(Q48912014)

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Selective hippocampal neurodegeneration in transgenic mice expressing small amounts of truncated Aβ is induced by pyroglutamate-Aβ formation.

scientific article published in September 2011

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Europe PubMed Central

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12 February 2020

Selective hippocampal neurodegeneration in transgenic mice expressing small amounts of truncated Aβ is induced by pyroglutamate-Aβ formation (English)

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12 February 2020

neurodegeneration

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9

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12 February 2020

Stephan von Hörsten

19

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12 February 2020

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Anca Alexandru

1

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12 February 2020

Wolfgang Jagla

2

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12 February 2020

Sigrid Graubner

3

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12 February 2020

Andreas Becker

4

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12 February 2020

Christoph Bäuscher

5

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12 February 2020

Stephanie Kohlmann

6

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12 February 2020

Reinhard Sedlmeier

7

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12 February 2020

Raik Rönicke

10

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12 February 2020

Klaus G Reymann

11

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12 February 2020

Maike Hartlage-Rübsamen

13

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12 February 2020

Alexander Waniek

14

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12 February 2020

Steffen Rossner

15

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12 February 2020

Stephan Schilling

16

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12 February 2020

Alexander P Osmand

17

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12 February 2020

Hans-Ulrich Demuth

18

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12 February 2020

Kerstin A Raber

8

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12 February 2020

Elisabeth Petrasch-Parwez

12

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12 February 2020

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1 September 2011

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12 February 2020

Journal of Neuroscience

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12 February 2020

31

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12 February 2020

36

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12 February 2020

12790-12801

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12 February 2020

The A beta 3-pyroglutamyl and 11-pyroglutamyl peptides found in senile plaque have greater beta-sheet forming and aggregation propensities in vitro than full-length A beta.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21900558

12 December 2020

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The biology of pro-thyrotropin-releasing hormone-derived peptides

1 reference

https://pubmed.ncbi.nlm.nih.gov/21900558

12 December 2020

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Application of silver degeneration stains for neurotoxicity testing

1 reference

https://pubmed.ncbi.nlm.nih.gov/21900558

12 December 2020

based on heuristic

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Age-dependent changes in brain, CSF, and plasma amyloid (beta) protein in the Tg2576 transgenic mouse model of Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21900558

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

APP transgenic mice Tg2576 accumulate Abeta peptides that are distinct from the chemically modified and insoluble peptides deposited in Alzheimer's disease senile plaques.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21900558

12 December 2020

based on heuristic

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The presence of astrocytes enhances beta amyloid-induced neurotoxicity in hippocampal cell cultures.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21900558

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Adult mouse astrocytes degrade amyloid-beta in vitro and in situ

1 reference

https://pubmed.ncbi.nlm.nih.gov/21900558

12 December 2020

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Behavioral phenotyping of mice in pharmacological and toxicological research

1 reference

https://pubmed.ncbi.nlm.nih.gov/21900558

12 December 2020

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Healthy aging and dementia: findings from the Nun Study

1 reference

https://pubmed.ncbi.nlm.nih.gov/21900558

12 December 2020

based on heuristic

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Glutaminyl cyclases unfold glutamyl cyclase activity under mild acid conditions

1 reference

https://pubmed.ncbi.nlm.nih.gov/21900558

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Massive CA1/2 neuronal loss with intraneuronal and N-terminal truncated Abeta42 accumulation in a novel Alzheimer transgenic model

1 reference

https://pubmed.ncbi.nlm.nih.gov/21900558

12 December 2020

based on heuristic

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Abeta42 is essential for parenchymal and vascular amyloid deposition in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/21900558

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Efficient and fast targeted production of murine models based on ENU mutagenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/21900558

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

beta-amyloid is different in normal aging and in Alzheimer disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21900558

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of glutaminyl cyclase alters pyroglutamate formation in mammalian cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/21900558

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: potential factors in amyloid plaque formation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21900558

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

On the seeding and oligomerization of pGlu-amyloid peptides (in vitro)

1 reference

https://pubmed.ncbi.nlm.nih.gov/21900558

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Imaging polyglutamine deposits in brain tissue

1 reference

https://pubmed.ncbi.nlm.nih.gov/21900558

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microglia-mediated neurotoxicity: uncovering the molecular mechanisms

1 reference

https://pubmed.ncbi.nlm.nih.gov/21900558

12 December 2020

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inferred from PubMed ID database lookup

Cellular and subcellular localization of Huntingtin [corrected] aggregates in the brain of a rat transgenic for Huntington disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/21900558

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Longitudinal, quantitative assessment of amyloid, neuroinflammation, and anti-amyloid treatment in a living mouse model of Alzheimer's disease enabled by positron emission tomography

1 reference

https://pubmed.ncbi.nlm.nih.gov/21900558

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alzheimer disease models and human neuropathology: similarities and differences

1 reference

https://pubmed.ncbi.nlm.nih.gov/21900558

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Review on the APP/PS1KI mouse model: intraneuronal Abeta accumulation triggers axonopathy, neuron loss and working memory impairment

1 reference

https://pubmed.ncbi.nlm.nih.gov/21900558

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Isolation of an isoenzyme of human glutaminyl cyclase: retention in the Golgi complex suggests involvement in the protein maturation machinery

1 reference

https://pubmed.ncbi.nlm.nih.gov/21900558

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Animal models of Alzheimer's disease and frontotemporal dementia

1 reference

https://pubmed.ncbi.nlm.nih.gov/21900558

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Trb2, a mouse homolog of tribbles, is dispensable for kidney and mouse development

1 reference

https://pubmed.ncbi.nlm.nih.gov/21900558

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glutaminyl cyclase inhibition attenuates pyroglutamate Abeta and Alzheimer's disease-like pathology

1 reference

https://pubmed.ncbi.nlm.nih.gov/21900558

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transient intraneuronal A beta rather than extracellular plaque pathology correlates with neuron loss in the frontal cortex of APP/PS1KI mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/21900558

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

APP/PS1KI bigenic mice develop early synaptic deficits and hippocampus atrophy

1 reference

https://pubmed.ncbi.nlm.nih.gov/21900558

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pyroglutamate formation influences solubility and amyloidogenicity of amyloid peptides

1 reference

https://pubmed.ncbi.nlm.nih.gov/21900558

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intraneuronal pyroglutamate-Abeta 3-42 triggers neurodegeneration and lethal neurological deficits in a transgenic mouse model

1 reference

https://pubmed.ncbi.nlm.nih.gov/21900558

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

N-terminal truncated pyroglutamyl beta amyloid peptide Abetapy3-42 shows a faster aggregation kinetics than the full-length Abeta1-42.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21900558

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pyroglutamate Abeta pathology in APP/PS1KI mice, sporadic and familial Alzheimer's disease cases

1 reference

https://pubmed.ncbi.nlm.nih.gov/21900558

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Early neuronal dysfunction by amyloid β oligomers depends on activation of NR2B-containing NMDA receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/21900558

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanism of amyloid plaque formation suggests an intracellular basis of Abeta pathogenicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/21900558

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intraneuronal beta-amyloid accumulation and synapse pathology in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/21900558

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A mouse model of amyloid beta oligomers: their contribution to synaptic alteration, abnormal tau phosphorylation, glial activation, and neuronal loss in vivo.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21900558

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Distinct glutaminyl cyclase expression in Edinger-Westphal nucleus, locus coeruleus and nucleus basalis Meynert contributes to pGlu-Abeta pathology in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/21900558

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Probing the biology of Alzheimer's disease in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/21900558

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intracellular accumulation of amyloid-Beta - a predictor for synaptic dysfunction and neuron loss in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/21900558

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Motor deficits, neuron loss, and reduced anxiety coinciding with axonal degeneration and intraneuronal Aβ aggregation in the 5XFAD mouse model of Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/21900558

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurotoxicity of Alzheimer's disease Aβ peptides is induced by small changes in the Aβ42 to Aβ40 ratio

1 reference

https://pubmed.ncbi.nlm.nih.gov/21900558

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Decreased clearance of CNS beta-amyloid in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/21900558

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glutaminyl cyclase contributes to the formation of focal and diffuse pyroglutamate (pGlu)-Aβ deposits in hippocampus via distinct cellular mechanisms

1 reference

https://pubmed.ncbi.nlm.nih.gov/21900558

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glutaminyl cyclase knock-out mice exhibit slight hypothyroidism but no hypogonadism: implications for enzyme function and drug development

1 reference

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12 December 2020

based on heuristic

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Processing of prothyrotropin-releasing hormone (Pro-TRH) by bovine intermediate lobe secretory vesicle membrane PC1 and PC2 enzymes

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An improved PCR method for walking in uncloned genomic DNA.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21900558

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dominant and differential deposition of distinct beta-amyloid peptide species, A beta N3(pE), in senile plaques.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21900558

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Visualization of A beta 42(43) and A beta 40 in senile plaques with end-specific A beta monoclonals: evidence that an initially deposited species is A beta 42(43).

1 reference

https://pubmed.ncbi.nlm.nih.gov/21900558

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Endogenous serine protease inhibitor modulates epileptic activity and hippocampal long-term potentiation

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Behavioral and functional analysis of mouse phenotype: SHIRPA, a proposed protocol for comprehensive phenotype assessment

1 reference

https://pubmed.ncbi.nlm.nih.gov/21900558

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.1794-11.2011

1 reference

Europe PubMed Central

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12 February 2020

release_fotannrpdvas3pfwfhtfr7gera

1 reference

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24 November 2022

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PMC publication ID

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Europe PubMed Central

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12 February 2020

PubMed publication ID

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21900558%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

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