(Q48527061)

12 February 2018

title

Ontogenic reduction of Aph-1b mRNA and gamma-secretase activity in rats with a complex neurodevelopmental phenotype. (English)

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12 February 2018

author

Marcel W Coolen

1

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12 February 2018

author name string

van Loo KM

2

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12 February 2018

Ellenbroek BA

3

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12 February 2018

Cools AR

4

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12 February 2018

Martens GJ

5

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12 February 2018

language of work or name

English

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publication date

23 May 2006

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12 February 2018

published in

Molecular Psychiatry

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12 February 2018

volume

11

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12 February 2018

issue

8

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12 February 2018

page(s)

787-793

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12 February 2018

https://scigraph.springernature.com/pub.10.1038/sj.mp.4001846

exact match

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cites work

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Adrenocortical Response to Stress in Rats with Lesions in Hippocampus and Amygdala

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Search after neurobiological profile of individual-specific features of wistar rats

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Apomorphine susceptibility and animal models for psychopathology: genes and environment

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The development of various somatic markers is retarded in an animal model for schizophrenia, namely apomorphine-susceptible rats

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Bimodal shape of individual variation in behavior of Wistar rats: the overall outcome of a fundamentally different make-up and reactivity of the brain, the endocrinological and the immunological system.

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Association of schizophrenia with low maternal body mass index, small size at birth, and thinness during childhood

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Gene dosage effect on gamma-secretase component Aph-1b in a rat model for neurodevelopmental disorders

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7 January 2021

Gamma-secretase: proteasome of the membrane?

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7 January 2021

Notch and Presenilin: regulated intramembrane proteolysis links development and degeneration.

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Identity and function of γ‐secretase

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7 January 2021

gamma-Secretase activity requires the presenilin-dependent trafficking of nicastrin through the Golgi apparatus but not its complex glycosylation

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Notch signaling: cell fate control and signal integration in development

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Regulation of neuregulin signaling by PSD-95 interacting with ErbB4 at CNS synapses

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Roles of amyloid precursor protein and its fragments in regulating neural activity, plasticity and memory

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7 January 2021

Expression profiles of two human APH-1 genes and their roles in formation of presenilin complexes.

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7 January 2021

Differential contribution of the three Aph1 genes to gamma-secretase activity in vivo

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7 January 2021

Identification of distinct gamma-secretase complexes with different APH-1 variants

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7 January 2021

Nicastrin Is Required for Assembly of Presenilin/γ-Secretase Complexes to Mediate Notch Signaling and for Processing and Trafficking of β-Amyloid Precursor Protein in Mammals

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7 January 2021

APH-1 interacts with mature and immature forms of presenilins and nicastrin and may play a role in maturation of presenilin.nicastrin complexes

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7 January 2021

Presenilin 1 and presenilin 2 have differential effects on the stability and maturation of nicastrin in Mammalian brain

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7 January 2021

Both the sequence and length of the C terminus of PEN-2 are critical for intermolecular interactions and function of presenilin complexes

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7 January 2021

Positive and negative regulation of the gamma-secretase activity by nicastrin in a murine model

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7 January 2021

The role of presenilin cofactors in the gamma-secretase complex

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7 January 2021

Nicastrin is critical for stability and trafficking but not association of other presenilin/gamma-secretase components

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7 January 2021

Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency

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7 January 2021

Reduced Aph-1b expression causes tissue- and substrate-specific changes in gamma-secretase activity in rats with a complex phenotype

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7 January 2021

The role of the hippocampus in feedback regulation of the hypothalamic-pituitary-adrenocortical axis

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7 January 2021

Convergence and segregation of ventral striatal inputs and outputs

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Combined dexamethasone/corticotropin-releasing hormone test in patients with schizophrenia and in normal controls: II

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Elevated response of growth hormone to graded doses of apomorphine in schizophrenic patients

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7 January 2021

Evidence for early-childhood, pan-developmental impairment specific to schizophreniform disorder: results from a longitudinal birth cohort

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7 January 2021

Childhood and adolescent predictors of schizophrenia in the Northern Finland 1966 birth cohort--a descriptive life-span model

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Morphometric studies of the entorhinal cortex in neuropsychiatric patients and controls: clusters of heterotopically displaced lamina II neurons are not indicative of schizophrenia

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7 January 2021

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7 January 2021

Normal brain development in PS1 hypomorphic mice with markedly reduced gamma-secretase cleavage of betaAPP.

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7 January 2021

APH-1a is the principal mammalian APH-1 isoform present in gamma-secretase complexes during embryonic development

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https://api.crossref.org/works/10.1038%2FSJ.MP.4001846

7 January 2021

Spatial learning deficit in mice expressing human 751-amino acid beta-amyloid precursor protein.

1 reference

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7 January 2021

Transgenic mice expressing the human C99 terminal fragment of betaAPP: effects on spatial learning, exploration, anxiety, and motor coordination

1 reference

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7 January 2021

Coordinated and widespread expression of gamma-secretase in vivo: evidence for size and molecular heterogeneity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001846

7 January 2021

Identifiers

DOI

10.1038/SJ.MP.4001846

1 reference

12 February 2018

1 reference

12 February 2018