(Q50057687)

24 February 2018

review article

1 reference

title

Transcription regulation by the Mediator complex. (English)

1 reference

24 February 2018

author

Julie Soutourina

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29209056%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

author name string

Julie Soutourina

series ordinal

1

1 reference

24 February 2018

publication date

6 December 2017

1 reference

24 February 2018

Nature Reviews Molecular Cell Biology

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29209056%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

volume

19

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29209056%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

issue

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29209056%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

page(s)

262-274

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29209056%20AND%20SRC:MED&resulttype=core&format=json

https://scigraph.springernature.com/pub.10.1038/nrm.2017.115

11 June 2020

exact match

0 references

cites work

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Direct interaction of RNA polymerase II and mediator required for transcription in vivo.

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General requirement for RNA polymerase II holoenzymes in vivo

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The TRAP100 component of the TRAP/Mediator complex is essential in broad transcriptional events and development

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Involvement of the TRAP220 component of the TRAP/SMCC coactivator complex in embryonic development and thyroid hormone action

21 January 2018

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Transcription control by E1A and MAP kinase pathway via Sur2 mediator subunit

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Ubiquitous expression and embryonic requirement for RNA polymerase II coactivator subunit Srb7 in mice

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Cdk8 is essential for preimplantation mouse development

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The metazoan Mediator co-activator complex as an integrative hub for transcriptional regulation

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Genome-wide structure and organization of eukaryotic pre-initiation complexes

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The Mediator complex and transcription regulation

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Mediator head module structure and functional interactions

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Mediator-dependent recruitment of TFIIH modules in preinitiation complex

21 January 2018

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Mediator independently orchestrates multiple steps of preinitiation complex assembly in vivo

21 January 2018

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Functional interplay between Mediator and TFIIB in preinitiation complex assembly in relation to promoter architecture

21 January 2018

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TFIID and human mediator coactivator complexes assemble cooperatively on promoter DNA

21 January 2018

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Structure and TBP binding of the Mediator head subcomplex Med8-Med18-Med20.

21 January 2018

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Human mediator subunit MED26 functions as a docking site for transcription elongation factors

21 January 2018

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A multiprotein mediator of transcriptional activation and its interaction with the C-terminal repeat domain of RNA polymerase II.

21 January 2018

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The Mediator complex: a central integrator of transcription

21 January 2018

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Comparative genomics supports a deep evolutionary origin for the large, four-module transcriptional mediator complex

21 January 2018

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Mediator and the mechanism of transcriptional activation

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Subunit architecture and functional modular rearrangements of the transcriptional mediator complex

21 January 2018

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Redefining the modular organization of the core Mediator complex

21 January 2018

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Reconstitution of active human core Mediator complex reveals a critical role of the MED14 subunit

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRM.2017.115

Architecture of the RNA polymerase II-Mediator core initiation complex

21 January 2018

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A structural perspective on Mediator function

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRM.2017.115

Architecture of the Mediator head module

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRM.2017.115

Structure of the Mediator head module

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRM.2017.115

Structure of the Mediator Head module bound to the carboxy-terminal domain of RNA polymerase II

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRM.2017.115

Core Mediator structure at 3.4 Å extends model of transcription initiation complex

21 January 2018

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Molecular architecture of the yeast Mediator complex

21 January 2018

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Structure of a Complete Mediator-RNA Polymerase II Pre-Initiation Complex

21 January 2018

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Mediator structure and rearrangements required for holoenzyme formation.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRM.2017.115

Role for the MED21-MED7 Hinge in Assembly of the Mediator-RNA Polymerase II Holoenzyme

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRM.2017.115

The human CDK8 subcomplex is a molecular switch that controls Mediator coactivator function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.115

A conserved Mediator-CDK8 kinase module association regulates Mediator-RNA polymerase II interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.115

The Ras/PKA signaling pathway directly targets the Srb9 protein, a component of the general RNA polymerase II transcription apparatus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.115

The SCF-Fbw7 ubiquitin ligase degrades MED13 and MED13L and regulates CDK8 module association with Mediator

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.115

Proteomic analysis of coregulators bound to ERα on DNA and nucleosomes reveals coregulator dynamics

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.115

Suppression of Mediator is regulated by Cdk8-dependent Grr1 turnover of the Med3 coactivator

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.115

The S. cerevisiae SUMO stress response is a conjugation-deconjugation cycle that targets the transcription machinery

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.115

Mediator phosphorylation prevents stress response transcription during non-stress conditions

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRM.2017.115

Mediator expression profiling epistasis reveals a signal transduction pathway with antagonistic submodules and highly specific downstream targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.115

Opposing effects of Elk-1 multisite phosphorylation shape its response to ERK activation

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRM.2017.115

Genome-wide location of the coactivator mediator: Binding without activation and transient Cdk8 interaction on DNA.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRM.2017.115

Mediator links transcription and DNA repair by facilitating Rad2/XPG recruitment

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.115

Mediator and cohesin connect gene expression and chromatin architecture

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.115

A comprehensive genomic binding map of gene and chromatin regulatory proteins in Saccharomyces

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.115

The Cyc8-Tup1 complex inhibits transcription primarily by masking the activation domain of the recruiting protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.115

Mediator complex association with constitutively transcribed genes in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.115

Association of the Mediator complex with enhancers of active genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.115

Selective inhibition of tumor oncogenes by disruption of super-enhancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.115

Master transcription factors and mediator establish super-enhancers at key cell identity genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.115

Kin28 regulates the transient association of Mediator with core promoters

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.115

TFIIH phosphorylation of the Pol II CTD stimulates mediator dissociation from the preinitiation complex and promoter escape.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.115

Mediator binding to UASs is broadly uncoupled from transcription and cooperative with TFIID recruitment to promoters.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.115

Tail and Kinase Modules Differently Regulate Core Mediator Recruitment and Function In Vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.115

Mediator Undergoes a Compositional Change during Transcriptional Activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.115

Activating RNAs associate with Mediator to enhance chromatin architecture and transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.115

Functional roles of enhancer RNAs for oestrogen-dependent transcriptional activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.115

Structural and functional characterization of PC2 and RNA polymerase II-associated subpopulations of metazoan Mediator

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.115

PARP-1 determines specificity in a retinoid signaling pathway via direct modulation of mediator

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.115

Thyroid hormone-induced juxtaposition of regulatory elements/factors and chromatin remodeling of Crabp1 dependent on MED1/TRAP220.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.115

Spatial and temporal recruitment of androgen receptor and its coactivators involves chromosomal looping and polymerase tracking

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.115

Intermediates in formation and activity of the RNA polymerase II preinitiation complex: holoenzyme recruitment and a postrecruitment role for the TATA box and TFIIB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.115

Mediator, TATA-binding protein, and RNA polymerase II contribute to low histone occupancy at active gene promoters in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.115

Role of Mediator in regulating Pol II elongation and nucleosome displacement in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.115

Med5(Nut1) and Med17(Srb4) are direct targets of mediator histone H4 tail interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.115

Mediator-nucleosome interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.115

Mediator-regulated transcription through the +1 nucleosome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.115

Histone modifications influence mediator interactions with chromatin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.115

An RNA polymerase II holoenzyme responsive to activators

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.115

A multisubunit complex associated with the RNA polymerase II CTD and TATA-binding protein in yeast.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.115

Activator-independent functions of the yeast mediator sin4 complex in preinitiation complex formation and transcription reinitiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.115

Protein characterization of Saccharomyces cerevisiae RNA polymerase II after in vivo cross-linking

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.115

Molecular architecture of the human Mediator-RNA polymerase II-TFIIF assembly

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.115

Requirement of TRAP/mediator for both activator-independent and activator-dependent transcription in conjunction with TFIID-associated TAF(II)s

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.115

Binding of TBP to promoters in vivo is stimulated by activators and requires Pol II holoenzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.115

Human Mediator enhances basal transcription by facilitating recruitment of transcription factor IIB during preinitiation complex assembly

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.115

Nucleosome positioning and gene regulation: advances through genomics

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.115

Understanding nucleosome dynamics and their links to gene expression and DNA replication

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.115

Dynamics of Replication-Independent Histone Turnover in Budding Yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.115

Proteomic analysis demonstrates activator- and chromatin-specific recruitment to promoters.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.115

Chromatin potentiates transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.115

TFIIS elongation factor and Mediator act in conjunction during transcription initiation in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.115

The transcription elongation factor TFIIS is a component of RNA polymerase II preinitiation complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.115

The RNA polymerase II CTD coordinates transcription and RNA processing.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.115

Dynamic Encounters of Genes and Transcripts with the Nuclear Pore.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.115

Coupling mRNA processing with transcription in time and space.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.115

Structural basis for binding the TREX2 complex to nuclear pores, GAL1 localisation and mRNA export

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.115

The Nuclear Pore-Associated TREX-2 Complex Employs Mediator to Regulate Gene Expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.115

Mapping Nucleosome Resolution Chromosome Folding in Yeast by Micro-C

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.115

Mechanisms of epigenetic memory

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.115

Epigenetic transcriptional memory

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.115

Set1/COMPASS and Mediator are repurposed to promote epigenetic transcriptional memory

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.115

The cyclin-dependent kinase 8 module sterically blocks Mediator interactions with RNA polymerase II.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.115

Human CRSP interacts with RNA polymerase II CTD and adopts a specific CTD-bound conformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.115

H2A.Z-mediated localization of genes at the nuclear periphery confers epigenetic memory of previous transcriptional state

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.115

Interaction of a DNA zip code with the nuclear pore complex promotes H2A.Z incorporation and INO1 transcriptional memory

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.115

Mediator and human disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.115

Mediator kinase inhibition further activates super-enhancer-associated genes in AML

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.115

Inhibiting fungal multidrug resistance by disrupting an activator-Mediator interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.115

CDK8 is a colorectal cancer oncogene that regulates beta-catenin activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.115

Super-enhancers in the control of cell identity and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.115

Identification of Mediator Kinase Substrates in Human Cells using Cortistatin A and Quantitative Phosphoproteomics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.115

The Acidic Transcription Activator Gcn4 Binds the Mediator Subunit Gal11/Med15 Using a Simple Protein Interface Forming a Fuzzy Complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.115

A nuclear receptor-like pathway regulating multidrug resistance in fungi

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.115

A sequence-specific transcription activator motif and powerful synthetic variants that bind Mediator using a fuzzy protein interface

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.115

TRAP/SMCC/mediator-dependent transcriptional activation from DNA and chromatin templates by orphan nuclear receptor hepatocyte nuclear factor 4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.115

Mediator requirement for both recruitment and postrecruitment steps in transcription initiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.115

A single-molecule view of transcription reveals convoys of RNA polymerases and multi-scale bursting

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.115

A mediator required for activation of RNA polymerase II transcription in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.115

A unified nomenclature for protein subunits of mediator complexes linking transcriptional regulators to RNA polymerase II

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.115

Evolution of disorder in Mediator complex and its functional relevance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.115

Malleable machines in transcription regulation: the mediator complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.115

Biomolecular condensates: organizers of cellular biochemistry

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.115

A Phase Separation Model for Transcriptional Control.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.115

Model of the Mediator middle module based on protein cross-linking.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.115

Evolution of protein complexes by duplication of homomeric interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.115

Mediator head subcomplex Med11/22 contains a common helix bundle building block with a specific function in transcription initiation complex stabilization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.115

A recurrent mutation in MED12 leading to R961W causes Opitz-Kaveggia syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.115

The original Lujan syndrome family has a novel missense mutation (p.N1007S) in the MED12 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.115

Infantile cerebral and cerebellar atrophy is associated with a mutation in the MED17 subunit of the transcription preinitiation mediator complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.115

MED23 mutation links intellectual disability to dysregulation of immediate early gene expression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.115

MED29, a component of the mediator complex, possesses both oncogenic and tumor suppressive characteristics in pancreatic cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.115

A coregulatory role for the mediator complex in prostate cancer cell proliferation and gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.115

Lentivirus-mediated inhibition of Med19 suppresses growth of breast cancer cells in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.115

Mammalian Srb/Mediator complex is targeted by adenovirus E1A protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.115

Identification of host proteins required for HIV infection through a functional genomic screen

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.115

Host cell factors in HIV replication: meta-analysis of genome-wide studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.115

Principal role of TRAP/mediator and SWI/SNF complexes in Kaposi's sarcoma-associated herpesvirus RTA-mediated lytic reactivation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.115

Structure of the VP16 transactivator target in the Mediator

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.115

A novel docking site on Mediator is critical for activation by VP16 in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.115

Structure and VP16 binding of the Mediator Med25 activator interaction domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.115

Eukaryotic Transcription Regulation: Getting to the Heart of the Matter: Commentary on Mediator Architecture and RNA Polymerase II Function by Plaschka et al.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.115

A transcription reinitiation intermediate that is stabilized by activator

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.115

Enhancement of TBP binding by activators and general transcription factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.115

A novel transcription factor reveals a functional link between the RNA polymerase II CTD and TFIID.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.115

Structure of the yeast RNA polymerase II holoenzyme: Mediator conformation and polymerase interaction

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.115

The structural and functional organization of the yeast mediator complex

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.115

Purification of a plant mediator from Arabidopsis thaliana identifies PFT1 as the Med25 subunit

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2017.115

Intragenic and extragenic suppressors of mutations in the heptapeptide repeat domain of Saccharomyces cerevisiae RNA polymerase II

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/29209056

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Involvement of Mediator complex in malignancy.

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/29209056

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NRM.2017.115

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29209056%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

1 reference