(Q48151533)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28692342%20AND%20SRC:MED&resulttype=core&format=json

24 March 2020

title

Targeting the α4-α5 interface of RAS results in multiple levels of inhibition (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28692342%20AND%20SRC:MED&resulttype=core&format=json

24 March 2020

author

Russell Spencer-Smith

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28692342%20AND%20SRC:MED&resulttype=core&format=json

24 March 2020

John P O'Bryan

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28692342%20AND%20SRC:MED&resulttype=core&format=json

24 March 2020

author name string

Lie Li

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28692342%20AND%20SRC:MED&resulttype=core&format=json

24 March 2020

Sheela Prasad

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28692342%20AND%20SRC:MED&resulttype=core&format=json

24 March 2020

Akiko Koide

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28692342%20AND%20SRC:MED&resulttype=core&format=json

24 March 2020

Shohei Koide

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28692342%20AND%20SRC:MED&resulttype=core&format=json

24 March 2020

publication date

31 December 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28692342%20AND%20SRC:MED&resulttype=core&format=json

24 March 2020

published in

Small GTPases (journal)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28692342%20AND%20SRC:MED&resulttype=core&format=json

24 March 2020

volume

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28692342%20AND%20SRC:MED&resulttype=core&format=json

24 March 2020

issue

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28692342%20AND%20SRC:MED&resulttype=core&format=json

24 March 2020

page(s)

378-387

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28692342%20AND%20SRC:MED&resulttype=core&format=json

describes a project that uses

24 March 2020

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC6748372/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

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US National Cancer Institute's new Ras project targets an old foe.

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Affinity profiling of the cellular kinome for the nucleotide cofactors ATP, ADP, and GTP.

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Interaction of GTP derivatives with cellular and oncogenic ras-p21 proteins

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Inhibition of purified p21ras farnesyl:protein transferase by Cys-AAX tetrapeptides

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K- and N-Ras are geranylgeranylated in cells treated with farnesyl protein transferase inhibitors

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Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity

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Discovery of Small Molecules that Bind to K-Ras and Inhibit Sos-Mediated Activation

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Approach for targeting Ras with small molecules that activate SOS-mediated nucleotide exchange

21 January 2018

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Inhibition of Ras-Effector Interaction by Cyclic Peptides

21 January 2018

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Direct Inhibitors of Ras-Effector Protein Interactions

21 January 2018

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Direct inhibition of oncogenic KRAS by hydrocarbon-stapled SOS1 helices

21 January 2018

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K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F21541248.2017.1333188

Allele-specific inhibitors inactivate mutant KRAS G12C by a trapping mechanism

21 January 2018

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Inhibition of RAS function through targeting an allosteric regulatory site.

21 January 2018

1 reference

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Dimerization opens new avenues into Ras signaling research

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Ras nanoclusters: Versatile lipid-based signaling platforms

21 January 2018

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N-Ras forms dimers at POPC membranes

21 January 2018

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The Ras G Domain Lacks the Intrinsic Propensity to Form Dimers

21 January 2018

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Structural basis of recognition of farnesylated and methylated KRAS4b by PDEδ.

21 January 2018

1 reference

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NMR characterization of full-length farnesylated and non-farnesylated H-Ras and its implications for Raf activation

21 January 2018

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https://api.crossref.org/works/10.1080%2F21541248.2017.1333188

Oncogenic and RASopathy-associated K-RAS mutations relieve membrane-dependent occlusion of the effector-binding site

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F21541248.2017.1333188

A polybasic domain or palmitoylation is required in addition to the CAAX motif to localize p21ras to the plasma membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F21541248.2017.1333188

The Ras-Membrane Interface: Isoform-specific Differences in The Catalytic Domain

21 January 2018

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https://api.crossref.org/works/10.1080%2F21541248.2017.1333188

Ras-GTP dimers activate the Mitogen-Activated Protein Kinase (MAPK) pathway

21 January 2018

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H-Ras forms dimers on membrane surfaces via a protein-protein interface.

21 January 2018

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Specific cancer-associated mutations in the switch III region of Ras increase tumorigenicity by nanocluster augmentation.

21 January 2018

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Ras membrane orientation and nanodomain localization generate isoform diversity

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F21541248.2017.1333188

A novel switch region regulates H-ras membrane orientation and signal output

21 January 2018

1 reference

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Three separable domains regulate GTP-dependent association of H-ras with the plasma membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F21541248.2017.1333188

GTP-dependent segregation of H-ras from lipid rafts is required for biological activity

21 January 2018

1 reference

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Nonradioactive determination of Ras-GTP levels using activated ras interaction assay

21 January 2018

1 reference

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Ras isoforms vary in their ability to activate Raf-1 and phosphoinositide 3-kinase

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/28692342

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1080/21541248.2017.1333188

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28692342%20AND%20SRC:MED&resulttype=core&format=json

release_kbql34f3nfhoxbsszlmf53qkg4

24 March 2020

Fatcat ID

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28692342%20AND%20SRC:MED&resulttype=core&format=json

24 March 2020

PubMed publication ID

28692342

1 reference