(Q47831558)

6 February 2018

title

Arginine mutations in antibody complementarity-determining regions display context-dependent affinity/specificity trade-offs. (English)

1 reference

6 February 2018

author name string

Kathryn E Tiller

1

1 reference

6 February 2018

Lijuan Li

2

1 reference

6 February 2018

Sandeep Kumar

3

1 reference

6 February 2018

Mark C Julian

4

1 reference

6 February 2018

Shekhar Garde

5

1 reference

6 February 2018

Peter M Tessier

6

1 reference

6 February 2018

language of work or name

English

0 references

publication date

4 August 2017

1 reference

6 February 2018

Journal of Biological Chemistry

published in

1 reference

6 February 2018

volume

292

1 reference

6 February 2018

issue

40

1 reference

6 February 2018

page(s)

16638-16652

1 reference

6 February 2018

Efficient affinity maturation of antibody variable domains requires co-selection of compensatory mutations to maintain thermodynamic stability

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Inhibition of aggregation of amyloid β42 by arginine-containing small compounds

29 September 2018

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29 September 2018

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29 September 2018

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29 September 2018

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Identification of novel short peptide inhibitors of soluble 37/48 kDa oligomers of amyloid β42.

29 September 2018

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A De Novo Protein Binding Pair By Computational Design and Directed Evolution

29 September 2018

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Beyond natural antibodies: the power of in vitro display technologies

29 September 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5633126

An improved coarse-grained model of solvation and the hydrophobic effect

29 September 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5633126

Selection of peptide inhibitors of soluble Aβ(1-42) oligomer formation by phage display

29 September 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5633126

Amyloid fibril recognition with the conformational B10 antibody fragment depends on electrostatic interactions

29 September 2018

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29 September 2018

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29 September 2018

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29 September 2018

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29 September 2018

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29 September 2018

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29 September 2018

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29 September 2018

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29 September 2018

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29 September 2018

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The intrinsic contributions of tyrosine, serine, glycine and arginine to the affinity and specificity of antibodies

29 September 2018

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Thermodynamically stable aggregation-resistant antibody domains through directed evolution

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5633126

Comprehensive analysis of the factors contributing to the stability and solubility of autonomous human VH domains

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5633126

Inhibition of protein aggregation: supramolecular assemblies of arginine hold the key

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5633126

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29 September 2018

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Computational design of antibody-affinity improvement beyond in vivo maturation

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5633126

Arginine mutation alters binding of a human monoclonal antibody to antigens linked to systemic lupus erythematosus and the antiphospholipid syndrome

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5633126

Using circular dichroism collected as a function of temperature to determine the thermodynamics of protein unfolding and binding interactions

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5633126

Isolating and engineering human antibodies using yeast surface display

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5633126

Comparison of multiple Amber force fields and development of improved protein backbone parameters

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5633126

Affinity enhancement of an in vivo matured therapeutic antibody using structure-based computational design

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5633126

Interfaces and the driving force of hydrophobic assembly

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5633126

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29 September 2018

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Selecting for antibody scFv fragments with improved stability using phage display with denaturation under reducing conditions

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5633126

The critical role of arginine residues in the binding of human monoclonal antibodies to cardiolipin

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5633126

A biomolecular force field based on the free enthalpy of hydration and solvation: the GROMOS force-field parameter sets 53A5 and 53A6

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5633126

Crystal structure of HEL4, a soluble, refoldable human V(H) single domain with a germ-line scaffold.

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5633126

Somatic mutations to arginine residues affect the binding of human monoclonal antibodies to DNA, histones, SmD and Ro antigen

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5633126

Expressed murine and human CDR-H3 intervals of equal length exhibit distinct repertoires that differ in their amino acid composition and predicted range of structures

29 September 2018

1 reference

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Contributions of CDR3 to V H H domain stability and the design of monobody scaffolds for naive antibody libraries

29 September 2018

1 reference

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Predominant autoantibody production by early human B cell precursors

29 September 2018

1 reference

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Redesigning an antibody fragment for faster association with its antigen.

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5633126

Complementary combining site contact residue mutations of the anti-digoxin Fab 26-10 permit high affinity wild-type binding

29 September 2018

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29 September 2018

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29 September 2018

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29 September 2018

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Canonical dynamics: Equilibrium phase-space distributions

29 September 2018

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Non-repetitive single-chain Fv linkers selected by selectively infective phage (SIP) technology

29 September 2018

1 reference

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Anatomy of hot spots in protein interfaces

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5633126

Yeast surface display for screening combinatorial polypeptide libraries

29 September 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5633126

X-ray structures of the antigen-binding domains from three variants of humanized anti-p185HER2 antibody 4D5 and comparison with molecular modeling

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5633126

Amino acid preferences at protein binding sites

29 September 2018

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High-affinity self-reactive human antibodies by design and selection: targeting the integrin ligand binding site

29 September 2018

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Filamentous fusion phage: novel expression vectors that display cloned antigens on the virion surface

29 September 2018

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Idiotypic selection of an antibody mutant with changed hapten binding specificity, resulting from a point mutation in position 50 of the heavy chain.

29 September 2018

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Particle mesh Ewald: An N⋅log(N) method for Ewald sums in large systems

29 September 2018

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A Second Generation Force Field for the Simulation of Proteins, Nucleic Acids, and Organic Molecules

21 January 2018

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Hydrophobic interactions in context

21 January 2018

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Dissecting protein-protein recognition sites

21 January 2018

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12 December 2020

Efficient method to characterize the context-dependent hydrophobicity of proteins

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12 December 2020

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12 December 2020

Rapid method for measuring ScFv thermal stability by yeast surface display

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12 December 2020

Aggregation-resistant domain antibodies selected on phage by heat denaturation

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12 December 2020

Identifiers

DOI

10.1074/JBC.M117.783837

1 reference

6 February 2018

0 references

1 reference

6 February 2018