(Q48532697)

English

Passive immunization targeting the N-terminal projection domain of tau decreases tau pathology and improves cognition in a transgenic mouse model of Alzheimer disease and tauopathies

scientific article published on 19 September 2014

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Europe PubMed Central

PubMed publication ID

12 February 2018

http://europepmc.org/abstract/MED/25233799

Passive immunization targeting the N-terminal projection domain of tau decreases tau pathology and improves cognition in a transgenic mouse model of Alzheimer disease and tauopathies (English)

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Europe PubMed Central

PubMed publication ID

12 February 2018

http://europepmc.org/abstract/MED/25233799

Alzheimer's disease

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passive immunization

1 reference

based on heuristic

inferred from title

Inge Grundke-Iqbal

6

object named as

Inge Grundke-Iqbal

1 reference

Europe PubMed Central

PubMed publication ID

12 February 2018

5

object named as

Cheng-Xin Gong

1 reference

Europe PubMed Central

PubMed publication ID

12 February 2018

author name string

Chun-ling Dai

1

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Europe PubMed Central

PubMed publication ID

12 February 2018

http://europepmc.org/abstract/MED/25233799

Xia Chen

2

1 reference

Europe PubMed Central

PubMed publication ID

12 February 2018

http://europepmc.org/abstract/MED/25233799

Syed Faraz Kazim

3

1 reference

Europe PubMed Central

PubMed publication ID

12 February 2018

http://europepmc.org/abstract/MED/25233799

Fei Liu

4

1 reference

Europe PubMed Central

PubMed publication ID

12 February 2018

http://europepmc.org/abstract/MED/25233799

Khalid Iqbal

7

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Europe PubMed Central

PubMed publication ID

12 February 2018

http://europepmc.org/abstract/MED/25233799

publication date

19 September 2014

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Europe PubMed Central

PubMed publication ID

12 February 2018

http://europepmc.org/abstract/MED/25233799

Journal of Neural Transmission

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Europe PubMed Central

PubMed publication ID

12 February 2018

http://europepmc.org/abstract/MED/25233799

122

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Europe PubMed Central

PubMed publication ID

12 February 2018

http://europepmc.org/abstract/MED/25233799

4

1 reference

Europe PubMed Central

PubMed publication ID

12 February 2018

http://europepmc.org/abstract/MED/25233799

607-617

1 reference

Europe PubMed Central

PubMed publication ID

12 February 2018

http://europepmc.org/abstract/MED/25233799

Histopathological criteria for progressive dementia disorders: clinical-pathological correlation and classification by multivariate data analysis

1 reference

https://api.crossref.org/works/10.1007%2FS00702-014-1315-Y

21 January 2018

Role of abnormally phosphorylated tau in the breakdown of microtubules in Alzheimer disease

1 reference

https://api.crossref.org/works/10.1007%2FS00702-014-1315-Y

21 January 2018

Alzheimer's disease hyperphosphorylated tau sequesters normal tau into tangles of filaments and disassembles microtubules.

1 reference

https://api.crossref.org/works/10.1007%2FS00702-014-1315-Y

21 January 2018

Role of N-terminal tau domain integrity on the survival of cerebellar granule neurons.

1 reference

https://api.crossref.org/works/10.1007%2FS00702-014-1315-Y

21 January 2018

NMDA receptor mediates tau-induced neurotoxicity by calpain and ERK/MAPK activation.

1 reference

https://api.crossref.org/works/10.1007%2FS00702-014-1315-Y

21 January 2018

Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1007%2FS00702-014-1315-Y

21 January 2018

Immunotherapy targeting pathological tau conformers in a tangle mouse model reduces brain pathology with associated functional improvements.

1 reference

https://api.crossref.org/works/10.1007%2FS00702-014-1315-Y

21 January 2018

Tau-targeted immunization impedes progression of neurofibrillary histopathology in aged P301L tau transgenic mice

1 reference

https://api.crossref.org/works/10.1007%2FS00702-014-1315-Y

21 January 2018

Efficacy and safety of immunization with phosphorylated tau against neurofibrillary tangles in mice

1 reference

https://api.crossref.org/works/10.1007%2FS00702-014-1315-Y

21 January 2018

Immunotherapy targeting pathological tau prevents cognitive decline in a new tangle mouse model

1 reference

https://api.crossref.org/works/10.1007%2FS00702-014-1315-Y

21 January 2018

Passive immunization targeting pathological phospho-tau protein in a mouse model reduces functional decline and clears tau aggregates from the brain

1 reference

https://api.crossref.org/works/10.1007%2FS00702-014-1315-Y

21 January 2018

Frequency of stages of Alzheimer-related lesions in different age categories

1 reference

https://api.crossref.org/works/10.1007%2FS00702-014-1315-Y

21 January 2018

Intraneuronal tau aggregation precedes diffuse plaque deposition, but amyloid-β changes occur before increases of tau in cerebrospinal fluid

1 reference

https://api.crossref.org/works/10.1007%2FS00702-014-1315-Y

21 January 2018

Passive immunization with Tau oligomer monoclonal antibody reverses tauopathy phenotypes without affecting hyperphosphorylated neurofibrillary tangles.

1 reference

https://api.crossref.org/works/10.1007%2FS00702-014-1315-Y

21 January 2018

Passive immunization with anti-Tau antibodies in two transgenic models: reduction of Tau pathology and delay of disease progression.

1 reference

https://api.crossref.org/works/10.1007%2FS00702-014-1315-Y

21 January 2018

Transmission and spreading of tauopathy in transgenic mouse brain

1 reference

https://api.crossref.org/works/10.1007%2FS00702-014-1315-Y

21 January 2018

Brain homogenates from human tauopathies induce tau inclusions in mouse brain

1 reference

https://api.crossref.org/works/10.1007%2FS00702-014-1315-Y

21 January 2018

Age-dependent sexual dimorphism in cognition and stress response in the 3xTg-AD mice

1 reference

https://api.crossref.org/works/10.1007%2FS00702-014-1315-Y

21 January 2018

Identification of a caspase-derived N-terminal tau fragment in cellular and animal Alzheimer's disease models.

1 reference

https://api.crossref.org/works/10.1007%2FS00702-014-1315-Y

21 January 2018

Tau passive immunotherapy in mutant P301L mice: antibody affinity versus specificity

1 reference

https://api.crossref.org/works/10.1007%2FS00702-014-1315-Y

21 January 2018

Knock-out and transgenic mouse models of tauopathies.

1 reference

https://api.crossref.org/works/10.1007%2FS00702-014-1315-Y

21 January 2018

Applications of the Morris water maze in the study of learning and memory

1 reference

https://api.crossref.org/works/10.1007%2FS00702-014-1315-Y

21 January 2018

Phase 3 trials of solanezumab for mild-to-moderate Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1007%2FS00702-014-1315-Y

21 January 2018

Neurodegenerative disease: Tau immunotherapy targets transcellular propagation

1 reference

https://api.crossref.org/works/10.1007%2FS00702-014-1315-Y

21 January 2018

Propagation of tau misfolding from the outside to the inside of a cell.

1 reference

https://api.crossref.org/works/10.1007%2FS00702-014-1315-Y

21 January 2018

Cleavage of Tau by calpain in Alzheimer's disease: the quest for the toxic 17 kD fragment

1 reference

https://api.crossref.org/works/10.1007%2FS00702-014-1315-Y

21 January 2018

Tangle and neuron numbers, but not amyloid load, predict cognitive status in Alzheimer’s disease

1 reference

https://api.crossref.org/works/10.1007%2FS00702-014-1315-Y

21 January 2018

Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

1 reference

https://api.crossref.org/works/10.1007%2FS00702-014-1315-Y

21 January 2018

Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology

1 reference

https://api.crossref.org/works/10.1007%2FS00702-014-1315-Y

21 January 2018

Two novel Tau antibodies targeting the 396/404 region are primarily taken up by neurons and reduce Tau protein pathology

1 reference

https://api.crossref.org/works/10.1007%2FS00702-014-1315-Y

21 January 2018

Long-term effects of Abeta42 immunisation in Alzheimer's disease: follow-up of a randomised, placebo-controlled phase I trial

1 reference

https://api.crossref.org/works/10.1007%2FS00702-014-1315-Y

21 January 2018

Defective brain microtubule assembly in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1007%2FS00702-014-1315-Y

21 January 2018

Anti-amyloid beta to tau - based immunization: Developments in immunotherapy for Alzheimer disease

1 reference

https://api.crossref.org/works/10.1007%2FS00702-014-1315-Y

21 January 2018

Structure, microtubule interactions, and phosphorylation of tau protein

1 reference

https://api.crossref.org/works/10.1007%2FS00702-014-1315-Y

21 January 2018

Effects of alpha-synuclein immunization in a mouse model of Parkinson's disease

1 reference

https://api.crossref.org/works/10.1007%2FS00702-014-1315-Y

21 January 2018

Place navigation impaired in rats with hippocampal lesions

1 reference

https://api.crossref.org/works/10.1007%2FS00702-014-1315-Y

21 January 2018

Amyloid deposition precedes tangle formation in a triple transgenic model of Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1007%2FS00702-014-1315-Y

21 January 2018

Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction

1 reference

https://api.crossref.org/works/10.1007%2FS00702-014-1315-Y

21 January 2018

The generation of a 17 kDa neurotoxic fragment: an alternative mechanism by which tau mediates beta-amyloid-induced neurodegeneration.

1 reference

https://api.crossref.org/works/10.1007%2FS00702-014-1315-Y

21 January 2018

Implicating calpain in tau-mediated toxicity in vivo

1 reference

https://api.crossref.org/works/10.1007%2FS00702-014-1315-Y

21 January 2018

Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer's disease mouse model

1 reference

https://api.crossref.org/works/10.1007%2FS00702-014-1315-Y

21 January 2018

Androgens regulate the development of neuropathology in a triple transgenic mouse model of Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1007%2FS00702-014-1315-Y

21 January 2018

Tauopathy-like abnormalities and neurologic deficits in mice immunized with neuronal tau protein

1 reference

https://api.crossref.org/works/10.1007%2FS00702-014-1315-Y

21 January 2018

Two phase 3 trials of bapineuzumab in mild-to-moderate Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1007%2FS00702-014-1315-Y

21 January 2018

Distinct tau prion strains propagate in cells and mice and define different tauopathies

1 reference

https://api.crossref.org/works/10.1007%2FS00702-014-1315-Y

21 January 2018

Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

1 reference

https://api.crossref.org/works/10.1007%2FS00702-014-1315-Y

21 January 2018

Observations on the brains of demented old people

1 reference

https://api.crossref.org/works/10.1007%2FS00702-014-1315-Y

21 January 2018

Targeting phospho-Ser422 by active Tau Immunotherapy in the THYTau22 mouse model: a suitable therapeutic approach

1 reference

https://api.crossref.org/works/10.1007%2FS00702-014-1315-Y

21 January 2018

A comparative study of histological and immunohistochemical methods for neurofibrillary tangles and senile plaques in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1007%2FS00702-014-1315-Y

21 January 2018

Morris water maze: procedures for assessing spatial and related forms of learning and memory

1 reference

https://api.crossref.org/works/10.1007%2FS00702-014-1315-Y

21 January 2018

Active immunotherapy options for Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1007%2FS00702-014-1315-Y

21 January 2018

Anti-tau antibodies that block tau aggregate seeding in vitro markedly decrease pathology and improve cognition in vivo.

1 reference

https://api.crossref.org/works/10.1007%2FS00702-014-1315-Y

21 January 2018

Immunotherapy targeting pathological tau protein in Alzheimer's disease and related tauopathies.

1 reference

https://pubmed.ncbi.nlm.nih.gov/25233799

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Assay of proteins in the presence of interfering materials

1 reference

https://pubmed.ncbi.nlm.nih.gov/25233799

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alzheimer's disease and the amyloid cascade hypothesis: a critical review

1 reference

https://pubmed.ncbi.nlm.nih.gov/25233799

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chaperone-like antibodies targeting misfolded tau protein: new vistas in the immunotherapy of neurodegenerative foldopathies

1 reference

https://pubmed.ncbi.nlm.nih.gov/25233799

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Disease modifying effect of chronic oral treatment with a neurotrophic peptidergic compound in a triple transgenic mouse model of Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/25233799

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

2013 Alzheimer's disease facts and figures

1 reference

https://pubmed.ncbi.nlm.nih.gov/25233799

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microtubule-associated protein tau. Abnormal phosphorylation of a non-paired helical filament pool in Alzheimer disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/25233799

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sources of extracellular tau and its signaling.

1 reference

https://pubmed.ncbi.nlm.nih.gov/25233799

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alzheimer disease therapy--moving from amyloid-β to tau.

1 reference

https://pubmed.ncbi.nlm.nih.gov/25233799

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S00702-014-1315-Y

1 reference

Europe PubMed Central

PubMed publication ID

12 February 2018

http://europepmc.org/abstract/MED/25233799

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

12 February 2018

http://europepmc.org/abstract/MED/25233799

ResearchGate publication ID

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