(Q48678102)

14 February 2018

title

Correction of lung inflammation in a F508del CFTR murine cystic fibrosis model by the sphingosine-1-phosphate lyase inhibitor LX2931. (English)

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14 February 2018

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Oleh Dzyubachyk

object named as

Oleh Dzyubachyk

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Juan B De Sanctis

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Juan B De Sanctis

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author name string

Mieke Veltman

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14 February 2018

Marta Stolarczyk

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14 February 2018

Gabriella Wojewodka

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14 February 2018

Willem A Dik

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14 February 2018

Tamas Oravecz

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14 February 2018

Ismé de Kleer

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14 February 2018

Bob J Scholte

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publication date

23 September 2016

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14 February 2018

American Journal of Physiology - Lung Cellular and Molecular Physiology

published in

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14 February 2018

volume

311

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14 February 2018

issue

5

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14 February 2018

page(s)

L1000-L1014

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14 February 2018

Intracellular sphingosine kinase 2-derived sphingosine-1-phosphate mediates epidermal growth factor-induced ezrin-radixin-moesin phosphorylation and cancer cell invasion

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21 January 2018

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Azithromycin reduces spontaneous and induced inflammation in DeltaF508 cystic fibrosis mice

21 January 2018

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Targeting S1P1 receptor protects against murine immunological hepatic injury through myeloid-derived suppressor cells

21 January 2018

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Sphingosine-1-phosphate and its analogue FTY720 diminish acute pulmonary injury in rats with acute necrotizing pancreatitis

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Expression of Intestinal and Lung Alkaline Sphingomyelinase and Neutral Ceramidase in Cystic Fibrosis F508del Transgenic Mice

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Infection, inflammation, and lung function decline in infants with cystic fibrosis.

21 January 2018

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Conventional and monocyte-derived CD11b(+) dendritic cells initiate and maintain T helper 2 cell-mediated immunity to house dust mite allergen

21 January 2018

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A neutrophil intrinsic impairment affecting Rab27a and degranulation in cystic fibrosis is corrected by CFTR potentiator therapy

21 January 2018

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Role of sphingosine 1-phosphate receptors, sphingosine kinases and sphingosine in cancer and inflammation

21 January 2018

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Monocyte-derived dendritic cells: targets as potent antigen-presenting cells for the design of vaccines against infectious diseases

21 January 2018

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Role of epithelial HCO3⁻ transport in mucin secretion: lessons from cystic fibrosis

21 January 2018

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Extracellular matrix defects in aneurysmal Fibulin-4 mice predispose to lung emphysema

21 January 2018

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Immunosuppressive MDSCs induced by TLR signaling during infection and role in resolution of inflammation

21 January 2018

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Transforming growth factor-beta2 upregulates sphingosine kinase-1 activity, which in turn attenuates the fibrotic response to TGF-beta2 by impeding CTGF expression.

21 January 2018

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Current concepts of immune dysregulation in cystic fibrosis.

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPLUNG.00298.2016

Correction of the Delta phe508 cystic fibrosis transmembrane conductance regulator trafficking defect by the bioavailable compound glafenine.

21 January 2018

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PRAGMA-CF. A Quantitative Structural Lung Disease Computed Tomography Outcome in Young Children with Cystic Fibrosis.

21 January 2018

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CFTR interacts with ZO-1 to regulate tight junction assembly and epithelial differentiation through the ZONAB pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00298.2016

Lymphocyte sequestration through S1P lyase inhibition and disruption of S1P gradients

21 January 2018

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The role of the NHERF family of PDZ scaffolding proteins in the regulation of salt and water transport

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPLUNG.00298.2016

Early intervention studies in infants and preschool children with cystic fibrosis: are we ready?

21 January 2018

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Cystic fibrosis pigs develop lung disease and exhibit defective bacterial eradication at birth

21 January 2018

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New concepts of IL-10-induced lung fibrosis: fibrocyte recruitment and M2 activation in a CCL2/CCR2 axis

21 January 2018

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Sphingosine 1-phosphate rescues canine LPS-induced acute lung injury and alters systemic inflammatory cytokine production in vivo

21 January 2018

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Lack of Sphingosine Causes Susceptibility to Pulmonary Staphylococcus Aureus Infections in Cystic Fibrosis

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPLUNG.00298.2016

Ceramide accumulation mediates inflammation, cell death and infection susceptibility in cystic fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00298.2016

A Th17- and Th2-skewed cytokine profile in cystic fibrosis lungs represents a potential risk factor for Pseudomonas aeruginosa infection.

21 January 2018

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Genetic Inhibition Of The Ubiquitin Ligase Rnf5 Attenuates Phenotypes Associated To F508del Cystic Fibrosis Mutation.

21 January 2018

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Considerations for the Conduct of Clinical Trials with Antiinflammatory Agents in Cystic Fibrosis. A Cystic Fibrosis Foundation Workshop Report

21 January 2018

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Sphingolipids in the lungs.

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPLUNG.00298.2016

Novel insights related to CF neutrophils

21 January 2018

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The β-human chorionic gonadotropin-related peptide LQGV reduces mortality and inflammation in a murine polymicrobial sepsis model.

21 January 2018

1 reference

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Incomplete inhibition of sphingosine 1-phosphate lyase modulates immune system function yet prevents early lethality and non-lymphoid lesions

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00298.2016

Rescue of murine F508del CFTR activity in native intestine by low temperature and proteasome inhibitors

21 January 2018

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Mouse models of cystic fibrosis: phenotypic analysis and research applications

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPLUNG.00298.2016

Ceramide in cystic fibrosis: a potential new target for therapeutic intervention

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00298.2016

Lipid metabolism in cystic fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00298.2016

Low sphingosine-1-phosphate impairs lung dendritic cells in cystic fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00298.2016

Pharmacological modulation of the AKT/microRNA-199a-5p/CAV1 pathway ameliorates cystic fibrosis lung hyper-inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPLUNG.00298.2016

10.1152/AJPLUNG.00298.2016

21 January 2018

Identifiers

DOI

1 reference

14 February 2018

PubMed ID

27663991

1 reference

14 February 2018