(Q50724133)

18 March 2018

title

The EMT-activator Zeb1 is a key factor for cell plasticity and promotes metastasis in pancreatic cancer. (English)

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18 March 2018

author

Hauke Busch

6

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18 March 2018

Christian Pilarsky

12

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18 March 2018

Melanie Boerries

5

object named as

Melanie Boerries

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18 March 2018

author name string

Angela M Krebs

1

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18 March 2018

Julia Mitschke

2

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18 March 2018

María Lasierra Losada

3

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18 March 2018

Otto Schmalhofer

4

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18 March 2018

Martin Boettcher

7

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18 March 2018

Dimitrios Mougiakakos

8

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18 March 2018

Wilfried Reichardt

9

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18 March 2018

Peter Bronsert

10

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18 March 2018

Valerie G Brunton

11

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18 March 2018

Thomas H Winkler

13

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18 March 2018

Simone Brabletz

14

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18 March 2018

Marc P Stemmler

15

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18 March 2018

Thomas Brabletz

16

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18 March 2018

publication date

17 April 2017

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18 March 2018

published in

Nature Cell Biology

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18 March 2018

volume

19

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18 March 2018

issue

5

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18 March 2018

page(s)

518-529

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18 March 2018

The basics of epithelial-mesenchymal transition

cites work

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21 January 2018

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The ZEB/miR-200 feedback loop--a motor of cellular plasticity in development and cancer?

21 January 2018

1 reference

The role of the ZEB family of transcription factors in development and disease.

21 January 2018

1 reference

ZEB1: at the crossroads of epithelial-mesenchymal transition, metastasis and therapy resistance

21 January 2018

1 reference

Epithelial-to-mesenchymal transition is not required for lung metastasis but contributes to chemoresistance

21 January 2018

1 reference

Epithelial-to-mesenchymal transition is dispensable for metastasis but induces chemoresistance in pancreatic cancer.

21 January 2018

1 reference

Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice

21 January 2018

1 reference

EMT and dissemination precede pancreatic tumor formation

21 January 2018

1 reference

Impairment of T cell development in deltaEF1 mutant mice

21 January 2018

1 reference

Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression

21 January 2018

1 reference

The activated stroma index is a novel and independent prognostic marker in pancreatic ductal adenocarcinoma

21 January 2018

1 reference

Depletion of carcinoma-associated fibroblasts and fibrosis induces immunosuppression and accelerates pancreas cancer with reduced survival

21 January 2018

1 reference

Stromal elements act to restrain, rather than support, pancreatic ductal adenocarcinoma

21 January 2018

1 reference

Spatiotemporal regulation of epithelial-mesenchymal transition is essential for squamous cell carcinoma metastasis

21 January 2018

1 reference

Metastatic colonization requires the repression of the epithelial-mesenchymal transition inducer Prrx1.

21 January 2018

1 reference

Direct targeting of Sec23a by miR-200s influences cancer cell secretome and promotes metastatic colonization

21 January 2018

1 reference

Concise Review: Stem Cells in Pancreatic Cancer: From Concept to Translation

21 January 2018

1 reference

Zeb1 regulates E-cadherin and Epcam (epithelial cell adhesion molecule) expression to control cell behavior in early zebrafish development

21 January 2018

1 reference

Cancer stem cell marker phenotypes are reversible and functionally homogeneous in a preclinical model of pancreatic cancer

21 January 2018

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The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs

21 January 2018

1 reference

SOX2 promotes dedifferentiation and imparts stem cell-like features to pancreatic cancer cells

21 January 2018

1 reference

Histopathologic evaluation of stepwise progression of pancreatic carcinoma with immunohistochemical analysis of gastric epithelial transcription factor SOX2: comparison of expression patterns between invasive components and cancerous or nonneoplasti

21 January 2018

1 reference

Antithetical NFATc1-Sox2 and p53-miR200 signaling networks govern pancreatic cancer cell plasticity

21 January 2018

1 reference

Mutant p53 in cancer: new functions and therapeutic opportunities

21 January 2018

1 reference

p53 orchestrates between normal differentiation and cancer.

21 January 2018

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Mutant p53 drives metastasis and overcomes growth arrest/senescence in pancreatic cancer

21 January 2018

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ZEB1 turns into a transcriptional activator by interacting with YAP1 in aggressive cancer types

21 January 2018

1 reference

The EMT-activator ZEB1 induces bone metastasis associated genes including BMP-inhibitors

21 January 2018

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The ZEB1/miR-200 feedback loop controls Notch signalling in cancer cells.

21 January 2018

1 reference

A gene expression signature associated with "K-Ras addiction" reveals regulators of EMT and tumor cell survival

21 January 2018

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Gene expression profile of metastatic human pancreatic cancer cells depends on the organ microenvironment

21 January 2018

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Subtypes of pancreatic ductal adenocarcinoma and their differing responses to therapy

21 January 2018

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Mutant p53 drives pancreatic cancer metastasis through cell-autonomous PDGF receptor β signaling

21 January 2018

1 reference

Epithelial-mesenchymal transition (EMT) and metastasis: yes, no, maybe?

21 January 2018

1 reference

Epithelial-Mesenchymal Plasticity: A Central Regulator of Cancer Progression

21 January 2018

1 reference

Transforming growth factor β as regulator of cancer stemness and metastasis

21 January 2018

1 reference

Targeting the transforming growth factor-beta signalling pathway in metastatic cancer

21 January 2018

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Metabolic Plasticity as a Determinant of Tumor Growth and Metastasis

21 January 2018

1 reference

Epithelial plasticity: a common theme in embryonic and cancer cells.

21 January 2018

1 reference

Variable beta-catenin expression in colorectal cancers indicates tumor progression driven by the tumor environment

21 January 2018

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Normal and neoplastic nonstem cells can spontaneously convert to a stem-like state

21 January 2018

1 reference

Oncogenic roles of EMT-inducing transcription factors

21 January 2018

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Poised chromatin at the ZEB1 promoter enables breast cancer cell plasticity and enhances tumorigenicity

21 January 2018

1 reference

YAP1 and TAZ Control Pancreatic Cancer Initiation in Mice by Direct Up-regulation of JAK-STAT3 Signaling

21 January 2018

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Downstream of mutant KRAS, the transcription regulator YAP is essential for neoplastic progression to pancreatic ductal adenocarcinoma

21 January 2018

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Virtual microdissection identifies distinct tumor- and stroma-specific subtypes of pancreatic ductal adenocarcinoma.

21 January 2018

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Expression of E-cadherin repressors SNAIL, ZEB1 and ZEB2 by tumour and stromal cells influences tumour-budding phenotype and suggests heterogeneity of stromal cells in pancreatic cancer

21 January 2018

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Prognostic significance of Zinc finger E-box binding homeobox 1 (ZEB1) expression in cancer cells and cancer-associated fibroblasts in pancreatic head cancer.

21 January 2018

1 reference

EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer

21 January 2018

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Oncogenic KRAS signalling in pancreatic cancer

21 January 2018

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Snail1-dependent p53 repression regulates expansion and activity of tumour-initiating cells in breast cancer

21 January 2018

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Metastasis as an evolutionary process

21 January 2018

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A switch in the expression of embryonic EMT-inducers drives the development of malignant melanoma.

21 January 2018

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Identification of a ZEB2-MITF-ZEB1 transcriptional network that controls melanogenesis and melanoma progression

21 January 2018

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Distinct EMT programs control normal mammary stem cells and tumour-initiating cells

21 January 2018

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Sox4 is a master regulator of epithelial-mesenchymal transition by controlling Ezh2 expression and epigenetic reprogramming

21 January 2018

1 reference

Transient SNAIL1 expression is necessary for metastatic competence in breast cancer

21 January 2018

1 reference

Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras

21 January 2018

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Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse

21 January 2018

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ZEB1-associated drug resistance in cancer cells is reversed by the class I HDAC inhibitor mocetinostat.

21 January 2018

1 reference

beadarray: R classes and methods for Illumina bead-based data.

21 January 2018

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Adjusting batch effects in microarray expression data using empirical Bayes methods

21 January 2018

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To differentiate or not--routes towards metastasis

21 January 2018

1 reference

7 January 2021

Generation and characterization of mice for conditional inactivation of Zeb1.

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7 January 2021

GATA6 regulates EMT and tumour dissemination, and is a marker of response to adjuvant chemotherapy in pancreatic cancer

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7 January 2021

Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome

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7 January 2021

Conditional expression of oncogenic K-ras from its endogenous promoter induces a myeloproliferative disease

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7 January 2021

Generation of a Snail1 (Snai1) conditional null allele

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7 January 2021

Z/EG, a double reporter mouse line that expresses enhanced green fluorescent protein upon Cre-mediated excision

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PubMed

https://pubmed.ncbi.nlm.nih.gov/28414315

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1038/NCB3513

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18 March 2018

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18 March 2018