(Q49430910)

http://europepmc.org/abstract/PMC/5199684

20 February 2018

title

The ominous triad of adipose tissue dysfunction: inflammation, fibrosis, and impaired angiogenesis. (English)

1 reference

http://europepmc.org/abstract/PMC/5199684

20 February 2018

author

Yu An

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28045400%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

3

Philipp E Scherer

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28045400%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

author name string

Clair Crewe

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28045400%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

language of work or name

English

0 references

publication date

3 January 2017

1 reference

http://europepmc.org/abstract/PMC/5199684

20 February 2018

published in

Journal of Clinical Investigation

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28045400%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

volume

127

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28045400%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

issue

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28045400%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

page(s)

74-82

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28045400%20AND%20SRC:MED&resulttype=core&format=json

Targeting adipose tissue in the treatment of obesity-associated diabetes

9 June 2020

cites work

1 reference

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Hypoxia-inducible factor prolyl hydroxylase 1 (PHD1) deficiency promotes hepatic steatosis and liver-specific insulin resistance in mice.

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Adipocyte-Specific Hypoxia-Inducible Factor 2α Deficiency Exacerbates Obesity-Induced Brown Adipose Tissue Dysfunction and Metabolic Dysregulation

22 May 2018

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Adiponectin promotes VEGF-A-dependent angiogenesis in human chondrosarcoma through PI3K, Akt, mTOR, and HIF-α pathway

22 May 2018

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22 May 2018

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Ablation of XP-V gene causes adipose tissue senescence and metabolic abnormalities

22 May 2018

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Cellular Senescence in Type 2 Diabetes: A Therapeutic Opportunity.

22 May 2018

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Angiopoietin-2: a multifaceted cytokine that functions in both angiogenesis and inflammation

22 May 2018

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Oxidative stress in obesity: a critical component in human diseases

22 May 2018

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An essential role for senescent cells in optimal wound healing through secretion of PDGF-AA

22 May 2018

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Naringenin suppresses macrophage infiltration into adipose tissue in an early phase of high-fat diet-induced obesity.

22 May 2018

1 reference

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Curcumin improves hypoxia induced dysfunctions in 3T3-L1 adipocytes by protecting mitochondria and down regulating inflammation

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5199684

Adipocyte inflammation is essential for healthy adipose tissue expansion and remodeling

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5199684

Increased adipocyte O2 consumption triggers HIF-1α, causing inflammation and insulin resistance in obesity

22 May 2018

1 reference

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Macrophages and the regulation of adipose tissue remodeling

22 May 2018

1 reference

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Hypoxia and adipocyte physiology: implications for adipose tissue dysfunction in obesity.

22 May 2018

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Control of adipose tissue expandability in response to high fat diet by the insulin-like growth factor-binding protein-4

22 May 2018

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Endotrophin triggers adipose tissue fibrosis and metabolic dysfunction

22 May 2018

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The extracellular matrix protein MAGP1 supports thermogenesis and protects against obesity and diabetes through regulation of TGF-β

22 May 2018

1 reference

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Contributions of adipose tissue architectural and tensile properties toward defining healthy and unhealthy obesity.

22 May 2018

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Dietary oleic acid increases m2 macrophages in the mesenteric adipose tissue

22 May 2018

1 reference

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Glutathionylated lipid aldehydes are products of adipocyte oxidative stress and activators of macrophage inflammation

22 May 2018

1 reference

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Senescent cardiac fibroblast is critical for cardiac fibrosis after myocardial infarction

22 May 2018

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Obesity impairs vasodilatation and blood flow increase mediated by endothelial nitric oxide: an overview

22 May 2018

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Salicylate (salsalate) in patients with type 2 diabetes: a randomized trial

22 May 2018

1 reference

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New insights into adipose tissue VEGF-A actions in the control of obesity and insulin resistance.

22 May 2018

1 reference

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Extracellular matrix signaling in morphogenesis and repair

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5199684

Selective inhibition of hypoxia-inducible factor 1α ameliorates adipose tissue dysfunction.

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5199684

Adipose deficiency of Nrf2 in ob/ob mice results in severe metabolic syndrome

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5199684

Adipocyte-derived endotrophin promotes malignant tumor progression

22 May 2018

1 reference

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Adipose tissue-resident immune cells: key players in immunometabolism.

22 May 2018

1 reference

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Mechanisms of fibrosis: therapeutic translation for fibrotic disease

22 May 2018

1 reference

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Short term high fat diet challenge promotes alternative macrophage polarization in adipose tissue via natural killer T cells and interleukin-4.

22 May 2018

1 reference

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Inflamed tumor-associated adipose tissue is a depot for macrophages that stimulate tumor growth and angiogenesis.

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5199684

Obesity-associated insulin resistance is correlated to adipose tissue vascular endothelial growth factors and metalloproteinase levels

22 May 2018

1 reference

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Dichotomous effects of VEGF-A on adipose tissue dysfunction.

22 May 2018

1 reference

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Zfp423 expression identifies committed preadipocytes and localizes to adipose endothelial and perivascular cells

22 May 2018

1 reference

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Increased angiogenesis protects against adipose hypoxia and fibrosis in metabolic disease-resistant 11β-hydroxysteroid dehydrogenase type 1 (HSD1)-deficient mice

22 May 2018

1 reference

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Inflammation is necessary for long-term but not short-term high-fat diet-induced insulin resistance

22 May 2018

1 reference

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Increased adipose tissue oxygen tension in obese compared with lean men is accompanied by insulin resistance, impaired adipose tissue capillarization, and inflammation

22 May 2018

1 reference

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B cells promote insulin resistance through modulation of T cells and production of pathogenic IgG antibodies

22 May 2018

1 reference

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Four faces of cellular senescence.

22 May 2018

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Diet-induced muscle insulin resistance is associated with extracellular matrix remodeling and interaction with integrin alpha2beta1 in mice

22 May 2018

1 reference

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Hyaluronan as an immune regulator in human diseases.

22 May 2018

1 reference

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Depot-specific differences and insufficient subcutaneous adipose tissue angiogenesis in human obesity

22 May 2018

1 reference

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Adipose tissue macrophages in insulin-resistant subjects are associated with collagen VI and fibrosis and demonstrate alternative activation.

22 May 2018

1 reference

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Adipose tissue-specific inhibition of hypoxia-inducible factor 1{alpha} induces obesity and glucose intolerance by impeding energy expenditure in mice

22 May 2018

1 reference

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Adipose tissue endothelial cells from obese human subjects: differences among depots in angiogenic, metabolic, and inflammatory gene expression and cellular senescence

22 May 2018

1 reference

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Genetic link between obesity and MMP14-dependent adipogenic collagen turnover

22 May 2018

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Transcriptional control of preadipocyte determination by Zfp423.

22 May 2018

1 reference

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Time-resolved and tissue-specific systems analysis of the pathogenesis of insulin resistance

22 May 2018

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Adipocyte apoptosis, a link between obesity, insulin resistance, and hepatic steatosis

22 May 2018

1 reference

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CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity

22 May 2018

1 reference

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Involvement of serum vascular endothelial growth factor family members in the development of obesity in mice and humans

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5199684

Curcumin inhibits adipogenesis in 3T3-L1 adipocytes and angiogenesis and obesity in C57/BL mice

22 May 2018

1 reference

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Obesity increases vascular senescence and susceptibility to ischemic injury through chronic activation of Akt and mTOR.

22 May 2018

1 reference

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Metabolic dysregulation and adipose tissue fibrosis: role of collagen VI.

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5199684

Reduced adipose tissue oxygenation in human obesity: evidence for rarefaction, macrophage chemotaxis, and inflammation without an angiogenic response

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5199684

White fat progenitor cells reside in the adipose vasculature.

22 May 2018

1 reference

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Senescence of activated stellate cells limits liver fibrosis

22 May 2018

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FOXC2 controls Ang-2 expression and modulates angiogenesis, vascular patterning, remodeling, and functions in adipose tissue

22 May 2018

1 reference

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In vivo imaging in mice reveals local cell dynamics and inflammation in obese adipose tissue

22 May 2018

1 reference

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A central role for hepatocyte growth factor in adipose tissue angiogenesis

22 May 2018

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Impaired adipose tissue development in mice with inactivation of placental growth factor function

22 May 2018

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Macrophages block insulin action in adipocytes by altering expression of signaling and glucose transport proteins.

22 May 2018

1 reference

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Hypoxia-induced alterations in hyaluronan and hyaluronidase

22 May 2018

1 reference

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CCR2 modulates inflammatory and metabolic effects of high-fat feeding

22 May 2018

1 reference

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The involvement of VEGF in endothelial permeability: a target for anti-inflammatory therapy.

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5199684

Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5199684

Reduction of macrophage infiltration and chemoattractant gene expression changes in white adipose tissue of morbidly obese subjects after surgery-induced weight loss

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5199684

Modulation of angiogenesis during adipose tissue development in murine models of obesity

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5199684

Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repair

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5199684

Increased oxidative stress in obesity and its impact on metabolic syndrome

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5199684

Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor

22 May 2018

1 reference

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Angiogenesis inhibitor, TNP-470, prevents diet-induced and genetic obesity in mice

22 May 2018

1 reference

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Adiponectin stimulates angiogenesis in response to tissue ischemia through stimulation of amp-activated protein kinase signaling

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5199684

Obesity is associated with macrophage accumulation in adipose tissue

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5199684

Regulatory mechanisms for the expression and activity of platelet-derived growth factor receptor

22 May 2018

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Interleukin-6 (IL-6) induces insulin resistance in 3T3-L1 adipocytes and is, like IL-8 and tumor necrosis factor-alpha, overexpressed in human fat cells from insulin-resistant subjects

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5199684

VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5199684

Adipose tissue mass can be regulated through the vasculature

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5199684

Gene expression profile of rat adipose tissue at the onset of high-fat-diet obesity

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5199684

Leptin induces vascular permeability and synergistically stimulates angiogenesis with FGF-2 and VEGF.

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5199684

Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5199684

Tumor necrosis factor (TNF)-alpha inhibits insulin signaling through stimulation of the p55 TNF receptor and activation of sphingomyelinase

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5199684

Free radicals in cutaneous biology

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5199684

Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5199684

Biosynthetic regulation of monobutyrin, an adipocyte-secreted lipid with angiogenic activity

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5199684

VEGFB/VEGFR1-Induced Expansion of Adipose Vasculature Counteracts Obesity and Related Metabolic Complications

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5199684

Anti-vascular endothelial growth factor treatment induces blood flow recovery through vascular remodeling in high-fat diet induced diabetic mice.

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5199684

Docosahexaenoic acid attenuates adipose tissue angiogenesis and insulin resistance in high fat diet-fed middle-aged mice via a sirt1-dependent mechanism.

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5199684

Irf5 deficiency in macrophages promotes beneficial adipose tissue expansion and insulin sensitivity during obesity.

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5199684

COL6A3 expression in adipocytes associates with insulin resistance and depends on PPARγ and adipocyte size

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5199684

Disturbed flow promotes endothelial senescence via a p53-dependent pathway.

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5199684

Tumor necrosis factor-α-activated mesenchymal stem cells promote endothelial progenitor cell homing and angiogenesis

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5199684

Prolyl hydroxylase domain protein 2 plays a critical role in diet-induced obesity and glucose intolerance

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5199684

Adipose tissue hypoxia induces inflammatory M1 polarity of macrophages in an HIF-1α-dependent and HIF-1α-independent manner in obese mice

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5199684

Roles of chemokine ligand-2 (CXCL2) and neutrophils in influencing endothelial cell function and inflammation of human adipose tissue

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5199684

Insulin-sensitive obesity

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5199684

Hypoxia-inducible factor 1alpha induces fibrosis and insulin resistance in white adipose tissue.

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5199684

Metformin decreases angiogenesis via NF-kappaB and Erk1/2/Erk5 pathways by increasing the antiangiogenic thrombospondin-1.

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5199684

Effect of plasminogen activator inhibitor-1 on adipogenesis in vivo.

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5199684

Induction of angiogenesis by murine resistin: putative role of PI3-kinase and NO-dependent pathways.

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5199684

Angiogenic role of LYVE-1-positive macrophages in adipose tissue.

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5199684

Anti-inflammatory effect of hepatocyte growth factor in chronic kidney disease: targeting the inflamed vascular endothelium.

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5199684

Angiopoietin-2 sensitizes endothelial cells to TNF-alpha and has a crucial role in the induction of inflammation

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5199684

Epigallocatechin gallate attenuates diet-induced obesity in mice by decreasing energy absorption and increasing fat oxidation

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5199684

Elevated serum vascular endothelial growth factor is associated with visceral fat accumulation in human obese subjects.

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5199684

Immune Cell Toll-like Receptor 4 Mediates the Development of Obesity- and Endotoxemia-Associated Adipose Tissue Fibrosis

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5199684

Adipocyte death, adipose tissue remodeling, and obesity complications

1 December 2018

1 reference

12 December 2020

Reduction of both number and proliferative activity of human endothelial progenitor cells in obesity

1 reference

12 December 2020

Macrophage infiltration into omental versus subcutaneous fat across different populations: effect of regional adiposity and the comorbidities of obesity

1 reference

12 December 2020

A crucial role for adipose tissue p53 in the regulation of insulin resistance

1 reference

12 December 2020

Vitamin E reduces adipose tissue fibrosis, inflammation, and oxidative stress and improves metabolic profile in obesity

1 reference

12 December 2020

Identifiers

DOI

10.1172/JCI88883

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28045400%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28045400%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

1 reference