBS.2017.09.002

Activation of the canonical IKK complex by K63/M1-linked hybrid ubiquitin chains

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TIBS.2017.09.002

The recognition of ubiquitinated proteins by the proteasome

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TIBS.2017.09.002

Protein Aggregates Are Recruited to Aggresome by Histone Deacetylase 6 via Unanchored Ubiquitin C Termini

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TIBS.2017.09.002

Epigenetic regulation of the expression of Il12 and Il23 and autoimmune inflammation by the deubiquitinase Trabid.

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TIBS.2017.09.002

Ubiquitin Modification by the E3 Ligase/ADP-Ribosyltransferase Dtx3L/Parp9.

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TIBS.2017.09.002

Self and nonself: how autophagy targets mitochondria and bacteria

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TIBS.2017.09.002

Parkin-mediated K63-linked polyubiquitination targets misfolded DJ-1 to aggresomes via binding to HDAC6

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TIBS.2017.09.002

In Vivo Ubiquitin Linkage-type Analysis Reveals that the Cdc48-Rad23/Dsk2 Axis Contributes to K48-Linked Chain Specificity of the Proteasome.

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TIBS.2017.09.002

Autoubiquitination of the 26S proteasome on Rpn13 regulates breakdown of ubiquitin conjugates

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TIBS.2017.09.002

RNF26 temporally regulates virus-triggered type I interferon induction by two distinct mechanisms

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TIBS.2017.09.002

The N-end rule proteolytic system in autophagy

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TIBS.2017.09.002

A proteolytic pathway that recognizes ubiquitin as a degradation signal

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TIBS.2017.09.002

USP30 and parkin homeostatically regulate atypical ubiquitin chains on mitochondria

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TIBS.2017.09.002

Specificity of the anaphase-promoting complex: a single-molecule study

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TIBS.2017.09.002

UBCH7 reactivity profile reveals parkin and HHARI to be RING/HECT hybrids

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TIBS.2017.09.002

Phosphorylation of ubiquitin at Ser65 affects its polymerization, targets, and proteome-wide turnover

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TIBS.2017.09.002

The N-end rule pathway: emerging functions and molecular principles of substrate recognition

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TIBS.2017.09.002

USP8 regulates mitophagy by removing K6-linked ubiquitin conjugates from parkin

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TIBS.2017.09.002

Quantitative proteomics reveals the function of unconventional ubiquitin chains in proteasomal degradation

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TIBS.2017.09.002

Quantitative proteomics reveal a feedforward mechanism for mitochondrial PARKIN translocation and ubiquitin chain synthesis.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TIBS.2017.09.002

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TIBS.2017.09.002

Receptor oligomerization guides pathway choice between proteasomal and autophagic degradation.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TIBS.2017.09.002

Assembly and structure of Lys33-linked polyubiquitin reveals distinct conformations

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TIBS.2017.09.002

Roles of linear ubiquitinylation, a crucial regulator of NF-κB and cell death, in the immune system

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TIBS.2017.09.002

Polyubiquitin chains: polymeric protein signals

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TIBS.2017.09.002

The E3 ubiquitin ligase AMFR and INSIG1 bridge the activation of TBK1 kinase by modifying the adaptor STING.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TIBS.2017.09.002

Monoubiquitination joins polyubiquitination as an esteemed proteasomal targeting signal

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TIBS.2017.09.002

The N-end rule pathway

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TIBS.2017.09.002

UBE2O remodels the proteome during terminal erythroid differentiation.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TIBS.2017.09.002

A novel ubiquitination factor, E4, is involved in multiubiquitin chain assembly.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TIBS.2017.09.002

Assembly and specific recognition of k29- and k33-linked polyubiquitin.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TIBS.2017.09.002

SUMO and the robustness of cancer

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TIBS.2017.09.002

Editing of ubiquitin conjugates by an isopeptidase in the 26S proteasome

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TIBS.2017.09.002

Enhanced protein degradation by branched ubiquitin chains.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TIBS.2017.09.002

Localization of the proteasomal ubiquitin receptors Rpn10 and Rpn13 by electron cryomicroscopy

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TIBS.2017.09.002

The Proteasome Distinguishes between Heterotypic and Homotypic Lysine-11-Linked Polyubiquitin Chains

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TIBS.2017.09.002

Defining roles of PARKIN and ubiquitin phosphorylation by PINK1 in mitochondrial quality control using a ubiquitin replacement strategy.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TIBS.2017.09.002

Complete subunit architecture of the proteasome regulatory particle

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TIBS.2017.09.002

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TIBS.2017.09.002

Linear ubiquitin chains: NF-κB signalling, cell death and beyond.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TIBS.2017.09.002

Export-deficient monoubiquitinated PEX5 triggers peroxisome removal in SV40 large T antigen-transformed mouse embryonic fibroblasts.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TIBS.2017.09.002

Mechanisms of regulation and diversification of deubiquitylating enzyme function.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TIBS.2017.09.002

RNF168 promotes noncanonical K27 ubiquitination to signal DNA damage.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TIBS.2017.09.002

Intracellular protein degradation: from a vague idea through the lysosome and the ubiquitin-proteasome system and onto human diseases and drug targeting

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TIBS.2017.09.002

Atypical ubiquitylation - the unexplored world of polyubiquitin beyond Lys48 and Lys63 linkages.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TIBS.2017.09.002

Ufd2p synthesizes branched ubiquitin chains to promote the degradation of substrates modified with atypical chains

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TIBS.2017.09.002

A perturbed ubiquitin landscape distinguishes between ubiquitin in trafficking and in proteolysis

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TIBS.2017.09.002

Ubiquitylation of autophagy receptor Optineurin by HACE1 activates selective autophagy for tumor suppression

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TIBS.2017.09.002

Protein Quality Control by Molecular Chaperones in Neurodegeneration

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TIBS.2017.09.002

Ubiquitin acetylation inhibits polyubiquitin chain elongation

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TIBS.2017.09.002

Modulation of SQSTM1/p62 activity by N-terminal arginylation of the endoplasmic reticulum chaperone HSPA5/GRP78/BiP.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TIBS.2017.09.002

Smurf1-mediated Lys29-linked nonproteolytic polyubiquitination of axin negatively regulates Wnt/β-catenin signaling

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TIBS.2017.09.002

The E3 ligase TRAF6 regulates Akt ubiquitination and activation

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TIBS.2017.09.002

Phosphoribosylation of Ubiquitin Promotes Serine Ubiquitination and Impairs Conventional Ubiquitination.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TIBS.2017.09.002

Diverse ubiquitin signaling in NF-κB activation

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TIBS.2017.09.002

Cezanne (OTUD7B) regulates HIF-1α homeostasis in a proteasome-independent manner.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TIBS.2017.09.002

USP30 deubiquitylates mitochondrial Parkin substrates and restricts apoptotic cell death

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TIBS.2017.09.002

Recognition of the polyubiquitin proteolytic signal

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TIBS.2017.09.002

Lys11- and Lys48-linked ubiquitin chains interact with p97 during endoplasmic-reticulum-associated degradation

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TIBS.2017.09.002

Ubiquitin chain diversity at a glance

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TIBS.2017.09.002

SUMO in the DNA Double-Stranded Break Response: Similarities, Differences, and Cooperation with Ubiquitin

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TIBS.2017.09.002

Amino-terminal arginylation targets endoplasmic reticulum chaperone BiP for autophagy through p62 binding

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TIBS.2017.09.002

The N-end rule pathway is mediated by a complex of the RING-type Ubr1 and HECT-type Ufd4 ubiquitin ligases

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TIBS.2017.09.002

K33-Linked Polyubiquitination of Coronin 7 by Cul3-KLHL20 Ubiquitin E3 Ligase Regulates Protein Trafficking

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TIBS.2017.09.002

The Emerging Role of Non-traditional Ubiquitination in Oncogenic Pathways.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TIBS.2017.09.002

Serine 403 phosphorylation of p62/SQSTM1 regulates selective autophagic clearance of ubiquitinated proteins.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TIBS.2017.09.002

p62/SQSTM1/Sequestosome-1 is an N-recognin of the N-end rule pathway which modulates autophagosome biogenesis

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TIBS.2017.09.002

K33-linked polyubiquitination of T cell receptor-zeta regulates proteolysis-independent T cell signaling

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TIBS.2017.09.002

Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes?

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TIBS.2017.09.002

SUMO-targeted ubiquitin ligases.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TIBS.2017.09.002

Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser65

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TIBS.2017.09.002

VCP/p97 cooperates with YOD1, UBXD1 and PLAA to drive clearance of ruptured lysosomes by autophagy

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TIBS.2017.09.002

Mechanism of ubiquitin chain synthesis employed by a HECT domain ubiquitin ligase.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TIBS.2017.09.002

A series of ubiquitin binding factors connects CDC48/p97 to substrate multiubiquitylation and proteasomal targeting

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TIBS.2017.09.002

Systematic and quantitative assessment of the ubiquitin-modified proteome

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TIBS.2017.09.002

OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TIBS.2017.09.002

Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TIBS.2017.09.002

Ubiquitination of substrates by esterification

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TIBS.2017.09.002

Uncovering global SUMOylation signaling networks in a site-specific manner

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TIBS.2017.09.002

SUMO conjugation - a mechanistic view

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TIBS.2017.09.002

Ubiquitin-like modifications in the DNA damage response

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TIBS.2017.09.002

A comprehensive compilation of SUMO proteomics.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TIBS.2017.09.002

Phosphorylation of OPTN by TBK1 enhances its binding to Ub chains and promotes selective autophagy of damaged mitochondria

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TIBS.2017.09.002

The unravelling of the ubiquitin system

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TIBS.2017.09.002

Ubiquitin is phosphorylated by PINK1 to activate parkin

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TIBS.2017.09.002

Substrate degradation by the proteasome: a single-molecule kinetic analysis

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TIBS.2017.09.002

PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TIBS.2017.09.002

Lys29-linkage of ASK1 by Skp1-Cullin 1-Fbxo21 ubiquitin ligase complex is required for antiviral innate response.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TIBS.2017.09.002

Numerous proteins with unique characteristics are degraded by the 26S proteasome following monoubiquitination

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TIBS.2017.09.002

A Rapid and Versatile Method for Generating Proteins with Defined Ubiquitin Chains

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TIBS.2017.09.002

Identification of a novel anti-apoptotic E3 ubiquitin ligase that ubiquitinates antagonists of inhibitor of apoptosis proteins SMAC, HtrA2, and ARTS

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TIBS.2017.09.002

Ubiquitin modifications

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TIBS.2017.09.002

Dual RING E3 Architectures Regulate Multiubiquitination and Ubiquitin Chain Elongation by APC/C.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TIBS.2017.09.002

ATM functions at the peroxisome to induce pexophagy in response to ROS.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TIBS.2017.09.002

Autophagy Receptors and Neurodegenerative Diseases

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TIBS.2017.09.002

The ubiquitin signal and autophagy: an orchestrated dance leading to mitochondrial degradation

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TIBS.2017.09.002

APC/C-mediated multiple monoubiquitylation provides an alternative degradation signal for cyclin B1

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TIBS.2017.09.002

Molecular architecture of the 26S proteasome holocomplex determined by an integrative approach

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TIBS.2017.09.002

Neuronal aggregates: formation, clearance, and spreading

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TIBS.2017.09.002

The PINK1-PARKIN Mitochondrial Ubiquitylation Pathway Drives a Program of OPTN/NDP52 Recruitment and TBK1 Activation to Promote Mitophagy

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TIBS.2017.09.002

The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TIBS.2017.09.002

The increasing complexity of the ubiquitin code

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TIBS.2017.09.002

Parkin mediates nonclassical, proteasomal-independent ubiquitination of synphilin-1: implications for Lewy body formation

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TIBS.2017.09.002

Identifiers

DOI

10.1016/J.TIBS.2017.09.002

1 reference

5 February 2018

1 reference

5 February 2018