(Q35575841)

8 August 2017

1 reference

title

Identity and function of gamma-secretase (English)

1 reference

8 August 2017

Identity and function of γ‐secretase (English)

1 reference

28 March 2024

author name string

W. Taylor Kimberly

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14598311

28 March 2024

Michael S. Wolfe

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14598311

28 March 2024

language of work or name

English

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=14598311

28 March 2024

publication date

1 November 2003

1 reference

full work available at URL

8 August 2017

https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fjnr.10736

1 reference

https://onlinelibrary.wiley.com/doi/pdf/10.1002/jnr.10736

28 March 2024

1 reference

Journal of Neuroscience Research

28 March 2024

published in

1 reference

8 August 2017

volume

74

1 reference

8 August 2017

issue

3

1 reference

8 August 2017

page(s)

353-360

1 reference

Presenilin and nicastrin regulate each other and determine amyloid beta-peptide production via complex formation

8 August 2017

cites work

1 reference

Crossref

https://api.crossref.org/works/10.1002%2FJNR.10736

The intracellular domain of the beta-amyloid precursor protein is stabilized by Fe65 and translocates to the nucleus in a notch-like manner

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1002%2FJNR.10736

Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity

21 January 2018

1 reference

COCI

https://opencitations.net/index/coci/api/v1/citations/10.1038/990107

Purification and cloning of amyloid precursor protein beta-secretase from human brain

15 July 2023

1 reference

COCI

https://opencitations.net/index/coci/api/v1/citations/10.1038/990114

Presenilin 1 controls gamma-secretase processing of amyloid precursor protein in pre-golgi compartments of hippocampal neurons

15 July 2023

1

1 reference

Notch signaling: cell fate control and signal integration in development

28 March 2024

2

1 reference

Exchange of N-CoR corepressor and Tip60 coactivator complexes links gene expression by NF-kappaB and beta-amyloid precursor protein

28 March 2024

3

1 reference

Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans

28 March 2024

4

1 reference

A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60

28 March 2024

5

1 reference

The proteolytic fragments of the Alzheimer's disease-associated presenilin-1 form heterodimers and occur as a 100-150-kDa molecular mass complex

28 March 2024

6

1 reference

Nicastrin is required for Presenilin-mediated transmembrane cleavage in Drosophila

28 March 2024

7

1 reference

Alzheimer's A beta(1-42) is generated in the endoplasmic reticulum/intermediate compartment of NT2N cells

28 March 2024

8

1 reference

Membrane topology of gamma-secretase component PEN-2.

28 March 2024

9

1 reference

The discrepancy between presenilin subcellular localization and gamma-secretase processing of amyloid precursor protein

28 March 2024

10

1 reference

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

28 March 2024

11

1 reference

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

28 March 2024

12

1 reference

Reconstitution of gamma-secretase activity

28 March 2024

14

1 reference

Amyloid-lowering isocoumarins are not direct inhibitors of gamma-secretase

28 March 2024

15

1 reference

Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1.

28 March 2024

16

1 reference

Activity-dependent isolation of the presenilin- gamma -secretase complex reveals nicastrin and a gamma substrate

28 March 2024

17

1 reference

A portrait of Alzheimer secretases--new features and familiar faces

28 March 2024

18

1 reference

aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation

28 March 2024

19

1 reference

APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos

28 March 2024

21

1 reference

Targeting of cell-surface beta-amyloid precursor protein to lysosomes: alternative processing into amyloid-bearing fragments.

28 March 2024

22

1 reference

Distinct sites of intracellular production for Alzheimer's disease A beta40/42 amyloid peptides.

28 March 2024

23

1 reference

Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells.

28 March 2024

24

1 reference

Inhibition of β-amyloid formation identifies proteolytic precursors and subcellular site of catabolism

28 March 2024

25

1 reference

Nicastrin is required for gamma-secretase cleavage of the Drosophila Notch receptor

28 March 2024

26

1 reference

The Notch ligands, Delta1 and Jagged2, are substrates for presenilin-dependent "gamma-secretase" cleavage

28 March 2024

27

1 reference

Presenilin-1 affects trafficking and processing of betaAPP and is targeted in a complex with nicastrin to the plasma membrane

28 March 2024

28

1 reference

Notch and the amyloid precursor protein are cleaved by similar gamma-secretase(s).

28 March 2024

29

1 reference

Complex N-linked glycosylated nicastrin associates with active gamma-secretase and undergoes tight cellular regulation

28 March 2024

30

1 reference

γ-Secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2

28 March 2024

31

1 reference

The transmembrane aspartates in presenilin 1 and 2 are obligatory for gamma-secretase activity and amyloid beta-protein generation

28 March 2024

32

1 reference

Presenilin-dependent intramembrane proteolysis of CD44 leads to the liberation of its intracellular domain and the secretion of an Abeta-like peptide

28 March 2024

34

1 reference

Presenilin 1 is required for maturation and cell surface accumulation of nicastrin

28 March 2024

35

1 reference

Assessment of normal and mutant human presenilin function in Caenorhabditis elegans

28 March 2024

36

1 reference

Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene

28 March 2024

37

1 reference

Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

28 March 2024

38

1 reference

Drosophila nicastrin is essential for the intramembranous cleavage of notch

28 March 2024

39

1 reference

A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions

28 March 2024

40

1 reference

Cell-free assays for gamma-secretase activity

28 March 2024

41

1 reference

Presenilin-dependent gamma-secretase activity mediates the intramembranous cleavage of CD44.

28 March 2024

42

1 reference

gamma -Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase

28 March 2024

43

1 reference

Mutagenesis identifies new signals for beta-amyloid precursor protein endocytosis, turnover, and the generation of secreted fragments, including Abeta42

28 March 2024

44

1 reference

New protease inhibitors prevent gamma-secretase-mediated production of Abeta40/42 without affecting Notch cleavage

28 March 2024

45

1 reference

Identification of a novel family of presenilin homologues

28 March 2024

46

1 reference

Endoproteolytic processing and stabilization of wild-type and mutant presenilin

28 March 2024

47

1 reference

Complementation cloning of S2P, a gene encoding a putative metalloprotease required for intramembrane cleavage of SREBPs

28 March 2024

48

1 reference

Cell surface presenilin-1 participates in the gamma-secretase-like proteolysis of Notch

28 March 2024

49

1 reference

A family of membrane-embedded metalloproteases involved in regulated proteolysis of membrane-associated transcription factors

28 March 2024

50

1 reference

Sterol-regulated release of SREBP-2 from cell membranes requires two sequential cleavages, one within a transmembrane segment

28 March 2024

51

1 reference

Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

28 March 2024

52

1 reference

Translating cell biology into therapeutic advances in Alzheimer's disease

28 March 2024

53

1 reference

Alzheimer's disease: genes, proteins, and therapy

28 March 2024

54

1 reference

Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons

28 March 2024

55

1 reference

Presenilin 1 negatively regulates beta-catenin/T cell factor/lymphoid enhancer factor-1 signaling independently of beta-amyloid precursor protein and notch processing

28 March 2024

57

1 reference

Expression of Alzheimer's disease-associated presenilin-1 is controlled by proteolytic degradation and complex formation

28 March 2024

58

1 reference

A loss of function mutation of presenilin-2 interferes with amyloid beta-peptide production and notch signaling

28 March 2024

59

1 reference

PEN-2 is an integral component of the gamma-secretase complex required for coordinated expression of presenilin and nicastrin

28 March 2024

60

1 reference

The role of presenilin cofactors in the gamma-secretase complex

28 March 2024

61

1 reference

Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

28 March 2024

62

1 reference

Evidence that levels of presenilins (PS1 and PS2) are coordinately regulated by competition for limiting cellular factors

28 March 2024

63

1 reference

Complex N-glycosylated form of nicastrin is stabilized and selectively bound to presenilin fragments.

28 March 2024

64

1 reference

Drosophila rhomboid-1 defines a family of putative intramembrane serine proteases

28 March 2024

65

1 reference

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

28 March 2024

66

1 reference

Identification of signal peptide peptidase, a presenilin-type aspartic protease

28 March 2024

67

1 reference

Intracellular generation and accumulation of amyloid beta-peptide terminating at amino acid 42.

28 March 2024

68

1 reference

Peptidomimetic probes and molecular modeling suggest that Alzheimer's gamma-secretase is an intramembrane-cleaving aspartyl protease

28 March 2024

69

1 reference

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

28 March 2024

70

1 reference

The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains beta-catenin

28 March 2024

72

1 reference

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

28 March 2024

73

1 reference

Presenilins are required for gamma-secretase cleavage of beta-APP and transmembrane cleavage of Notch-1

28 March 2024

74

1 reference

28 March 2024

Identifiers

DOI

10.1002/JNR.10736

1 reference

release_ctwczrywffdldarfqy3jqbib6m

8 August 2017

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/ctwczrywffdldarfqy3jqbib6m

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference