(Q48243218)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29334375%20AND%20SRC:MED&resulttype=core&format=json

9 April 2020

title

A small-molecule inhibitor of the ubiquitin activating enzyme for cancer treatment (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29334375%20AND%20SRC:MED&resulttype=core&format=json

9 April 2020

author name string

Marc L Hyer

1

1 reference

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9 April 2020

Michael A Milhollen

2

1 reference

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9 April 2020

Jeff Ciavarri

3

1 reference

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9 April 2020

Paul Fleming

4

1 reference

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9 April 2020

Tary Traore

5

1 reference

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9 April 2020

Darshan Sappal

6

1 reference

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9 April 2020

Jessica Huck

7

1 reference

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9 April 2020

Judy Shi

8

1 reference

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9 April 2020

James Gavin

9

1 reference

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9 April 2020

Jim Brownell

10

1 reference

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9 April 2020

Yu Yang

11

1 reference

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9 April 2020

Bradley Stringer

12

1 reference

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9 April 2020

Robert Griffin

13

1 reference

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9 April 2020

Frank Bruzzese

14

1 reference

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9 April 2020

Teresa Soucy

15

1 reference

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9 April 2020

Jennifer Duffy

16

1 reference

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9 April 2020

Claudia Rabino

17

1 reference

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9 April 2020

Jessica Riceberg

18

1 reference

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9 April 2020

Kara Hoar

19

1 reference

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9 April 2020

Anya Lublinsky

20

1 reference

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9 April 2020

Saurabh Menon

21

1 reference

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9 April 2020

Michael Sintchak

22

1 reference

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9 April 2020

Nancy Bump

23

1 reference

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9 April 2020

Sai M Pulukuri

24

1 reference

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9 April 2020

Steve Langston

25

1 reference

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9 April 2020

Stephen Tirrell

26

1 reference

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9 April 2020

Mike Kuranda

27

1 reference

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9 April 2020

John Newcomb

29

1 reference

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9 April 2020

Ping Li

30

1 reference

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9 April 2020

Jing Tao Wu

31

1 reference

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9 April 2020

Josh Powe

32

1 reference

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9 April 2020

Paul Greenspan

34

1 reference

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9 April 2020

Katherine Galvin

35

1 reference

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9 April 2020

Mark Manfredi

36

1 reference

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9 April 2020

Chris Claiborne

37

1 reference

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9 April 2020

Benjamin S Amidon

38

1 reference

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9 April 2020

Neil F Bence

39

1 reference

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9 April 2020

language of work or name

English

0 references

publication date

15 January 2018

1 reference

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9 April 2020

1 reference

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9 April 2020

volume

24

1 reference

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9 April 2020

issue

2

1 reference

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9 April 2020

page(s)

186-193

1 reference

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https://scigraph.springernature.com/pub.10.1038/nm.4474

9 April 2020

exact match

0 references

cites work

Dual E1 activation systems for ubiquitin differentially regulate E2 enzyme charging

1 reference

21 January 2018

Ubiquitin modifications

1 reference

21 January 2018

1 reference

A phase 2 study of bortezomib in relapsed, refractory myeloma

21 January 2018

1 reference

Substrate-assisted inhibition of ubiquitin-like protein-activating enzymes: the NEDD8 E1 inhibitor MLN4924 forms a NEDD8-AMP mimetic in situ

21 January 2018

1 reference

Drugging the undruggables: exploring the ubiquitin system for drug development

21 January 2018

1 reference

Ubiquitin-like protein conjugation and the ubiquitin-proteasome system as drug targets

21 January 2018

1 reference

Targeting the AAA ATPase p97 as an Approach to Treat Cancer through Disruption of Protein Homeostasis

21 January 2018

1 reference

Lenalidomide induces ubiquitination and degradation of CK1α in del(5q) MDS.

21 January 2018

1 reference

E1 ubiquitin-activating enzyme UBA-1 plays multiple roles throughout C. elegans development

21 January 2018

1 reference

Dissecting the Specificity of Adenosyl Sulfamate Inhibitors Targeting the Ubiquitin-Activating Enzyme.

21 January 2018

1 reference

An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer

21 January 2018

1 reference

The ubiquitin system for protein degradation and some of its roles in the control of the cell division cycle

21 January 2018

1 reference

MLN2238, a proteasome inhibitor, induces caspase-dependent cell death, cell cycle arrest, and potentiates the cytotoxic activity of chemotherapy agents in rituximab-chemotherapy-sensitive or rituximab-chemotherapy-resistant B-cell lymphoma preclinic

21 January 2018

1 reference

Inhibition of NEDD8-activating enzyme induces rereplication and apoptosis in human tumor cells consistent with deregulating CDT1 turnover

21 January 2018

1 reference

Ubiquitin and SUMO in DNA repair at a glance

21 January 2018

1 reference

Cleaning up in the endoplasmic reticulum: ubiquitin in charge

21 January 2018

1 reference

Ubiquitin-activating enzyme UBA1 is required for cellular response to DNA damage

21 January 2018

1 reference

Identification and mechanistic studies of a novel ubiquitin E1 inhibitor.

21 January 2018

1 reference

The comet assay for DNA damage and repair: principles, applications, and limitations

21 January 2018

1 reference

The ubiquitin-proteasome system in cancer, a major player in DNA repair. Part 2: transcriptional regulation

21 January 2018

1 reference

Pharmacogenomic approach to identify drug sensitivity in small-cell lung cancer

21 January 2018

1 reference

BRAF(V600E) protein expression and outcome from BRAF inhibitor treatment in BRAF(V600E) metastatic melanoma.

21 January 2018

1 reference

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity

21 January 2018

1 reference

NEDD8 Inhibition Overcomes CKS1B-Induced Drug Resistance by Upregulation of p21 in Multiple Myeloma

21 January 2018

1 reference

Treatment-emergent mutations in NAEβ confer resistance to the NEDD8-activating enzyme inhibitor MLN4924.

21 January 2018

1 reference

Inhibitors of ubiquitin-activating enzyme (E1), a new class of potential cancer therapeutics.

21 January 2018

1 reference

The ubiquitin-activating enzyme E1 as a therapeutic target for the treatment of leukemia and multiple myeloma

21 January 2018

1 reference

Genome-Scale CRISPR-Mediated Control of Gene Repression and Activation

21 January 2018

1 reference

Genetic screens in human cells using the CRISPR-Cas9 system

21 January 2018

1 reference

The increasing complexity of the ubiquitin code

21 January 2018

1 reference

Mechanistic studies of substrate-assisted inhibition of ubiquitin-activating enzyme by adenosine sulfamate analogues

21 January 2018

1 reference

Mechanistic studies on activation of ubiquitin and di-ubiquitin-like protein, FAT10, by ubiquitin-like modifier activating enzyme 6, Uba6

21 January 2018

1 reference

The integration of macromolecular diffraction data

21 January 2018

1 reference

Scaling and assessment of data quality

21 January 2018

1 reference

Coot: model-building tools for molecular graphics

21 January 2018

1 reference

A graphical user interface to the CCP4 program suite

21 January 2018

1 reference

Refinement of macromolecular structures by the maximum-likelihood method

21 January 2018

1 reference

Antitumor activity of MLN8054, an orally active small-molecule inhibitor of Aurora A kinase

21 January 2018

1 reference

Sequential Treatment Assignment with Balancing for Prognostic Factors in the Controlled Clinical Trial

21 January 2018

1 reference

Discovery of a potent and orally bioavailable benzolactam-derived inhibitor of Polo-like kinase 1 (MLN0905)

21 January 2018

1 reference

UBA 1: an essential yeast gene encoding ubiquitin-activating enzyme

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/29334375

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NM.4474

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29334375%20AND%20SRC:MED&resulttype=core&format=json

9 April 2020

1 reference