(Q48237622)

English

Melatonin ameliorates amyloid beta-induced memory deficits, tau hyperphosphorylation and neurodegeneration via PI3/Akt/GSk3β pathway in the mouse hippocampus.

scientific article published on 12 May 2015

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scholarly article

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Europe PubMed Central

PubMed publication ID

9 February 2018

http://europepmc.org/abstract/MED/25858697

Melatonin ameliorates amyloid beta-induced memory deficits, tau hyperphosphorylation and neurodegeneration via PI3/Akt/GSk3β pathway in the mouse hippocampus. (English)

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Europe PubMed Central

PubMed publication ID

9 February 2018

http://europepmc.org/abstract/MED/25858697

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neurodegeneration

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based on heuristic

inferred from title

1

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Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25858697%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

author name string

Myeong Ok Kim

2

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Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25858697%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

publication date

12 May 2015

1 reference

Europe PubMed Central

PubMed publication ID

9 February 2018

http://europepmc.org/abstract/MED/25858697

Journal of Pineal Research

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Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25858697%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

59

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8 June 2020

1

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8 June 2020

47-59

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8 June 2020

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Role of melatonin and its receptors in the vertebrate retina

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Melatonin impairs NADPH oxidase assembly and decreases superoxide anion production in microglia exposed to amyloid-beta1-42

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Melatonin increases survival and inhibits oxidative and amyloid pathology in a transgenic model of Alzheimer's disease

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21 January 2018

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21 January 2018

A review of the molecular aspects of melatonin's anti-inflammatory actions: recent insights and new perspectives.

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21 January 2018

Melatonin attenuates D-galactose-induced memory impairment, neuroinflammation and neurodegeneration via RAGE/NF-K B/JNK signaling pathway in aging mouse model

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21 January 2018

The inhibition of apoptosis by melatonin in VSC4.1 motoneurons exposed to oxidative stress, glutamate excitotoxicity, or TNF-alpha toxicity involves membrane melatonin receptors

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21 January 2018

Protective effects of melatonin in reducing oxidative stress and in preserving the fluidity of biological membranes: a review

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21 January 2018

Potential role of tryptophan derivatives in stress responses characterized by the generation of reactive oxygen and nitrogen species.

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21 January 2018

Reducing oxidative/nitrosative stress: a newly-discovered genre for melatonin

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21 January 2018

On the free radical scavenging activities of melatonin's metabolites, AFMK and AMK.

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21 January 2018

Kynuramines, metabolites of melatonin and other indoles: the resurrection of an almost forgotten class of biogenic amines

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21 January 2018

Melatonin, cardiolipin and mitochondrial bioenergetics in health and disease

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21 January 2018

The pineal gland and melatonin in relation to aging: a summary of the theories and of the data

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21 January 2018

Melatonin affects the metabolism of the beta-amyloid precursor protein in different cell types

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Melatonin stimulates the nonamyloidogenic processing of βAPP through the positive transcriptional regulation of ADAM10 and ADAM17.

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Evaluation of potential pro-survival pathways regulated by melatonin in a murine senescence model

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21 January 2018

Sustained activation of Akt by melatonin contributes to the protection against kainic acid-induced neuronal death in hippocampus

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21 January 2018

Melatonin attenuates kainic acid-induced neurotoxicity in mouse hippocampus via inhibition of autophagy and α-synuclein aggregation.

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21 January 2018

Long-term oral administration of melatonin improves spatial learning and memory and protects against cholinergic degeneration in middle-aged Ts65Dn mice, a model of Down syndrome

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21 January 2018

Hypothermia-induced hyperphosphorylation: a new model to study tau kinase inhibitors

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Apomorphine attenuates ethanol-induced neurodegeneration in the adult rat cortex.

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Novel osmotin attenuates glutamate-induced synaptic dysfunction and neurodegeneration via the JNK/PI3K/Akt pathway in postnatal rat brain

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Soluble oligomers of amyloid-β peptide disrupt membrane trafficking of α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor contributing to early synapse dysfunction.

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Hyperphosphorylation of Tau induced by naturally secreted amyloid-β at nanomolar concentrations is modulated by insulin-dependent Akt-GSK3β signaling pathway

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Melatonin attenuates isoproterenol-induced protein kinase A overactivation and tau hyperphosphorylation in rat brain.

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Amyloid-beta neurotoxicity in organotypic culture is attenuated by melatonin: involvement of GSK-3beta, tau and neuroinflammation

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Amyloid-beta causes apoptosis of neuronal cells via caspase cascade, which can be prevented by amyloid-beta-derived short peptides

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Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide

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Calpain activation promotes BACE1 expression, amyloid precursor protein processing, and amyloid plaque formation in a transgenic mouse model of Alzheimer disease

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Identifiers

10.1111/JPI.12238

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25858697%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25858697%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

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