(Q48593409)

English

Excitotoxicity downregulates TrkB.FL signaling and upregulates the neuroprotective truncated TrkB receptors in cultured hippocampal and striatal neurons.

scientific article published in March 2012

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27 January 2020

Excitotoxicity downregulates TrkB.FL signaling and upregulates the neuroprotective truncated TrkB receptors in cultured hippocampal and striatal neurons (English)

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27 January 2020

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Patricia Monteiro

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27 January 2020

Ramiro D. Almeida

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27 January 2020

Carlos B. Duarte

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27 January 2020

1

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27 January 2020

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27 January 2020

Maria Joana Pinto

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27 January 2020

Tadeusz Wieloch

8

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27 January 2020

10

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27 January 2020

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Carlos V Melo

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27 January 2020

Ana Isabel Inácio

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Ana R Inácio

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27 January 2020

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Federico Felizzi

4

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27 January 2020

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1 March 2012

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27 January 2020

Journal of Neuroscience

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27 January 2020

32

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27 January 2020

13

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27 January 2020

4610-4622

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27 January 2020

describes a project that uses

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC6622054/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

Caspase and calpain substrates: roles in synaptic plasticity and cell death

1 reference

https://pubmed.ncbi.nlm.nih.gov/22457507

12 December 2020

based on heuristic

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Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms

1 reference

https://pubmed.ncbi.nlm.nih.gov/22457507

12 December 2020

based on heuristic

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Calpain and caspase: can you tell the difference?

1 reference

https://pubmed.ncbi.nlm.nih.gov/22457507

12 December 2020

based on heuristic

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Implication of cysteine proteases calpain, cathepsin and caspase in ischemic neuronal death of primates

1 reference

https://pubmed.ncbi.nlm.nih.gov/22457507

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transgenic Mice Overexpressing Truncated trkB Neurotrophin Receptors in Neurons Show Increased Susceptibility to Cortical Injury after Focal Cerebral Ischemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/22457507

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Small GTP-binding proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/22457507

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Truncated trkB.T1 is dominant negative inhibitor of trkB.TK+-mediated cell survival.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22457507

12 December 2020

based on heuristic

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Brain-derived neurotrophic factor reduces cortical cell death by ischemia after middle cerebral artery occlusion in the rat.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22457507

12 December 2020

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A new mathematical model for relative quantification in real-time RT-PCR

1 reference

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12 December 2020

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Neuroprotection for Parkinson's disease: a new approach for a new millennium

1 reference

https://pubmed.ncbi.nlm.nih.gov/22457507

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Analysis of the human TrkB gene genomic organization reveals novel TrkB isoforms, unusual gene length, and splicing mechanism

1 reference

https://pubmed.ncbi.nlm.nih.gov/22457507

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vivo role of caspases in excitotoxic neuronal death: generation and analysis of transgenic mice expressing baculoviral caspase inhibitor, p35, in postnatal neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/22457507

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Animal models of focal and global cerebral ischemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/22457507

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vivo role of truncated trkb receptors during sensory ganglion neurogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/22457507

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Trk receptors: roles in neuronal signal transduction

1 reference

https://pubmed.ncbi.nlm.nih.gov/22457507

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Truncated TrkB-T1 mediates neurotrophin-evoked calcium signalling in glia cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/22457507

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The small GTP-binding protein RhoA regulates c-jun by a ROCK-JNK signaling axis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22457507

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Huntingtin controls neurotrophic support and survival of neurons by enhancing BDNF vesicular transport along microtubules

1 reference

https://pubmed.ncbi.nlm.nih.gov/22457507

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Truncated TrkB receptor-induced outgrowth of dendritic filopodia involves the p75 neurotrophin receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/22457507

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Calpain mediates excitotoxic DNA fragmentation via mitochondrial pathways in adult brains: evidence from calpastatin mutant mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22457507

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Distinct mechanistic roles of calpain and caspase activation in neurodegeneration as revealed in mice overexpressing their specific inhibitors.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22457507

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A truncated tropomyosin-related kinase B receptor, T1, regulates glial cell morphology via Rho GDP dissociation inhibitor 1

1 reference

https://pubmed.ncbi.nlm.nih.gov/22457507

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuroprotection by BDNF against glutamate-induced apoptotic cell death is mediated by ERK and PI3-kinase pathways.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22457507

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enriched environment enhances recovery of motor function after focal ischemia in mice, and downregulates the transcription factor NGFI-A.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22457507

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential expression of the truncated TrkB receptor, T1, in the primary motor and prefrontal cortices of the adult macaque monkey

1 reference

https://pubmed.ncbi.nlm.nih.gov/22457507

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The yin and yang of neurotrophin action

1 reference

https://pubmed.ncbi.nlm.nih.gov/22457507

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Long-term adeno-associated viral vector-mediated expression of truncated TrkB in the adult rat facial nucleus results in motor neuron degeneration.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22457507

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TrkB-T1 regulates the RhoA signaling and actin cytoskeleton in glioma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/22457507

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vivo restoration of physiological levels of truncated TrkB.T1 receptor rescues neuronal cell death in a trisomic mouse model.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22457507

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurotrophin-regulated signalling pathways

1 reference

https://pubmed.ncbi.nlm.nih.gov/22457507

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Calpain-mediated mGluR1alpha truncation: a key step in excitotoxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/22457507

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Brain-derived neurotrophic factor regulates the expression and synaptic delivery of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor subunits in hippocampal neurons.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22457507

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rho mediates calcium-dependent activation of p38alpha and subsequent excitotoxic cell death

1 reference

https://pubmed.ncbi.nlm.nih.gov/22457507

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A mutant alphaII-spectrin designed to resist calpain and caspase cleavage questions the functional importance of this process in vivo.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22457507

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Spatial memory training modifies the expression of brain-derived neurotrophic factor tyrosine kinase receptors in young and aged rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22457507

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Calpain inhibition is sufficient to suppress aggregation of polyglutamine-expanded ataxin-3.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22457507

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanistic role of calpains in postischemic neurodegeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/22457507

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Validation of internal control genes for expression studies: effects of the neurotrophin BDNF on hippocampal neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/22457507

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Calpain activity contributes to the control of SNAP-25 levels in neurons.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22457507

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Vascular endothelial growth factor protects motoneurons from serum deprivation-induced cell death through phosphatidylinositol 3-kinase-mediated p38 mitogen-activated protein kinase inhibition.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22457507

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transient global ischemia in rat brain promotes different NMDA receptor regulation depending on the brain structure studied

1 reference

https://pubmed.ncbi.nlm.nih.gov/22457507

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TrkBT1 induces liver metastasis of pancreatic cancer cells by sequestering Rho GDP dissociation inhibitor and promoting RhoA activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/22457507

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Noradrenaline activation of neurotrophic pathways protects against neuronal amyloid toxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/22457507

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human TrkB gene: novel alternative transcripts, protein isoforms and expression pattern in the prefrontal cerebral cortex during postnatal development

1 reference

https://pubmed.ncbi.nlm.nih.gov/22457507

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glutamate receptors, neurotoxicity and neurodegeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/22457507

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cleavage of the vesicular GABA transporter under excitotoxic conditions is followed by accumulation of the truncated transporter in nonsynaptic sites.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22457507

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparison of the specificity of Trk inhibitors in recombinant and neuronal assays.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22457507

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The trkB tyrosine protein kinase gene codes for a second neurogenic receptor that lacks the catalytic kinase domain

1 reference

https://pubmed.ncbi.nlm.nih.gov/22457507

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Calcium and excitotoxic neuronal injury.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22457507

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Trk family of neurotrophin receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/22457507

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of TrkB autophosphorylation sites and evidence that phospholipase C-gamma 1 is a substrate of the TrkB receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/22457507

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Optimized survival of hippocampal neurons in B27-supplemented Neurobasal, a new serum-free medium combination

1 reference

https://pubmed.ncbi.nlm.nih.gov/22457507

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Naturally occurring truncated trkB receptors have dominant inhibitory effects on brain-derived neurotrophic factor signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/22457507

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of neuronal survival by the serine-threonine protein kinase Akt

1 reference

https://pubmed.ncbi.nlm.nih.gov/22457507

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/22457507

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Endogenous BDNF protein is increased in adult rat hippocampus after a kainic acid induced excitotoxic insult but exogenous BDNF is not neuroprotective.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22457507

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of a dominant negative TrkB receptor, T1, reveals a requirement for presynaptic signaling in BDNF-induced synaptic potentiation in cultured hippocampal neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/22457507

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

BDNF, and full length and truncated TrkB expression in the hippocampus of the rat following kainic acid excitotoxic damage. Evidence of complex time-dependent and cell-specific responses.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22457507

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Self-inactivating lentivirus vector for safe and efficient in vivo gene delivery

1 reference

https://pubmed.ncbi.nlm.nih.gov/22457507

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.0374-12.2012

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22457507%20AND%20SRC:MED&resulttype=core&format=json

27 January 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22457507%20AND%20SRC:MED&resulttype=core&format=json

27 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22457507%20AND%20SRC:MED&resulttype=core&format=json

27 January 2020

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