(Q48460242)

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Inhibition of Wnt signaling induces amyloidogenic processing of amyloid precursor protein and the production and aggregation of Amyloid-β (Aβ)42 peptides

scientific article published on 25 October 2016

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Europe PubMed Central

PubMed publication ID

11 February 2018

http://europepmc.org/abstract/MED/27778356

Inhibition of Wnt signaling induces amyloidogenic processing of amyloid precursor protein and the production and aggregation of Amyloid-β (Aβ)42 peptides (English)

1 reference

Europe PubMed Central

PubMed publication ID

11 February 2018

http://europepmc.org/abstract/MED/27778356

author name string

Cheril Tapia-Rojas

1

1 reference

Europe PubMed Central

PubMed publication ID

11 February 2018

http://europepmc.org/abstract/MED/27778356

Patricia V Burgos

2

1 reference

Europe PubMed Central

PubMed publication ID

11 February 2018

http://europepmc.org/abstract/MED/27778356

Nibaldo C Inestrosa

3

1 reference

Europe PubMed Central

PubMed publication ID

11 February 2018

http://europepmc.org/abstract/MED/27778356

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publication date

25 October 2016

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Europe PubMed Central

PubMed publication ID

11 February 2018

http://europepmc.org/abstract/MED/27778356

number of pages

17

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Journal of Neurochemistry

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Europe PubMed Central

PubMed publication ID

11 February 2018

http://europepmc.org/abstract/MED/27778356

139

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Europe PubMed Central

PubMed publication ID

11 February 2018

http://europepmc.org/abstract/MED/27778356

6

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Europe PubMed Central

PubMed publication ID

11 February 2018

http://europepmc.org/abstract/MED/27778356

1175-1191

1 reference

Europe PubMed Central

PubMed publication ID

11 February 2018

http://europepmc.org/abstract/MED/27778356

Postsynaptic dysfunction is associated with spatial and object recognition memory loss in a natural model of Alzheimer's disease

1 reference

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Elucidation of primary structure elements controlling early amyloid beta-protein oligomerization.

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Clusters of hyperactive neurons near amyloid plaques in a mouse model of Alzheimer's disease

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Turnover of C99 is controlled by a crosstalk between ERAD and ubiquitin-independent lysosomal degradation in human neuroglioma cells

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21 January 2018

Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is associated with neuronal degeneration in Alzheimer's brain

1 reference

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21 January 2018

Tetrahydrohyperforin Inhibits the Proteolytic Processing of Amyloid Precursor Protein and Enhances Its Degradation by Atg5-Dependent Autophagy

1 reference

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21 January 2018

The Maze of APP Processing in Alzheimer's Disease: Where Did We Go Wrong in Reasoning?

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21 January 2018

Activity-dependent synaptic Wnt release regulates hippocampal long term potentiation

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21 January 2018

Potential inplications of endogenous aldehydes in beta-amyloid misfolding, oligomerization and fibrillogenesis

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21 January 2018

Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer

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21 January 2018

Wnt/β-catenin signaling in Alzheimer's disease.

1 reference

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21 January 2018

The secretases: enzymes with therapeutic potential in Alzheimer disease

1 reference

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21 January 2018

Soluble amyloid precursor protein alpha inhibits tau phosphorylation through modulation of GSK3β signaling pathway

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13873

21 January 2018

A small molecule inhibitor of beta-catenin/CREB-binding protein transcription [corrected]

1 reference

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21 January 2018

Increase in extracellular NCAM and amyloid precursor protein following induction of long-term potentiation in the dentate gyrus of anaesthetized rats

1 reference

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21 January 2018

Isolation and biochemical characterization of the human Dkk-1 homologue, a novel inhibitor of mammalian Wnt signaling

1 reference

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21 January 2018

CREB-binding protein activation by presenilin 1 but not by its M146L mutant

1 reference

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21 January 2018

p300 activation by Presenilin 1 but not by its M146L mutant.

1 reference

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21 January 2018

Isoelectric focusing and two-dimensional gel electrophoresis

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13873

21 January 2018

Linking calcium to Abeta and Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13873

21 January 2018

Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13873

21 January 2018

The ins and outs of APC and beta-catenin nuclear transport

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13873

21 January 2018

Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13873

21 January 2018

Emerging roles of Wnts in the adult nervous system

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13873

21 January 2018

The role of Wnt signaling in neuronal dysfunction in Alzheimer's Disease

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13873

21 January 2018

Wnt signaling in the nervous system and in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13873

21 January 2018

Wnt signaling: role in Alzheimer disease and schizophrenia

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13873

21 January 2018

Wnt signaling from membrane to nucleus: β-catenin caught in a loop.

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13873

21 January 2018

Targeting the β-catenin nuclear transport pathway in cancer

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13873

21 January 2018

GSK-3α/β kinases and amyloid production in vivo

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13873

21 January 2018

Soluble amyloid beta-protein dimers isolated from Alzheimer cortex directly induce Tau hyperphosphorylation and neuritic degeneration

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13873

21 January 2018

Abeta40 inhibits amyloid deposition in vivo.

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13873

21 January 2018

Glutamate-stimulated secretion of amyloid precursor protein from cortical rat brain slices

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13873

21 January 2018

Neurotoxicity of Alzheimer's disease Aβ peptides is induced by small changes in the Aβ42 to Aβ40 ratio

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13873

21 January 2018

A Oligomer-Induced Aberrations in Synapse Composition, Shape, and Density Provide a Molecular Basis for Loss of Connectivity in Alzheimer's Disease

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13873

21 January 2018

Role of Wnt Signaling in Central Nervous System Injury

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13873

21 January 2018

Brain amyloid-β oligomers in ageing and Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13873

21 January 2018

Deficiency in LRP6-mediated Wnt signaling contributes to synaptic abnormalities and amyloid pathology in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13873

21 January 2018

Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13873

21 January 2018

Amyloid-beta binds to the extracellular cysteine-rich domain of Frizzled and inhibits Wnt/beta-catenin signaling

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13873

21 January 2018

Biochemistry and cell biology of tau protein in neurofibrillary degeneration

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13873

21 January 2018

Biochemistry of amyloid β-protein and amyloid deposits in Alzheimer disease

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13873

21 January 2018

Structure and function of amyloid in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13873

21 January 2018

Beta-catenin hits chromatin: regulation of Wnt target gene activation

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13873

21 January 2018

Neurotoxicity of amyloid β-protein: synaptic and network dysfunction

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13873

21 January 2018

Hippocampal proNGF signaling pathways and β-amyloid levels in mild cognitive impairment and Alzheimer disease

1 reference

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21 January 2018

Three dimensions of the amyloid hypothesis: time, space and 'wingmen'

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13873

21 January 2018

Glycogen synthase kinase 3 inhibition promotes lysosomal biogenesis and autophagic degradation of the amyloid-β precursor protein

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13873

21 January 2018

Activation of the Wnt/β-catenin pathway represses the transcription of the β-amyloid precursor protein cleaving enzyme (BACE1) via binding of T-cell factor-4 to BACE1 promoter

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13873

21 January 2018

Structural basis for increased toxicity of pathological aβ42:aβ40 ratios in Alzheimer disease

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13873

21 January 2018

GSK-3alpha regulates production of Alzheimer's disease amyloid-beta peptides

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13873

21 January 2018

Aggregation of secreted amyloid beta-protein into sodium dodecyl sulfate-stable oligomers in cell culture

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13873

21 January 2018

Oligomerization of endogenous and synthetic amyloid beta-protein at nanomolar levels in cell culture and stabilization of monomer by Congo red.

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13873

21 January 2018

Increased Dickkopf-1 expression in transgenic mouse models of neurodegenerative disease

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13873

21 January 2018

Constitutive overactivation of protein kinase C in guinea pig brain increases alpha-secretory APP processing without decreasing beta-amyloid generation

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13873

21 January 2018

Divergent roles of GSK3 and CDK5 in APP processing

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13873

21 January 2018

Inhibition of Wnt signaling, modulation of Tau phosphorylation and induction of neuronal cell death by DKK1.

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13873

21 January 2018

Deciphering Alzheimer disease

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13873

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Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13873

21 January 2018

Lithium inhibits amyloid secretion in COS7 cells transfected with amyloid precursor protein C100.

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13873

21 January 2018

Andrographolide activates the canonical Wnt signalling pathway by a mechanism that implicates the non-ATP competitive inhibition of GSK-3β: autoregulation of GSK-3β in vivo

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13873

21 January 2018

Effects of secreted oligomers of amyloid beta-protein on hippocampal synaptic plasticity: a potent role for trimers

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13873

21 January 2018

The many faces and functions of β-catenin

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13873

21 January 2018

In vivo activation of Wnt signaling pathway enhances cognitive function of adult mice and reverses cognitive deficits in an Alzheimer's disease model.

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13873

21 January 2018

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13873

21 January 2018

Synthesis and multitarget biological profiling of a novel family of rhein derivatives as disease-modifying anti-Alzheimer agents.

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13873

21 January 2018

Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13873

21 January 2018

The role of Wnt signaling in the development of Alzheimer's disease: a potential therapeutic target?

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13873

21 January 2018

Armadillo coactivates transcription driven by the product of the Drosophila segment polarity gene dTCF

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13873

21 January 2018

Specific Compositions of Amyloid-β Peptides as the Determinant of Toxic β-Aggregation

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13873

21 January 2018

Proteolytic processing of Alzheimer's β-amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13873

21 January 2018

The APP intracellular domain (AICD) inhibits Wnt signalling and promotes neurite outgrowth.

1 reference

https://api.crossref.org/works/10.1111%2FJNC.13873

21 January 2018

Identifiers

10.1111/JNC.13873

1 reference

Europe PubMed Central

PubMed publication ID

11 February 2018

http://europepmc.org/abstract/MED/27778356

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

11 February 2018

http://europepmc.org/abstract/MED/27778356

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