(Q48925414)

16 February 2018

title

Metformin-induced mitochondrial function and ABCD2 up-regulation in X-linked adrenoleukodystrophy involves AMP-activated protein kinase. (English)

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16 February 2018

X-linked adrenoleukodystrophy

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Jaspreet Singh

1

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16 February 2018

Brittany Olle

2

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16 February 2018

Hamid Suhail

3

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16 February 2018

Michelle M Felicella

4

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16 February 2018

Shailendra Giri

5

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16 February 2018

language of work or name

English

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publication date

5 February 2016

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16 February 2018

Journal of Neurochemistry

published in

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16 February 2018

volume

138

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16 February 2018

issue

1

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16 February 2018

page(s)

86-100

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16 February 2018

Decreased expression of ABCD4 and BG1 genes early in the pathogenesis of X-linked adrenoleukodystrophy

cites work

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Pathophysiology of X-linked adrenoleukodystrophy

21 January 2018

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Low concentrations of metformin suppress glucose production in hepatocytes through AMP-activated protein kinase (AMPK).

21 January 2018

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AMPKα1 deficiency amplifies proinflammatory myeloid APC activity and CD40 signaling

21 January 2018

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Hematopoietic stem cell gene therapy with a lentiviral vector in X-linked adrenoleukodystrophy

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Topology of ATP-binding domain of adrenoleukodystrophy gene product in peroxisomes

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Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome

21 January 2018

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Metformin: from mechanisms of action to therapies

21 January 2018

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Targeted inactivation of the X-linked adrenoleukodystrophy gene in mice

21 January 2018

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Fibrate induction of the adrenoleukodystrophy-related gene (ABCD2): promoter analysis and role of the peroxisome proliferator-activated receptor PPARalpha

21 January 2018

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Valproic acid induces antioxidant effects in X-linked adrenoleukodystrophy

21 January 2018

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Oxidative stress, mitochondrial and proteostasis malfunction in adrenoleukodystrophy: A paradigm for axonal degeneration

21 January 2018

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Hematopoietic AMPK β1 reduces mouse adipose tissue macrophage inflammation and insulin resistance in obesity

21 January 2018

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5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside inhibits proinflammatory response in glial cells: a possible role of AMP-activated protein kinase.

21 January 2018

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Phenylbutyrate up-regulates the adrenoleukodystrophy-related gene as a nonclassical peroxisome proliferator

21 January 2018

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Fatty acids revert the inhibition of respiration caused by the antidiabetic drug metformin to facilitate their mitochondrial β-oxidation.

21 January 2018

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Does long-term metformin treatment increase cardiac lipoprotein lipase?

21 January 2018

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Induced pluripotent stem cell models from X-linked adrenoleukodystrophy patients

21 January 2018

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Nucleotide sequence of the human 70 kDa peroxisomal membrane protein: a member of ATP-binding cassette transporters

21 January 2018

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Metformin selectively attenuates mitochondrial H2O2 emission without affecting respiratory capacity in skeletal muscle of obese rats

21 January 2018

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Gene redundancy and pharmacological gene therapy: implications for X-linked adrenoleukodystrophy.

21 January 2018

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Very long-chain fatty acid accumulation causes lipotoxic response via 5-lipoxygenase in cerebral adrenoleukodystrophy

21 January 2018

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Adrenoleukodystrophy protein-deficient mice represent abnormality of very long chain fatty acid metabolism

21 January 2018

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Vascular and cardiac impairments in rats inhaling ozone and diesel exhaust particles

21 January 2018

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Two weeks of metformin treatment enhances mitochondrial respiration in skeletal muscle of AMPK kinase dead but not wild type mice

21 January 2018

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21 January 2018

Thiazolidinedione safety

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Quantification of metformin by the HPLC method in brain regions, cerebrospinal fluid and plasma of rats treated with lipopolysaccharide.

21 January 2018

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Metformin-treated patients with type 2 diabetes have normal mitochondrial complex I respiration.

21 January 2018

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Novel small-molecule AMPK activator orally exerts beneficial effects on diabetic db/db mice.

21 January 2018

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A mouse model for X-linked adrenoleukodystrophy

21 January 2018

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Metformin improves healthspan and lifespan in mice

21 January 2018

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An energetic tale of AMPK-independent effects of metformin.

21 January 2018

1 reference

Pioglitazone halts axonal degeneration in a mouse model of X-linked adrenoleukodystrophy

21 January 2018

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Peroxisomal ABC transporters: structure, function and role in disease

21 January 2018

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Therapy of X-linked adrenoleukodystrophy

21 January 2018

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AMPKα1 regulates macrophage skewing at the time of resolution of inflammation during skeletal muscle regeneration

21 January 2018

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5-aminoimidazole-4-carboxamide ribonucleoside: a novel immunomodulator with therapeutic efficacy in experimental autoimmune encephalomyelitis.

21 January 2018

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Metformin attenuated the autoimmune disease of the central nervous system in animal models of multiple sclerosis

21 January 2018

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Loss of AMPK exacerbates experimental autoimmune encephalomyelitis disease severity

21 January 2018

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Adrenoleukodystrophy-related protein can compensate functionally for adrenoleukodystrophy protein deficiency (X-ALD): implications for therapy

21 January 2018

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The role of ELOVL1 in very long-chain fatty acid homeostasis and X-linked adrenoleukodystrophy

21 January 2018

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Metabolism of inflammation limited by AMPK and pseudo-starvation

21 January 2018

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AMP-activated protein kinase (AMPK) beta1beta2 muscle null mice reveal an essential role for AMPK in maintaining mitochondrial content and glucose uptake during exercise.

21 January 2018

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AMPK regulation of fatty acid metabolism and mitochondrial biogenesis: implications for obesity.

21 January 2018

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Correlation of very long chain fatty acid accumulation and inflammatory disease progression in childhood X-ALD: implications for potential therapies.

21 January 2018

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Small molecule antagonizes autoinhibition and activates AMP-activated protein kinase in cells

21 January 2018

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ABCD2 is a direct target of β-catenin and TCF-4: implications for X-linked adrenoleukodystrophy therapy

21 January 2018

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Dissociation of hyperglycemia from altered vascular contraction and relaxation mechanisms in caveolin-1 null mice

21 January 2018

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5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside attenuates experimental autoimmune encephalomyelitis via modulation of endothelial-monocyte interaction.

21 January 2018

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Functional overlap between ABCD1 (ALD) and ABCD2 (ALDR) transporters: a therapeutic target for X-adrenoleukodystrophy

21 January 2018

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The role of AMP-activated protein kinase in mitochondrial biogenesis

21 January 2018

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Defining the mechanism of activation of AMP-activated protein kinase by the small molecule A-769662, a member of the thienopyridone family.

21 January 2018

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Functional genomic analysis unravels a metabolic-inflammatory interplay in adrenoleukodystrophy

21 January 2018

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Loss of AMP-activated protein kinase in X-linked adrenoleukodystrophy patient-derived fibroblasts and lymphocytes.

21 January 2018

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Pathomechanisms underlying X-adrenoleukodystrophy: a three-hit hypothesis.

21 January 2018

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Silencing of Abcd1 and Abcd2 genes sensitizes astrocytes for inflammation: implication for X-adrenoleukodystrophy

21 January 2018

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HDAC inhibitor SAHA normalizes the levels of VLCFAs in human skin fibroblasts from X-ALD patients and downregulates the expression of proinflammatory cytokines in Abcd1/2-silenced mouse astrocytes

21 January 2018

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Histone deacetylase inhibitor upregulates peroxisomal fatty acid oxidation and inhibits apoptotic cell death in abcd1-deficient glial cells

21 January 2018

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Caffeic acid phenethyl ester induces adrenoleukodystrophy (Abcd2) gene in human X-ALD fibroblasts and inhibits the proinflammatory response in Abcd1/2 silenced mouse primary astrocytes

21 January 2018

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Loss of AMP-activated protein kinase induces mitochondrial dysfunction and proinflammatory response in unstimulated Abcd1-knockout mice mixed glial cells.

21 January 2018

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Mammalian AMP-activated protein kinase subfamily

21 January 2018

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Metformin-mediated Bambi expression in hepatic stellate cells induces prosurvival Wnt/β-catenin signaling

21 January 2018

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Oxidative imbalance in nonstimulated X-adrenoleukodystrophy-derived lymphoblasts

21 January 2018

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Cellular and molecular mechanisms of metformin: an overview

21 January 2018

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Wnt/β-Catenin Mediates AICAR Effect to Increase GATA3 Expression and Inhibit Adipogenesis

21 January 2018

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Oxygen flux analysis to understand the biological function of sirtuins

21 January 2018

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AMP-activated protein kinase (AMPK) activity is not required for neuronal development but regulates axogenesis during metabolic stress

21 January 2018

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Mechanism of AMPK suppression of LXR-dependent Srebp-1c transcription

21 January 2018

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LXR antagonists induce ABCD2 expression

21 January 2018

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21 January 2018

Identifiers

DOI

10.1111/JNC.13562

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16 February 2018

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16 February 2018