(Q48199895)

9 February 2018

title

The neuronal adaptor protein X11alpha reduces Abeta levels in the brains of Alzheimer's APPswe Tg2576 transgenic mice (English)

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9 February 2018

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7

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9 February 2018

Declan McLoughlin

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9 February 2018

Kwok-Fai Lau

object named as

Kwok-Fai Lau

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author name string

Ju-Hyun Lee

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9 February 2018

Michael S Perkinton

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9 February 2018

Claire L Standen

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9 February 2018

Stephen J A Shemilt

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9 February 2018

Luc Mercken

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9 February 2018

Christopher C J Miller

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9 February 2018

language of work or name

English

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publication date

11 September 2003

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9 February 2018

Journal of Biological Chemistry

published in

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9 February 2018

volume

278

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9 February 2018

issue

47

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9 February 2018

page(s)

47025-47029

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9 February 2018

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

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The regions of the Fe65 protein homologous to the phosphotyrosine interaction/phosphotyrosine binding domain of Shc bind the intracellular domain of the Alzheimer's amyloid precursor protein

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The intracellular cytoplasmic domain of the Alzheimer's disease amyloid precursor protein interacts with phosphotyrosine-binding domain proteins in the yeast two-hybrid system

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cDNA cloning and chromosome mapping of the human Fe65 gene: interaction of the conserved cytoplasmic domains of the human beta-amyloid precursor protein and its homologues with the mouse Fe65 protein

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The phosphotyrosine interaction domains of X11 and FE65 bind to distinct sites on the YENPTY motif of amyloid precursor protein

21 January 2018

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Interaction of the phosphotyrosine interaction/phosphotyrosine binding-related domains of Fe65 with wild-type and mutant Alzheimer's beta-amyloid precursor proteins

21 January 2018

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Sequence-specific recognition of the internalization motif of the Alzheimer's amyloid precursor protein by the X11 PTB domain

21 January 2018

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Fe65L2: a new member of the Fe65 protein family interacting with the intracellular domain of the Alzheimer's beta-amyloid precursor protein

21 January 2018

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Interaction of cytosolic adaptor proteins with neuronal apolipoprotein E receptors and the amyloid precursor protein

21 January 2018

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Interaction of a neuron-specific protein containing PDZ domains with Alzheimer's amyloid precursor protein

21 January 2018

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The disabled 1 phosphotyrosine-binding domain binds to the internalization signals of transmembrane glycoproteins and to phospholipids

21 January 2018

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Modulation of amyloid precursor protein metabolism by X11alpha /Mint-1. A deletion analysis of protein-protein interaction domains.

21 January 2018

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Interaction of Alzheimer's beta -amyloid precursor family proteins with scaffold proteins of the JNK signaling cascade

21 January 2018

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Association of a novel human FE65-like protein with the cytoplasmic domain of the beta-amyloid precursor protein

21 January 2018

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A tripartite protein complex with the potential to couple synaptic vesicle exocytosis to cell adhesion in brain

21 January 2018

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Identification of an evolutionarily conserved heterotrimeric protein complex involved in protein targeting

21 January 2018

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Mints, Munc18-interacting proteins in synaptic vesicle exocytosis

21 January 2018

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Mint 3: a ubiquitous mint isoform that does not bind to munc18-1 or -2

21 January 2018

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Interaction of rat lin-10 with brain-enriched F-actin-binding protein, neurabin-II/spinophilin

21 January 2018

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Mints as adaptors. Direct binding to neurexins and recruitment of munc18

21 January 2018

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Association of neuronal calcium channels with modular adaptor proteins

21 January 2018

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Kinesin superfamily motor protein KIF17 and mLin-10 in NMDA receptor-containing vesicle transport

21 January 2018

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The neuronal adaptor protein X11alpha interacts with the copper chaperone for SOD1 and regulates SOD1 activity

21 January 2018

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The X11alpha protein slows cellular amyloid precursor protein processing and reduces Abeta40 and Abeta42 secretion

21 January 2018

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X11 interaction with beta-amyloid precursor protein modulates its cellular stabilization and reduces amyloid beta-protein secretion

21 January 2018

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Synergistic effects of Munc18a and X11 proteins on amyloid precursor protein metabolism

21 January 2018

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Generation of beta-amyloid in the secretory pathway in neuronal and nonneuronal cells

21 January 2018

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Amyloids beta40 and beta42 are generated intracellularly in cultured human neurons and their secretion increases with maturation

21 January 2018

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Intracellular and secreted Alzheimer beta-amyloid species are generated by distinct mechanisms in cultured hippocampal neurons

21 January 2018

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Alzheimer's A beta(1-42) is generated in the endoplasmic reticulum/intermediate compartment of NT2N cells

21 January 2018

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Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins

21 January 2018

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Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice

21 January 2018

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Mint2/X11-like colocalizes with the Alzheimer's disease amyloid precursor protein and is associated with neuritic plaques in Alzheimer's disease

21 January 2018

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Cyclin-dependent kinase-5/p35 phosphorylates Presenilin 1 to regulate carboxy-terminal fragment stability.

21 January 2018

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Early phenotypic changes in transgenic mice that overexpress different mutants of amyloid precursor protein in brain

21 January 2018

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Neuronal expression of mint1 and mint2, novel multimodular proteins, in adult murine brain

21 January 2018

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Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes

21 January 2018

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Expression of human beta-secretase in the mouse brain increases the steady-state level of beta-amyloid.

21 January 2018

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Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice

21 January 2018

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Accelerated plaque accumulation, associative learning deficits, and up-regulation of alpha 7 nicotinic receptor protein in transgenic mice co-expressing mutant human presenilin 1 and amyloid precursor proteins

21 January 2018

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Progress in the modeling of neurodegenerative diseases in transgenic mice

21 January 2018

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Genetically engineered mouse models of neurodegenerative diseases

21 January 2018

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X11L2, a new member of the X11 protein family, interacts with Alzheimer's beta-amyloid precursor protein

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M300503200

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

21 January 2018

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APP processing and synaptic plasticity in presenilin-1 conditional knockout mice

21 January 2018

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Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

21 January 2018

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Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

21 January 2018

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Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1.

21 January 2018

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Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells.

21 January 2018

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Neurodegenerative changes associated with beta-amyloid deposition in the brains of mice carrying mutant amyloid precursor protein and mutant presenilin-1 transgenes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300503200

21 January 2018

Identifiers

DOI

10.1074/JBC.M300503200

1 reference

9 February 2018

1 reference

9 February 2018