(Q48319851)

English

Reduced dynamin-related protein 1 protects against phosphorylated Tau-induced mitochondrial dysfunction and synaptic damage in Alzheimer's disease

scientific article published in November 2016

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scholarly article

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Europe PubMed Central

PubMed publication ID

10 February 2018

http://europepmc.org/abstract/MED/28173111

Reduced dynamin-related protein 1 protects against phosphorylated Tau-induced mitochondrial dysfunction and synaptic damage in Alzheimer's disease (English)

1 reference

Europe PubMed Central

PubMed publication ID

10 February 2018

http://europepmc.org/abstract/MED/28173111

Alzheimer's disease

0 references

phosphorylation

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author name string

David Fry

3

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28173111%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

Yeguvapalli Suneetha

4

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28173111%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

Hiromi Sesaki

5

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28173111%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

P Hemachandra Reddy

6

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28173111%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

publication date

1 November 2016

1 reference

Europe PubMed Central

PubMed publication ID

10 February 2018

http://europepmc.org/abstract/MED/28173111

Human Molecular Genetics

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28173111%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

25

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28173111%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

22

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28173111%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

4881-4897

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28173111%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

Mitochondria-targeted catalase reduces abnormal APP processing, amyloid β production and BACE1 in a mouse model of Alzheimer's disease: implications for neuroprotection and lifespan extension.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW312

21 January 2018

CSF ubiquitin as a specific biomarker in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW312

21 January 2018

siRNA against presenilin 1 (PS1) down regulates amyloid β42 production in IMR-32 cells.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW312

21 January 2018

A "mitochondrial cascade hypothesis" for sporadic Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW312

21 January 2018

Amyloid-beta overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW312

21 January 2018

Impaired balance of mitochondrial fission and fusion in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW312

21 January 2018

Amyloid beta, mitochondrial structural and functional dynamics in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW312

21 January 2018

Mitochondria are a direct site of A beta accumulation in Alzheimer's disease neurons: implications for free radical generation and oxidative damage in disease progression

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW312

21 January 2018

Mitochondrial Abeta: a potential focal point for neuronal metabolic dysfunction in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW312

21 January 2018

Copper-dependent inhibition of human cytochrome c oxidase by a dimeric conformer of amyloid-beta1-42.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW312

21 January 2018

Accumulation of amyloid precursor protein in the mitochondrial import channels of human Alzheimer's disease brain is associated with mitochondrial dysfunction.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW312

21 January 2018

The amyloid beta-peptide is imported into mitochondria via the TOM import machinery and localized to mitochondrial cristae

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW312

21 January 2018

Mitochondrial bioenergetic deficit precedes Alzheimer's pathology in female mouse model of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW312

21 January 2018

Apo-Eε4 allele in conjunction with Aβ42 and tau in CSF: biomarker for Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW312

21 January 2018

Mitochondria-targeted antioxidants protect against amyloid-beta toxicity in Alzheimer's disease neurons

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW312

21 January 2018

Evidence of oxidative damage in Alzheimer's disease brain: central role for amyloid beta-peptide

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW312

21 January 2018

Mitochondrial amyloid-beta levels are associated with the extent of mitochondrial dysfunction in different brain regions and the degree of cognitive impairment in Alzheimer's transgenic mice

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW312

21 January 2018

Abnormalities of mitochondrial enzymes in Alzheimer disease

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW312

21 January 2018

A selective defect of cytochrome c oxidase is present in brain of Alzheimer disease patients.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW312

21 January 2018

Gene expression profiles of transcripts in amyloid precursor protein transgenic mice: up-regulation of mitochondrial metabolism and apoptotic genes is an early cellular change in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW312

21 January 2018

Oxidative damage in Alzheimer's.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW312

21 January 2018

Increased plaque burden in brains of APP mutant MnSOD heterozygous knockout mice.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW312

21 January 2018

Amyloid beta impairs mitochondrial anterograde transport and degenerates synapses in Alzheimer's disease neurons

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW312

21 January 2018

Abnormal tau, mitochondrial dysfunction, impaired axonal transport of mitochondria, and synaptic deprivation in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW312

21 January 2018

Amyloid beta, mitochondrial dysfunction and synaptic damage: implications for cognitive decline in aging and Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW312

21 January 2018

Increased oxidative damage in nuclear and mitochondrial DNA in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW312

21 January 2018

CSF p-Tau levels in the prediction of Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW312

21 January 2018

Microtubule-associated protein tau in development, degeneration and protection of neurons

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW312

21 January 2018

Overexpression of tau protein inhibits kinesin-dependent trafficking of vesicles, mitochondria, and endoplasmic reticulum: implications for Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW312

21 January 2018

Tau blocks traffic of organelles, neurofilaments, and APP vesicles in neurons and enhances oxidative stress

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW312

21 January 2018

Clogging of axons by tau, inhibition of axonal traffic and starvation of synapses

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW312

21 January 2018

Tau inhibits anterograde axonal transport and perturbs stability in growing axonal neurites in part by displacing kinesin cargo: neurofilaments attenuate tau-mediated neurite instability

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW312

21 January 2018

Tau reduction prevents Abeta-induced defects in axonal transport.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW312

21 January 2018

Brain oxidative stress in a triple-transgenic mouse model of Alzheimer disease.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW312

21 January 2018

Altered oxidant-mediated intraneuronal zinc mobilization in a triple transgenic mouse model of Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW312

21 January 2018

Amyloid-beta and tau synergistically impair the oxidative phosphorylation system in triple transgenic Alzheimer's disease mice

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW312

21 January 2018

Early dysregulation of the mitochondrial proteome in a mouse model of Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW312

21 January 2018

Mitochondrial abnormalities in Alzheimer's disease: possible targets for therapeutic intervention

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW312

21 January 2018

Mitochondrial loss, dysfunction and altered dynamics in Huntington's disease

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW312

21 January 2018

Mitochondrial fission and cristae disruption increase the response of cell models of Huntington's disease to apoptotic stimuli

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW312

21 January 2018

Mutant huntingtin binds the mitochondrial fission GTPase dynamin-related protein-1 and increases its enzymatic activity

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW312

21 January 2018

Abnormal mitochondrial dynamics, mitochondrial loss and mutant huntingtin oligomers in Huntington's disease: implications for selective neuronal damage

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW312

21 January 2018

Mutant huntingtin's interaction with mitochondrial protein Drp1 impairs mitochondrial biogenesis and causes defective axonal transport and synaptic degeneration in Huntington's disease

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW312

21 January 2018

Mutant SOD1G93A triggers mitochondrial fragmentation in spinal cord motor neurons: neuroprotection by SIRT3 and PGC-1α.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW312

21 January 2018

Abnormal mitochondrial transport and morphology are common pathological denominators in SOD1 and TDP43 ALS mouse models

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW312

21 January 2018

Mutant SOD1 in neuronal mitochondria causes toxicity and mitochondrial dynamics abnormalities

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW312

21 January 2018

Mitochondrial dynamics and bioenergetic dysfunction is associated with synaptic alterations in mutant SOD1 motor neurons

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW312

21 January 2018

Parkinson's disease-associated DJ-1 mutations impair mitochondrial dynamics and cause mitochondrial dysfunction

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW312

21 January 2018

Inhibition of mitochondrial fusion by α-synuclein is rescued by PINK1, Parkin and DJ-1.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW312

21 January 2018

Alpha-synuclein impairs normal dynamics of mitochondria in cell and animal models of Parkinson's disease

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW312

21 January 2018

LRRK2 regulates mitochondrial dynamics and function through direct interaction with DLP1

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW312

21 January 2018

Parkinson's disease-associated mutant VPS35 causes mitochondrial dysfunction by recycling DLP1 complexes

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW312

21 January 2018

Abnormal interaction between the mitochondrial fission protein Drp1 and hyperphosphorylated tau in Alzheimer's disease neurons: implications for mitochondrial dysfunction and neuronal damage

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW312

21 January 2018

The importance of dendritic mitochondria in the morphogenesis and plasticity of spines and synapses

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW312

21 January 2018

Division versus fusion: Dnm1p and Fzo1p antagonistically regulate mitochondrial shape

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW312

21 January 2018

Dynamin-related protein 1 and mitochondrial fragmentation in neurodegenerative diseases

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW312

21 January 2018

Multiple faces of dynamin-related protein 1 and its role in Alzheimer's disease pathogenesis

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW312

21 January 2018

Drp1 levels constitutively regulate mitochondrial dynamics and cell survival in cortical neurons.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW312

21 January 2018

The dynamin-related GTPase Drp1 is required for embryonic and brain development in mice

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW312

21 January 2018

Mitochondrial fission factor Drp1 is essential for embryonic development and synapse formation in mice

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW312

21 January 2018

Impaired mitochondrial dynamics and abnormal interaction of amyloid beta with mitochondrial protein Drp1 in neurons from patients with Alzheimer's disease: implications for neuronal damage

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW312

21 January 2018

Dynamin-related protein 1 heterozygote knockout mice do not have synaptic and mitochondrial deficiencies

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW312

21 January 2018

Impaired mitochondrial biogenesis, defective axonal transport of mitochondria, abnormal mitochondrial dynamics and synaptic degeneration in a mouse model of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW312

21 January 2018

Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW312

21 January 2018

Mitochondrial division inhibitor 1 protects against mutant huntingtin-induced abnormal mitochondrial dynamics and neuronal damage in Huntington's disease

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW312

21 January 2018

Widespread heterogeneous neuronal loss across the cerebral cortex in Huntington's disease

1 reference

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2 November 2018

Nigrostriatal neuronal death following chronic dichlorvos exposure: crosstalk between mitochondrial impairments, α synuclein aggregation, oxidative damage and behavioral changes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6078590

2 November 2018

Mitochondria morphology and DNA content upon sublethal exposure to beta-amyloid(1-42) peptide

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6078590

2 November 2018

Alzheimer's disease: genes, proteins, and therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6078590

2 November 2018

Soluble Beta-Amyloid Leads to Mitochondrial Defects in Amyloid Precursor Protein and Tau Transgenic Mice

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW312

21 January 2018

Amyloid precursor protein and amyloid β-peptide bind to ATP synthase and regulate its activity at the surface of neural cells

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW312

21 January 2018

Cytochrome oxidase deficiency in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/28173111

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1093/HMG/DDW312

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28173111%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28173111%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28173111%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

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